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The map label for this gene is hda [H]

Identifier: 99081697

GI number: 99081697

Start: 1957540

End: 1958217

Strand: Direct

Name: hda [H]

Synonym: TM1040_1856

Alternate gene names: 99081697

Gene position: 1957540-1958217 (Clockwise)

Preceding gene: 99081696

Following gene: 99081698

Centisome position: 61.16

GC content: 65.04

Gene sequence:

>678_bases
ATGTCCGAACAGCTGAGCTTTGATCTCCCGGCGAAACCCGCGCTGGGGCGCGATGATTTCTTTGTCGCCCCTTCCAACGC
AATGGCAGTGGCGCTGATTGACCCGGCCTTTGCCTGGCCGTCGGGCAAGCTGGTGCTGACGGGACCAAAGGGGTCGGGCA
AGACGCACCTGGCGCATGTCTGGGCCAAGGAAAGCGGTGCCAGGGTGGTTCCGGCCCATGCGCTCACCGAGGCAGATGTG
CCAGAGCTTGCAAGCGGCCCTGTCGCGATCGAGGACGTGCCCGATATTGCCGAGGATGCGCTTGCCCAAAAGGCGCTCTT
TCACCTGCACAACATGGTTCTGACCCATGGCCATCGGCTGATGCTGACGGGCCGTCCGGCGCCGAACCTCTGGGGGCTTG
GGCTCGCGGATCTGCAAAGCCGGGTGCAGGCGGCGACTCATGCCGCGCTCGAAGCGCCCGATGATGCGCTGCTGGCGGTG
GTGCTCGCCAAACTCTTCAATGACCGCCAGATCACGCCGAAACCGGATGTGATTCCCTATCTGGTGGGACGCATGGATCG
CAGCTTTGCCGCGGCCGCCGCGGTGGTGGAACAGCTGGACCGGCTGGCGCTTGCAGAGCAGCGCACCCTCAGCCGCGCGC
TGGCAATCCGCCTGATGTCCAGCGACCAGAAGGGCTGA

Upstream 100 bases:

>100_bases
GGGATGCGAATGTCCGCACCTCCGAGGATACACCGACCGACATCTGAACCGCGCCCCGCAAGCCACAGCCCCTCTCCCGC
ATGTAACAAGCAGACTGCCC

Downstream 100 bases:

>100_bases
CGCCGATGCTTGGACGGACAGCACCTCTGCCCTGCCAAGCAATGACCGTGATTGGCGAAAGTGCCACGCCATGCCCGCAG
CATCTCCCGATTTTCGGCGC

Product: chromosomal replication initiator, DnaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MSEQLSFDLPAKPALGRDDFFVAPSNAMAVALIDPAFAWPSGKLVLTGPKGSGKTHLAHVWAKESGARVVPAHALTEADV
PELASGPVAIEDVPDIAEDALAQKALFHLHNMVLTHGHRLMLTGRPAPNLWGLGLADLQSRVQAATHAALEAPDDALLAV
VLAKLFNDRQITPKPDVIPYLVGRMDRSFAAAAAVVEQLDRLALAEQRTLSRALAIRLMSSDQKG

Sequences:

>Translated_225_residues
MSEQLSFDLPAKPALGRDDFFVAPSNAMAVALIDPAFAWPSGKLVLTGPKGSGKTHLAHVWAKESGARVVPAHALTEADV
PELASGPVAIEDVPDIAEDALAQKALFHLHNMVLTHGHRLMLTGRPAPNLWGLGLADLQSRVQAATHAALEAPDDALLAV
VLAKLFNDRQITPKPDVIPYLVGRMDRSFAAAAAVVEQLDRLALAEQRTLSRALAIRLMSSDQKG
>Mature_224_residues
SEQLSFDLPAKPALGRDDFFVAPSNAMAVALIDPAFAWPSGKLVLTGPKGSGKTHLAHVWAKESGARVVPAHALTEADVP
ELASGPVAIEDVPDIAEDALAQKALFHLHNMVLTHGHRLMLTGRPAPNLWGLGLADLQSRVQAATHAALEAPDDALLAVV
LAKLFNDRQITPKPDVIPYLVGRMDRSFAAAAAVVEQLDRLALAEQRTLSRALAIRLMSSDQKG

Specific function: Mediates the interactions of dnaA with the beta subunit sliding clamp, promoting hydrolysis of dnaA-bound ATP. It is essential for the control of initiation of DNA replication by inhibiting reinitiation of replication [H]

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family. HdA subfamily [H]

Homologues:

Organism=Escherichia coli, GI226510964, Length=206, Percent_Identity=31.5533980582524, Blast_Score=73, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020591
- InterPro:   IPR017788
- InterPro:   IPR013317
- InterPro:   IPR022864 [H]

Pfam domain/function: PF00308 Bac_DnaA [H]

EC number: NA

Molecular weight: Translated: 23961; Mature: 23830

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQLSFDLPAKPALGRDDFFVAPSNAMAVALIDPAFAWPSGKLVLTGPKGSGKTHLAHV
CCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCEEEECCCCCCCCEEEEE
WAKESGARVVPAHALTEADVPELASGPVAIEDVPDIAEDALAQKALFHLHNMVLTHGHRL
EECCCCCEEECHHHHCCCCCCHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
MLTGRPAPNLWGLGLADLQSRVQAATHAALEAPDDALLAVVLAKLFNDRQITPKPDVIPY
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHH
LVGRMDRSFAAAAAVVEQLDRLALAEQRTLSRALAIRLMSSDQKG
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SEQLSFDLPAKPALGRDDFFVAPSNAMAVALIDPAFAWPSGKLVLTGPKGSGKTHLAHV
CCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCEEEECCCCCCCCEEEEE
WAKESGARVVPAHALTEADVPELASGPVAIEDVPDIAEDALAQKALFHLHNMVLTHGHRL
EECCCCCEEECHHHHCCCCCCHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
MLTGRPAPNLWGLGLADLQSRVQAATHAALEAPDDALLAVVLAKLFNDRQITPKPDVIPY
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHH
LVGRMDRSFAAAAAVVEQLDRLALAEQRTLSRALAIRLMSSDQKG
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA