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The map label for this gene is mcpA [H]

Identifier: 99081328

GI number: 99081328

Start: 1588830

End: 1590218

Strand: Direct

Name: mcpA [H]

Synonym: TM1040_1487

Alternate gene names: 99081328

Gene position: 1588830-1590218 (Clockwise)

Preceding gene: 99081321

Following gene: 99081329

Centisome position: 49.64

GC content: 56.95

Gene sequence:

>1389_bases
ATGCTTTTTAAGAAGTCCAAAACCGCTGCGTCCTCCAGCCTGAATGACGATCAGAAGCTGCGCGCGATGATCGAAAACAC
CCAGGCCGTCATCGAGTTCAAGGTCGATGGGACCATCATTCGCGCAAACAAGGTCTTTTTGGACACGCTGGGCTACACGC
TTGAGGAAATCGAGGGCCAACACCACAGCATGTTTGTCTATCCGAGTTTTGTGAGAAAAGACGCCTACAAGCAGATGTGG
CGCGATCTGGCTGCGGGCAATCCGCTGACGGATCAGTTTCCGAGGCTGCGCAAGGACGGAGAAGTTGTTTGGATTCAAGC
AACCTACGCGCCGTTCTTCAATGAAGATGGGACCGTCGACCGGATCGTGAAAATCGCGTCCAACATCACCAAGCGCCGAA
TGGAAATTCTTGGAATTGCCGCCGCGCTGGAACAACTGAGAAACGGTGATTTGACCTATCGATGCGCCCCCTCCGACATC
GATGACATCGGGCGTCTCTCCACAGCCTATAACGAGGCTGTCAGCTCTCTGCAAAACACCATTCGCACGGTGCGCGAAGT
GGCAGATGGCGTCACACGCACGGCGGGTCAGTTGAATGACTCCTCCTCTGAACTGTCGCAACGCACGGAAAATCAGGCGG
CGACACTGGAGGAAACAGCCGCCGCAGTCGAGGAGTTGACAGCAACCGTCCGCTCTTCGGCGGATGGCGCACGCGAAGTC
GAGGACAATGTTCGCCAGGCCCGCGTGACCGCTGAGAAAAGCGGCCAGGTCGTCAGTGACGCTGTAAAAGCAATGTCCAA
GATCGAAGAATCCTCGCAAAGCATTTCAAAGATCATCTCCGTGATCGACGACATCGCCTTTCAGACCAACCTGCTGGCCT
TGAACGCTGGCGTCGAAGCTGCGCGCGCAGGCGAAGCGGGGCGCGGATTTGCCGTGGTTGCCTCCGAGGTCCGAAATCTA
GCGCTTCGCTCTGCGGATGCCGCTGGTGAAATCAAAGGCTTGATCGATCAAAGCGCCACCCATGTCTCTGACGGCGTGAC
CCTGGTGGGCCGCACCGGCACAGAACTCGAGGCGATCATCAGCAGCGTGAACTCGATTTCTGAGAACGTCAGCGTCATCG
CACGCGGAGCCGAGGAACAAGCCGTAACGCTCAGCGAAATCAACAGCGGCATCGGTCATCTTGATGAGGTGACACAAAAC
AACGTCGCTATGGTGGAAGAGACCACTGGCGCAAGCCAGACCCTCGCCAGCGATGCCTCGGTGATGTCGAAAGAGATCGC
GAATTTTGTATCCGAGGGCGAAATCAAGATCGCAAAACATGTCGCGCCGATCCCGAACACGCCGCCGCCAACCGTGGAAC
CTGAACTGGAACTGCGCACCGGCACCTAG

Upstream 100 bases:

>100_bases
GCATTGGCGGAAGGATTATGTTAGGAATTCAACGCTAATCTGGCGGGAAGTTTCGCCGAGCGGTATCGGCGTCGATCCAC
TCCTGCGATGGAACTCCTAC

Downstream 100 bases:

>100_bases
TCCTCTAGAGTCCCCCCCGGTTGGGACTCATCCCAAGCCATTCCGATCTAAGGGCGCGGTCGGCACTCATGCCACCGCGC
CTTTCCCATCGAAGGTGTGG

Product: methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor

Products: NA

Alternate protein names: Methyl-accepting chemotaxis protein [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MLFKKSKTAASSSLNDDQKLRAMIENTQAVIEFKVDGTIIRANKVFLDTLGYTLEEIEGQHHSMFVYPSFVRKDAYKQMW
RDLAAGNPLTDQFPRLRKDGEVVWIQATYAPFFNEDGTVDRIVKIASNITKRRMEILGIAAALEQLRNGDLTYRCAPSDI
DDIGRLSTAYNEAVSSLQNTIRTVREVADGVTRTAGQLNDSSSELSQRTENQAATLEETAAAVEELTATVRSSADGAREV
EDNVRQARVTAEKSGQVVSDAVKAMSKIEESSQSISKIISVIDDIAFQTNLLALNAGVEAARAGEAGRGFAVVASEVRNL
ALRSADAAGEIKGLIDQSATHVSDGVTLVGRTGTELEAIISSVNSISENVSVIARGAEEQAVTLSEINSGIGHLDEVTQN
NVAMVEETTGASQTLASDASVMSKEIANFVSEGEIKIAKHVAPIPNTPPPTVEPELELRTGT

Sequences:

>Translated_462_residues
MLFKKSKTAASSSLNDDQKLRAMIENTQAVIEFKVDGTIIRANKVFLDTLGYTLEEIEGQHHSMFVYPSFVRKDAYKQMW
RDLAAGNPLTDQFPRLRKDGEVVWIQATYAPFFNEDGTVDRIVKIASNITKRRMEILGIAAALEQLRNGDLTYRCAPSDI
DDIGRLSTAYNEAVSSLQNTIRTVREVADGVTRTAGQLNDSSSELSQRTENQAATLEETAAAVEELTATVRSSADGAREV
EDNVRQARVTAEKSGQVVSDAVKAMSKIEESSQSISKIISVIDDIAFQTNLLALNAGVEAARAGEAGRGFAVVASEVRNL
ALRSADAAGEIKGLIDQSATHVSDGVTLVGRTGTELEAIISSVNSISENVSVIARGAEEQAVTLSEINSGIGHLDEVTQN
NVAMVEETTGASQTLASDASVMSKEIANFVSEGEIKIAKHVAPIPNTPPPTVEPELELRTGT
>Mature_462_residues
MLFKKSKTAASSSLNDDQKLRAMIENTQAVIEFKVDGTIIRANKVFLDTLGYTLEEIEGQHHSMFVYPSFVRKDAYKQMW
RDLAAGNPLTDQFPRLRKDGEVVWIQATYAPFFNEDGTVDRIVKIASNITKRRMEILGIAAALEQLRNGDLTYRCAPSDI
DDIGRLSTAYNEAVSSLQNTIRTVREVADGVTRTAGQLNDSSSELSQRTENQAATLEETAAAVEELTATVRSSADGAREV
EDNVRQARVTAEKSGQVVSDAVKAMSKIEESSQSISKIISVIDDIAFQTNLLALNAGVEAARAGEAGRGFAVVASEVRNL
ALRSADAAGEIKGLIDQSATHVSDGVTLVGRTGTELEAIISSVNSISENVSVIARGAEEQAVTLSEINSGIGHLDEVTQN
NVAMVEETTGASQTLASDASVMSKEIANFVSEGEIKIAKHVAPIPNTPPPTVEPELELRTGT

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein. Note=Localized at the flagellum-bearing pole of the swarmer cell [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=312, Percent_Identity=41.3461538461538, Blast_Score=214, Evalue=9e-57,
Organism=Escherichia coli, GI1788195, Length=331, Percent_Identity=39.5770392749245, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1788194, Length=312, Percent_Identity=41.025641025641, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI2367378, Length=263, Percent_Identity=44.4866920152091, Blast_Score=194, Evalue=8e-51,
Organism=Escherichia coli, GI1789453, Length=304, Percent_Identity=34.2105263157895, Blast_Score=149, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 49673; Mature: 49673

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50113 PAC ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFKKSKTAASSSLNDDQKLRAMIENTQAVIEFKVDGTIIRANKVFLDTLGYTLEEIEGQ
CCCCCCCCHHHCCCCHHHHHHHHHHCCCEEEEEEECCEEEECCHHHHHHHHHHHHHHCCC
HHSMFVYPSFVRKDAYKQMWRDLAAGNPLTDQFPRLRKDGEVVWIQATYAPFFNEDGTVD
CCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEEEECCCCCCCCCHH
RIVKIASNITKRRMEILGIAAALEQLRNGDLTYRCAPSDIDDIGRLSTAYNEAVSSLQNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
IRTVREVADGVTRTAGQLNDSSSELSQRTENQAATLEETAAAVEELTATVRSSADGAREV
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
EDNVRQARVTAEKSGQVVSDAVKAMSKIEESSQSISKIISVIDDIAFQTNLLALNAGVEA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCHH
ARAGEAGRGFAVVASEVRNLALRSADAAGEIKGLIDQSATHVSDGVTLVGRTGTELEAII
HHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
SSVNSISENVSVIARGAEEQAVTLSEINSGIGHLDEVTQNNVAMVEETTGASQTLASDAS
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCHHHHHHHHH
VMSKEIANFVSEGEIKIAKHVAPIPNTPPPTVEPELELRTGT
HHHHHHHHHHHCCCEEEEHHCCCCCCCCCCCCCCCCEEECCC
>Mature Secondary Structure
MLFKKSKTAASSSLNDDQKLRAMIENTQAVIEFKVDGTIIRANKVFLDTLGYTLEEIEGQ
CCCCCCCCHHHCCCCHHHHHHHHHHCCCEEEEEEECCEEEECCHHHHHHHHHHHHHHCCC
HHSMFVYPSFVRKDAYKQMWRDLAAGNPLTDQFPRLRKDGEVVWIQATYAPFFNEDGTVD
CCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEEEECCCCCCCCCHH
RIVKIASNITKRRMEILGIAAALEQLRNGDLTYRCAPSDIDDIGRLSTAYNEAVSSLQNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
IRTVREVADGVTRTAGQLNDSSSELSQRTENQAATLEETAAAVEELTATVRSSADGAREV
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
EDNVRQARVTAEKSGQVVSDAVKAMSKIEESSQSISKIISVIDDIAFQTNLLALNAGVEA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCHH
ARAGEAGRGFAVVASEVRNLALRSADAAGEIKGLIDQSATHVSDGVTLVGRTGTELEAII
HHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
SSVNSISENVSVIARGAEEQAVTLSEINSGIGHLDEVTQNNVAMVEETTGASQTLASDAS
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCHHHHHHHHH
VMSKEIANFVSEGEIKIAKHVAPIPNTPPPTVEPELELRTGT
HHHHHHHHHHHCCCEEEEHHCCCCCCCCCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1577276; 11259647 [H]