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The map label for this gene is xseA

Identifier: 99081786

GI number: 99081786

Start: 2048352

End: 2049860

Strand: Reverse

Name: xseA

Synonym: TM1040_1945

Alternate gene names: 99081786

Gene position: 2049860-2048352 (Counterclockwise)

Preceding gene: 99081788

Following gene: 99081784

Centisome position: 64.04

GC content: 64.81

Gene sequence:

>1509_bases
ATGTCCGACCTCCTTGATGATCCAACCCCGGGCCAGAACGCACCGGAGTTTTCCGTCTCCGAGATTTCCGGCGAGGTCAA
ACGCACGCTTGAGGGCACCTTTGGCCGCATCCGCGTGCGGGGCGAGGTCGGGCGTGTGTTCAAGGCGCGCTCCGGTCATC
TTTATTACGACATCAAGGATGATCGCTCGGTGCTGGCCTGCACGACCTGGAAGGGCCAGATTTCGGGACTGTCCGTGGTG
CCCGAAGAAGGGCTTGAGGTGGTGGTGACCGGGCGCCTCACGGCCTTTGGCGGACAATCCAAATACAATATGAATGTCGA
TGAGGTCGCGGTTGCAGGCCAGGGCGCGCTGATGGCGCTCTTGGAAAAGCGCAAGGCGCAACTGGCCGCTGAAGGGCTGT
TTGCACCCGAGCGCAAGAAACCGCTGCCCTATCTGCCGGGGATCATCGGCGTCATCACGTCGCCTTCAGGCGCTGTGATC
CGTGACATCCTGCATCGGCTTCGGGATCGCTTCCCGCGCAAGGTGCTGGTCTGGCCCGTGGCCGTGCAGGGCAGCAACTC
GGCCCCCGAGGTGGCGCGCGCCATCGATGGGTTCAACGCTCTGACGCCCGGCGGCGCCTTGCCCCGGCCGGACCTGATCA
TTGTCGCGCGCGGCGGCGGGTCCATCGAGGACCTCTGGGGTTTTAACGAGGAGATCGTCGCCCGCGCCACCGCCGCAAGT
GACATCCCGCTGATTTCGGCGGTGGGCCATGAGACGGATACCACGCTGATCGACTACGTTTCGGATCTGCGTGCCCCCAC
GCCCACGGCGGCGGCAGAACACGCGGTGCCCGTGCGGCTCGAGTTGTTGGGCTGGGTCGAAAATCAGGGCGCGCGCATGG
CCAATGCCGCCAGCCGCGCGGTGCAGCTGCGCCGCCAGCGGCTCGGAGATATGGCGCGCGCTCTGCCGCGCCCGGATACG
CTCTTGGAAACCCCGCGCCAGCGGCTCGACAGAGTCTCTGACCGGCTGCCCAATGCGCTGATTTCGGGCGTGCAACGGCG
CAAACTCACGCTCAGCGACCGCGCCGCCTCCCTCAGACCCGCCACCCTGCGCGGTCTTGTTTCCAGCCGTCAGGACAAGC
TCAAAAACCTTTCTTCGCGTCTCACCCTACGCCCGATCACTCAGGATCTGGGGCGCAAACGAGACGCGCTGGACCGCATC
ACCAAGCGCCTTAACACTGCCCAAAGCAGCCGCATCGACCGCCAGATTGATCGTCTGTCAGCCACGGCGCGACAGCTTGA
TATTCTGAGCTACAAGGCCACGTTGCGTCGCGGGTATGCTGTGGTGCGCGATGGCGCGGCCCTGGTCACATCCACCGAAG
GCGCCCGGAAGGCCGCTGAACTCTCTATCGAATTTGCTGACGGCACGTTTGATGTCGCCAGCGCCCCCAGCACCACAAAG
AAATCCGCGCCCAAACCGGCGGCCCCGAAGGCGCCCAAAACGCCCGGAGAGCAGGGCTCTCTATTCTGA

Upstream 100 bases:

>100_bases
GCGTCCCATAAACAAGAACACCCTTGCCGGGGGCGCCCTCTGGTGGCAGGTGTCGGAGCCGACACCCCCCTCCTCTGATC
AAACCGGAGCCTTCTTTTCG

Downstream 100 bases:

>100_bases
CAGGCAGGGCTTTCTTCTAACAAAAAATATCCCGGAGCGCGAGGCAGCGCCTCGCTTCTGCGCGGGCCTCAGACGCCGAC
TTCGGGGCCGAGACAAACCA

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MSDLLDDPTPGQNAPEFSVSEISGEVKRTLEGTFGRIRVRGEVGRVFKARSGHLYYDIKDDRSVLACTTWKGQISGLSVV
PEEGLEVVVTGRLTAFGGQSKYNMNVDEVAVAGQGALMALLEKRKAQLAAEGLFAPERKKPLPYLPGIIGVITSPSGAVI
RDILHRLRDRFPRKVLVWPVAVQGSNSAPEVARAIDGFNALTPGGALPRPDLIIVARGGGSIEDLWGFNEEIVARATAAS
DIPLISAVGHETDTTLIDYVSDLRAPTPTAAAEHAVPVRLELLGWVENQGARMANAASRAVQLRRQRLGDMARALPRPDT
LLETPRQRLDRVSDRLPNALISGVQRRKLTLSDRAASLRPATLRGLVSSRQDKLKNLSSRLTLRPITQDLGRKRDALDRI
TKRLNTAQSSRIDRQIDRLSATARQLDILSYKATLRRGYAVVRDGAALVTSTEGARKAAELSIEFADGTFDVASAPSTTK
KSAPKPAAPKAPKTPGEQGSLF

Sequences:

>Translated_502_residues
MSDLLDDPTPGQNAPEFSVSEISGEVKRTLEGTFGRIRVRGEVGRVFKARSGHLYYDIKDDRSVLACTTWKGQISGLSVV
PEEGLEVVVTGRLTAFGGQSKYNMNVDEVAVAGQGALMALLEKRKAQLAAEGLFAPERKKPLPYLPGIIGVITSPSGAVI
RDILHRLRDRFPRKVLVWPVAVQGSNSAPEVARAIDGFNALTPGGALPRPDLIIVARGGGSIEDLWGFNEEIVARATAAS
DIPLISAVGHETDTTLIDYVSDLRAPTPTAAAEHAVPVRLELLGWVENQGARMANAASRAVQLRRQRLGDMARALPRPDT
LLETPRQRLDRVSDRLPNALISGVQRRKLTLSDRAASLRPATLRGLVSSRQDKLKNLSSRLTLRPITQDLGRKRDALDRI
TKRLNTAQSSRIDRQIDRLSATARQLDILSYKATLRRGYAVVRDGAALVTSTEGARKAAELSIEFADGTFDVASAPSTTK
KSAPKPAAPKAPKTPGEQGSLF
>Mature_501_residues
SDLLDDPTPGQNAPEFSVSEISGEVKRTLEGTFGRIRVRGEVGRVFKARSGHLYYDIKDDRSVLACTTWKGQISGLSVVP
EEGLEVVVTGRLTAFGGQSKYNMNVDEVAVAGQGALMALLEKRKAQLAAEGLFAPERKKPLPYLPGIIGVITSPSGAVIR
DILHRLRDRFPRKVLVWPVAVQGSNSAPEVARAIDGFNALTPGGALPRPDLIIVARGGGSIEDLWGFNEEIVARATAASD
IPLISAVGHETDTTLIDYVSDLRAPTPTAAAEHAVPVRLELLGWVENQGARMANAASRAVQLRRQRLGDMARALPRPDTL
LETPRQRLDRVSDRLPNALISGVQRRKLTLSDRAASLRPATLRGLVSSRQDKLKNLSSRLTLRPITQDLGRKRDALDRIT
KRLNTAQSSRIDRQIDRLSATARQLDILSYKATLRRGYAVVRDGAALVTSTEGARKAAELSIEFADGTFDVASAPSTTKK
SAPKPAAPKAPKTPGEQGSLF

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=340, Percent_Identity=38.2352941176471, Blast_Score=228, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_SILST (Q1GF88)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_613940.1
- STRING:   Q1GF88
- GeneID:   4076896
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_1945
- NMPDR:   fig|292414.1.peg.332
- eggNOG:   COG1570
- HOGENOM:   HBG634411
- OMA:   LVWPVKV
- PhylomeDB:   Q1GF88
- ProtClustDB:   PRK00286
- BioCyc:   SSP292414:TM1040_1945-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L

EC number: =3.1.11.6

Molecular weight: Translated: 54267; Mature: 54136

Theoretical pI: Translated: 10.69; Mature: 10.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLLDDPTPGQNAPEFSVSEISGEVKRTLEGTFGRIRVRGEVGRVFKARSGHLYYDIKD
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHCCCCCCEEEEECC
DRSVLACTTWKGQISGLSVVPEEGLEVVVTGRLTAFGGQSKYNMNVDEVAVAGQGALMAL
CCCEEEEEECCCCCCCEEECCCCCCEEEEEEEEEEECCCCCCCCCHHHHEECCCHHHHHH
LEKRKAQLAAEGLFAPERKKPLPYLPGIIGVITSPSGAVIRDILHRLRDRFPRKVLVWPV
HHHHHHHHHHHCCCCCCCCCCCCCCCCHHHEEECCCCHHHHHHHHHHHHHCCCEEEEEEE
AVQGSNSAPEVARAIDGFNALTPGGALPRPDLIIVARGGGSIEDLWGFNEEIVARATAAS
EEECCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCHHHHHHHHCCC
DIPLISAVGHETDTTLIDYVSDLRAPTPTAAAEHAVPVRLELLGWVENQGARMANAASRA
CCCCHHHCCCCCCHHHHHHHHHHCCCCCCCHHCCCCCEEEEEEHHHHCCCCHHHHHHHHH
VQLRRQRLGDMARALPRPDTLLETPRQRLDRVSDRLPNALISGVQRRKLTLSDRAASLRP
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEHHHHHCCCCH
ATLRGLVSSRQDKLKNLSSRLTLRPITQDLGRKRDALDRITKRLNTAQSSRIDRQIDRLS
HHHHHHHHHHHHHHHHHHHCCEECHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATARQLDILSYKATLRRGYAVVRDGAALVTSTEGARKAAELSIEFADGTFDVASAPSTTK
HHHHHHHHHHHHHHHHHCCEEEECCCEEEECCCCHHHHEEEEEEECCCCEECCCCCCCCC
KSAPKPAAPKAPKTPGEQGSLF
CCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDLLDDPTPGQNAPEFSVSEISGEVKRTLEGTFGRIRVRGEVGRVFKARSGHLYYDIKD
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHCCCCCCEEEEECC
DRSVLACTTWKGQISGLSVVPEEGLEVVVTGRLTAFGGQSKYNMNVDEVAVAGQGALMAL
CCCEEEEEECCCCCCCEEECCCCCCEEEEEEEEEEECCCCCCCCCHHHHEECCCHHHHHH
LEKRKAQLAAEGLFAPERKKPLPYLPGIIGVITSPSGAVIRDILHRLRDRFPRKVLVWPV
HHHHHHHHHHHCCCCCCCCCCCCCCCCHHHEEECCCCHHHHHHHHHHHHHCCCEEEEEEE
AVQGSNSAPEVARAIDGFNALTPGGALPRPDLIIVARGGGSIEDLWGFNEEIVARATAAS
EEECCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCHHHHHHHHCCC
DIPLISAVGHETDTTLIDYVSDLRAPTPTAAAEHAVPVRLELLGWVENQGARMANAASRA
CCCCHHHCCCCCCHHHHHHHHHHCCCCCCCHHCCCCCEEEEEEHHHHCCCCHHHHHHHHH
VQLRRQRLGDMARALPRPDTLLETPRQRLDRVSDRLPNALISGVQRRKLTLSDRAASLRP
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEHHHHHCCCCH
ATLRGLVSSRQDKLKNLSSRLTLRPITQDLGRKRDALDRITKRLNTAQSSRIDRQIDRLS
HHHHHHHHHHHHHHHHHHHCCEECHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATARQLDILSYKATLRRGYAVVRDGAALVTSTEGARKAAELSIEFADGTFDVASAPSTTK
HHHHHHHHHHHHHHHHHCCEEEECCCEEEECCCCHHHHEEEEEEECCCCEECCCCCCCCC
KSAPKPAAPKAPKTPGEQGSLF
CCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA