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The map label for this gene is accA1 [H]

Identifier: 99080579

GI number: 99080579

Start: 795827

End: 797764

Strand: Direct

Name: accA1 [H]

Synonym: TM1040_0738

Alternate gene names: 99080579

Gene position: 795827-797764 (Clockwise)

Preceding gene: 99080578

Following gene: 99080580

Centisome position: 24.86

GC content: 63.36

Gene sequence:

>1938_bases
ATGTTCAACAAGATCCTGATTGCCAACCGCGGCGAAATTGCATGCCGGGTGATGGAAACCGCCCGTCGTCTGGGTGTACG
CACCGTCGCCGTCTACTCCGATGCTGACCGAGACGCCAAACATGTGGCCCTTGCGGATGAGGCTGTCCATGTCGGTCATG
GACCTGCCCCGGCGGATAGCTACCTGCTGCAGGACGAGATCCTCGCCGCCGCCAAAGCCACCGGCGCGCAAGGCATACAC
CCTGGCTATGGGTTTCTGTCGGAGAATCCCGATTTTGTGGAAAAGGTCGAGGCAGCCGGTCTCGCCTTCATCGGCCCCTC
TGCCAGTGCGATCCGCAAGATGGGTCTCAAGGACGCCGCCAAGGCACTGATGGAAGAGGCGGGCGTTCCGGTGGTTCCCG
GCTATCACGGCGACACGCAGGATGCGGGCTTCCTCGCCAAACAGGCGGACAGCATCGGCTATCCGGTCCTGATCAAGGCG
GTTGCAGGCGGCGGTGGCAAGGGCATGCGGCTGGTCGAGGACCCCAAGGATTTCAACGATGCGCTCGCCTCGGCGCAGGG
CGAAGCCACCACGTCCTTTGGCAATCCGGCGGTGCTGATTGAAAAATACATCCAGAAGCCGCGCCATATCGAGGTACAGG
TCTTTGGGGACGGCACATCGGCGGTGCATCTGTTTGAACGCGACTGTTCGCTGCAACGTCGCCACCAAAAGGTGATCGAA
GAAGCCCCGGCCCCGGGCATGACCGACGAGATGCGCGCCGCCATGGGACAGGCCGCCGTGCGTGCCGCCGAGGCGATCGG
CTATGCGGGCGCGGGCACGGTGGAGTTCATTGTGGACGGCTCGGAAGGGCTGCGTGCGGACGGGTTCTGGTTCATGGAGA
TGAACACCCGTTTGCAGGTGGAACACCCGGTTACCGAGCTCATCACTGGCGTCGATCTGGTGGAGTGGCAGCTGCGCGTC
GCCTCTGGCGAAGGGCTGCCCATGCAACAGGACGACCTTTCCATTACCGGCCACGCCTTTGAGGCGCGGCTCTATGCCGA
GGATGTGCCCAAGGGCTTTTTGCCCGCCACCGGCACGCTCTCGCATCTGGCCTTTCCCGAAGGGGTGCGCGCCGACAGCG
GTGTGCGGGCAGGGGACACCATCAGCCCTTGGTATGATCCGATGATCTCCAAGGTGATCGTGCATGGCCCCTCGCGCGCG
GCAGCGCTGCGTCAGCTGGATGACGCGCTCGCGCGGACCGAGGTTGCCGGAACCGTAACAAACCTTGCCTTCCTCGGTGC
GCTCACCCGGCATGCAGGCTTTGCTGCGGGCGACGTGGACACGGGCCTGATCGCGCGCGATCTCGACAGTCTTGCTGCCG
CGCCGGAGATGAGGGCCGAACACAAGATCGCGGCTGCGATGGTGGCGCTTGATGTGATCGATCCCAAACCCGAAATGGGC
TTCACGCTTTGGGCGGACCTACACCGTTCCGTTACGCTTGAAGCGCAGGGCGAGAGTTTCGAAGCCTCGGTCGAGTTGAG
CGGCCCGGATCGTCAGGACTGGATCCTTGATGGAGATATGTTTGCCGTCAATCGCATGGGGTCGGGCTGGGTTATCAGCG
GCATGGCCTTGCCACCCTATGCAAAAAGTGGCGACGCCATCACGATTTTTGACGGCTATGGGCTGAGCTTCAAGGTCGTT
GACCCGCTGGACCGTGCCGCAGGCGCTGCCGGGGATGGCAACCTCATTGAGGCCCCGATGCCGGGCTTGGTCAAGGCGGT
CTTTGCCGAGGCGGGCGCCGCAGTCAAAGAAGGCGACCGGCTCGCCATCCTTGAGGCCATGAAAATGGAGCACTCTTTGC
TAGCCGCCCGTGACGGCGTGGTTGCAGAAGTTCTTGCGCAAGCGGGCGATCAGGTGGAGGCTGGTGCAGCGCTGGTGCGG
CTCGAGGAAGAGGCCTGA

Upstream 100 bases:

>100_bases
TTGGCGTGTTCCGCATGTAACCTCTTCTAACCTCAAATATCCCGGGGGTCCGGGGGCAGAGCCCCCGGCCGCGACGGTCC
CTCAAAAGGAGCACCGCAAG

Downstream 100 bases:

>100_bases
GCCGCGCGCATGAACCGGGAGGAGTAAAACCCATGAAAGACCGCGTCGAGATCTTTGAGGTGGGCCCACGCGACGGGCTG
CAGAACGAAAAGCGTGACAT

Product: 3-methylcrotonoyl-CoA carboxylase, alpha subunit

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 645; Mature: 645

Protein sequence:

>645_residues
MFNKILIANRGEIACRVMETARRLGVRTVAVYSDADRDAKHVALADEAVHVGHGPAPADSYLLQDEILAAAKATGAQGIH
PGYGFLSENPDFVEKVEAAGLAFIGPSASAIRKMGLKDAAKALMEEAGVPVVPGYHGDTQDAGFLAKQADSIGYPVLIKA
VAGGGGKGMRLVEDPKDFNDALASAQGEATTSFGNPAVLIEKYIQKPRHIEVQVFGDGTSAVHLFERDCSLQRRHQKVIE
EAPAPGMTDEMRAAMGQAAVRAAEAIGYAGAGTVEFIVDGSEGLRADGFWFMEMNTRLQVEHPVTELITGVDLVEWQLRV
ASGEGLPMQQDDLSITGHAFEARLYAEDVPKGFLPATGTLSHLAFPEGVRADSGVRAGDTISPWYDPMISKVIVHGPSRA
AALRQLDDALARTEVAGTVTNLAFLGALTRHAGFAAGDVDTGLIARDLDSLAAAPEMRAEHKIAAAMVALDVIDPKPEMG
FTLWADLHRSVTLEAQGESFEASVELSGPDRQDWILDGDMFAVNRMGSGWVISGMALPPYAKSGDAITIFDGYGLSFKVV
DPLDRAAGAAGDGNLIEAPMPGLVKAVFAEAGAAVKEGDRLAILEAMKMEHSLLAARDGVVAEVLAQAGDQVEAGAALVR
LEEEA

Sequences:

>Translated_645_residues
MFNKILIANRGEIACRVMETARRLGVRTVAVYSDADRDAKHVALADEAVHVGHGPAPADSYLLQDEILAAAKATGAQGIH
PGYGFLSENPDFVEKVEAAGLAFIGPSASAIRKMGLKDAAKALMEEAGVPVVPGYHGDTQDAGFLAKQADSIGYPVLIKA
VAGGGGKGMRLVEDPKDFNDALASAQGEATTSFGNPAVLIEKYIQKPRHIEVQVFGDGTSAVHLFERDCSLQRRHQKVIE
EAPAPGMTDEMRAAMGQAAVRAAEAIGYAGAGTVEFIVDGSEGLRADGFWFMEMNTRLQVEHPVTELITGVDLVEWQLRV
ASGEGLPMQQDDLSITGHAFEARLYAEDVPKGFLPATGTLSHLAFPEGVRADSGVRAGDTISPWYDPMISKVIVHGPSRA
AALRQLDDALARTEVAGTVTNLAFLGALTRHAGFAAGDVDTGLIARDLDSLAAAPEMRAEHKIAAAMVALDVIDPKPEMG
FTLWADLHRSVTLEAQGESFEASVELSGPDRQDWILDGDMFAVNRMGSGWVISGMALPPYAKSGDAITIFDGYGLSFKVV
DPLDRAAGAAGDGNLIEAPMPGLVKAVFAEAGAAVKEGDRLAILEAMKMEHSLLAARDGVVAEVLAQAGDQVEAGAALVR
LEEEA
>Mature_645_residues
MFNKILIANRGEIACRVMETARRLGVRTVAVYSDADRDAKHVALADEAVHVGHGPAPADSYLLQDEILAAAKATGAQGIH
PGYGFLSENPDFVEKVEAAGLAFIGPSASAIRKMGLKDAAKALMEEAGVPVVPGYHGDTQDAGFLAKQADSIGYPVLIKA
VAGGGGKGMRLVEDPKDFNDALASAQGEATTSFGNPAVLIEKYIQKPRHIEVQVFGDGTSAVHLFERDCSLQRRHQKVIE
EAPAPGMTDEMRAAMGQAAVRAAEAIGYAGAGTVEFIVDGSEGLRADGFWFMEMNTRLQVEHPVTELITGVDLVEWQLRV
ASGEGLPMQQDDLSITGHAFEARLYAEDVPKGFLPATGTLSHLAFPEGVRADSGVRAGDTISPWYDPMISKVIVHGPSRA
AALRQLDDALARTEVAGTVTNLAFLGALTRHAGFAAGDVDTGLIARDLDSLAAAPEMRAEHKIAAAMVALDVIDPKPEMG
FTLWADLHRSVTLEAQGESFEASVELSGPDRQDWILDGDMFAVNRMGSGWVISGMALPPYAKSGDAITIFDGYGLSFKVV
DPLDRAAGAAGDGNLIEAPMPGLVKAVFAEAGAAVKEGDRLAILEAMKMEHSLLAARDGVVAEVLAQAGDQVEAGAALVR
LEEEA

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=679, Percent_Identity=44.918998527246, Blast_Score=553, Evalue=1e-157,
Organism=Homo sapiens, GI65506442, Length=684, Percent_Identity=42.3976608187134, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI189095269, Length=684, Percent_Identity=42.3976608187134, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI295821183, Length=665, Percent_Identity=41.3533834586466, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI106049528, Length=477, Percent_Identity=42.7672955974843, Blast_Score=355, Evalue=6e-98,
Organism=Homo sapiens, GI106049295, Length=477, Percent_Identity=42.7672955974843, Blast_Score=355, Evalue=6e-98,
Organism=Homo sapiens, GI106049292, Length=477, Percent_Identity=42.7672955974843, Blast_Score=355, Evalue=6e-98,
Organism=Homo sapiens, GI38679974, Length=733, Percent_Identity=28.5129604365621, Blast_Score=237, Evalue=3e-62,
Organism=Homo sapiens, GI38679971, Length=733, Percent_Identity=28.5129604365621, Blast_Score=237, Evalue=3e-62,
Organism=Homo sapiens, GI38679977, Length=733, Percent_Identity=28.5129604365621, Blast_Score=237, Evalue=3e-62,
Organism=Homo sapiens, GI38679967, Length=733, Percent_Identity=28.5129604365621, Blast_Score=237, Evalue=3e-62,
Organism=Homo sapiens, GI38679960, Length=733, Percent_Identity=28.5129604365621, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI134142062, Length=732, Percent_Identity=29.3715846994535, Blast_Score=221, Evalue=1e-57,
Organism=Escherichia coli, GI1789654, Length=456, Percent_Identity=48.0263157894737, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI71987519, Length=671, Percent_Identity=45.3055141579732, Blast_Score=533, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17567343, Length=448, Percent_Identity=50.2232142857143, Blast_Score=426, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17562816, Length=469, Percent_Identity=41.36460554371, Blast_Score=331, Evalue=7e-91,
Organism=Caenorhabditis elegans, GI71997168, Length=529, Percent_Identity=28.5444234404537, Blast_Score=201, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI71997163, Length=493, Percent_Identity=29.8174442190669, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI133931226, Length=519, Percent_Identity=30.2504816955684, Blast_Score=190, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6319685, Length=447, Percent_Identity=44.9664429530201, Blast_Score=401, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6319695, Length=451, Percent_Identity=43.4589800443459, Blast_Score=323, Evalue=5e-89,
Organism=Saccharomyces cerevisiae, GI6321376, Length=451, Percent_Identity=43.4589800443459, Blast_Score=313, Evalue=4e-86,
Organism=Saccharomyces cerevisiae, GI6324343, Length=735, Percent_Identity=28.1632653061224, Blast_Score=229, Evalue=7e-61,
Organism=Saccharomyces cerevisiae, GI6323863, Length=478, Percent_Identity=32.0083682008368, Blast_Score=207, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24651757, Length=679, Percent_Identity=46.0972017673049, Blast_Score=567, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24651759, Length=640, Percent_Identity=44.6875, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI281363050, Length=486, Percent_Identity=43.2098765432099, Blast_Score=351, Evalue=9e-97,
Organism=Drosophila melanogaster, GI24652224, Length=486, Percent_Identity=43.2098765432099, Blast_Score=351, Evalue=9e-97,
Organism=Drosophila melanogaster, GI24652222, Length=486, Percent_Identity=43.2098765432099, Blast_Score=351, Evalue=9e-97,
Organism=Drosophila melanogaster, GI24652220, Length=486, Percent_Identity=43.2098765432099, Blast_Score=351, Evalue=9e-97,
Organism=Drosophila melanogaster, GI24652218, Length=486, Percent_Identity=43.2098765432099, Blast_Score=351, Evalue=9e-97,
Organism=Drosophila melanogaster, GI24652212, Length=486, Percent_Identity=43.2098765432099, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI24652210, Length=486, Percent_Identity=43.2098765432099, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI24652214, Length=486, Percent_Identity=43.2098765432099, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI19921944, Length=486, Percent_Identity=43.2098765432099, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI24652216, Length=486, Percent_Identity=43.2098765432099, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI161076409, Length=734, Percent_Identity=28.4741144414169, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI161076407, Length=734, Percent_Identity=28.4741144414169, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24586460, Length=734, Percent_Identity=28.4741144414169, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24586458, Length=734, Percent_Identity=28.4741144414169, Blast_Score=221, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 68037; Mature: 68037

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNKILIANRGEIACRVMETARRLGVRTVAVYSDADRDAKHVALADEAVHVGHGPAPADS
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCEEECCCCCCCCHH
YLLQDEILAAAKATGAQGIHPGYGFLSENPDFVEKVEAAGLAFIGPSASAIRKMGLKDAA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHCHHHHH
KALMEEAGVPVVPGYHGDTQDAGFLAKQADSIGYPVLIKAVAGGGGKGMRLVEDPKDFND
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEEECCCCCCCEECCCCCHHHH
ALASAQGEATTSFGNPAVLIEKYIQKPRHIEVQVFGDGTSAVHLFERDCSLQRRHQKVIE
HHHCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCEEEEEHHHHHHHHHHHHHHH
EAPAPGMTDEMRAAMGQAAVRAAEAIGYAGAGTVEFIVDGSEGLRADGFWFMEMNTRLQV
HCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEEEECCEEEE
EHPVTELITGVDLVEWQLRVASGEGLPMQQDDLSITGHAFEARLYAEDVPKGFLPATGTL
CCCHHHHHHCCCEEEEEEEEECCCCCCCCCCCCEEECCCEEEEEEHHHCCCCCCCCCCCH
SHLAFPEGVRADSGVRAGDTISPWYDPMISKVIVHGPSRAAALRQLDDALARTEVAGTVT
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHH
NLAFLGALTRHAGFAAGDVDTGLIARDLDSLAAAPEMRAEHKIAAAMVALDVIDPKPEMG
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCC
FTLWADLHRSVTLEAQGESFEASVELSGPDRQDWILDGDMFAVNRMGSGWVISGMALPPY
EEEEEECCCEEEEEECCCCEEEEEEECCCCCCCEEECCCEEEEECCCCCEEEECCCCCCC
AKSGDAITIFDGYGLSFKVVDPLDRAAGAAGDGNLIEAPMPGLVKAVFAEAGAAVKEGDR
CCCCCEEEEEECCCCEEEEECCHHHHCCCCCCCCEEECCCHHHHHHHHHHCCCHHHCCCC
LAILEAMKMEHSLLAARDGVVAEVLAQAGDQVEAGAALVRLEEEA
EEHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MFNKILIANRGEIACRVMETARRLGVRTVAVYSDADRDAKHVALADEAVHVGHGPAPADS
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCEEECCCCCCCCHH
YLLQDEILAAAKATGAQGIHPGYGFLSENPDFVEKVEAAGLAFIGPSASAIRKMGLKDAA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHCHHHHH
KALMEEAGVPVVPGYHGDTQDAGFLAKQADSIGYPVLIKAVAGGGGKGMRLVEDPKDFND
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEEECCCCCCCEECCCCCHHHH
ALASAQGEATTSFGNPAVLIEKYIQKPRHIEVQVFGDGTSAVHLFERDCSLQRRHQKVIE
HHHCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCEEEEEHHHHHHHHHHHHHHH
EAPAPGMTDEMRAAMGQAAVRAAEAIGYAGAGTVEFIVDGSEGLRADGFWFMEMNTRLQV
HCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEEEECCEEEE
EHPVTELITGVDLVEWQLRVASGEGLPMQQDDLSITGHAFEARLYAEDVPKGFLPATGTL
CCCHHHHHHCCCEEEEEEEEECCCCCCCCCCCCEEECCCEEEEEEHHHCCCCCCCCCCCH
SHLAFPEGVRADSGVRAGDTISPWYDPMISKVIVHGPSRAAALRQLDDALARTEVAGTVT
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHH
NLAFLGALTRHAGFAAGDVDTGLIARDLDSLAAAPEMRAEHKIAAAMVALDVIDPKPEMG
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCC
FTLWADLHRSVTLEAQGESFEASVELSGPDRQDWILDGDMFAVNRMGSGWVISGMALPPY
EEEEEECCCEEEEEECCCCEEEEEEECCCCCCCEEECCCEEEEECCCCCEEEECCCCCCC
AKSGDAITIFDGYGLSFKVVDPLDRAAGAAGDGNLIEAPMPGLVKAVFAEAGAAVKEGDR
CCCCCEEEEEECCCCEEEEECCHHHHCCCCCCCCEEECCCHHHHHHHHHHCCCHHHCCCC
LAILEAMKMEHSLLAARDGVVAEVLAQAGDQVEAGAALVRLEEEA
EEHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]