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The map label for this gene is degP [H]

Identifier: 99081793

GI number: 99081793

Start: 2056616

End: 2058115

Strand: Reverse

Name: degP [H]

Synonym: TM1040_1953

Alternate gene names: 99081793

Gene position: 2058115-2056616 (Counterclockwise)

Preceding gene: 99081795

Following gene: 99081789

Centisome position: 64.3

GC content: 62.53

Gene sequence:

>1500_bases
GTGCATCCAATCTCATCATCCAAGGCAATAGGCCGTGCGCGCGTCCATGAGGGGGCGCACAGCGGCTGGCGCTTGTTCTG
GATCAGCGTCCTCGGGACCGCGCTGTTGGTCATGCAGTCGCTTTCGGCGGCGGCCCGTCCCGAAAGCCTCGCGCCACTGG
CCGAAAAAGTCAGCCCGGCGGTGGTCAATATCACCACGTCGACCGTGGTCGAGGGCCGCACTGGCCCGCAGGGGATCGTG
CCCGAGGGCTCCCCGTTTGAGGATTTCTTTCGCGAGTTCCAGGACCGCAACGGCGGCGGCACGCGGCCACGTCGTTCCTC
GGCGCTTGGCTCGGGGTTCGTGATCTCGGAAGACGGCTACATCGTCACCAACAACCATGTGATCGAGGGGGCTGACGAGA
TCGAAATCGAGTTCTTCCCCGGTGAAGGCCAGCCTGCTGACCTGCTGCCAGCCACTGTTGTTGGCACCGATCCCAACACC
GATATTGCGCTGTTGAAAGTGGACGCGCCGATGCCGCTGAGCTTTGTGAAGTTCGGTGACAGCGACAAGGCGCGCGTGGG
CGACTGGGTTGTCGCCATGGGTAACCCGCTGGGGCAGGGATTTTCGCTCTCGGCAGGGATCGTATCTGCACGCAACCGGG
CGCTTTCGGGCTCTTATGACGACTACATTCAGACCGATGCGGCCATCAACCGTGGCAACTCGGGCGGTCCACTCTTTAAC
ATGGATGGCGAAGTCGTTGGCGTGAACACCGCAATCCTGTCGCCGAACGGCGGCTCCATCGGGATCGGCTTCTCCATGGC
GTCAAATGTAGTGACCAAAGTGGTGAGCCAGCTCAAGGAGTTCGGGGAAACCCGCCGGGGTTGGCTTGGCGTGCGCATTC
AGGACGTCACCGATGATCTGGCCGAAGCGATCGGGCTGGCGAGCGACGAAGGTGTGCTGATCACCGATGTCCCCGAAGGT
CCCGCCAAAGAGGCTGGTCTCCTGGCACGCGACGTCATCACCAGCTTTGACGGGTTTGAGGTGAAAGACACCCGCGATCT
CGTGCGTCGCGTGGGCGACACCGAAGTCGGCAAGACCGTGCGTGTCGTGGTGTTCCGCGATGGCAAAACCGAGACGATCC
GCGTCACGCTGGGACGTCGCGAAGATGCGGTGGGCAACGGCACCGAAGGTGGCGGCGCTGAAGCCGTTCCGGATGAAGGC
GAAAAAGAGCTCCTCGGGCTGACCGTGGGCGTTGTGCGCGACGACATGCGCGAGGATCTGAACCTCGATGCGGGCACCAC
TGGTCTGGTGATCCTCTCCGTGGATGAGACCTCTGGCGCGTGGGAAAAAGGTCTGCGTGCAGGCGACGTGATCACTGAGG
CAGGCCAGAACAAGCTCTCTTCGATTGCCGATCTCGAAGCGCAGATCGCCGCTGCCGAAGAAGGCGGCCGCAAATCGATC
TTCCTGATGGTGCGCCGTGCTGGTGAGCCGCGCTTTGTCGCGCTCAATCTTGAGGACTGA

Upstream 100 bases:

>100_bases
CCCGCGTCGGCGTCGCGCCTGAGGCATGGGTGCCCCCTTTCCCCTTTCGCGATGGGGCGGGCGGAGACAGAGTTGACAGG
CCAATTCAAGGAGTATGTCC

Downstream 100 bases:

>100_bases
TCTCGCGTGCCAACGGCATTTGCCTCAAGTCGGGGCATCTAAGAAACAAGACCGGCCGGCCCCAAGGGGTCGGCCGTTTT
CTTGAAAGACAGCACAGAAG

Product: peptidase S1C, Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MHPISSSKAIGRARVHEGAHSGWRLFWISVLGTALLVMQSLSAAARPESLAPLAEKVSPAVVNITTSTVVEGRTGPQGIV
PEGSPFEDFFREFQDRNGGGTRPRRSSALGSGFVISEDGYIVTNNHVIEGADEIEIEFFPGEGQPADLLPATVVGTDPNT
DIALLKVDAPMPLSFVKFGDSDKARVGDWVVAMGNPLGQGFSLSAGIVSARNRALSGSYDDYIQTDAAINRGNSGGPLFN
MDGEVVGVNTAILSPNGGSIGIGFSMASNVVTKVVSQLKEFGETRRGWLGVRIQDVTDDLAEAIGLASDEGVLITDVPEG
PAKEAGLLARDVITSFDGFEVKDTRDLVRRVGDTEVGKTVRVVVFRDGKTETIRVTLGRREDAVGNGTEGGGAEAVPDEG
EKELLGLTVGVVRDDMREDLNLDAGTTGLVILSVDETSGAWEKGLRAGDVITEAGQNKLSSIADLEAQIAAAEEGGRKSI
FLMVRRAGEPRFVALNLED

Sequences:

>Translated_499_residues
MHPISSSKAIGRARVHEGAHSGWRLFWISVLGTALLVMQSLSAAARPESLAPLAEKVSPAVVNITTSTVVEGRTGPQGIV
PEGSPFEDFFREFQDRNGGGTRPRRSSALGSGFVISEDGYIVTNNHVIEGADEIEIEFFPGEGQPADLLPATVVGTDPNT
DIALLKVDAPMPLSFVKFGDSDKARVGDWVVAMGNPLGQGFSLSAGIVSARNRALSGSYDDYIQTDAAINRGNSGGPLFN
MDGEVVGVNTAILSPNGGSIGIGFSMASNVVTKVVSQLKEFGETRRGWLGVRIQDVTDDLAEAIGLASDEGVLITDVPEG
PAKEAGLLARDVITSFDGFEVKDTRDLVRRVGDTEVGKTVRVVVFRDGKTETIRVTLGRREDAVGNGTEGGGAEAVPDEG
EKELLGLTVGVVRDDMREDLNLDAGTTGLVILSVDETSGAWEKGLRAGDVITEAGQNKLSSIADLEAQIAAAEEGGRKSI
FLMVRRAGEPRFVALNLED
>Mature_499_residues
MHPISSSKAIGRARVHEGAHSGWRLFWISVLGTALLVMQSLSAAARPESLAPLAEKVSPAVVNITTSTVVEGRTGPQGIV
PEGSPFEDFFREFQDRNGGGTRPRRSSALGSGFVISEDGYIVTNNHVIEGADEIEIEFFPGEGQPADLLPATVVGTDPNT
DIALLKVDAPMPLSFVKFGDSDKARVGDWVVAMGNPLGQGFSLSAGIVSARNRALSGSYDDYIQTDAAINRGNSGGPLFN
MDGEVVGVNTAILSPNGGSIGIGFSMASNVVTKVVSQLKEFGETRRGWLGVRIQDVTDDLAEAIGLASDEGVLITDVPEG
PAKEAGLLARDVITSFDGFEVKDTRDLVRRVGDTEVGKTVRVVVFRDGKTETIRVTLGRREDAVGNGTEGGGAEAVPDEG
EKELLGLTVGVVRDDMREDLNLDAGTTGLVILSVDETSGAWEKGLRAGDVITEAGQNKLSSIADLEAQIAAAEEGGRKSI
FLMVRRAGEPRFVALNLED

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=323, Percent_Identity=32.5077399380805, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI22129776, Length=258, Percent_Identity=32.1705426356589, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI24308541, Length=257, Percent_Identity=33.852140077821, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI7019477, Length=292, Percent_Identity=34.9315068493151, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1786356, Length=476, Percent_Identity=35.7142857142857, Blast_Score=252, Evalue=3e-68,
Organism=Escherichia coli, GI1789629, Length=449, Percent_Identity=37.4164810690423, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1789630, Length=275, Percent_Identity=35.2727272727273, Blast_Score=150, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24646839, Length=289, Percent_Identity=31.1418685121107, Blast_Score=129, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 52631; Mature: 52631

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPISSSKAIGRARVHEGAHSGWRLFWISVLGTALLVMQSLSAAARPESLAPLAEKVSPA
CCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCE
VVNITTSTVVEGRTGPQGIVPEGSPFEDFFREFQDRNGGGTRPRRSSALGSGFVISEDGY
EEEEEEHEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHCCCCCEEEECCCE
IVTNNHVIEGADEIEIEFFPGEGQPADLLPATVVGTDPNTDIALLKVDAPMPLSFVKFGD
EEECCEEECCCCEEEEEEECCCCCCCCCCCEEEECCCCCCCEEEEEECCCCCEEEEEECC
SDKARVGDWVVAMGNPLGQGFSLSAGIVSARNRALSGSYDDYIQTDAAINRGNSGGPLFN
CCCCCCCCEEEEECCCCCCCEEECCHHHHHCCCCCCCCCHHHHHCCHHHCCCCCCCCEEE
MDGEVVGVNTAILSPNGGSIGIGFSMASNVVTKVVSQLKEFGETRRGWLGVRIQDVTDDL
CCCCEEEEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHHHHHH
AEAIGLASDEGVLITDVPEGPAKEAGLLARDVITSFDGFEVKDTRDLVRRVGDTEVGKTV
HHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEECCHHHHHHHCCCCCCCCEE
RVVVFRDGKTETIRVTLGRREDAVGNGTEGGGAEAVPDEGEKELLGLTVGVVRDDMREDL
EEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHEEHHHHHHHHHHHHC
NLDAGTTGLVILSVDETSGAWEKGLRAGDVITEAGQNKLSSIADLEAQIAAAEEGGRKSI
CCCCCCCEEEEEEECCCCCHHHHCCCCCHHHHHHCHHHHHHHHHHHHHHEECCCCCCCEE
FLMVRRAGEPRFVALNLED
EEEEEECCCCEEEEEEECC
>Mature Secondary Structure
MHPISSSKAIGRARVHEGAHSGWRLFWISVLGTALLVMQSLSAAARPESLAPLAEKVSPA
CCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCE
VVNITTSTVVEGRTGPQGIVPEGSPFEDFFREFQDRNGGGTRPRRSSALGSGFVISEDGY
EEEEEEHEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHCCCCCEEEECCCE
IVTNNHVIEGADEIEIEFFPGEGQPADLLPATVVGTDPNTDIALLKVDAPMPLSFVKFGD
EEECCEEECCCCEEEEEEECCCCCCCCCCCEEEECCCCCCCEEEEEECCCCCEEEEEECC
SDKARVGDWVVAMGNPLGQGFSLSAGIVSARNRALSGSYDDYIQTDAAINRGNSGGPLFN
CCCCCCCCEEEEECCCCCCCEEECCHHHHHCCCCCCCCCHHHHHCCHHHCCCCCCCCEEE
MDGEVVGVNTAILSPNGGSIGIGFSMASNVVTKVVSQLKEFGETRRGWLGVRIQDVTDDL
CCCCEEEEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHHHHHH
AEAIGLASDEGVLITDVPEGPAKEAGLLARDVITSFDGFEVKDTRDLVRRVGDTEVGKTV
HHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEECCHHHHHHHCCCCCCCCEE
RVVVFRDGKTETIRVTLGRREDAVGNGTEGGGAEAVPDEGEKELLGLTVGVVRDDMREDL
EEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHEEHHHHHHHHHHHHC
NLDAGTTGLVILSVDETSGAWEKGLRAGDVITEAGQNKLSSIADLEAQIAAAEEGGRKSI
CCCCCCCEEEEEEECCCCCHHHHCCCCCHHHHHHCHHHHHHHHHHHHHHEECCCCCCCEE
FLMVRRAGEPRFVALNLED
EEEEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]