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The map label for this gene is cysG [H]

Identifier: 99081597

GI number: 99081597

Start: 1847652

End: 1848404

Strand: Direct

Name: cysG [H]

Synonym: TM1040_1756

Alternate gene names: 99081597

Gene position: 1847652-1848404 (Clockwise)

Preceding gene: 99081595

Following gene: 99081598

Centisome position: 57.72

GC content: 63.75

Gene sequence:

>753_bases
ATGTGTCCGGGTGTCGTAGCCTTTGCGGGATCCGGTCCCGGAGATGTGGACCTGTTGACGCTCAAGGTGCTGAAGGCCCT
TGGTGAGGCGGATGTCATCCTCTTTGACCGGCTGGTGAGCAAGGACATCATGGCGCTGGCGCATGAGGGTGCGTTGCTTG
AAGATGTCGGAAAAGAGGGCTTCGGGCCATCAATGGCGCAGGAAGAAATCTGCGCGCGGCTGGTGCATCACGCCAAACGC
GGCCTCAAGGTGCTGCGGCTCAAATCGGGCGACCCCACCATCTTTGGCCGGCTGGACGAAGAACTCTCGGCCTGCGAAGC
GGCAGATGTCGACACGCAGATCCTGCCGGGGATCACCGCCGCCTCGGCGGCCGTCGCCGCCATTGGTCAGAGCCTGACAC
AACGGGGGCGCAATACCTCGGTGCGGTTCCTGACCGGTCATGACATGAAGGGGTTTGCCGACCACGACTGGGCCCAGCTT
GCGCGCCGCGGCGAAGTGGCCGCTGTTTACATGGGCAAGAAATCCGCTCGTTTTGTGCAGGGGCGTATGCTGATGCATGG
CGCCGATCTCACAACCCCCGTGACGGTGGTCGAAAACGCCTCTCGCGCAGATCAGCGTGTGCTGGCCACCACCCTGGAGC
ATTTGCCCGCCGATCTGGCCGCTGCGCACTTCAGCGGCCCGGCGCTCACCTTCCTTGGGCTTGCGCCGCGACAGGCGGCC
GCCCTTACCGACATTCAGATGGAGCTTGCCTGA

Upstream 100 bases:

>100_bases
CTAGGGTCACGTCAAACACCAAAAAATGGACCGATGGATGCCCCGCGACACGCATTATATCCCGCCCCTCACGCCGCCCC
TGCCGGGAGCCATGGGCGTG

Downstream 100 bases:

>100_bases
TGGCCCGTGCATTCACCCCCAAAGTTGTCACCGCCAATCACTTGCTGGAGGGCGATGTGATTTACCTCACAGCTGAAAAT
GACTGGACCCGCGCTTTGAG

Product: uroporphyrinogen-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MCPGVVAFAGSGPGDVDLLTLKVLKALGEADVILFDRLVSKDIMALAHEGALLEDVGKEGFGPSMAQEEICARLVHHAKR
GLKVLRLKSGDPTIFGRLDEELSACEAADVDTQILPGITAASAAVAAIGQSLTQRGRNTSVRFLTGHDMKGFADHDWAQL
ARRGEVAAVYMGKKSARFVQGRMLMHGADLTTPVTVVENASRADQRVLATTLEHLPADLAAAHFSGPALTFLGLAPRQAA
ALTDIQMELA

Sequences:

>Translated_250_residues
MCPGVVAFAGSGPGDVDLLTLKVLKALGEADVILFDRLVSKDIMALAHEGALLEDVGKEGFGPSMAQEEICARLVHHAKR
GLKVLRLKSGDPTIFGRLDEELSACEAADVDTQILPGITAASAAVAAIGQSLTQRGRNTSVRFLTGHDMKGFADHDWAQL
ARRGEVAAVYMGKKSARFVQGRMLMHGADLTTPVTVVENASRADQRVLATTLEHLPADLAAAHFSGPALTFLGLAPRQAA
ALTDIQMELA
>Mature_250_residues
MCPGVVAFAGSGPGDVDLLTLKVLKALGEADVILFDRLVSKDIMALAHEGALLEDVGKEGFGPSMAQEEICARLVHHAKR
GLKVLRLKSGDPTIFGRLDEELSACEAADVDTQILPGITAASAAVAAIGQSLTQRGRNTSVRFLTGHDMKGFADHDWAQL
ARRGEVAAVYMGKKSARFVQGRMLMHGADLTTPVTVVENASRADQRVLATTLEHLPADLAAAHFSGPALTFLGLAPRQAA
ALTDIQMELA

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=230, Percent_Identity=41.7391304347826, Blast_Score=159, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322922, Length=232, Percent_Identity=32.3275862068966, Blast_Score=95, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 26418; Mature: 26418

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCPGVVAFAGSGPGDVDLLTLKVLKALGEADVILFDRLVSKDIMALAHEGALLEDVGKEG
CCCCEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCC
FGPSMAQEEICARLVHHAKRGLKVLRLKSGDPTIFGRLDEELSACEAADVDTQILPGITA
CCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCHHHHHHHHHCCCCHHHHCCCHH
ASAAVAAIGQSLTQRGRNTSVRFLTGHDMKGFADHDWAQLARRGEVAAVYMGKKSARFVQ
HHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHCCCEEEEEECCCCHHHHH
GRMLMHGADLTTPVTVVENASRADQRVLATTLEHLPADLAAAHFSGPALTFLGLAPRQAA
HHHHEECCCCCCHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEECCCHHHH
ALTDIQMELA
HHHHEEEECC
>Mature Secondary Structure
MCPGVVAFAGSGPGDVDLLTLKVLKALGEADVILFDRLVSKDIMALAHEGALLEDVGKEG
CCCCEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCC
FGPSMAQEEICARLVHHAKRGLKVLRLKSGDPTIFGRLDEELSACEAADVDTQILPGITA
CCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCHHHHHHHHHCCCCHHHHCCCHH
ASAAVAAIGQSLTQRGRNTSVRFLTGHDMKGFADHDWAQLARRGEVAAVYMGKKSARFVQ
HHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHCCCEEEEEECCCCHHHHH
GRMLMHGADLTTPVTVVENASRADQRVLATTLEHLPADLAAAHFSGPALTFLGLAPRQAA
HHHHEECCCCCCHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEECCCHHHH
ALTDIQMELA
HHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA