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The map label for this gene is cysH [H]

Identifier: 99081600

GI number: 99081600

Start: 1850388

End: 1851149

Strand: Direct

Name: cysH [H]

Synonym: TM1040_1759

Alternate gene names: 99081600

Gene position: 1850388-1851149 (Clockwise)

Preceding gene: 99081599

Following gene: 99081601

Centisome position: 57.81

GC content: 62.47

Gene sequence:

>762_bases
ATGACCCGTATAGATCAGGAGATCAGGGGCCATCCCGCCGCTGCTGGCAGCGCTGAGGCCCTGGCCGAGCAGGTTGCGGC
GCTCAATGCCCGCTTCAAACACCACTCGGCCACCTCCGTGATGGAAGGGGCGCTGCGGGATGCTGGCAATATCGCGCTGG
TGTCGTCCTTTGGGGCGGAATCGGTGGTGCTGTTGCATATGGCCGCCGTGATCGACCCCTCGGTGCCGGTGCTCTTTGTG
GACACGGAACTCTTGTTCACAGAGACGCTGGTCTACCAGCAAGAAGTGAGCGAGCGCCTAGGCCTCAGGAATGTGCATGT
CATCAAGGCGGATGACATCGCCGAAAAAGACCCCTATGGCGCGATGCGGTTTTCCGACACCGACGCCTGCTGCACCCTGC
GCAAGACCATTCCGCTGCAAAAGGCGCTCGCCGGCTATGACGGCTGGATCACCGGGCGCAAACGGTTTCAGTCCGGCACC
CGCGCCGCGCTCGACTTCTTTGAGGTCGAGGATGGCACCGGACGAATGAAGATCAACCCACTGGCCCATTGGGCGCCCGA
AGACGTGCGCGCCTATATGGATGAAAACCGCCTGCCCCGTCACCCGCTGGTGGCCAAGGGCTATCCATCGATCGGCTGCG
AACCCTGCACCAGCCCGGTCGCAGAAGGCGAAGACCCCCGCGCCGGTCGCTGGCGCAACCAGAACAAGGAAGAATGCGGC
ATCCACGTTGTGGATGGCAAATTCGTCCGTACAGGAGCTTGA

Upstream 100 bases:

>100_bases
GAGCGCCGAAGAAGAGTTCCTGCAAACCTACCGCCGCGTCGGCATGGAGCCCTTCAAGGCGGCGCTCTACCCGGCCTCCG
AGAAAAAGGTGGCCTGAGGG

Downstream 100 bases:

>100_bases
GTAATATGAGCGTTATCGTAACCGACACGGGCTTTGCCCATGACGACTGGACCGGCGGCTTTGAGGGTGCAAATGTGCTT
GATCTGGCCTCCGACACAGA

Product: phosphoadenosine phosphosulfate reductase

Products: NA

Alternate protein names: 3'-phosphoadenylylsulfate reductase; PAPS reductase, thioredoxin dependent; PAPS sulfotransferase; PAdoPS reductase [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MTRIDQEIRGHPAAAGSAEALAEQVAALNARFKHHSATSVMEGALRDAGNIALVSSFGAESVVLLHMAAVIDPSVPVLFV
DTELLFTETLVYQQEVSERLGLRNVHVIKADDIAEKDPYGAMRFSDTDACCTLRKTIPLQKALAGYDGWITGRKRFQSGT
RAALDFFEVEDGTGRMKINPLAHWAPEDVRAYMDENRLPRHPLVAKGYPSIGCEPCTSPVAEGEDPRAGRWRNQNKEECG
IHVVDGKFVRTGA

Sequences:

>Translated_253_residues
MTRIDQEIRGHPAAAGSAEALAEQVAALNARFKHHSATSVMEGALRDAGNIALVSSFGAESVVLLHMAAVIDPSVPVLFV
DTELLFTETLVYQQEVSERLGLRNVHVIKADDIAEKDPYGAMRFSDTDACCTLRKTIPLQKALAGYDGWITGRKRFQSGT
RAALDFFEVEDGTGRMKINPLAHWAPEDVRAYMDENRLPRHPLVAKGYPSIGCEPCTSPVAEGEDPRAGRWRNQNKEECG
IHVVDGKFVRTGA
>Mature_252_residues
TRIDQEIRGHPAAAGSAEALAEQVAALNARFKHHSATSVMEGALRDAGNIALVSSFGAESVVLLHMAAVIDPSVPVLFVD
TELLFTETLVYQQEVSERLGLRNVHVIKADDIAEKDPYGAMRFSDTDACCTLRKTIPLQKALAGYDGWITGRKRFQSGTR
AALDFFEVEDGTGRMKINPLAHWAPEDVRAYMDENRLPRHPLVAKGYPSIGCEPCTSPVAEGEDPRAGRWRNQNKEECGI
HVVDGKFVRTGA

Specific function: Reduction of activated sulfate into sulfite [H]

COG id: COG0175

COG function: function code EH; 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAPS reductase family. CysH subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789121, Length=226, Percent_Identity=30.0884955752212, Blast_Score=92, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6325425, Length=204, Percent_Identity=34.8039215686275, Blast_Score=113, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004511
- InterPro:   IPR002500
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01507 PAPS_reduct [H]

EC number: =1.8.4.8 [H]

Molecular weight: Translated: 27701; Mature: 27569

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRIDQEIRGHPAAAGSAEALAEQVAALNARFKHHSATSVMEGALRDAGNIALVSSFGAE
CCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
SVVLLHMAAVIDPSVPVLFVDTELLFTETLVYQQEVSERLGLRNVHVIKADDIAEKDPYG
HHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC
AMRFSDTDACCTLRKTIPLQKALAGYDGWITGRKRFQSGTRAALDFFEVEDGTGRMKINP
CEEECCCHHHHHHHHHCCHHHHHCCCCCCCCCHHHHCCCCHHHEEEEEECCCCCEEEECC
LAHWAPEDVRAYMDENRLPRHPLVAKGYPSIGCEPCTSPVAEGEDPRAGRWRNQNKEECG
CCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCC
IHVVDGKFVRTGA
EEEECCEEEECCC
>Mature Secondary Structure 
TRIDQEIRGHPAAAGSAEALAEQVAALNARFKHHSATSVMEGALRDAGNIALVSSFGAE
CCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
SVVLLHMAAVIDPSVPVLFVDTELLFTETLVYQQEVSERLGLRNVHVIKADDIAEKDPYG
HHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC
AMRFSDTDACCTLRKTIPLQKALAGYDGWITGRKRFQSGTRAALDFFEVEDGTGRMKINP
CEEECCCHHHHHHHHHCCHHHHHCCCCCCCCCHHHHCCCCHHHEEEEEECCCCCEEEECC
LAHWAPEDVRAYMDENRLPRHPLVAKGYPSIGCEPCTSPVAEGEDPRAGRWRNQNKEECG
CCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCC
IHVVDGKFVRTGA
EEEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]