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The map label for this gene is adk [H]

Identifier: 99081331

GI number: 99081331

Start: 1595898

End: 1596581

Strand: Direct

Name: adk [H]

Synonym: TM1040_1490

Alternate gene names: 99081331

Gene position: 1595898-1596581 (Clockwise)

Preceding gene: 99081330

Following gene: 99081332

Centisome position: 49.86

GC content: 62.43

Gene sequence:

>684_bases
ATGACCACAGATGTTATGACCCGCCCCGCGGTACTGATCCTGCTGGGCCCTCCGGGGGCTGGCAAAGGCACGCAGGCGCG
GATGCTTCAGGAAAAATACGGCCTTGTGCAGCTTTCCACCGGGGATCTTCTGCGTGCGGCCGTGGCTGCGGGCACCGATG
CGGGCAAACAGGCCAAGGCGGTGATGGATGCGGGCGGTCTGGTCTCTGACGAGATCGTCATCGCCATCCTCAAGGACCGG
ATGAACGACGCAGATTGCCGCAACGGGGTCATCCTCGACGGCTTCCCGCGCACAACCGTGCAGGCCAAAGCGCTGGATGG
GCTGCTGGCCTCGACCGGACAGCGGATCAACGCAGCAATCAGCCTCGAAGTGAATGACAGCGCGATGGTGACACGGATCT
CCGGGCGCTCCACCTGCGCGGATTGCGGAGAAGGCTATCACGACACCTTCAAGCCGCCTATGCCGGGTGAAGTCTGCGCC
AAATGCGGCGGTGAAACCCTCACGCGGCGCGCTGATGATCGGGCAGAGACAGTGGCCAGCCGGCTTGAGGCCTATCATGC
GCAGACCGCACCGCTGATCGCCTATTACCAAGAGGCCGGCGTGCTGAAATCCGTGGATGCAATGGCGGAAATCAGCAGCG
TTGCGACGCAGATATCCTCTGTGGTGGAAACGATCCTGCACTAA

Upstream 100 bases:

>100_bases
GGAGAATGATTTTGGCAGCCTCGGCGACACCTCGACCCTCGCGGATCCTTCGGTCGTCGATGATCTGATCTCCAACCGTG
CCAACAAGGGTTAAGCGACC

Downstream 100 bases:

>100_bases
GGTCGCCCTCTGCGCGAGAGCATCAGATGCCTCCGCCCCGAGGGTCGGAGGCATCTGATTTATTTTCTTTTGCATCCAAG
GGCAGAGGTTGAAATAAGGG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MTTDVMTRPAVLILLGPPGAGKGTQARMLQEKYGLVQLSTGDLLRAAVAAGTDAGKQAKAVMDAGGLVSDEIVIAILKDR
MNDADCRNGVILDGFPRTTVQAKALDGLLASTGQRINAAISLEVNDSAMVTRISGRSTCADCGEGYHDTFKPPMPGEVCA
KCGGETLTRRADDRAETVASRLEAYHAQTAPLIAYYQEAGVLKSVDAMAEISSVATQISSVVETILH

Sequences:

>Translated_227_residues
MTTDVMTRPAVLILLGPPGAGKGTQARMLQEKYGLVQLSTGDLLRAAVAAGTDAGKQAKAVMDAGGLVSDEIVIAILKDR
MNDADCRNGVILDGFPRTTVQAKALDGLLASTGQRINAAISLEVNDSAMVTRISGRSTCADCGEGYHDTFKPPMPGEVCA
KCGGETLTRRADDRAETVASRLEAYHAQTAPLIAYYQEAGVLKSVDAMAEISSVATQISSVVETILH
>Mature_226_residues
TTDVMTRPAVLILLGPPGAGKGTQARMLQEKYGLVQLSTGDLLRAAVAAGTDAGKQAKAVMDAGGLVSDEIVIAILKDRM
NDADCRNGVILDGFPRTTVQAKALDGLLASTGQRINAAISLEVNDSAMVTRISGRSTCADCGEGYHDTFKPPMPGEVCAK
CGGETLTRRADDRAETVASRLEAYHAQTAPLIAYYQEAGVLKSVDAMAEISSVATQISSVVETILH

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=198, Percent_Identity=45.4545454545455, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI7524346, Length=195, Percent_Identity=45.6410256410256, Blast_Score=191, Evalue=4e-49,
Organism=Homo sapiens, GI19923437, Length=212, Percent_Identity=33.9622641509434, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI310110345, Length=195, Percent_Identity=34.3589743589744, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI53832003, Length=195, Percent_Identity=34.3589743589744, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI8051579, Length=195, Percent_Identity=34.3589743589744, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI53832001, Length=195, Percent_Identity=34.3589743589744, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI4502011, Length=217, Percent_Identity=31.3364055299539, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI28144899, Length=228, Percent_Identity=29.8245614035088, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI28144897, Length=228, Percent_Identity=29.8245614035088, Blast_Score=103, Evalue=9e-23,
Organism=Homo sapiens, GI22749187, Length=189, Percent_Identity=32.8042328042328, Blast_Score=93, Evalue=2e-19,
Organism=Escherichia coli, GI1786680, Length=216, Percent_Identity=48.6111111111111, Blast_Score=193, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI17552384, Length=222, Percent_Identity=43.2432432432432, Blast_Score=186, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17567503, Length=206, Percent_Identity=30.5825242718447, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17550688, Length=217, Percent_Identity=29.0322580645161, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17533833, Length=214, Percent_Identity=26.1682242990654, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17537943, Length=190, Percent_Identity=30, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=208, Percent_Identity=45.6730769230769, Blast_Score=198, Evalue=7e-52,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=35.3846153846154, Blast_Score=123, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322828, Length=191, Percent_Identity=27.7486910994764, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI22026816, Length=211, Percent_Identity=46.4454976303318, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI17737899, Length=191, Percent_Identity=37.696335078534, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24645822, Length=191, Percent_Identity=37.696335078534, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17647141, Length=218, Percent_Identity=28.4403669724771, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24663208, Length=217, Percent_Identity=28.5714285714286, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221459597, Length=221, Percent_Identity=25.7918552036199, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21356893, Length=221, Percent_Identity=25.7918552036199, Blast_Score=87, Evalue=7e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23767; Mature: 23636

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDVMTRPAVLILLGPPGAGKGTQARMLQEKYGLVQLSTGDLLRAAVAAGTDAGKQAKA
CCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHHHCCCCCHHHHH
VMDAGGLVSDEIVIAILKDRMNDADCRNGVILDGFPRTTVQAKALDGLLASTGQRINAAI
HHHCCCCCCHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCEEEEEE
SLEVNDSAMVTRISGRSTCADCGEGYHDTFKPPMPGEVCAKCGGETLTRRADDRAETVAS
EEEECCCEEEEEECCCCCHHHHCCCCCCCCCCCCCHHHHHHCCCHHHHHCCCHHHHHHHH
RLEAYHAQTAPLIAYYQEAGVLKSVDAMAEISSVATQISSVVETILH
HHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTDVMTRPAVLILLGPPGAGKGTQARMLQEKYGLVQLSTGDLLRAAVAAGTDAGKQAKA
CCCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHHHCCCCCHHHHH
VMDAGGLVSDEIVIAILKDRMNDADCRNGVILDGFPRTTVQAKALDGLLASTGQRINAAI
HHHCCCCCCHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCEEEEEE
SLEVNDSAMVTRISGRSTCADCGEGYHDTFKPPMPGEVCAKCGGETLTRRADDRAETVAS
EEEECCCEEEEEECCCCCHHHHCCCCCCCCCCCCCHHHHHHCCCHHHHHCCCHHHHHHHH
RLEAYHAQTAPLIAYYQEAGVLKSVDAMAEISSVATQISSVVETILH
HHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA