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The map label for this gene is acsA [H]

Identifier: 99081330

GI number: 99081330

Start: 1593933

End: 1595891

Strand: Direct

Name: acsA [H]

Synonym: TM1040_1489

Alternate gene names: 99081330

Gene position: 1593933-1595891 (Clockwise)

Preceding gene: 99081329

Following gene: 99081331

Centisome position: 49.8

GC content: 60.08

Gene sequence:

>1959_bases
ATGACCACGCCCGAGAGCGCAGTTTACCCACCGTCTGAGGACATCGTCAAAAACGCCCATGTCAATGCGGCAAAATACGA
CGAGATGTACGCGCAATCCCTTGAGAACCCAGAGAAGTTCTGGGCAGAGCAGGCTGAACGCATCGACTGGATCAAGCCGT
TCACCAAGGTCAAGAATGTGTCCTATGATTTTGGCAACGTGGACATCAAATGGTTCGAGGACGGTCAGCTGAACGTCGCA
GCCAACTGCATCGACCGCCATCTGGAGACCCGTGGCGATCAGACCGCGATCATCTGGGAGCCTGATGATCCATCCGATGA
GGCCAAGCACATCTCCTACAAGGAGCTGCACCTCAGAACCTGCCGCATGGCCAACATCCTCGAGAGCATGGGTGTCGGCA
AAGGCGACCGAGTGGTGATCTACCTGCCCATGATCCCCGAAGCCGCCTATGCCATGCTGGCCTGCGCGCGCATCGGTGCG
ATCCACTCAATTGTTTTTGCAGGGTTTTCACCGGACGCCCTGGCGGCGCGGATTAATGGCTGCGACGCCAAGGTTGTGAT
CACCGCCGACGAGGCCCCGCGCGGAGGGCGCAAGACGCCTCTGAAGTCGAACGCCGACGCCGCCCTGCTGCACTGCAAGG
AAAGCGTGAAGTGCCTCGTGGTGCGCCGCACCGGCGGTCAGACCACATGGATCGACGGTCGCGACCACGACTATAACGAG
ATGGCGCTGGAGGCGAATGACTACTGCAAACCCGCCGCAATGGACGCAGAGGATCCGCTGTTCATTCTCTACACCTCCGG
TTCGACCGGGCAGCCCAAGGGCGTTGTACACACCACCGGTGGCTACCTCACCTATGCCGCACTCACCCATGAGGTGACGT
TTGATTACCACGATGGCGACATCTACTGGTGTACGGCCGATGTGGGCTGGGTCACGGGCCATAGCTATATCGTGTATGGC
CCCCTCGCCAATGGCGCCACCACATTGATGTTTGAGGGCGTGCCCACCTACCCCGATGCGGGCCGGTTCTGGGCGGTCTG
CGAAAAGCACAAGGTCAACCAGTTCTACACGGCACCGACGGCGATCCGCGCCCTGATGGGGCAAGGGACGGAATTTGTCG
AGAAATACGACCTCTCCGACCTGAAGCTCCTCGGCACAGTGGGCGAGCCCATCAACCCGGAGGCCTGGAACTGGTACAAT
GATGTGGTCGGCAAGAGCAAATGCCCGATCGTCGATACCTGGTGGCAGACTGAGACCGGCGGACACCTGATGACCCCGCT
GCCTGGCGCCCACGCCACCAAACCGGGTGCTGCGATGAAGCCCTTCTTTGGCGTGGAGCCTGTCGTCCTCGATCCGCAGT
CGGGCGCTGAAATCGACGGCAACGGCGTTGAGGGCGTGCTCTGTATCAAGGACAGCTGGCCGGGCCAGATGCGTACAGTC
TGGGGCGATCACGAACGTTTCGAGAAGACCTACTTCTCTGATTACAAAGGCTATTATTTCACGGGTGATGGGTGCCGCCG
CGATGCCGACGGCGACTATTGGATCACCGGGCGCGTGGACGATGTGATCAACGTCTCTGGTCACCGCATGGGCACCGCCG
AGGTGGAAAGCGCGCTTGTCGCACATGCCGCCGTGGCCGAAGCCGCTGTTGTGGGCTACCCGCATGAGATCAAGGGCCAG
GGCATCTACTGCTATGTCACCCTGATGAATGATCGCGAGCCTTCTGACGAGCTCCTGAAGGAGCTGCGTCAGTGGGTGCG
CACCGAGATTGGCCCCATTGCATCGCCTGATGTAATCCAATGGGCGCCTGGCCTGCCGAAGACACGTTCGGGCAAGATCA
TGCGCCGCATCCTGCGTAAAATTGCGGAGAATGATTTTGGCAGCCTCGGCGACACCTCGACCCTCGCGGATCCTTCGGTC
GTCGATGATCTGATCTCCAACCGTGCCAACAAGGGTTAA

Upstream 100 bases:

>100_bases
ACTTCGCTTATTATCACGCCCAAGGTTGGAGAAGGTTTGACTCTTGGCGCACTTCCATGTGGAGATCGCGCCCAAGAGAA
TTTTGGAGGGAGGACATTCC

Downstream 100 bases:

>100_bases
GCGACCATGACCACAGATGTTATGACCCGCCCCGCGGTACTGATCCTGCTGGGCCCTCCGGGGGCTGGCAAAGGCACGCA
GGCGCGGATGCTTCAGGAAA

Product: acetyl-coenzyme A synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 652; Mature: 651

Protein sequence:

>652_residues
MTTPESAVYPPSEDIVKNAHVNAAKYDEMYAQSLENPEKFWAEQAERIDWIKPFTKVKNVSYDFGNVDIKWFEDGQLNVA
ANCIDRHLETRGDQTAIIWEPDDPSDEAKHISYKELHLRTCRMANILESMGVGKGDRVVIYLPMIPEAAYAMLACARIGA
IHSIVFAGFSPDALAARINGCDAKVVITADEAPRGGRKTPLKSNADAALLHCKESVKCLVVRRTGGQTTWIDGRDHDYNE
MALEANDYCKPAAMDAEDPLFILYTSGSTGQPKGVVHTTGGYLTYAALTHEVTFDYHDGDIYWCTADVGWVTGHSYIVYG
PLANGATTLMFEGVPTYPDAGRFWAVCEKHKVNQFYTAPTAIRALMGQGTEFVEKYDLSDLKLLGTVGEPINPEAWNWYN
DVVGKSKCPIVDTWWQTETGGHLMTPLPGAHATKPGAAMKPFFGVEPVVLDPQSGAEIDGNGVEGVLCIKDSWPGQMRTV
WGDHERFEKTYFSDYKGYYFTGDGCRRDADGDYWITGRVDDVINVSGHRMGTAEVESALVAHAAVAEAAVVGYPHEIKGQ
GIYCYVTLMNDREPSDELLKELRQWVRTEIGPIASPDVIQWAPGLPKTRSGKIMRRILRKIAENDFGSLGDTSTLADPSV
VDDLISNRANKG

Sequences:

>Translated_652_residues
MTTPESAVYPPSEDIVKNAHVNAAKYDEMYAQSLENPEKFWAEQAERIDWIKPFTKVKNVSYDFGNVDIKWFEDGQLNVA
ANCIDRHLETRGDQTAIIWEPDDPSDEAKHISYKELHLRTCRMANILESMGVGKGDRVVIYLPMIPEAAYAMLACARIGA
IHSIVFAGFSPDALAARINGCDAKVVITADEAPRGGRKTPLKSNADAALLHCKESVKCLVVRRTGGQTTWIDGRDHDYNE
MALEANDYCKPAAMDAEDPLFILYTSGSTGQPKGVVHTTGGYLTYAALTHEVTFDYHDGDIYWCTADVGWVTGHSYIVYG
PLANGATTLMFEGVPTYPDAGRFWAVCEKHKVNQFYTAPTAIRALMGQGTEFVEKYDLSDLKLLGTVGEPINPEAWNWYN
DVVGKSKCPIVDTWWQTETGGHLMTPLPGAHATKPGAAMKPFFGVEPVVLDPQSGAEIDGNGVEGVLCIKDSWPGQMRTV
WGDHERFEKTYFSDYKGYYFTGDGCRRDADGDYWITGRVDDVINVSGHRMGTAEVESALVAHAAVAEAAVVGYPHEIKGQ
GIYCYVTLMNDREPSDELLKELRQWVRTEIGPIASPDVIQWAPGLPKTRSGKIMRRILRKIAENDFGSLGDTSTLADPSV
VDDLISNRANKG
>Mature_651_residues
TTPESAVYPPSEDIVKNAHVNAAKYDEMYAQSLENPEKFWAEQAERIDWIKPFTKVKNVSYDFGNVDIKWFEDGQLNVAA
NCIDRHLETRGDQTAIIWEPDDPSDEAKHISYKELHLRTCRMANILESMGVGKGDRVVIYLPMIPEAAYAMLACARIGAI
HSIVFAGFSPDALAARINGCDAKVVITADEAPRGGRKTPLKSNADAALLHCKESVKCLVVRRTGGQTTWIDGRDHDYNEM
ALEANDYCKPAAMDAEDPLFILYTSGSTGQPKGVVHTTGGYLTYAALTHEVTFDYHDGDIYWCTADVGWVTGHSYIVYGP
LANGATTLMFEGVPTYPDAGRFWAVCEKHKVNQFYTAPTAIRALMGQGTEFVEKYDLSDLKLLGTVGEPINPEAWNWYND
VVGKSKCPIVDTWWQTETGGHLMTPLPGAHATKPGAAMKPFFGVEPVVLDPQSGAEIDGNGVEGVLCIKDSWPGQMRTVW
GDHERFEKTYFSDYKGYYFTGDGCRRDADGDYWITGRVDDVINVSGHRMGTAEVESALVAHAAVAEAAVVGYPHEIKGQG
IYCYVTLMNDREPSDELLKELRQWVRTEIGPIASPDVIQWAPGLPKTRSGKIMRRILRKIAENDFGSLGDTSTLADPSVV
DDLISNRANKG

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=674, Percent_Identity=52.5222551928783, Blast_Score=702, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=687, Percent_Identity=51.528384279476, Blast_Score=700, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=624, Percent_Identity=50.9615384615385, Blast_Score=653, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=631, Percent_Identity=37.7179080824089, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI38505220, Length=512, Percent_Identity=28.90625, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI42544132, Length=519, Percent_Identity=28.9017341040462, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI122937307, Length=551, Percent_Identity=26.8602540834846, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI115511026, Length=555, Percent_Identity=27.9279279279279, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI31982927, Length=619, Percent_Identity=23.4248788368336, Blast_Score=164, Evalue=3e-40,
Organism=Homo sapiens, GI58082049, Length=521, Percent_Identity=27.063339731286, Blast_Score=156, Evalue=6e-38,
Organism=Homo sapiens, GI157311624, Length=522, Percent_Identity=27.0114942528736, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI157311622, Length=522, Percent_Identity=27.0114942528736, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI187761345, Length=389, Percent_Identity=27.7634961439589, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI187761343, Length=389, Percent_Identity=27.7634961439589, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI42544134, Length=332, Percent_Identity=25.6024096385542, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI195947378, Length=466, Percent_Identity=25.3218884120172, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI156151445, Length=394, Percent_Identity=24.3654822335025, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1790505, Length=637, Percent_Identity=62.7943485086342, Blast_Score=833, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=631, Percent_Identity=38.351822503962, Blast_Score=419, Evalue=1e-118,
Organism=Escherichia coli, GI145693145, Length=513, Percent_Identity=24.9512670565302, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1788107, Length=569, Percent_Identity=24.4288224956063, Blast_Score=86, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71982997, Length=662, Percent_Identity=49.2447129909366, Blast_Score=612, Evalue=1e-175,
Organism=Caenorhabditis elegans, GI71983001, Length=662, Percent_Identity=49.2447129909366, Blast_Score=612, Evalue=1e-175,
Organism=Caenorhabditis elegans, GI17569507, Length=595, Percent_Identity=22.1848739495798, Blast_Score=127, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17559526, Length=529, Percent_Identity=24.007561436673, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17557194, Length=556, Percent_Identity=22.6618705035971, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17538037, Length=176, Percent_Identity=30.1136363636364, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560140, Length=392, Percent_Identity=21.6836734693878, Blast_Score=76, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323182, Length=640, Percent_Identity=50.3125, Blast_Score=640, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319264, Length=638, Percent_Identity=47.8056426332288, Blast_Score=601, Evalue=1e-172,
Organism=Saccharomyces cerevisiae, GI6319699, Length=386, Percent_Identity=23.3160621761658, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667955, Length=665, Percent_Identity=55.0375939849624, Blast_Score=715, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=564, Percent_Identity=58.8652482269503, Blast_Score=649, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=522, Percent_Identity=60.1532567049808, Blast_Score=611, Evalue=1e-175,
Organism=Drosophila melanogaster, GI21355225, Length=636, Percent_Identity=34.4339622641509, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI21355181, Length=553, Percent_Identity=24.0506329113924, Blast_Score=109, Evalue=6e-24,
Organism=Drosophila melanogaster, GI18859661, Length=177, Percent_Identity=30.5084745762712, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 71977; Mature: 71845

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPESAVYPPSEDIVKNAHVNAAKYDEMYAQSLENPEKFWAEQAERIDWIKPFTKVKNV
CCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
SYDFGNVDIKWFEDGQLNVAANCIDRHLETRGDQTAIIWEPDDPSDEAKHISYKELHLRT
CCCCCCEEEEEEECCCEEEHHHHHHHHHHCCCCCEEEEECCCCCCCHHHCCCHHHHHHHH
CRMANILESMGVGKGDRVVIYLPMIPEAAYAMLACARIGAIHSIVFAGFSPDALAARING
HHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEECC
CDAKVVITADEAPRGGRKTPLKSNADAALLHCKESVKCLVVRRTGGQTTWIDGRDHDYNE
CCEEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCEEEEEEEECCCCEEEECCCCCCCCC
MALEANDYCKPAAMDAEDPLFILYTSGSTGQPKGVVHTTGGYLTYAALTHEVTFDYHDGD
EEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEECCCCEEEEEEEEEEEEEEEECCE
IYWCTADVGWVTGHSYIVYGPLANGATTLMFEGVPTYPDAGRFWAVCEKHKVNQFYTAPT
EEEEECCCCEEECCCEEEEECCCCCEEEEEECCCCCCCCCCCEEEHHHHCCCCEEECCHH
AIRALMGQGTEFVEKYDLSDLKLLGTVGEPINPEAWNWYNDVVGKSKCPIVDTWWQTETG
HHHHHHCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHCCCCCCCEEECCCCCCCC
GHLMTPLPGAHATKPGAAMKPFFGVEPVVLDPQSGAEIDGNGVEGVLCIKDSWPGQMRTV
CEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEECCCCCCEEEEEECCCCCCEEEE
WGDHERFEKTYFSDYKGYYFTGDGCRRDADGDYWITGRVDDVINVSGHRMGTAEVESALV
CCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEECCCCEEECCCCCCCHHHHHHHHH
AHAAVAEAAVVGYPHEIKGQGIYCYVTLMNDREPSDELLKELRQWVRTEIGPIASPDVIQ
HHHHHHHHHHCCCCHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCEE
WAPGLPKTRSGKIMRRILRKIAENDFGSLGDTSTLADPSVVDDLISNRANKG
ECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TTPESAVYPPSEDIVKNAHVNAAKYDEMYAQSLENPEKFWAEQAERIDWIKPFTKVKNV
CCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
SYDFGNVDIKWFEDGQLNVAANCIDRHLETRGDQTAIIWEPDDPSDEAKHISYKELHLRT
CCCCCCEEEEEEECCCEEEHHHHHHHHHHCCCCCEEEEECCCCCCCHHHCCCHHHHHHHH
CRMANILESMGVGKGDRVVIYLPMIPEAAYAMLACARIGAIHSIVFAGFSPDALAARING
HHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEECC
CDAKVVITADEAPRGGRKTPLKSNADAALLHCKESVKCLVVRRTGGQTTWIDGRDHDYNE
CCEEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCEEEEEEEECCCCEEEECCCCCCCCC
MALEANDYCKPAAMDAEDPLFILYTSGSTGQPKGVVHTTGGYLTYAALTHEVTFDYHDGD
EEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEECCCCEEEEEEEEEEEEEEEECCE
IYWCTADVGWVTGHSYIVYGPLANGATTLMFEGVPTYPDAGRFWAVCEKHKVNQFYTAPT
EEEEECCCCEEECCCEEEEECCCCCEEEEEECCCCCCCCCCCEEEHHHHCCCCEEECCHH
AIRALMGQGTEFVEKYDLSDLKLLGTVGEPINPEAWNWYNDVVGKSKCPIVDTWWQTETG
HHHHHHCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHCCCCCCCEEECCCCCCCC
GHLMTPLPGAHATKPGAAMKPFFGVEPVVLDPQSGAEIDGNGVEGVLCIKDSWPGQMRTV
CEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEECCCCCCEEEEEECCCCCCEEEE
WGDHERFEKTYFSDYKGYYFTGDGCRRDADGDYWITGRVDDVINVSGHRMGTAEVESALV
CCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEECCCCEEECCCCCCCHHHHHHHHH
AHAAVAEAAVVGYPHEIKGQGIYCYVTLMNDREPSDELLKELRQWVRTEIGPIASPDVIQ
HHHHHHHHHHCCCCHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCEE
WAPGLPKTRSGKIMRRILRKIAENDFGSLGDTSTLADPSVVDDLISNRANKG
ECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9256491 [H]