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The map label for this gene is aroB

Identifier: 99081273

GI number: 99081273

Start: 1529139

End: 1530260

Strand: Direct

Name: aroB

Synonym: TM1040_1432

Alternate gene names: 99081273

Gene position: 1529139-1530260 (Clockwise)

Preceding gene: 99081272

Following gene: 99081274

Centisome position: 47.77

GC content: 63.73

Gene sequence:

>1122_bases
ATGGAACAAACCGTTCACGTTCCCCTTGGCGCGCGCGCCTATGATGTGGTGATCGGCCCCGATCTTGTTGCACAGGCGGG
CCAGCGTATTGCGCCCCTCCTGCGCCGCAAGACAGTGGCTGTGCTCACGGATGAGACCGTGGCCGCGCTTCATCTTGAGG
CTCTGCGCGCGGGACTCGCAGCCGACGGCATCGAGATGGAAGCACTTGCCTTGCCGCCCGGCGAGGCCACTAAAGGCTGG
CCCCAGTTCACCCGCGCGGTGGAGTGGCTCTTGGACAAGAAAGTCGAGCGCGGCGACATCGTCATTGCCTTTGGCGGGGG
CGTCATCGGCGATCTGGCGGGTTTTGCCGCAGCCGTGCTGCGCCGGGGCGTTCGTTTTGTCCAGATCCCCACATCCCTGC
TGGCGCAGGTCGACAGTTCCGTCGGGGGCAAAACCGGCATCAACGCTCCGCAAGGCAAGAACCTGATCGGCGCCTTCCAC
CAGCCCAGCCTGGTACTGGCCGATACAGCGGTTCTTGGCACGCTCACAGAGCGCGATTTTCTTGCCGGCTACGGTGAGGT
GGTGAAATACGGGCTCTTGGGCGATGCGGCCTTTTTTGACTGGCTCGAAGAAAATGCCCCGGCAATGGCGGCAGGTGACA
TGGCGCTGCGGGTCGAAGCCGTGGCGCGTTCGGTTCAGATGAAAGCCGACATCGTGGCCCGCGACGAAACCGAACAAGGC
GACCGGGCGCTGTTGAACCTTGGTCATACCTTCTGTCACGCGCTGGAAGCGGCGACCGGCTACAGCGACCGGTTGCTGCA
TGGCGAAGGCGTGGCGATCGGCTGTGCGTTGGCCTTTGAGCTCTCAGCCCGCCTCGGCCTCTGCAGTCAGGAAGATCCCA
GCCGCGTGCGCGCGCACCTCAAGGCGATGGGCATGAAAACAGACCTCTCGGACATTCCCGGCGATCTTCCCCCCGCCCAA
GAGCTTCTGGATCTCATGGCGCAGGACAAGAAGGTCGTGGATGGTCAGCTGCGCTTCATCCTCGCGCGCGGCATCGGAGC
GGCCTTTGTCACCGCCGATGTGCCCTCTGAAAAGGTGCTTGAGGTGCTGCAAGAGGCGCTGGCGCATACACAACCCGCCT
GA

Upstream 100 bases:

>100_bases
ATCTCAAGGTGATCTCTGACGGGCAGGTTTCGATCGACAATATGGTGGACCGGGTGCTGGAGGCCTTGCGCACCCGACCG
GATGTACTGGAGTTTGACTG

Downstream 100 bases:

>100_bases
TCTCGATGGGGCAAGAGATGAACGCTGGCCCGTCACAACATATGCCGAAATTGGCCATTCTCCTGCTGGCGGCGGGCGCA
TCGTCACGAATGCGCGGGCG

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MEQTVHVPLGARAYDVVIGPDLVAQAGQRIAPLLRRKTVAVLTDETVAALHLEALRAGLAADGIEMEALALPPGEATKGW
PQFTRAVEWLLDKKVERGDIVIAFGGGVIGDLAGFAAAVLRRGVRFVQIPTSLLAQVDSSVGGKTGINAPQGKNLIGAFH
QPSLVLADTAVLGTLTERDFLAGYGEVVKYGLLGDAAFFDWLEENAPAMAAGDMALRVEAVARSVQMKADIVARDETEQG
DRALLNLGHTFCHALEAATGYSDRLLHGEGVAIGCALAFELSARLGLCSQEDPSRVRAHLKAMGMKTDLSDIPGDLPPAQ
ELLDLMAQDKKVVDGQLRFILARGIGAAFVTADVPSEKVLEVLQEALAHTQPA

Sequences:

>Translated_373_residues
MEQTVHVPLGARAYDVVIGPDLVAQAGQRIAPLLRRKTVAVLTDETVAALHLEALRAGLAADGIEMEALALPPGEATKGW
PQFTRAVEWLLDKKVERGDIVIAFGGGVIGDLAGFAAAVLRRGVRFVQIPTSLLAQVDSSVGGKTGINAPQGKNLIGAFH
QPSLVLADTAVLGTLTERDFLAGYGEVVKYGLLGDAAFFDWLEENAPAMAAGDMALRVEAVARSVQMKADIVARDETEQG
DRALLNLGHTFCHALEAATGYSDRLLHGEGVAIGCALAFELSARLGLCSQEDPSRVRAHLKAMGMKTDLSDIPGDLPPAQ
ELLDLMAQDKKVVDGQLRFILARGIGAAFVTADVPSEKVLEVLQEALAHTQPA
>Mature_373_residues
MEQTVHVPLGARAYDVVIGPDLVAQAGQRIAPLLRRKTVAVLTDETVAALHLEALRAGLAADGIEMEALALPPGEATKGW
PQFTRAVEWLLDKKVERGDIVIAFGGGVIGDLAGFAAAVLRRGVRFVQIPTSLLAQVDSSVGGKTGINAPQGKNLIGAFH
QPSLVLADTAVLGTLTERDFLAGYGEVVKYGLLGDAAFFDWLEENAPAMAAGDMALRVEAVARSVQMKADIVARDETEQG
DRALLNLGHTFCHALEAATGYSDRLLHGEGVAIGCALAFELSARLGLCSQEDPSRVRAHLKAMGMKTDLSDIPGDLPPAQ
ELLDLMAQDKKVVDGQLRFILARGIGAAFVTADVPSEKVLEVLQEALAHTQPA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=366, Percent_Identity=43.7158469945355, Blast_Score=263, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6320332, Length=321, Percent_Identity=35.202492211838, Blast_Score=171, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_SILST (Q1GGQ1)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_613427.1
- ProteinModelPortal:   Q1GGQ1
- SMR:   Q1GGQ1
- STRING:   Q1GGQ1
- GeneID:   4078062
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_1432
- NMPDR:   fig|292414.1.peg.3465
- eggNOG:   COG0337
- HOGENOM:   HBG632303
- OMA:   PRREWIN
- PhylomeDB:   Q1GGQ1
- ProtClustDB:   PRK00002
- BioCyc:   SSP292414:TM1040_1432-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 39432; Mature: 39432

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQTVHVPLGARAYDVVIGPDLVAQAGQRIAPLLRRKTVAVLTDETVAALHLEALRAGLA
CCCEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHHH
ADGIEMEALALPPGEATKGWPQFTRAVEWLLDKKVERGDIVIAFGGGVIGDLAGFAAAVL
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHH
RRGVRFVQIPTSLLAQVDSSVGGKTGINAPQGKNLIGAFHQPSLVLADTAVLGTLTERDF
HCCCEEEEECHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCCEEEEHHHHHHHHHHHHH
LAGYGEVVKYGLLGDAAFFDWLEENAPAMAAGDMALRVEAVARSVQMKADIVARDETEQG
HHHHHHHHHHHHCHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHEECCCCCCC
DRALLNLGHTFCHALEAATGYSDRLLHGEGVAIGCALAFELSARLGLCSQEDPSRVRAHL
HHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEEHHHHHHHHHHHHCCCCCCCHHHHHHHH
KAMGMKTDLSDIPGDLPPAQELLDLMAQDKKVVDGQLRFILARGIGAAFVTADVPSEKVL
HHHCCCCCHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHH
EVLQEALAHTQPA
HHHHHHHHHCCCC
>Mature Secondary Structure
MEQTVHVPLGARAYDVVIGPDLVAQAGQRIAPLLRRKTVAVLTDETVAALHLEALRAGLA
CCCEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHHH
ADGIEMEALALPPGEATKGWPQFTRAVEWLLDKKVERGDIVIAFGGGVIGDLAGFAAAVL
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHH
RRGVRFVQIPTSLLAQVDSSVGGKTGINAPQGKNLIGAFHQPSLVLADTAVLGTLTERDF
HCCCEEEEECHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCCEEEEHHHHHHHHHHHHH
LAGYGEVVKYGLLGDAAFFDWLEENAPAMAAGDMALRVEAVARSVQMKADIVARDETEQG
HHHHHHHHHHHHCHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHEECCCCCCC
DRALLNLGHTFCHALEAATGYSDRLLHGEGVAIGCALAFELSARLGLCSQEDPSRVRAHL
HHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEEHHHHHHHHHHHHCCCCCCCHHHHHHHH
KAMGMKTDLSDIPGDLPPAQELLDLMAQDKKVVDGQLRFILARGIGAAFVTADVPSEKVL
HHHCCCCCHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHH
EVLQEALAHTQPA
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA