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The map label for this gene is fabG [H]

Identifier: 99081644

GI number: 99081644

Start: 1894822

End: 1895601

Strand: Reverse

Name: fabG [H]

Synonym: TM1040_1803

Alternate gene names: 99081644

Gene position: 1895601-1894822 (Counterclockwise)

Preceding gene: 99081646

Following gene: 99081643

Centisome position: 59.22

GC content: 64.1

Gene sequence:

>780_bases
ATGGATCTGGGCATTCGCGGCAAGCGCGCATTGGTGTGCGCATCGAGCAAGGGATTGGGTCTGGGCTGTGCAGAGGCGCT
GGCCGAGGCAGGTGTCGATCTGTTGATGAACGCGCGTGGCTCCGAGGCACTGGAGGCCTCGGCACAGGACCTGCGCGACC
GCTTCGGTGTGCGTGTGGAGACGCTGGCCTGCGATGTGACCGACGAAGGCGCGCGCGCCGAGCTTATCGACCGCGCCAAA
GGGGTCGACATTCTGGTGACCAATGCGGGCGGCCCACCTCCGGGTGTCTGGAGCGACTGGGACCGCGCCGATTTCATCAA
GGCGCTCGACGCCAATATGCTTACCCCCATTGCGCTGATGAAAGCGTTGCTGCCCGCGATGATGGAAGCCGGTTGGGGCC
GGGTGGTGAATATCACTTCGCAGTCCGTCAAAGCGCCCATCGCGGCGCTTGGGCTCTCCAATTCCGCGCGGGCGGGCCTC
ACTGGCTATGTAGCGGGCACTGCACGTCAGGTTGCGGGCCAAGGTGTTGTGATCAATAATCTATTGCCAGGCATCCACGC
CACCGACCGGGCGGTTTCCCTTGATACGGGCGTGGCGCAGGCACAGGGGATTTCCATGGATGAGGCCCGCGCGCAGCGCG
CCGCCACGATCCCTGCCGGACGCTATGGCACGCGGCAGGAATTTGGGGCGACCTGCGCGTTCCTCTGCTCGCAGCATGCG
GGTTTCATCATTGGCCAGAATATCCTGCTGGATGGCGGTGCCACCAATATGACGCTCTGA

Upstream 100 bases:

>100_bases
CGCGGAGGAAATTTTCTGGCCGATGCATGCTTTGTCATCTGGAAAACCGGTCCGCGCGCTGTCAGGGTCTGCCTCAAACA
CGCAACAGCAGGAGAGTTTC

Downstream 100 bases:

>100_bases
CCTGATGGCCGAGTCGTTTTCGCTGAAGGATCAGCTTTTTAACGTGGAAAAGACCCGCTATCTGGCGGGGCTTTTTGACG
CGGCTTCGGTGGAGTTTGAC

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MDLGIRGKRALVCASSKGLGLGCAEALAEAGVDLLMNARGSEALEASAQDLRDRFGVRVETLACDVTDEGARAELIDRAK
GVDILVTNAGGPPPGVWSDWDRADFIKALDANMLTPIALMKALLPAMMEAGWGRVVNITSQSVKAPIAALGLSNSARAGL
TGYVAGTARQVAGQGVVINNLLPGIHATDRAVSLDTGVAQAQGISMDEARAQRAATIPAGRYGTRQEFGATCAFLCSQHA
GFIIGQNILLDGGATNMTL

Sequences:

>Translated_259_residues
MDLGIRGKRALVCASSKGLGLGCAEALAEAGVDLLMNARGSEALEASAQDLRDRFGVRVETLACDVTDEGARAELIDRAK
GVDILVTNAGGPPPGVWSDWDRADFIKALDANMLTPIALMKALLPAMMEAGWGRVVNITSQSVKAPIAALGLSNSARAGL
TGYVAGTARQVAGQGVVINNLLPGIHATDRAVSLDTGVAQAQGISMDEARAQRAATIPAGRYGTRQEFGATCAFLCSQHA
GFIIGQNILLDGGATNMTL
>Mature_259_residues
MDLGIRGKRALVCASSKGLGLGCAEALAEAGVDLLMNARGSEALEASAQDLRDRFGVRVETLACDVTDEGARAELIDRAK
GVDILVTNAGGPPPGVWSDWDRADFIKALDANMLTPIALMKALLPAMMEAGWGRVVNITSQSVKAPIAALGLSNSARAGL
TGYVAGTARQVAGQGVVINNLLPGIHATDRAVSLDTGVAQAQGISMDEARAQRAATIPAGRYGTRQEFGATCAFLCSQHA
GFIIGQNILLDGGATNMTL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=253, Percent_Identity=28.8537549407115, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI5031737, Length=254, Percent_Identity=27.5590551181102, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI19923817, Length=262, Percent_Identity=27.4809160305344, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI66933014, Length=211, Percent_Identity=26.5402843601896, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI7705855, Length=195, Percent_Identity=25.6410256410256, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI226371731, Length=188, Percent_Identity=26.5957446808511, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI40254992, Length=249, Percent_Identity=26.5060240963855, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI33667109, Length=186, Percent_Identity=30.6451612903226, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI20149619, Length=220, Percent_Identity=29.5454545454545, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI4503301, Length=263, Percent_Identity=27.7566539923954, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=257, Percent_Identity=31.5175097276265, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI87082160, Length=260, Percent_Identity=26.9230769230769, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI87082100, Length=259, Percent_Identity=30.8880308880309, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788459, Length=256, Percent_Identity=27.34375, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787905, Length=256, Percent_Identity=26.5625, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790717, Length=256, Percent_Identity=23.046875, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1789208, Length=260, Percent_Identity=27.3076923076923, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17560676, Length=255, Percent_Identity=29.4117647058824, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17559104, Length=263, Percent_Identity=28.1368821292776, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=262, Percent_Identity=26.7175572519084, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=269, Percent_Identity=28.2527881040892, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=269, Percent_Identity=28.996282527881, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=270, Percent_Identity=27.037037037037, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17561402, Length=257, Percent_Identity=25.2918287937743, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17565030, Length=261, Percent_Identity=28.3524904214559, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=268, Percent_Identity=26.865671641791, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=261, Percent_Identity=27.2030651340996, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=268, Percent_Identity=26.4925373134328, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=271, Percent_Identity=26.1992619926199, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=271, Percent_Identity=28.0442804428044, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=266, Percent_Identity=26.3157894736842, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=267, Percent_Identity=26.9662921348315, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=267, Percent_Identity=26.2172284644195, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17544670, Length=262, Percent_Identity=24.8091603053435, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17536025, Length=277, Percent_Identity=27.0758122743682, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI21355319, Length=254, Percent_Identity=29.1338582677165, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI23397609, Length=259, Percent_Identity=30.1158301158301, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24640442, Length=198, Percent_Identity=27.7777777777778, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21357041, Length=259, Percent_Identity=25.0965250965251, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 26731; Mature: 26731

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLGIRGKRALVCASSKGLGLGCAEALAEAGVDLLMNARGSEALEASAQDLRDRFGVRVE
CCCCCCCCEEEEEECCCCCCCHHHHHHHHCCHHEEECCCCCHHHHHHHHHHHHHHCCEEE
TLACDVTDEGARAELIDRAKGVDILVTNAGGPPPGVWSDWDRADFIKALDANMLTPIALM
EEEEECCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHH
KALLPAMMEAGWGRVVNITSQSVKAPIAALGLSNSARAGLTGYVAGTARQVAGQGVVINN
HHHHHHHHHCCCCEEEEECCHHHHCCHHHHCCCCCCCCCEEEEEHHHHHHHCCCCEEECC
LLPGIHATDRAVSLDTGVAQAQGISMDEARAQRAATIPAGRYGTRQEFGATCAFLCSQHA
CCCCCCCCCCEEECCCCHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCC
GFIIGQNILLDGGATNMTL
CEEEECEEEEECCCCCCCC
>Mature Secondary Structure
MDLGIRGKRALVCASSKGLGLGCAEALAEAGVDLLMNARGSEALEASAQDLRDRFGVRVE
CCCCCCCCEEEEEECCCCCCCHHHHHHHHCCHHEEECCCCCHHHHHHHHHHHHHHCCEEE
TLACDVTDEGARAELIDRAKGVDILVTNAGGPPPGVWSDWDRADFIKALDANMLTPIALM
EEEEECCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHH
KALLPAMMEAGWGRVVNITSQSVKAPIAALGLSNSARAGLTGYVAGTARQVAGQGVVINN
HHHHHHHHHCCCCEEEEECCHHHHCCHHHHCCCCCCCCCEEEEEHHHHHHHCCCCEEECC
LLPGIHATDRAVSLDTGVAQAQGISMDEARAQRAATIPAGRYGTRQEFGATCAFLCSQHA
CCCCCCCCCCEEECCCCHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCC
GFIIGQNILLDGGATNMTL
CEEEECEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]