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The map label for this gene is thrS

Identifier: 99081562

GI number: 99081562

Start: 1819028

End: 1820974

Strand: Direct

Name: thrS

Synonym: TM1040_1721

Alternate gene names: 99081562

Gene position: 1819028-1820974 (Clockwise)

Preceding gene: 99081558

Following gene: 99081563

Centisome position: 56.83

GC content: 60.25

Gene sequence:

>1947_bases
ATGGCCCAGATTTCCCTCACATTCCCCGATGGCAACGCACGTTCCTACGACGCAGGGATTACCCCTGCCGAGGTCGCAGC
CGACATCTCCACTTCCCTTGCCAAAAAAGCGATCTCTGCCACCGTGGACGGTCAACACTGGGACCTGCAATGGCCAGTGA
CCCAGGATGCCGCCATCGCCATCCACACGATGAAGGACGAGGCGCAGGCCAATGAGCTCATCCGGCACGACCTTGCGCAT
ATCATGGCGCGCGCGGTGCAGGAGATCTGGCCCGATACCAAGGTCACCATTGGCCCGGTCATCGAAAATGGCTGGTATTA
TGACTTTGATCGTGCGGAACCCTTCACCCCCGAAGATCTCGGCACGATCGAAAAGAAGATGAAAGAGATCATCAACAAGC
GCGAACCCGTGACCACAGAGGTTTGGGAGCGCGAGAAGGCGATCCAGTATTACACCGACAACAACGAGCCCTATAAGGTC
GAGCTGATCGACAGCATCCCCGGCGATGAGCCGCTGCGGATGTATTGGCATGGCGACTGGCAGGATCTCTGCCGCGGGCC
GCACCTGCAGCACACCGGCCAGGTGCCGGGCGATGCCTTCAAGCTGATGTCGATCGCCGGCGCCTACTGGCGCGGCGACA
GCGATCGCCAGATGCTCCAGCGCATCTACGGCGTGGCCTTCACCGGCAAGGAAAAGCTCAAGGCGCATCTCACCATGCTC
GAGGAGGCCGCCAAGCGCGACCACCGCAAGCTGGGCCGCGAGATGAACCTTTTCCACATGCAGGAAGAAGCACCCGGCCA
GGTGTTCTGGCATCCGAACGGATGGCGCATCTACACCACGCTTCAGGACTACATGCGCCGCATGCAGGATCGCGACGGCT
ATGTAGAGGTCAACACGCCTCAGGTGGTGGACCGCAAACTCTGGGAAAAGTCCGGCCACTGGGACAAGTATCAGGAAAAC
ATGTTCATTGTTGAGGTCGACGAGGATCACGCCCGCGAAAAGGCCGTGAACGCCCTGAAGCCGATGAACTGCCCCTGCCA
CGTGCAGGTGTTCAACCAGGGGCTCAAGTCCTATCGCGACTTGCCTCTGCGCATGGCAGAGTTCGGCTCCTGCGCGCGCT
ACGAACCCTCGGGCGCCCTGCATGGCATCATGCGCGTGCGCGGCTTCACGCAGGATGATGGCCACATCTTCTGCACCGAA
GATCAGATTACATCCGAGACCGCAAAGTTCATCGCCTTCCTCTCCAAAGTCTATGCAGATCTCGGCTTTGACAATTGGAC
CATCAAGCTCTCCACCCGCCCCGAACAGCGGATCGGCTCGGATGAGACATGGGACAATATGGAACAGGCCCTTGGCGATG
CCTGCAAGGCCGCGGGCTACGACTATGAGATCCTCGAAGGCGAAGGCGCCTTCTATGGTCCCAAACTCGAGTTCACCCTG
ACCGACGCCATCGGCCGGAACTGGCAATGCGGCACACTTCAGGTGGATGCCAACCTGCCCGAACGGCTCGAAGCGAGCTT
TATCGGTCAGGACGGCAGCAAGCACCGTCCGGTCATGCTGCACCGCGCCACCCTTGGCTCGTTCGAGCGCTTCATCGGCA
TCCTGATCGAAGAGCACGCTGGCAAGCTCCCGTTCTGGCTCGCGCCGCGTCAGGTGGTGGTCGCCTCGATTACGTCAGAG
GCGGACGACTATGTGAACGAAGTGGTCGAGACCCTGCGCGCCGCCGGTGTGCGAGCCGAGGCCGATACGCGCAATGAGAA
GATCAACTACAAGGTCCGCGAGCATTCGGTTGGCAAAGTGCCGGTGATTCTCGCCGTTGGCCACCGCGAGGTTGAGGAGC
GCACCGTCTCCGTGCGTCGTCTTGGCGAGAAACAGACCAAGGTTGAGAGCCTCACAAATGTTACAGAGGAACTGGCAAAG
GCCGCAACGCCGCCAGATCTTCTGTAA

Upstream 100 bases:

>100_bases
CTATCTTGACCTTGACCGCGCCCTCCGCCAAACAGCTCAGACGCATATAACCCGCAACCGGGCGTTCTGTGGGCGCCAAA
CCGACGAGGAGAGCCAGACT

Downstream 100 bases:

>100_bases
TATTTACCCGGTTTTTGAACAAAGGCGGCCCCCACTCGGGGGCCGTTTTGTTTCAAAACCCCAGAAATCGCAGCAATTTG
GCACCAAACGCGCGGGTTCT

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 648; Mature: 647

Protein sequence:

>648_residues
MAQISLTFPDGNARSYDAGITPAEVAADISTSLAKKAISATVDGQHWDLQWPVTQDAAIAIHTMKDEAQANELIRHDLAH
IMARAVQEIWPDTKVTIGPVIENGWYYDFDRAEPFTPEDLGTIEKKMKEIINKREPVTTEVWEREKAIQYYTDNNEPYKV
ELIDSIPGDEPLRMYWHGDWQDLCRGPHLQHTGQVPGDAFKLMSIAGAYWRGDSDRQMLQRIYGVAFTGKEKLKAHLTML
EEAAKRDHRKLGREMNLFHMQEEAPGQVFWHPNGWRIYTTLQDYMRRMQDRDGYVEVNTPQVVDRKLWEKSGHWDKYQEN
MFIVEVDEDHAREKAVNALKPMNCPCHVQVFNQGLKSYRDLPLRMAEFGSCARYEPSGALHGIMRVRGFTQDDGHIFCTE
DQITSETAKFIAFLSKVYADLGFDNWTIKLSTRPEQRIGSDETWDNMEQALGDACKAAGYDYEILEGEGAFYGPKLEFTL
TDAIGRNWQCGTLQVDANLPERLEASFIGQDGSKHRPVMLHRATLGSFERFIGILIEEHAGKLPFWLAPRQVVVASITSE
ADDYVNEVVETLRAAGVRAEADTRNEKINYKVREHSVGKVPVILAVGHREVEERTVSVRRLGEKQTKVESLTNVTEELAK
AATPPDLL

Sequences:

>Translated_648_residues
MAQISLTFPDGNARSYDAGITPAEVAADISTSLAKKAISATVDGQHWDLQWPVTQDAAIAIHTMKDEAQANELIRHDLAH
IMARAVQEIWPDTKVTIGPVIENGWYYDFDRAEPFTPEDLGTIEKKMKEIINKREPVTTEVWEREKAIQYYTDNNEPYKV
ELIDSIPGDEPLRMYWHGDWQDLCRGPHLQHTGQVPGDAFKLMSIAGAYWRGDSDRQMLQRIYGVAFTGKEKLKAHLTML
EEAAKRDHRKLGREMNLFHMQEEAPGQVFWHPNGWRIYTTLQDYMRRMQDRDGYVEVNTPQVVDRKLWEKSGHWDKYQEN
MFIVEVDEDHAREKAVNALKPMNCPCHVQVFNQGLKSYRDLPLRMAEFGSCARYEPSGALHGIMRVRGFTQDDGHIFCTE
DQITSETAKFIAFLSKVYADLGFDNWTIKLSTRPEQRIGSDETWDNMEQALGDACKAAGYDYEILEGEGAFYGPKLEFTL
TDAIGRNWQCGTLQVDANLPERLEASFIGQDGSKHRPVMLHRATLGSFERFIGILIEEHAGKLPFWLAPRQVVVASITSE
ADDYVNEVVETLRAAGVRAEADTRNEKINYKVREHSVGKVPVILAVGHREVEERTVSVRRLGEKQTKVESLTNVTEELAK
AATPPDLL
>Mature_647_residues
AQISLTFPDGNARSYDAGITPAEVAADISTSLAKKAISATVDGQHWDLQWPVTQDAAIAIHTMKDEAQANELIRHDLAHI
MARAVQEIWPDTKVTIGPVIENGWYYDFDRAEPFTPEDLGTIEKKMKEIINKREPVTTEVWEREKAIQYYTDNNEPYKVE
LIDSIPGDEPLRMYWHGDWQDLCRGPHLQHTGQVPGDAFKLMSIAGAYWRGDSDRQMLQRIYGVAFTGKEKLKAHLTMLE
EAAKRDHRKLGREMNLFHMQEEAPGQVFWHPNGWRIYTTLQDYMRRMQDRDGYVEVNTPQVVDRKLWEKSGHWDKYQENM
FIVEVDEDHAREKAVNALKPMNCPCHVQVFNQGLKSYRDLPLRMAEFGSCARYEPSGALHGIMRVRGFTQDDGHIFCTED
QITSETAKFIAFLSKVYADLGFDNWTIKLSTRPEQRIGSDETWDNMEQALGDACKAAGYDYEILEGEGAFYGPKLEFTLT
DAIGRNWQCGTLQVDANLPERLEASFIGQDGSKHRPVMLHRATLGSFERFIGILIEEHAGKLPFWLAPRQVVVASITSEA
DDYVNEVVETLRAAGVRAEADTRNEKINYKVREHSVGKVPVILAVGHREVEERTVSVRRLGEKQTKVESLTNVTEELAKA
ATPPDLL

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=643, Percent_Identity=38.2581648522551, Blast_Score=445, Evalue=1e-125,
Organism=Homo sapiens, GI38570111, Length=604, Percent_Identity=38.5761589403974, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI20070344, Length=640, Percent_Identity=37.34375, Blast_Score=424, Evalue=1e-118,
Organism=Escherichia coli, GI1788013, Length=636, Percent_Identity=50.1572327044025, Blast_Score=651, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=171, Percent_Identity=28.0701754385965, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71984184, Length=619, Percent_Identity=39.0953150242326, Blast_Score=456, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI71984192, Length=619, Percent_Identity=39.0953150242326, Blast_Score=456, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6322112, Length=638, Percent_Identity=39.4984326018809, Blast_Score=449, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6322654, Length=409, Percent_Identity=35.6968215158924, Blast_Score=279, Evalue=1e-75,
Organism=Drosophila melanogaster, GI24583839, Length=642, Percent_Identity=40.0311526479751, Blast_Score=464, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24583842, Length=642, Percent_Identity=40.0311526479751, Blast_Score=464, Evalue=1e-130,
Organism=Drosophila melanogaster, GI28574141, Length=642, Percent_Identity=40.0311526479751, Blast_Score=464, Evalue=1e-130,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_SILST (Q1GFW2)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_613716.1
- ProteinModelPortal:   Q1GFW2
- SMR:   Q1GFW2
- STRING:   Q1GFW2
- GeneID:   4075785
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_1721
- NMPDR:   fig|292414.1.peg.3209
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   GFEYEVE
- PhylomeDB:   Q1GFW2
- ProtClustDB:   PRK00413
- BioCyc:   SSP292414:TM1040_1721-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 73772; Mature: 73641

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQISLTFPDGNARSYDAGITPAEVAADISTSLAKKAISATVDGQHWDLQWPVTQDAAIA
CCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCCCCCEEE
IHTMKDEAQANELIRHDLAHIMARAVQEIWPDTKVTIGPVIENGWYYDFDRAEPFTPEDL
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCCCCCCHHH
GTIEKKMKEIINKREPVTTEVWEREKAIQYYTDNNEPYKVELIDSIPGDEPLRMYWHGDW
HHHHHHHHHHHHCCCCCCHHHHHHHCCEEEEECCCCCEEEEEEECCCCCCCEEEEECCCH
QDLCRGPHLQHTGQVPGDAFKLMSIAGAYWRGDSDRQMLQRIYGVAFTGKEKLKAHLTML
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCEEECCHHHHHHHHHHH
EEAAKRDHRKLGREMNLFHMQEEAPGQVFWHPNGWRIYTTLQDYMRRMQDRDGYVEVNTP
HHHHHHHHHHHCCCCCEEEECCCCCCEEEECCCCCEEEHHHHHHHHHHHCCCCEEEECCH
QVVDRKLWEKSGHWDKYQENMFIVEVDEDHAREKAVNALKPMNCPCHVQVFNQGLKSYRD
HHHHHHHHHCCCCCCHHHCCEEEEEECCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHC
LPLRMAEFGSCARYEPSGALHGIMRVRGFTQDDGHIFCTEDQITSETAKFIAFLSKVYAD
CCHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHH
LGFDNWTIKLSTRPEQRIGSDETWDNMEQALGDACKAAGYDYEILEGEGAFYGPKLEFTL
CCCCCEEEEEECCCHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEECCEEEEEE
TDAIGRNWQCGTLQVDANLPERLEASFIGQDGSKHRPVMLHRATLGSFERFIGILIEEHA
EHHHCCCCCCEEEEECCCCCHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCC
GKLPFWLAPRQVVVASITSEADDYVNEVVETLRAAGVRAEADTRNEKINYKVREHSVGKV
CCCCEEECCHHEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCC
PVILAVGHREVEERTVSVRRLGEKQTKVESLTNVTEELAKAATPPDLL
EEEEEECCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AQISLTFPDGNARSYDAGITPAEVAADISTSLAKKAISATVDGQHWDLQWPVTQDAAIA
CEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCCCCCEEE
IHTMKDEAQANELIRHDLAHIMARAVQEIWPDTKVTIGPVIENGWYYDFDRAEPFTPEDL
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCCCCCCHHH
GTIEKKMKEIINKREPVTTEVWEREKAIQYYTDNNEPYKVELIDSIPGDEPLRMYWHGDW
HHHHHHHHHHHHCCCCCCHHHHHHHCCEEEEECCCCCEEEEEEECCCCCCCEEEEECCCH
QDLCRGPHLQHTGQVPGDAFKLMSIAGAYWRGDSDRQMLQRIYGVAFTGKEKLKAHLTML
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCEEECCHHHHHHHHHHH
EEAAKRDHRKLGREMNLFHMQEEAPGQVFWHPNGWRIYTTLQDYMRRMQDRDGYVEVNTP
HHHHHHHHHHHCCCCCEEEECCCCCCEEEECCCCCEEEHHHHHHHHHHHCCCCEEEECCH
QVVDRKLWEKSGHWDKYQENMFIVEVDEDHAREKAVNALKPMNCPCHVQVFNQGLKSYRD
HHHHHHHHHCCCCCCHHHCCEEEEEECCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHC
LPLRMAEFGSCARYEPSGALHGIMRVRGFTQDDGHIFCTEDQITSETAKFIAFLSKVYAD
CCHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHH
LGFDNWTIKLSTRPEQRIGSDETWDNMEQALGDACKAAGYDYEILEGEGAFYGPKLEFTL
CCCCCEEEEEECCCHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEECCEEEEEE
TDAIGRNWQCGTLQVDANLPERLEASFIGQDGSKHRPVMLHRATLGSFERFIGILIEEHA
EHHHCCCCCCEEEEECCCCCHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCC
GKLPFWLAPRQVVVASITSEADDYVNEVVETLRAAGVRAEADTRNEKINYKVREHSVGKV
CCCCEEECCHHEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCC
PVILAVGHREVEERTVSVRRLGEKQTKVESLTNVTEELAKAATPPDLL
EEEEEECCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA