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The map label for this gene is hisM [H]

Identifier: 99081555

GI number: 99081555

Start: 1811789

End: 1812595

Strand: Direct

Name: hisM [H]

Synonym: TM1040_1714

Alternate gene names: 99081555

Gene position: 1811789-1812595 (Clockwise)

Preceding gene: 99081554

Following gene: 99081557

Centisome position: 56.6

GC content: 58.74

Gene sequence:

>807_bases
ATGAGCTGCTTTGAAACCTTTCAGGCCTATGCGCTGCGCTCAATCGGGATTGGCGAACGGTTGCTGCCGCGCAGTGACTT
TACGCTCTGCGATCAATTTGTCCTGATCGGTTCCGGCCTGATCTGGAACGTCTACTTCGGCGCGATTGCGATTTTCACCG
GGTTCTTCTTTGCCAATGCCCTCGCGGTGGCGAAGAACTCCCACAAGCGCTGGCTGCGCGCACCGGCAAACGGGTTCATC
TTTGTGTTCCGGGGCTCGCCGCTGTTCATCCAGTTCTTCTTTGCCTATTTCGTGTTCCTGTCGCTCAAGAGTGTTTCACC
GATCTTTGATCCGCTCTCGGCGGCCTGGCTTGGTGCGCTGATCGTGCTGTTCCTCAATACCTCGGCCTATTCGGCAGAGA
TCTTCTACGGCGCGCTGCGCTCGATCCCCAAAGGCGACCTCGAAGCCGCCGACGCCTATGGTCTGTCGGGCTGGAGCCGC
TTTCGCAGGGTGATCTGGCCCACCATGATGCGGCTGGCCTGGCCCGCCTATACCAACGAGGCGATCTTTCTGTTCCACGC
CACGACACTGGTCTATTTCTCGGGCTTTCCGGCGTGGCGCCAAAAGGGCGATGCGCTGTATTACGCGAACTACTTCGCGG
ATAAGACCTTCAACCCGTTCGTCCCCTACCCGATCCTTGCGTTCTATTTCATCCTGCTGACGCTGGCGATCATCGCGGTG
TTTGGAATGATCAACACGCGGCTCAACCGGCATATGCCACAGGAGCTGCGCCGCAAGATCCGGGTGCGCCCGCAGCTGAT
GCGCTAA

Upstream 100 bases:

>100_bases
AGGTCTCTGAAATCGTCCTGGCCCGTATTTCCCGCCGCCTGTCCCATGGGCAGGCCACCCTCGCCGGCGAAGCCCAACGC
AAAGCCGAAGGAGCCGCAAC

Downstream 100 bases:

>100_bases
GGGCGCGACACCCGCAAAGAAAAAACGCCCCGCTGATCAGATCAGCGGGGCGTTTTCTTATCCACGCGCCTTGGCACGCA
CATAGTTGCCCGGCGCCTGT

Product: amino acid ABC transporter permease

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MSCFETFQAYALRSIGIGERLLPRSDFTLCDQFVLIGSGLIWNVYFGAIAIFTGFFFANALAVAKNSHKRWLRAPANGFI
FVFRGSPLFIQFFFAYFVFLSLKSVSPIFDPLSAAWLGALIVLFLNTSAYSAEIFYGALRSIPKGDLEAADAYGLSGWSR
FRRVIWPTMMRLAWPAYTNEAIFLFHATTLVYFSGFPAWRQKGDALYYANYFADKTFNPFVPYPILAFYFILLTLAIIAV
FGMINTRLNRHMPQELRRKIRVRPQLMR

Sequences:

>Translated_268_residues
MSCFETFQAYALRSIGIGERLLPRSDFTLCDQFVLIGSGLIWNVYFGAIAIFTGFFFANALAVAKNSHKRWLRAPANGFI
FVFRGSPLFIQFFFAYFVFLSLKSVSPIFDPLSAAWLGALIVLFLNTSAYSAEIFYGALRSIPKGDLEAADAYGLSGWSR
FRRVIWPTMMRLAWPAYTNEAIFLFHATTLVYFSGFPAWRQKGDALYYANYFADKTFNPFVPYPILAFYFILLTLAIIAV
FGMINTRLNRHMPQELRRKIRVRPQLMR
>Mature_267_residues
SCFETFQAYALRSIGIGERLLPRSDFTLCDQFVLIGSGLIWNVYFGAIAIFTGFFFANALAVAKNSHKRWLRAPANGFIF
VFRGSPLFIQFFFAYFVFLSLKSVSPIFDPLSAAWLGALIVLFLNTSAYSAEIFYGALRSIPKGDLEAADAYGLSGWSRF
RRVIWPTMMRLAWPAYTNEAIFLFHATTLVYFSGFPAWRQKGDALYYANYFADKTFNPFVPYPILAFYFILLTLAIIAVF
GMINTRLNRHMPQELRRKIRVRPQLMR

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=219, Percent_Identity=31.5068493150685, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1788226, Length=222, Percent_Identity=30.1801801801802, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787086, Length=120, Percent_Identity=35, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787030, Length=174, Percent_Identity=32.7586206896552, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87082239, Length=159, Percent_Identity=30.188679245283, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788646, Length=167, Percent_Identity=29.3413173652695, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787087, Length=239, Percent_Identity=25.1046025104602, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 30741; Mature: 30610

Theoretical pI: Translated: 10.33; Mature: 10.33

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSCFETFQAYALRSIGIGERLLPRSDFTLCDQFVLIGSGLIWNVYFGAIAIFTGFFFANA
CCHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LAVAKNSHKRWLRAPANGFIFVFRGSPLFIQFFFAYFVFLSLKSVSPIFDPLSAAWLGAL
HHHHHCCHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
IVLFLNTSAYSAEIFYGALRSIPKGDLEAADAYGLSGWSRFRRVIWPTMMRLAWPAYTNE
HHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCC
AIFLFHATTLVYFSGFPAWRQKGDALYYANYFADKTFNPFVPYPILAFYFILLTLAIIAV
EEEEEEHHHHHHHCCCHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FGMINTRLNRHMPQELRRKIRVRPQLMR
HHHHHHHHHHCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SCFETFQAYALRSIGIGERLLPRSDFTLCDQFVLIGSGLIWNVYFGAIAIFTGFFFANA
CHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LAVAKNSHKRWLRAPANGFIFVFRGSPLFIQFFFAYFVFLSLKSVSPIFDPLSAAWLGAL
HHHHHCCHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
IVLFLNTSAYSAEIFYGALRSIPKGDLEAADAYGLSGWSRFRRVIWPTMMRLAWPAYTNE
HHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCC
AIFLFHATTLVYFSGFPAWRQKGDALYYANYFADKTFNPFVPYPILAFYFILLTLAIIAV
EEEEEEHHHHHHHCCCHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FGMINTRLNRHMPQELRRKIRVRPQLMR
HHHHHHHHHHCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]