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The map label for this gene is deoA [H]

Identifier: 99081412

GI number: 99081412

Start: 1678773

End: 1680077

Strand: Reverse

Name: deoA [H]

Synonym: TM1040_1571

Alternate gene names: 99081412

Gene position: 1680077-1678773 (Counterclockwise)

Preceding gene: 99081413

Following gene: 99081411

Centisome position: 52.49

GC content: 65.59

Gene sequence:

>1305_bases
ATGGATGCGCGCGCGGTCATTGCCCGGTTAAGGCAGAAACACACCCCAAGCACCGAGGAGCTGCGCTGGTTTGCCGAGGG
GCTTGCCAGTGGCGCCGTCAGCGACGCGCAGGCGGGCGCCTTTGCTATGGCGATCTGTCTCAACGGGTTGCCAGCCGCGG
CGCGCTCTGACCTGACACTTGCGATGCGCGACAGCGGCGATGTTCTGACGTGGGATCTGCCGGGGCCGGTGGTGGACAAA
CACTCGACCGGTGGGGTCGGCGATTGCGTGTCGCTTCTTCTGGCGCCTGCGCTTGCGGAATGTGGCGCTTATGTCCCGAT
GATCTCGGGACGCGGTCTTGGGCACACCGGTGGCACGCTCGACAAGCTGGAGGCGATCCCCGGTCTAAGCACCGAGGTCA
CGCAAGATCGGCTGGCGGGAATTGTGGCCGACGTTGGCTGCGCCATCGTGGGGGCAACCGCGCGGATTGCCCCGGCGGAC
AAGCGGCTTTATGCGGTGCGCGATGTGACGGCCACGGTGGAGAGCCTCGATCTGATTACAGCATCGATCCTTTCGAAAAA
GCTGGCTGCCAGCCCCGAGGCATTGGTGCTGGATGTCAAAATCGGCTCGGGCGCCTTTATGAAAACTGTGGAGGAGGCGC
GCGCTTTGGCGACCTCTCTGGTGGAAACCTCAAAGGCGGCGGGGTGTCCGACGCAGGCGCTGATCACCGACATGAACCAG
CCGCTTGTTCCAGCCTTGGGCAATGCGCTTGAGGTTGCCGAAGTGGTGCGGGCGCTCACCGGTCAGTCGAGCGGGCAGAT
CATCGAGATCACCGTGGCACTTGGTGGCGCGCTGTTGCAGCAGGCGGGACTTGCCCCCAACCAAGAGGCGGGCGAGACGC
AAATTGCCGCCGCAATCGCCGAAGGTCGCGCGGCAGAGCGGTTTGCCCGAATGATTGCCGCGCAGGGTGGTCCGTCCACA
GAGCTTGAGACATGGGCGCGCGCGCTGCCGCAAGCACCGGTCTGCGCAGAGGTCACGGCCGAGGACGCAGGCTATGTTGC
GGCGATCGACGGCGAGGCCCTTGGTCTGCTGGTGGTTCGGCTGGGCGGCGGGCGTATGGTTGAAAGCGACCGTATCGACC
CTGCGGTCGGGATCTCGGACCTGCTGCACTTGGGGGCCAAAGTGGCCAGGGGCGATGTCATTGCGCGCGTTCATGCCGCC
CACGCAGAGGCCGCGCAAGATGCGATCTCGGCCTTGCGGGCGGCGGTGAGGCTTGCACCTGCCGCACCCGACCTGCCGCC
GCTGTTGCATGAGAGGATCAGCTGA

Upstream 100 bases:

>100_bases
GTGACCCTTGCAACCACCGATGGCGTCGAAATGCAGACCACGATTGGTGATCTGCTGCCTGGCGCGTTTGACGCAGGCCA
TATGGAGCGGAGCTGAGGGC

Downstream 100 bases:

>100_bases
TGGCGCGTGCCTTTCTGGTTGTATTGGACTCGGTTGGTATCGGCGGCGCGCCGGATGCCGGGGCCTATTACAACAAGGAT
CTGCCCGATCTCGGGGCCAA

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MDARAVIARLRQKHTPSTEELRWFAEGLASGAVSDAQAGAFAMAICLNGLPAAARSDLTLAMRDSGDVLTWDLPGPVVDK
HSTGGVGDCVSLLLAPALAECGAYVPMISGRGLGHTGGTLDKLEAIPGLSTEVTQDRLAGIVADVGCAIVGATARIAPAD
KRLYAVRDVTATVESLDLITASILSKKLAASPEALVLDVKIGSGAFMKTVEEARALATSLVETSKAAGCPTQALITDMNQ
PLVPALGNALEVAEVVRALTGQSSGQIIEITVALGGALLQQAGLAPNQEAGETQIAAAIAEGRAAERFARMIAAQGGPST
ELETWARALPQAPVCAEVTAEDAGYVAAIDGEALGLLVVRLGGGRMVESDRIDPAVGISDLLHLGAKVARGDVIARVHAA
HAEAAQDAISALRAAVRLAPAAPDLPPLLHERIS

Sequences:

>Translated_434_residues
MDARAVIARLRQKHTPSTEELRWFAEGLASGAVSDAQAGAFAMAICLNGLPAAARSDLTLAMRDSGDVLTWDLPGPVVDK
HSTGGVGDCVSLLLAPALAECGAYVPMISGRGLGHTGGTLDKLEAIPGLSTEVTQDRLAGIVADVGCAIVGATARIAPAD
KRLYAVRDVTATVESLDLITASILSKKLAASPEALVLDVKIGSGAFMKTVEEARALATSLVETSKAAGCPTQALITDMNQ
PLVPALGNALEVAEVVRALTGQSSGQIIEITVALGGALLQQAGLAPNQEAGETQIAAAIAEGRAAERFARMIAAQGGPST
ELETWARALPQAPVCAEVTAEDAGYVAAIDGEALGLLVVRLGGGRMVESDRIDPAVGISDLLHLGAKVARGDVIARVHAA
HAEAAQDAISALRAAVRLAPAAPDLPPLLHERIS
>Mature_434_residues
MDARAVIARLRQKHTPSTEELRWFAEGLASGAVSDAQAGAFAMAICLNGLPAAARSDLTLAMRDSGDVLTWDLPGPVVDK
HSTGGVGDCVSLLLAPALAECGAYVPMISGRGLGHTGGTLDKLEAIPGLSTEVTQDRLAGIVADVGCAIVGATARIAPAD
KRLYAVRDVTATVESLDLITASILSKKLAASPEALVLDVKIGSGAFMKTVEEARALATSLVETSKAAGCPTQALITDMNQ
PLVPALGNALEVAEVVRALTGQSSGQIIEITVALGGALLQQAGLAPNQEAGETQIAAAIAEGRAAERFARMIAAQGGPST
ELETWARALPQAPVCAEVTAEDAGYVAAIDGEALGLLVVRLGGGRMVESDRIDPAVGISDLLHLGAKVARGDVIARVHAA
HAEAAQDAISALRAAVRLAPAAPDLPPLLHERIS

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [H]

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=417, Percent_Identity=42.9256594724221, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI4503445, Length=417, Percent_Identity=42.9256594724221, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI166158922, Length=417, Percent_Identity=42.9256594724221, Blast_Score=252, Evalue=4e-67,
Organism=Escherichia coli, GI1790842, Length=436, Percent_Identity=48.1651376146789, Blast_Score=383, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 44277; Mature: 44277

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDARAVIARLRQKHTPSTEELRWFAEGLASGAVSDAQAGAFAMAICLNGLPAAARSDLTL
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEE
AMRDSGDVLTWDLPGPVVDKHSTGGVGDCVSLLLAPALAECGAYVPMISGRGLGHTGGTL
EEECCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCH
DKLEAIPGLSTEVTQDRLAGIVADVGCAIVGATARIAPADKRLYAVRDVTATVESLDLIT
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCEEEHHHHHHHHHHHHHHH
ASILSKKLAASPEALVLDVKIGSGAFMKTVEEARALATSLVETSKAAGCPTQALITDMNQ
HHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCC
PLVPALGNALEVAEVVRALTGQSSGQIIEITVALGGALLQQAGLAPNQEAGETQIAAAIA
CCHHHHCCHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHH
EGRAAERFARMIAAQGGPSTELETWARALPQAPVCAEVTAEDAGYVAAIDGEALGLLVVR
HCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEE
LGGGRMVESDRIDPAVGISDLLHLGAKVARGDVIARVHAAHAEAAQDAISALRAAVRLAP
ECCCEEECCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AAPDLPPLLHERIS
CCCCCCHHHHHHCC
>Mature Secondary Structure
MDARAVIARLRQKHTPSTEELRWFAEGLASGAVSDAQAGAFAMAICLNGLPAAARSDLTL
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEE
AMRDSGDVLTWDLPGPVVDKHSTGGVGDCVSLLLAPALAECGAYVPMISGRGLGHTGGTL
EEECCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCH
DKLEAIPGLSTEVTQDRLAGIVADVGCAIVGATARIAPADKRLYAVRDVTATVESLDLIT
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCEEEHHHHHHHHHHHHHHH
ASILSKKLAASPEALVLDVKIGSGAFMKTVEEARALATSLVETSKAAGCPTQALITDMNQ
HHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCC
PLVPALGNALEVAEVVRALTGQSSGQIIEITVALGGALLQQAGLAPNQEAGETQIAAAIA
CCHHHHCCHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHH
EGRAAERFARMIAAQGGPSTELETWARALPQAPVCAEVTAEDAGYVAAIDGEALGLLVVR
HCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEE
LGGGRMVESDRIDPAVGISDLLHLGAKVARGDVIARVHAAHAEAAQDAISALRAAVRLAP
ECCCEEECCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AAPDLPPLLHERIS
CCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA