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The map label for this gene is maeB [H]

Identifier: 99081414

GI number: 99081414

Start: 1680851

End: 1683130

Strand: Direct

Name: maeB [H]

Synonym: TM1040_1573

Alternate gene names: 99081414

Gene position: 1680851-1683130 (Clockwise)

Preceding gene: 99081408

Following gene: 99081415

Centisome position: 52.51

GC content: 60.96

Gene sequence:

>2280_bases
ATGCCCGACAAGACCTCGGAATCCCTGCGCGACGCGGCTCTGCGCTACCACGAGTTCCCGCGTCCCGGTAAACTGGAAAT
TCGCGCCACAAAACCGCTGGCCACTGGCAACGACCTTGCACGGGCCTACTCACCCGGCGTGGCTGAAGCCTGTCTTGAGA
TCAAGGACGACGAGGCCAATGCCGCGCGCTACACGGCGCGGGGCAATCTGGTTGCGGTGGTCTCCAACGGCTCTGCGGTT
CTGGGACTTGGCAACATCGGTGCGCTGGCCTCCAAACCGGTGATGGAAGGCAAGGCGGTTCTATTCAAGAACTTCGCCAA
TATCGACTGCTTTGACATTGAATTGAACGAGAGCGATCCTGAGAAACTGGCCGACATCGTCTGCGCGCTGGAGCCGACCT
TTGGCGCGGTAAACCTTGAAGACATCAAGGCACCTGATTGTTTTATCGTCGAAAAACTCTGTCGCGAGCGGATGAACATC
CCCGTGTTTCACGATGACCAGCATGGCACCGCGATCGTTGTCGGCGCCGCGGCCAAGAACGCGCTCCATGTAGCGGGCAA
GAAGTTCGAGGACATCAAGATCGTCTCGACCGGCGGCGGGGCAGCGGGCATTGCCTGCCTCAACATGCTGCTGAAACTTG
GGGTCAAGCGAGAGAACGTCTGGCTCTGCGATATTCACGGCTTGGTCTATGAAGGCCGCGAGGAGGACATGAACCCGCAC
AAGGCGGCCTTTGCTCAGGCTTCTGAGAAACGGACGCTGGATGAGGTGATCGACGGCGCGGATCTGTTCCTTGGCCTTTC
CGGTCCCAATGTGCTCAAGCCCGAGATGGTCACGAAGATGGCGAAACGCCCGATCATCTTTGCGCTGGCGAACCCGACCC
CGGAGATCATGCCCGATGAGGCGCGCAAGGTGGCGCCAGACGCTATCATCGCCACGGGTCGCAGCGATTTTCCCAATCAG
GTCAACAACGTACTGTGCTTTCCGTTTATCTTCCGTGGCGCGCTGGACGTTGGCGCCACTGAGATCAACGACGAGATGCA
GATTGCCTGTGTCGAGGGGATCGCAGAGCTTGCGCGGACCACAACCTCAGCCGAGGCGGCTGCGGCCTACAAGGGGGAGC
AGCTCACCTTTGGCGCGGATTACCTGATCCCAAAGCCTTTTGACCCGCGTCTGGTGGCGGTGGTTTCCTCTGCCGTTGCG
CGCGCGGCCATGTCCAGCGGCGTGGCCAAGCGGCCGATCGACGATCTGGGGGCTTACCGCGCCAAGCTGAACCAAAGCGT
GTTCAAATCCGCGCTCCTGATGAAACCTGTGTTCGAGGCCGCTCGCGCGGCAGCCCGCCGGATCGTCTTTGCTGAAGGCG
AAGACGAGCGCGTCTTGCGCACCGCACAGGAGATGCTGCGCGAGACCACAGAGACTCCGATCCTGATTGGTCGACCGGAG
GTGATCGAGCACCGCTGCCAGCGTCTGGGACTGTCGATCCGTCCCGGTCAGGACGTTCAAATTGTGAACCCTGAAAACGA
TCCGCGCTACCGTGACTATTGGACCAGCTATCATCGGATCATGGAGCGCCGGGGGGTGACGCCGGATCTCGCCAAAGCGA
TCCTGCGCACCAACACCACCGCGATTGGCGCCATCATGGTGCATCGCGGAGAGGCGGACAGCCTGATCTGCGGCACGTTC
GGAGAGTACCGCTGGCACCTCAACTATGTGCAGCAGATCCTGGGCGGCGGTTCTTATGCGCCACATGGGGCGCTCTCGAT
GATGATCCTCGACGATGGGCCGATGTTCATTGCCGACACCCAGGTCCGCATTGAACCGACTCCAGAAGAAATCGCCGAAA
CCGTGATCGGTGCAGCGCGCCATGTGCGCCGATTTGGTCTGAAGCCGCAGATTGCGCTCTGTTCGCAGAGCCAGTTCGGC
AACATCCAATGCGACACCGGGGAGCGTCTGCGCGCAGCTTTGGCGATCCTCGACGACAAGCGGCGCGATTTTGTCTACGA
GGGCGAAATGAACATCGACACCGCGCTCGACCCGGAGCTGCGTGAGCGGATCTTCCCCAATTCGCGGCTAGAAGGTGCTG
CCAATGTGCTGGTCTTTGCCCATGCGGATGCGGCGTCTGGTGTGCGCAACATCCTCAAGATGCGCTCTGGCGGGCTTGAG
GTCGGGCCGATCCTGATGGGCATGGGCAACCGCGCTCATATTGTTTCCCCGTCGATCACCGCACGCGGATTGTTGAACAT
GGCCGCCATCGCGGGCACTCCGGTCGCCCATTACGGCTGA

Upstream 100 bases:

>100_bases
ATGCAAAGCCTTGCCGATGATCTGCGCCTTGTGCAAAAGGCGGTTCCCCTCACCCGCAAGATAGTTTAGCACTAAACTAT
CACCATCAGGAGCGACCTTC

Downstream 100 bases:

>100_bases
CGCCCAGCGCAGCGCAAAATGATCTCTGCGAGGGGCAGCCCTGCCCTTCGCCCTCCACGCGCGGCGCGCCGTGGCCTCGA
CCTTGACCTTGACCTAAGGT

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 759; Mature: 758

Protein sequence:

>759_residues
MPDKTSESLRDAALRYHEFPRPGKLEIRATKPLATGNDLARAYSPGVAEACLEIKDDEANAARYTARGNLVAVVSNGSAV
LGLGNIGALASKPVMEGKAVLFKNFANIDCFDIELNESDPEKLADIVCALEPTFGAVNLEDIKAPDCFIVEKLCRERMNI
PVFHDDQHGTAIVVGAAAKNALHVAGKKFEDIKIVSTGGGAAGIACLNMLLKLGVKRENVWLCDIHGLVYEGREEDMNPH
KAAFAQASEKRTLDEVIDGADLFLGLSGPNVLKPEMVTKMAKRPIIFALANPTPEIMPDEARKVAPDAIIATGRSDFPNQ
VNNVLCFPFIFRGALDVGATEINDEMQIACVEGIAELARTTTSAEAAAAYKGEQLTFGADYLIPKPFDPRLVAVVSSAVA
RAAMSSGVAKRPIDDLGAYRAKLNQSVFKSALLMKPVFEAARAAARRIVFAEGEDERVLRTAQEMLRETTETPILIGRPE
VIEHRCQRLGLSIRPGQDVQIVNPENDPRYRDYWTSYHRIMERRGVTPDLAKAILRTNTTAIGAIMVHRGEADSLICGTF
GEYRWHLNYVQQILGGGSYAPHGALSMMILDDGPMFIADTQVRIEPTPEEIAETVIGAARHVRRFGLKPQIALCSQSQFG
NIQCDTGERLRAALAILDDKRRDFVYEGEMNIDTALDPELRERIFPNSRLEGAANVLVFAHADAASGVRNILKMRSGGLE
VGPILMGMGNRAHIVSPSITARGLLNMAAIAGTPVAHYG

Sequences:

>Translated_759_residues
MPDKTSESLRDAALRYHEFPRPGKLEIRATKPLATGNDLARAYSPGVAEACLEIKDDEANAARYTARGNLVAVVSNGSAV
LGLGNIGALASKPVMEGKAVLFKNFANIDCFDIELNESDPEKLADIVCALEPTFGAVNLEDIKAPDCFIVEKLCRERMNI
PVFHDDQHGTAIVVGAAAKNALHVAGKKFEDIKIVSTGGGAAGIACLNMLLKLGVKRENVWLCDIHGLVYEGREEDMNPH
KAAFAQASEKRTLDEVIDGADLFLGLSGPNVLKPEMVTKMAKRPIIFALANPTPEIMPDEARKVAPDAIIATGRSDFPNQ
VNNVLCFPFIFRGALDVGATEINDEMQIACVEGIAELARTTTSAEAAAAYKGEQLTFGADYLIPKPFDPRLVAVVSSAVA
RAAMSSGVAKRPIDDLGAYRAKLNQSVFKSALLMKPVFEAARAAARRIVFAEGEDERVLRTAQEMLRETTETPILIGRPE
VIEHRCQRLGLSIRPGQDVQIVNPENDPRYRDYWTSYHRIMERRGVTPDLAKAILRTNTTAIGAIMVHRGEADSLICGTF
GEYRWHLNYVQQILGGGSYAPHGALSMMILDDGPMFIADTQVRIEPTPEEIAETVIGAARHVRRFGLKPQIALCSQSQFG
NIQCDTGERLRAALAILDDKRRDFVYEGEMNIDTALDPELRERIFPNSRLEGAANVLVFAHADAASGVRNILKMRSGGLE
VGPILMGMGNRAHIVSPSITARGLLNMAAIAGTPVAHYG
>Mature_758_residues
PDKTSESLRDAALRYHEFPRPGKLEIRATKPLATGNDLARAYSPGVAEACLEIKDDEANAARYTARGNLVAVVSNGSAVL
GLGNIGALASKPVMEGKAVLFKNFANIDCFDIELNESDPEKLADIVCALEPTFGAVNLEDIKAPDCFIVEKLCRERMNIP
VFHDDQHGTAIVVGAAAKNALHVAGKKFEDIKIVSTGGGAAGIACLNMLLKLGVKRENVWLCDIHGLVYEGREEDMNPHK
AAFAQASEKRTLDEVIDGADLFLGLSGPNVLKPEMVTKMAKRPIIFALANPTPEIMPDEARKVAPDAIIATGRSDFPNQV
NNVLCFPFIFRGALDVGATEINDEMQIACVEGIAELARTTTSAEAAAAYKGEQLTFGADYLIPKPFDPRLVAVVSSAVAR
AAMSSGVAKRPIDDLGAYRAKLNQSVFKSALLMKPVFEAARAAARRIVFAEGEDERVLRTAQEMLRETTETPILIGRPEV
IEHRCQRLGLSIRPGQDVQIVNPENDPRYRDYWTSYHRIMERRGVTPDLAKAILRTNTTAIGAIMVHRGEADSLICGTFG
EYRWHLNYVQQILGGGSYAPHGALSMMILDDGPMFIADTQVRIEPTPEEIAETVIGAARHVRRFGLKPQIALCSQSQFGN
IQCDTGERLRAALAILDDKRRDFVYEGEMNIDTALDPELRERIFPNSRLEGAANVLVFAHADAASGVRNILKMRSGGLEV
GPILMGMGNRAHIVSPSITARGLLNMAAIAGTPVAHYG

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI62420882, Length=346, Percent_Identity=26.878612716763, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI62420880, Length=346, Percent_Identity=26.878612716763, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI239049447, Length=346, Percent_Identity=26.878612716763, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI4505143, Length=346, Percent_Identity=26.3005780346821, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI4505145, Length=337, Percent_Identity=24.0356083086053, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI270265879, Length=319, Percent_Identity=24.7648902821317, Blast_Score=70, Evalue=1e-11,
Organism=Escherichia coli, GI1788806, Length=749, Percent_Identity=55.1401869158878, Blast_Score=843, Evalue=0.0,
Organism=Escherichia coli, GI1788800, Length=322, Percent_Identity=27.0186335403727, Blast_Score=105, Evalue=2e-23,
Organism=Escherichia coli, GI1788635, Length=309, Percent_Identity=25.5663430420712, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI87081919, Length=297, Percent_Identity=26.2626262626263, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322823, Length=236, Percent_Identity=30.9322033898305, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356279, Length=393, Percent_Identity=25.1908396946565, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281362672, Length=393, Percent_Identity=25.1908396946565, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281362674, Length=393, Percent_Identity=25.1908396946565, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646388, Length=347, Percent_Identity=27.9538904899135, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646386, Length=347, Percent_Identity=27.9538904899135, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI78707242, Length=398, Percent_Identity=25.3768844221106, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI78707238, Length=398, Percent_Identity=25.3768844221106, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI78707240, Length=342, Percent_Identity=25.4385964912281, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI78707232, Length=352, Percent_Identity=25.8522727272727, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281363505, Length=352, Percent_Identity=25.8522727272727, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI78707236, Length=352, Percent_Identity=25.8522727272727, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281363503, Length=352, Percent_Identity=25.8522727272727, Blast_Score=68, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 82413; Mature: 82281

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDKTSESLRDAALRYHEFPRPGKLEIRATKPLATGNDLARAYSPGVAEACLEIKDDEAN
CCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHCCCCHHHHHHHCCCCCCC
AARYTARGNLVAVVSNGSAVLGLGNIGALASKPVMEGKAVLFKNFANIDCFDIELNESDP
CEEEEECCCEEEEEECCCEEEEECCCCCHHCCCCCCCCCEEEECCCCCEEEEEEECCCCH
EKLADIVCALEPTFGAVNLEDIKAPDCFIVEKLCRERMNIPVFHDDQHGTAIVVGAAAKN
HHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEECCCCC
ALHVAGKKFEDIKIVSTGGGAAGIACLNMLLKLGVKRENVWLCDIHGLVYEGREEDMNPH
HHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCEECCCCCCCCHH
KAAFAQASEKRTLDEVIDGADLFLGLSGPNVLKPEMVTKMAKRPIIFALANPTPEIMPDE
HHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCH
ARKVAPDAIIATGRSDFPNQVNNVLCFPFIFRGALDVGATEINDEMQIACVEGIAELART
HHHCCCCCEEECCCCCCCHHHHCEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
TTSAEAAAAYKGEQLTFGADYLIPKPFDPRLVAVVSSAVARAAMSSGVAKRPIDDLGAYR
CCCHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
AKLNQSVFKSALLMKPVFEAARAAARRIVFAEGEDERVLRTAQEMLRETTETPILIGRPE
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCCEEECCHH
VIEHRCQRLGLSIRPGQDVQIVNPENDPRYRDYWTSYHRIMERRGVTPDLAKAILRTNTT
HHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
AIGAIMVHRGEADSLICGTFGEYRWHLNYVQQILGGGSYAPHGALSMMILDDGPMFIADT
EEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEECC
QVRIEPTPEEIAETVIGAARHVRRFGLKPQIALCSQSQFGNIQCDTGERLRAALAILDDK
EEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEECCCHHHHHHHHHHCCC
RRDFVYEGEMNIDTALDPELRERIFPNSRLEGAANVLVFAHADAASGVRNILKMRSGGLE
CCCEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCE
VGPILMGMGNRAHIVSPSITARGLLNMAAIAGTPVAHYG
ECHHEECCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PDKTSESLRDAALRYHEFPRPGKLEIRATKPLATGNDLARAYSPGVAEACLEIKDDEAN
CCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHCCCCHHHHHHHCCCCCCC
AARYTARGNLVAVVSNGSAVLGLGNIGALASKPVMEGKAVLFKNFANIDCFDIELNESDP
CEEEEECCCEEEEEECCCEEEEECCCCCHHCCCCCCCCCEEEECCCCCEEEEEEECCCCH
EKLADIVCALEPTFGAVNLEDIKAPDCFIVEKLCRERMNIPVFHDDQHGTAIVVGAAAKN
HHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEECCCCC
ALHVAGKKFEDIKIVSTGGGAAGIACLNMLLKLGVKRENVWLCDIHGLVYEGREEDMNPH
HHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCEECCCCCCCCHH
KAAFAQASEKRTLDEVIDGADLFLGLSGPNVLKPEMVTKMAKRPIIFALANPTPEIMPDE
HHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCH
ARKVAPDAIIATGRSDFPNQVNNVLCFPFIFRGALDVGATEINDEMQIACVEGIAELART
HHHCCCCCEEECCCCCCCHHHHCEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
TTSAEAAAAYKGEQLTFGADYLIPKPFDPRLVAVVSSAVARAAMSSGVAKRPIDDLGAYR
CCCHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
AKLNQSVFKSALLMKPVFEAARAAARRIVFAEGEDERVLRTAQEMLRETTETPILIGRPE
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCCEEECCHH
VIEHRCQRLGLSIRPGQDVQIVNPENDPRYRDYWTSYHRIMERRGVTPDLAKAILRTNTT
HHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
AIGAIMVHRGEADSLICGTFGEYRWHLNYVQQILGGGSYAPHGALSMMILDDGPMFIADT
EEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEECC
QVRIEPTPEEIAETVIGAARHVRRFGLKPQIALCSQSQFGNIQCDTGERLRAALAILDDK
EEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEECCCHHHHHHHHHHCCC
RRDFVYEGEMNIDTALDPELRERIFPNSRLEGAANVLVFAHADAASGVRNILKMRSGGLE
CCCEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCE
VGPILMGMGNRAHIVSPSITARGLLNMAAIAGTPVAHYG
ECHHEECCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]