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The map label for this gene is gloA [C]

Identifier: 99081704

GI number: 99081704

Start: 1963667

End: 1964164

Strand: Direct

Name: gloA [C]

Synonym: TM1040_1863

Alternate gene names: 99081704

Gene position: 1963667-1964164 (Clockwise)

Preceding gene: 99081698

Following gene: 99081708

Centisome position: 61.35

GC content: 63.45

Gene sequence:

>498_bases
ATGAATACCCCCCAAACGCCCGAGGATTGGGCCGCTGAGCATATCCTTGGCATATACGAGACCCACCTGCCCGTGCGCGA
CCTCGACCGTTCGCTGGCGTTTTACACCGGGCAGCTGGGGCTGAAGCTCGCTCGCCGCCTACCCGAACGCGACGTCGCAT
TTCTGTGGACCGGCCCCAAGGAGGTGGGGATGCTGGGGCTATGGGGTGCGGGCAGTGCGCCCCTTGGGATGTCCCTGCAT
TTTGCCTTTCGCGCCACCAAGGCGGCAGTGCTTGGCGCCTGCACGCAGTTGCCGGCGCAGGGCATCACACCGCTGGGGTT
CACCGGAGATCCGATCACAGAGCCGGTGGTGCTGGGCTGGATGCCCGCGATCTCGGTCTATTTCAAGGATCCTGACGGCC
ACTCGATCGAGATGCTGCATATGCTGGAGGACGCGGCGGATCCGGCCTTTGGCGTCCAAAGCTATAGTGATTGGCAAAAC
CGGGCGTCACAGGCGTAA

Upstream 100 bases:

>100_bases
ACGCTTGATCTAAAGTGAGCTTGAGGAATTACGGTGTTCCTGCCGCCCCGCGTGTGACCCGCAGAGCCGGGGCGGGCAGA
TCTGAGACTGGAGCAGAGCG

Downstream 100 bases:

>100_bases
ATCTTGGGCTGATCTCTCGGCGCGAGACTGCTGGGCAATACCCGGTACGGCTCCCGCCCGCCCTGGTGGCATGGCACATG
CCACTACGCCCGTTGGGCGT

Product: glyoxalase/bleomycin resistance protein/dioxygenase

Products: (R)-S-Lactoylglutathione [C]

Alternate protein names: Glyoxalase Family Protein; Glyoxalase/Bleomycin Resistance Protein; Glutathione Transferase; Lactoylglutathione Lyase Protein; Fosfomycin Resistance Protein

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MNTPQTPEDWAAEHILGIYETHLPVRDLDRSLAFYTGQLGLKLARRLPERDVAFLWTGPKEVGMLGLWGAGSAPLGMSLH
FAFRATKAAVLGACTQLPAQGITPLGFTGDPITEPVVLGWMPAISVYFKDPDGHSIEMLHMLEDAADPAFGVQSYSDWQN
RASQA

Sequences:

>Translated_165_residues
MNTPQTPEDWAAEHILGIYETHLPVRDLDRSLAFYTGQLGLKLARRLPERDVAFLWTGPKEVGMLGLWGAGSAPLGMSLH
FAFRATKAAVLGACTQLPAQGITPLGFTGDPITEPVVLGWMPAISVYFKDPDGHSIEMLHMLEDAADPAFGVQSYSDWQN
RASQA
>Mature_165_residues
MNTPQTPEDWAAEHILGIYETHLPVRDLDRSLAFYTGQLGLKLARRLPERDVAFLWTGPKEVGMLGLWGAGSAPLGMSLH
FAFRATKAAVLGACTQLPAQGITPLGFTGDPITEPVVLGWMPAISVYFKDPDGHSIEMLHMLEDAADPAFGVQSYSDWQN
RASQA

Specific function: Catalyzes The Conversion Of Hemimercaptal, Formed From Methylglyoxal And Glutathione, To S-Lactoylglutathione. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.4.1.5 [C]

Molecular weight: Translated: 17979; Mature: 17979

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPQTPEDWAAEHILGIYETHLPVRDLDRSLAFYTGQLGLKLARRLPERDVAFLWTGPK
CCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHH
EVGMLGLWGAGSAPLGMSLHFAFRATKAAVLGACTQLPAQGITPLGFTGDPITEPVVLGW
HHCEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEHCC
MPAISVYFKDPDGHSIEMLHMLEDAADPAFGVQSYSDWQNRASQA
CCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MNTPQTPEDWAAEHILGIYETHLPVRDLDRSLAFYTGQLGLKLARRLPERDVAFLWTGPK
CCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHH
EVGMLGLWGAGSAPLGMSLHFAFRATKAAVLGACTQLPAQGITPLGFTGDPITEPVVLGW
HHCEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEHCC
MPAISVYFKDPDGHSIEMLHMLEDAADPAFGVQSYSDWQNRASQA
CCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): 20280 [C]

Specific activity: NA

Km value (mM): 0.0272 {methylglyoxal/glutathione} [C]

Substrates: Reduced glutathione; Methylglyoxal [C]

Specific reaction: Reduced glutathione + Methylglyoxal --> (R)-S-Lactoylglutathione [C]

General reaction: addition of RSH [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA