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The map label for this gene is gppA [H]

Identifier: 99081698

GI number: 99081698

Start: 1958393

End: 1960039

Strand: Direct

Name: gppA [H]

Synonym: TM1040_1857

Alternate gene names: 99081698

Gene position: 1958393-1960039 (Clockwise)

Preceding gene: 99081697

Following gene: 99081704

Centisome position: 61.18

GC content: 64.6

Gene sequence:

>1647_bases
ATGACCATTCAGCCCGATGCCCCGCACCGCGACCTCGACACGACGCCCCCTGTGGCGGATGCCCCGGAGGCCGCAGCGCC
TGATGCGGCGGCAGAGGATTGGGGGCCGTTTGGTCGCCCGCTTTTTGACGATCCCGATGCCCGCGCCCTGAGCCGGGTGG
GTGTGGTCGATGTGGGGTCGAACTCTGTGCGCCTGGTGGTTTTTGACGGCGCCGCCCGCAGCCCCGCCTATTTCTACAAC
GAGAAAATCATGTGCGGCCTGGGCGCGGGCCTCTCTGAGACCGGCAAGCTCAACCCCAAGGGGCGCGCGCGCGCGCTCGA
GGCGCTGAAACGGTTCCAGATGCTGGCCAAGGGGCTCTTGAGCGACCCGCTGACGGTGGTGGCCACCGCGGCGGTGCGCG
ATGCCAGCGACGGGCCGGAGTTCTGCGCCGAGGTCGAGGCCGCCACGGGCCTGCGCATCCGCGTCATCACCGGCGAGGAA
GAGGCGCGGCTCTCGGCGCAAGGCGTGCTCTTGGGCTGGCCCGGCGCCTATGGGCTGATCTGCGATATCGGCGGATCCTC
GATGGAGCTTGCGGAAATTCAGGACGGCGAGGTCGGCCGATGCGTGACCTCCAATCTCGGGCCCCTGAAGCTCAAGGATA
TCAAGGGCGGGCGCAAGGGACGCAAGGCGCATATCGACGAGGTGATGGCCTCTTTGCGCGACCAGTTGGGCGATCAGCGG
GATCGCCTGTTCCTCGTGGGGGGGAGCTGGCGTGCGATTGCGCGGCTCGACATGCTGCGGCGCAACTATCCGCTGACGGT
GCAGCACGAATACCGCATGACCGCCAAGGACGTGCGCGAGACGATCAAGTTCATCGAACAGAACGACCTTGAGAAACTGC
GCTCTGACTGCGGGGTCTCCTCGGCGCGGATGGCGCTTGTGCCCTATGCAATCGACGTGTTGGCGCGTCTCATCAAGACG
TTCCGCCCCAAGGACATTGCGATTTCCAGCTATGGCATCCGCGAGGGGCTTTTGTATGAGCAGATGCCGGATCGGCTGCG
CCAACGCGATCCGCTCATTGAAGCGGCGCGTTTTGCCGAGGCCAAGGACGCGCGAGTTCCGGGCTTTGGGAAGACGCTCT
ACACCTTTGTAAAACCGCTGTTTTCCGGCGCGCCCTACGCCAAGATGCGGCTCGTCAAAGCGGCCTGCGTGCTGCATGAC
GTAAGCTGGCGCGCGCATCCCGATTATCGCGCGGAGGTCTGTTTTGACAACGCCACCCGCGCCAACCTTGGTGGGCTCAA
ACATTCCGAGCGGATCTTTCTGGGGCTGGCGCTGCTGCATCGCTATCGCAACAAGCGTCAGGGCACCCATTTTGAGCATC
TCTATGATCTGCTGCCGTCCGAAAAGCAGAAAGAGGCGGAAATTCTAGGCAAGGCGATGCGCTTTGGCGCGATGCTGATG
GTGGGCGAGGATCAGGACATTGGCCGCCTGCGCTGGCAGCCGCGCAAACGCACGCTGCATGTGGAACTCCCCGCAGAGAG
CGCGGCGCTCTTTGGGGAGGTGGCGCAGTCGCGGCTGATGTCCCTCGTCAACACACTCAAGGCCGAAGTCCGTGTGAGCG
TTGCAGGCCGACGCGGCGCGCTGCTGGAAAAAGACGCGCGCGACTGA

Upstream 100 bases:

>100_bases
CGCAGCATCTCCCGATTTTCGGCGCCTTTCGCTGCGCACGAATTGACCTGATCGCCCCGATAGACCATCCTCACCCCAGC
AAAAACGCCCCGGAGTCTGC

Downstream 100 bases:

>100_bases
GCGCGCCCTTTGCACCCCGCACGCTCCTGAGTTTCACGCAACGGAGTTTCACGCAACAGAGCGCTGTTCAGAGCTCGATA
CTGTCGTCGGGCTGAGGGGC

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MTIQPDAPHRDLDTTPPVADAPEAAAPDAAAEDWGPFGRPLFDDPDARALSRVGVVDVGSNSVRLVVFDGAARSPAYFYN
EKIMCGLGAGLSETGKLNPKGRARALEALKRFQMLAKGLLSDPLTVVATAAVRDASDGPEFCAEVEAATGLRIRVITGEE
EARLSAQGVLLGWPGAYGLICDIGGSSMELAEIQDGEVGRCVTSNLGPLKLKDIKGGRKGRKAHIDEVMASLRDQLGDQR
DRLFLVGGSWRAIARLDMLRRNYPLTVQHEYRMTAKDVRETIKFIEQNDLEKLRSDCGVSSARMALVPYAIDVLARLIKT
FRPKDIAISSYGIREGLLYEQMPDRLRQRDPLIEAARFAEAKDARVPGFGKTLYTFVKPLFSGAPYAKMRLVKAACVLHD
VSWRAHPDYRAEVCFDNATRANLGGLKHSERIFLGLALLHRYRNKRQGTHFEHLYDLLPSEKQKEAEILGKAMRFGAMLM
VGEDQDIGRLRWQPRKRTLHVELPAESAALFGEVAQSRLMSLVNTLKAEVRVSVAGRRGALLEKDARD

Sequences:

>Translated_548_residues
MTIQPDAPHRDLDTTPPVADAPEAAAPDAAAEDWGPFGRPLFDDPDARALSRVGVVDVGSNSVRLVVFDGAARSPAYFYN
EKIMCGLGAGLSETGKLNPKGRARALEALKRFQMLAKGLLSDPLTVVATAAVRDASDGPEFCAEVEAATGLRIRVITGEE
EARLSAQGVLLGWPGAYGLICDIGGSSMELAEIQDGEVGRCVTSNLGPLKLKDIKGGRKGRKAHIDEVMASLRDQLGDQR
DRLFLVGGSWRAIARLDMLRRNYPLTVQHEYRMTAKDVRETIKFIEQNDLEKLRSDCGVSSARMALVPYAIDVLARLIKT
FRPKDIAISSYGIREGLLYEQMPDRLRQRDPLIEAARFAEAKDARVPGFGKTLYTFVKPLFSGAPYAKMRLVKAACVLHD
VSWRAHPDYRAEVCFDNATRANLGGLKHSERIFLGLALLHRYRNKRQGTHFEHLYDLLPSEKQKEAEILGKAMRFGAMLM
VGEDQDIGRLRWQPRKRTLHVELPAESAALFGEVAQSRLMSLVNTLKAEVRVSVAGRRGALLEKDARD
>Mature_547_residues
TIQPDAPHRDLDTTPPVADAPEAAAPDAAAEDWGPFGRPLFDDPDARALSRVGVVDVGSNSVRLVVFDGAARSPAYFYNE
KIMCGLGAGLSETGKLNPKGRARALEALKRFQMLAKGLLSDPLTVVATAAVRDASDGPEFCAEVEAATGLRIRVITGEEE
ARLSAQGVLLGWPGAYGLICDIGGSSMELAEIQDGEVGRCVTSNLGPLKLKDIKGGRKGRKAHIDEVMASLRDQLGDQRD
RLFLVGGSWRAIARLDMLRRNYPLTVQHEYRMTAKDVRETIKFIEQNDLEKLRSDCGVSSARMALVPYAIDVLARLIKTF
RPKDIAISSYGIREGLLYEQMPDRLRQRDPLIEAARFAEAKDARVPGFGKTLYTFVKPLFSGAPYAKMRLVKAACVLHDV
SWRAHPDYRAEVCFDNATRANLGGLKHSERIFLGLALLHRYRNKRQGTHFEHLYDLLPSEKQKEAEILGKAMRFGAMLMV
GEDQDIGRLRWQPRKRTLHVELPAESAALFGEVAQSRLMSLVNTLKAEVRVSVAGRRGALLEKDARD

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=298, Percent_Identity=26.1744966442953, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 60485; Mature: 60354

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIQPDAPHRDLDTTPPVADAPEAAAPDAAAEDWGPFGRPLFDDPDARALSRVGVVDVGS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCHHHHHHCCEEEECC
NSVRLVVFDGAARSPAYFYNEKIMCGLGAGLSETGKLNPKGRARALEALKRFQMLAKGLL
CCEEEEEECCCCCCCCEEECCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
SDPLTVVATAAVRDASDGPEFCAEVEAATGLRIRVITGEEEARLSAQGVLLGWPGAYGLI
CCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHCEEEEECCCCCEEE
CDIGGSSMELAEIQDGEVGRCVTSNLGPLKLKDIKGGRKGRKAHIDEVMASLRDQLGDQR
EECCCCCEEEEECCCCCCCCHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCC
DRLFLVGGSWRAIARLDMLRRNYPLTVQHEYRMTAKDVRETIKFIEQNDLEKLRSDCGVS
CEEEEECCCHHHHHHHHHHHCCCCEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
SARMALVPYAIDVLARLIKTFRPKDIAISSYGIREGLLYEQMPDRLRQRDPLIEAARFAE
HHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHCHHHHHHHHHHHHCCCHHHHHHHHC
AKDARVPGFGKTLYTFVKPLFSGAPYAKMRLVKAACVLHDVSWRAHPDYRAEVCFDNATR
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCC
ANLGGLKHSERIFLGLALLHRYRNKRQGTHFEHLYDLLPSEKQKEAEILGKAMRFGAMLM
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCEEEE
VGEDQDIGRLRWQPRKRTLHVELPAESAALFGEVAQSRLMSLVNTLKAEVRVSVAGRRGA
ECCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCC
LLEKDARD
CCCCCCCC
>Mature Secondary Structure 
TIQPDAPHRDLDTTPPVADAPEAAAPDAAAEDWGPFGRPLFDDPDARALSRVGVVDVGS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCHHHHHHCCEEEECC
NSVRLVVFDGAARSPAYFYNEKIMCGLGAGLSETGKLNPKGRARALEALKRFQMLAKGLL
CCEEEEEECCCCCCCCEEECCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
SDPLTVVATAAVRDASDGPEFCAEVEAATGLRIRVITGEEEARLSAQGVLLGWPGAYGLI
CCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHCEEEEECCCCCEEE
CDIGGSSMELAEIQDGEVGRCVTSNLGPLKLKDIKGGRKGRKAHIDEVMASLRDQLGDQR
EECCCCCEEEEECCCCCCCCHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCC
DRLFLVGGSWRAIARLDMLRRNYPLTVQHEYRMTAKDVRETIKFIEQNDLEKLRSDCGVS
CEEEEECCCHHHHHHHHHHHCCCCEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
SARMALVPYAIDVLARLIKTFRPKDIAISSYGIREGLLYEQMPDRLRQRDPLIEAARFAE
HHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHCHHHHHHHHHHHHCCCHHHHHHHHC
AKDARVPGFGKTLYTFVKPLFSGAPYAKMRLVKAACVLHDVSWRAHPDYRAEVCFDNATR
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCC
ANLGGLKHSERIFLGLALLHRYRNKRQGTHFEHLYDLLPSEKQKEAEILGKAMRFGAMLM
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCEEEE
VGEDQDIGRLRWQPRKRTLHVELPAESAALFGEVAQSRLMSLVNTLKAEVRVSVAGRRGA
ECCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCC
LLEKDARD
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA