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The map label for this gene is purM

Identifier: 99081317

GI number: 99081317

Start: 1576197

End: 1577243

Strand: Reverse

Name: purM

Synonym: TM1040_1476

Alternate gene names: 99081317

Gene position: 1577243-1576197 (Counterclockwise)

Preceding gene: 99081318

Following gene: 99081316

Centisome position: 49.27

GC content: 62.94

Gene sequence:

>1047_bases
ATGACCAGCGGCAAGAACGGGCTGACCTATGCGGATGCAGGGGTCGATATTGATGCGGGCAACGAACTTGTGGACCGGAT
CAAACCGGCCGCTAAGCGAACCAACCGCCCCGGCGTGATGAGCGGCCTTGGCGGCTTTGGCGCGCTGTTTGACCTGAAGG
CTGCTGGCTACGAGGATCCAATCCTTGTAGGCGCGACCGATGGGGTGGGCACTAAGCTGCGGATTGCCATTGATACGGGT
CTCGTGGACGGCGTCGGCATCGATCTTGTGGCGATGTGTGTCAACGATCTGGTTTGTCAGGGCGCAGAGCCGCTGTTCTT
TCTCGACTATTTTGCCACCGGCAAGCTGGAAACCGATGTCGCGGCGCGAATCATCGAAGGCATCGCCGAAGGCTGCGTGC
GCTCTGGCTGTGCGCTGATCGGCGGCGAGACCGCCGAGATGCCCGGCATGTACCCCAAAGGTGATTTTGACCTCGCCGGG
TTTGCCGTGGGCGCCATGGAGCGTGGCACAGCCCTGCCGGCAGGTGTCAGCGAAGGCGATGTCCTCTTGGGGCTGGCCTC
CGATGGCGTGCATTCCAACGGCTACTCTCTGGTGCGGCAGATCGTGAAATACTCCGGTCTGGGCTGGGATGGCGACAACC
CGTTTGGCGAGGGCAAACTGGGCGAGGCGCTGCTGACCCCCACGCGTCTCTATGTCAAACAATCCCTTGCCGCAGTGCGG
GCCGGGGGCGTCAATGCACTTGCGCATATCACAGGCGGCGGCCTCACGGAGAACCTGCCGCGGGTTCTGCCCGACGACCT
TGGTGCGGACATCGACCTCGGCGCCTGGGAGCTTCCGGGTGTGTTCAAGTGGATGGCGCAAACCGGTGGCATTGAAGAGA
GCGAAATGCTCAAGACCTTCAACTGCGGGATTGGCATGATCCTCGTTGTGAAAGCCGACCGGGCCGATGCGCTCACCGAG
GTGCTCGAGGGTGAGGGCGAGACCGTTGCGCGGCTTGGCACTGTGACGCGCGGGGAGGGTATTCGCTACACGGGCGCGCT
GCTGTGA

Upstream 100 bases:

>100_bases
CTTTGCTGTGTCGCTCAGTGTGCGGAGGGGCAGATTCCCTTGTTTCCTTCATGCGTCCTATAGGCTAAACGCTGCGCAAC
CATTGCGAAGGAGCCATGCG

Downstream 100 bases:

>100_bases
GCGACAAGAAACGCGTTGCGATCCTGATTTCCGGCGGGGGCTCCAATATGGTGTCCCTCGTCGACAGCATGTTGAACGAC
GCCGATCATCCGGGTTCGCC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MTSGKNGLTYADAGVDIDAGNELVDRIKPAAKRTNRPGVMSGLGGFGALFDLKAAGYEDPILVGATDGVGTKLRIAIDTG
LVDGVGIDLVAMCVNDLVCQGAEPLFFLDYFATGKLETDVAARIIEGIAEGCVRSGCALIGGETAEMPGMYPKGDFDLAG
FAVGAMERGTALPAGVSEGDVLLGLASDGVHSNGYSLVRQIVKYSGLGWDGDNPFGEGKLGEALLTPTRLYVKQSLAAVR
AGGVNALAHITGGGLTENLPRVLPDDLGADIDLGAWELPGVFKWMAQTGGIEESEMLKTFNCGIGMILVVKADRADALTE
VLEGEGETVARLGTVTRGEGIRYTGALL

Sequences:

>Translated_348_residues
MTSGKNGLTYADAGVDIDAGNELVDRIKPAAKRTNRPGVMSGLGGFGALFDLKAAGYEDPILVGATDGVGTKLRIAIDTG
LVDGVGIDLVAMCVNDLVCQGAEPLFFLDYFATGKLETDVAARIIEGIAEGCVRSGCALIGGETAEMPGMYPKGDFDLAG
FAVGAMERGTALPAGVSEGDVLLGLASDGVHSNGYSLVRQIVKYSGLGWDGDNPFGEGKLGEALLTPTRLYVKQSLAAVR
AGGVNALAHITGGGLTENLPRVLPDDLGADIDLGAWELPGVFKWMAQTGGIEESEMLKTFNCGIGMILVVKADRADALTE
VLEGEGETVARLGTVTRGEGIRYTGALL
>Mature_347_residues
TSGKNGLTYADAGVDIDAGNELVDRIKPAAKRTNRPGVMSGLGGFGALFDLKAAGYEDPILVGATDGVGTKLRIAIDTGL
VDGVGIDLVAMCVNDLVCQGAEPLFFLDYFATGKLETDVAARIIEGIAEGCVRSGCALIGGETAEMPGMYPKGDFDLAGF
AVGAMERGTALPAGVSEGDVLLGLASDGVHSNGYSLVRQIVKYSGLGWDGDNPFGEGKLGEALLTPTRLYVKQSLAAVRA
GGVNALAHITGGGLTENLPRVLPDDLGADIDLGAWELPGVFKWMAQTGGIEESEMLKTFNCGIGMILVVKADRADALTEV
LEGEGETVARLGTVTRGEGIRYTGALL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=340, Percent_Identity=54.4117647058823, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI209869995, Length=340, Percent_Identity=54.4117647058823, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI209869993, Length=340, Percent_Identity=54.4117647058823, Blast_Score=375, Evalue=1e-104,
Organism=Escherichia coli, GI1788845, Length=333, Percent_Identity=55.8558558558559, Blast_Score=363, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17567511, Length=353, Percent_Identity=44.7592067988669, Blast_Score=292, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6321203, Length=339, Percent_Identity=56.3421828908555, Blast_Score=383, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24582400, Length=285, Percent_Identity=47.0175438596491, Blast_Score=255, Evalue=3e-68,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_SILST (Q1GGK7)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_613471.1
- ProteinModelPortal:   Q1GGK7
- SMR:   Q1GGK7
- STRING:   Q1GGK7
- GeneID:   4077773
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_1476
- NMPDR:   fig|292414.1.peg.3423
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- PhylomeDB:   Q1GGK7
- ProtClustDB:   PRK05385
- BioCyc:   SSP292414:TM1040_1476-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 35929; Mature: 35798

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSGKNGLTYADAGVDIDAGNELVDRIKPAAKRTNRPGVMSGLGGFGALFDLKAAGYEDP
CCCCCCCCEEECCCCEECCCHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHCCCCCCC
ILVGATDGVGTKLRIAIDTGLVDGVGIDLVAMCVNDLVCQGAEPLFFLDYFATGKLETDV
EEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHH
AARIIEGIAEGCVRSGCALIGGETAEMPGMYPKGDFDLAGFAVGAMERGTALPAGVSEGD
HHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
VLLGLASDGVHSNGYSLVRQIVKYSGLGWDGDNPFGEGKLGEALLTPTRLYVKQSLAAVR
EEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHH
AGGVNALAHITGGGLTENLPRVLPDDLGADIDLGAWELPGVFKWMAQTGGIEESEMLKTF
CCCCEEEEEECCCCCHHCCCHHCHHHCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHH
NCGIGMILVVKADRADALTEVLEGEGETVARLGTVTRGEGIRYTGALL
CCCCEEEEEEECCCHHHHHHHHCCCCCEEHHHCCEECCCCCEECCCCC
>Mature Secondary Structure 
TSGKNGLTYADAGVDIDAGNELVDRIKPAAKRTNRPGVMSGLGGFGALFDLKAAGYEDP
CCCCCCCEEECCCCEECCCHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHCCCCCCC
ILVGATDGVGTKLRIAIDTGLVDGVGIDLVAMCVNDLVCQGAEPLFFLDYFATGKLETDV
EEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHH
AARIIEGIAEGCVRSGCALIGGETAEMPGMYPKGDFDLAGFAVGAMERGTALPAGVSEGD
HHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
VLLGLASDGVHSNGYSLVRQIVKYSGLGWDGDNPFGEGKLGEALLTPTRLYVKQSLAAVR
EEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHH
AGGVNALAHITGGGLTENLPRVLPDDLGADIDLGAWELPGVFKWMAQTGGIEESEMLKTF
CCCCEEEEEECCCCCHHCCCHHCHHHCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHH
NCGIGMILVVKADRADALTEVLEGEGETVARLGTVTRGEGIRYTGALL
CCCCEEEEEEECCCHHHHHHHHCCCCCEEHHHCCEECCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA