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The map label for this gene is mcpA [H]

Identifier: 99081817

GI number: 99081817

Start: 2081321

End: 2082778

Strand: Reverse

Name: mcpA [H]

Synonym: TM1040_1977

Alternate gene names: 99081817

Gene position: 2082778-2081321 (Counterclockwise)

Preceding gene: 99081819

Following gene: 99081812

Centisome position: 65.07

GC content: 60.7

Gene sequence:

>1458_bases
ATGACATTTGATATGAACGCATTACTCGCGACCTACGATCTGGACGGCGCCAATCAGGCGCTGCTTCAAAAACGGGCCAA
GATGATCCTTGGGCTTTTGCCGGAGGTTCTCGACCACTTTTATGACCGCGTCGGACGTGAGCCGGAGATGGCCGCGTTTT
TTAAGACCGAAGCCATGATGGAGCGTGCCAAGGGCGAGCAACTCCAACACTGGTCGCGCCTGTTTTCGGGCGACTTTGGC
GAGGACTATATCCAGTCCGCGCGCAACATCGGTCGGGTTCATACCCGCATCGGGCTGCCGTTCTCCTTTTTCAATGCGGG
CTATGCCCATGCCAATGCGCATATCCAAGCGCTGATACTCAAGCGCCATTCGGGCGGTTTGATGCGGCGCGCGACCGAAA
CACATGCGCTGCTTGGGGTTCTGTCGCGAGCCATGGCGCTCGATATACAGTTGATCTTCGACGCCCATGCCGAGGCGATG
CAGGAGGAGCATACGCGCGGCGTGCGCTATATCACCGAGGCGATCGAAGCGCTGGCAGCGCAGGATCTGAGCCATGAAAT
GCCGTCGGCACAAACTGGCGATTTCCCATCGGAATTCAACGGCGTGCGCGAGAGTCTCAATGCGGCCTTTGGCGCGCTGC
GTCAGGTGATCCAGGGAATCCGCAGCACTGCGCAGCAATTGGACACCGGAGCCGCCGAGGTGTCACATGCCTCGCAGGAT
TTGTCCCAACGCACGGAATCCCAGGCCGCGACACTTGAGGAAACCACCGCGGCGGTGGAGGAGATCACTGTCAGCATGCG
CGCCTCTGCCGAGGCCACGCAGCAGACCCGAAACGCGGTCGATACCACTCGCAGACGGGCCGAGGAAGGCAGCGCCGTGG
TGCGCAATGCGGTTGAAAAGATGAACGAGATCGCGGACTCCTCAGTCCAGATTTCCAAGATCATCTCCATCATCGATGAC
ATTTCGTTCCAGACCAACCTGTTGGCGCTGAATGCCGGGGTGGAGGCTGCGCGCGCCGGCGAAAGCGGGCGGGGCTTTGC
GGTGGTGGCCTCGGAGGTGCGCAATCTTGCGCAGCGCACGGCTGATTCCGCCGCCGAAATCAAAGGGCTGATCGACATCA
GCAACGATCACGTCGAAAGCGGCGTCGAACTGGTCGGCAATGCGGGTCGGATGCTGGAGAGCATCGTGCGCCACATCAAG
GAAGCCTCCGAACTGACAGAGCAGGTCGCAAGCGCCGCCGAGCAGCAATCGACCGCTTTTGGAGAGATCAATATCGGGAT
GTCCCAGCTCGACACGGTGACCCAGCAAAATGCCGCGATGGTAGAACAGAGCACGGCAGCGCTTGTGGAGATGCGCAACG
ACGCCTCTGCGCTCAACGCTCTGGTTGAAGTGTTTCGGCTGCGGGCAGGGGAGCAAGGGGGCGGCGGACAGGAGATCGCG
CTGCGTGCCGCAAGCTAG

Upstream 100 bases:

>100_bases
ATTTCGTTTGGATCTTCTCCATAACGCTCATGCCCCATATCCCAGACTTTATCGGTAATCTTACGAACGCTGGGTGGGAG
TTGCTGCGGAGGAGTAGCTT

Downstream 100 bases:

>100_bases
TCCCAGTTAGATATGAAACAGAAAAGGCCGCAGCAAAAACTGCGGCCTTTGCGCTTCTTTCAGGCTCGGCGCTTAGAGCG
AGGCGTTATAGATCTTGTCG

Product: methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: Methyl-accepting chemotaxis protein [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MTFDMNALLATYDLDGANQALLQKRAKMILGLLPEVLDHFYDRVGREPEMAAFFKTEAMMERAKGEQLQHWSRLFSGDFG
EDYIQSARNIGRVHTRIGLPFSFFNAGYAHANAHIQALILKRHSGGLMRRATETHALLGVLSRAMALDIQLIFDAHAEAM
QEEHTRGVRYITEAIEALAAQDLSHEMPSAQTGDFPSEFNGVRESLNAAFGALRQVIQGIRSTAQQLDTGAAEVSHASQD
LSQRTESQAATLEETTAAVEEITVSMRASAEATQQTRNAVDTTRRRAEEGSAVVRNAVEKMNEIADSSVQISKIISIIDD
ISFQTNLLALNAGVEAARAGESGRGFAVVASEVRNLAQRTADSAAEIKGLIDISNDHVESGVELVGNAGRMLESIVRHIK
EASELTEQVASAAEQQSTAFGEINIGMSQLDTVTQQNAAMVEQSTAALVEMRNDASALNALVEVFRLRAGEQGGGGQEIA
LRAAS

Sequences:

>Translated_485_residues
MTFDMNALLATYDLDGANQALLQKRAKMILGLLPEVLDHFYDRVGREPEMAAFFKTEAMMERAKGEQLQHWSRLFSGDFG
EDYIQSARNIGRVHTRIGLPFSFFNAGYAHANAHIQALILKRHSGGLMRRATETHALLGVLSRAMALDIQLIFDAHAEAM
QEEHTRGVRYITEAIEALAAQDLSHEMPSAQTGDFPSEFNGVRESLNAAFGALRQVIQGIRSTAQQLDTGAAEVSHASQD
LSQRTESQAATLEETTAAVEEITVSMRASAEATQQTRNAVDTTRRRAEEGSAVVRNAVEKMNEIADSSVQISKIISIIDD
ISFQTNLLALNAGVEAARAGESGRGFAVVASEVRNLAQRTADSAAEIKGLIDISNDHVESGVELVGNAGRMLESIVRHIK
EASELTEQVASAAEQQSTAFGEINIGMSQLDTVTQQNAAMVEQSTAALVEMRNDASALNALVEVFRLRAGEQGGGGQEIA
LRAAS
>Mature_484_residues
TFDMNALLATYDLDGANQALLQKRAKMILGLLPEVLDHFYDRVGREPEMAAFFKTEAMMERAKGEQLQHWSRLFSGDFGE
DYIQSARNIGRVHTRIGLPFSFFNAGYAHANAHIQALILKRHSGGLMRRATETHALLGVLSRAMALDIQLIFDAHAEAMQ
EEHTRGVRYITEAIEALAAQDLSHEMPSAQTGDFPSEFNGVRESLNAAFGALRQVIQGIRSTAQQLDTGAAEVSHASQDL
SQRTESQAATLEETTAAVEEITVSMRASAEATQQTRNAVDTTRRRAEEGSAVVRNAVEKMNEIADSSVQISKIISIIDDI
SFQTNLLALNAGVEAARAGESGRGFAVVASEVRNLAQRTADSAAEIKGLIDISNDHVESGVELVGNAGRMLESIVRHIKE
ASELTEQVASAAEQQSTAFGEINIGMSQLDTVTQQNAAMVEQSTAALVEMRNDASALNALVEVFRLRAGEQGGGGQEIAL
RAAS

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein. Note=Localized at the flagellum-bearing pole of the swarmer cell [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788194, Length=271, Percent_Identity=42.8044280442804, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI1787690, Length=323, Percent_Identity=36.5325077399381, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI2367378, Length=332, Percent_Identity=39.7590361445783, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1788195, Length=278, Percent_Identity=42.4460431654676, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1789453, Length=253, Percent_Identity=34.7826086956522, Blast_Score=154, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 52454; Mature: 52323

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFDMNALLATYDLDGANQALLQKRAKMILGLLPEVLDHFYDRVGREPEMAAFFKTEAMM
CCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ERAKGEQLQHWSRLFSGDFGEDYIQSARNIGRVHTRIGLPFSFFNAGYAHANAHIQALIL
HHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHEE
KRHSGGLMRRATETHALLGVLSRAMALDIQLIFDAHAEAMQEEHTRGVRYITEAIEALAA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDLSHEMPSAQTGDFPSEFNGVRESLNAAFGALRQVIQGIRSTAQQLDTGAAEVSHASQD
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LSQRTESQAATLEETTAAVEEITVSMRASAEATQQTRNAVDTTRRRAEEGSAVVRNAVEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNEIADSSVQISKIISIIDDISFQTNLLALNAGVEAARAGESGRGFAVVASEVRNLAQRT
HHHHHCCHHHHHHHHHHHHHCCHHHCEEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHH
ADSAAEIKGLIDISNDHVESGVELVGNAGRMLESIVRHIKEASELTEQVASAAEQQSTAF
CCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GEINIGMSQLDTVTQQNAAMVEQSTAALVEMRNDASALNALVEVFRLRAGEQGGGGQEIA
CEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
LRAAS
EEECC
>Mature Secondary Structure 
TFDMNALLATYDLDGANQALLQKRAKMILGLLPEVLDHFYDRVGREPEMAAFFKTEAMM
CCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ERAKGEQLQHWSRLFSGDFGEDYIQSARNIGRVHTRIGLPFSFFNAGYAHANAHIQALIL
HHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHEE
KRHSGGLMRRATETHALLGVLSRAMALDIQLIFDAHAEAMQEEHTRGVRYITEAIEALAA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDLSHEMPSAQTGDFPSEFNGVRESLNAAFGALRQVIQGIRSTAQQLDTGAAEVSHASQD
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LSQRTESQAATLEETTAAVEEITVSMRASAEATQQTRNAVDTTRRRAEEGSAVVRNAVEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNEIADSSVQISKIISIIDDISFQTNLLALNAGVEAARAGESGRGFAVVASEVRNLAQRT
HHHHHCCHHHHHHHHHHHHHCCHHHCEEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHH
ADSAAEIKGLIDISNDHVESGVELVGNAGRMLESIVRHIKEASELTEQVASAAEQQSTAF
CCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GEINIGMSQLDTVTQQNAAMVEQSTAALVEMRNDASALNALVEVFRLRAGEQGGGGQEIA
CEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
LRAAS
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1577276; 11259647 [H]