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The map label for this gene is yngE [H]

Identifier: 99080578

GI number: 99080578

Start: 794142

End: 795746

Strand: Direct

Name: yngE [H]

Synonym: TM1040_0737

Alternate gene names: 99080578

Gene position: 794142-795746 (Clockwise)

Preceding gene: 99080577

Following gene: 99080579

Centisome position: 24.81

GC content: 62.87

Gene sequence:

>1605_bases
ATGAAACTTCAATCCAAGGCAATGCCCTCCTCTGAAGGGTTCAAGGCAAACAAAGCTGCCCATCTCTCCGCTCTGGCCGA
GATCAGCGAGGCCGCCGAGGCTGCACGCTTGGGCGGGGGCGAGAAATCCCGCGCCCGACATGAAAGTCGCGGCAAGATGC
TGCCGCGCCGCCGGGTGGCGAACCTGCTTGATCCCGGCTCGCCCTTTTTGGAGGTTGGTGCGACGGCGGCCCATGGCATG
TATGGTGGCGCAGCCCCGGCGGCAGGCGTGATTGCTGGTATCGGGCGTGTCCACGGTCAGGAGGTCATGGTGGTCTGCAA
CGACGCCACCGTGAAGGGTGGCACCTACTTCCCGATGACGGTGAAAAAACATCTGCGCGCTCAAGAGATTGCCGAGGAAA
ACAACCTTCCTTGCGTCTATCTGGTGGACAGTGGCGGCGCCAACCTGCCGCAGCAGGATGAGGTCTTTCCCGACCGCGAC
CACTTTGGCCGCATCTTTTACAATCAGGCGCGGATGTCGGCCAAGGGCATTCCGCAGATCGCCGTGGTCATGGGCTCCTG
TACCGCAGGTGGTGCTTATGTGCCGGCAATGTCCGACGTCACCATCATCGTTAAGGAACAGGGCACCATCTTCCTTGCAG
GCCCGCCGCTGGTGAAGGCCGCCACCGGCGAGGTCGTCTCGGCCGAGGATCTGGGCGGCGGGGATGTGCACACGCGGCTT
TCGGGCGTGGCGGATTACCTCGCTGAGGATGACGCCCATGCGCTGGCCCTCGCGCGGCGCGCGGTCAGCCATCTCAATCG
CACCAAACCCCAGGGCGTGAACTGGCAGAGCCCGGAAGAGCCCGCCTACGATCCCGAGGAGATCCTTGGCGTGGTGCCGG
GCGATCTGCGCACGCCCTATGACATCCGCGAGGTGATCGCGCGTCTCGTTGATGGTTCGCGCTTTGATGAGTTCAAACCC
CGCTTTGGCGAAACGCTGGTCACCGGCTTTGCCCACCTCAAGGGCTGCCCCATCGGCATCATCGCCAACAACGGCGTGCT
CTTTTCAGAAGCCGCACAAAAGGGCGCGCATTTCGTGGAACTCTGTAGCCAGCGCAAGATCCCGCTGGTCTTCCTGCAAA
ACATCACCGGTTTCATGGTGGGCCGCAAATACGAAAACGAAGGCATCGCCCGCCATGGGGCCAAGATGGTAACGGCGGTG
GCCTCCACCAATGTGCCCAAGATCACCATGCTGGTGGGCGGCTCCTTTGGTGCGGGCAACTACGGCATGGCAGGGCGGGC
CTATTCACCCCGGTTCCTCTGGACATGGCCCAACTCGCGCATCTCCGTGATGGGCGGCGAGCAGGCGGCGGGCGTTCTGG
CCACGGTCAAACGCGATGCGATCGAGCGCCAGGGCGGCACATGGTCCGCCGAAGAAGAGGCGCAGTTCAAACAGCCCACC
ATCGATATGTTCGCCGAACAAAGCCACCCGCTCTACGCCTCGGCACGGCTCTGGGATGACGGCATTATCGACCCACGCAA
AAGCCGCGATGTGCTGTCGCTGTCGCTTAGCGCTGCCCTCAACGCCCCCATCGAGGACACACGCTTTGGCGTGTTCCGCA
TGTAA

Upstream 100 bases:

>100_bases
AGACCAAGCTGCGTTTCGTGGCTTTCCCATTCCTGGTTTTCTCCGCTTTGGCGTCCGTACTATTTTTTTCACGTCGTCTC
CCTTTGGAAGAGGAACCGAA

Downstream 100 bases:

>100_bases
CCTCTTCTAACCTCAAATATCCCGGGGGTCCGGGGGCAGAGCCCCCGGCCGCGACGGTCCCTCAAAAGGAGCACCGCAAG
ATGTTCAACAAGATCCTGAT

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 534; Mature: 534

Protein sequence:

>534_residues
MKLQSKAMPSSEGFKANKAAHLSALAEISEAAEAARLGGGEKSRARHESRGKMLPRRRVANLLDPGSPFLEVGATAAHGM
YGGAAPAAGVIAGIGRVHGQEVMVVCNDATVKGGTYFPMTVKKHLRAQEIAEENNLPCVYLVDSGGANLPQQDEVFPDRD
HFGRIFYNQARMSAKGIPQIAVVMGSCTAGGAYVPAMSDVTIIVKEQGTIFLAGPPLVKAATGEVVSAEDLGGGDVHTRL
SGVADYLAEDDAHALALARRAVSHLNRTKPQGVNWQSPEEPAYDPEEILGVVPGDLRTPYDIREVIARLVDGSRFDEFKP
RFGETLVTGFAHLKGCPIGIIANNGVLFSEAAQKGAHFVELCSQRKIPLVFLQNITGFMVGRKYENEGIARHGAKMVTAV
ASTNVPKITMLVGGSFGAGNYGMAGRAYSPRFLWTWPNSRISVMGGEQAAGVLATVKRDAIERQGGTWSAEEEAQFKQPT
IDMFAEQSHPLYASARLWDDGIIDPRKSRDVLSLSLSAALNAPIEDTRFGVFRM

Sequences:

>Translated_534_residues
MKLQSKAMPSSEGFKANKAAHLSALAEISEAAEAARLGGGEKSRARHESRGKMLPRRRVANLLDPGSPFLEVGATAAHGM
YGGAAPAAGVIAGIGRVHGQEVMVVCNDATVKGGTYFPMTVKKHLRAQEIAEENNLPCVYLVDSGGANLPQQDEVFPDRD
HFGRIFYNQARMSAKGIPQIAVVMGSCTAGGAYVPAMSDVTIIVKEQGTIFLAGPPLVKAATGEVVSAEDLGGGDVHTRL
SGVADYLAEDDAHALALARRAVSHLNRTKPQGVNWQSPEEPAYDPEEILGVVPGDLRTPYDIREVIARLVDGSRFDEFKP
RFGETLVTGFAHLKGCPIGIIANNGVLFSEAAQKGAHFVELCSQRKIPLVFLQNITGFMVGRKYENEGIARHGAKMVTAV
ASTNVPKITMLVGGSFGAGNYGMAGRAYSPRFLWTWPNSRISVMGGEQAAGVLATVKRDAIERQGGTWSAEEEAQFKQPT
IDMFAEQSHPLYASARLWDDGIIDPRKSRDVLSLSLSAALNAPIEDTRFGVFRM
>Mature_534_residues
MKLQSKAMPSSEGFKANKAAHLSALAEISEAAEAARLGGGEKSRARHESRGKMLPRRRVANLLDPGSPFLEVGATAAHGM
YGGAAPAAGVIAGIGRVHGQEVMVVCNDATVKGGTYFPMTVKKHLRAQEIAEENNLPCVYLVDSGGANLPQQDEVFPDRD
HFGRIFYNQARMSAKGIPQIAVVMGSCTAGGAYVPAMSDVTIIVKEQGTIFLAGPPLVKAATGEVVSAEDLGGGDVHTRL
SGVADYLAEDDAHALALARRAVSHLNRTKPQGVNWQSPEEPAYDPEEILGVVPGDLRTPYDIREVIARLVDGSRFDEFKP
RFGETLVTGFAHLKGCPIGIIANNGVLFSEAAQKGAHFVELCSQRKIPLVFLQNITGFMVGRKYENEGIARHGAKMVTAV
ASTNVPKITMLVGGSFGAGNYGMAGRAYSPRFLWTWPNSRISVMGGEQAAGVLATVKRDAIERQGGTWSAEEEAQFKQPT
IDMFAEQSHPLYASARLWDDGIIDPRKSRDVLSLSLSAALNAPIEDTRFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=522, Percent_Identity=64.176245210728, Blast_Score=685, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=528, Percent_Identity=31.0606060606061, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI295821216, Length=548, Percent_Identity=29.9270072992701, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI310133460, Length=132, Percent_Identity=55.3030303030303, Blast_Score=135, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17552936, Length=526, Percent_Identity=59.8859315589354, Blast_Score=662, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=529, Percent_Identity=31.9470699432892, Blast_Score=241, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI25147359, Length=504, Percent_Identity=32.7380952380952, Blast_Score=241, Evalue=7e-64,
Organism=Drosophila melanogaster, GI24586065, Length=549, Percent_Identity=61.5664845173042, Blast_Score=689, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 57213; Mature: 57213

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLQSKAMPSSEGFKANKAAHLSALAEISEAAEAARLGGGEKSRARHESRGKMLPRRRVA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHH
NLLDPGSPFLEVGATAAHGMYGGAAPAAGVIAGIGRVHGQEVMVVCNDATVKGGTYFPMT
HHCCCCCCHHHHCCHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCEECCCEECCHH
VKKHLRAQEIAEENNLPCVYLVDSGGANLPQQDEVFPDRDHFGRIFYNQARMSAKGIPQI
HHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHEEHHHHHCCCCCCEE
AVVMGSCTAGGAYVPAMSDVTIIVKEQGTIFLAGPPLVKAATGEVVSAEDLGGGDVHTRL
EEEEECCCCCCEECCCCCCEEEEEECCCEEEEECCCCEEECCCCEEECCCCCCCHHHHHH
SGVADYLAEDDAHALALARRAVSHLNRTKPQGVNWQSPEEPAYDPEEILGVVPGDLRTPY
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHEECCCCCCCCH
DIREVIARLVDGSRFDEFKPRFGETLVTGFAHLKGCPIGIIANNGVLFSEAAQKGAHFVE
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCEEEHHHHHCCHHHHH
LCSQRKIPLVFLQNITGFMVGRKYENEGIARHGAKMVTAVASTNVPKITMLVGGSFGAGN
HHHCCCCCEEEECCCHHHHHCCEECCCCHHHHCHHHHHHHHCCCCCEEEEEEECCCCCCC
YGMAGRAYSPRFLWTWPNSRISVMGGEQAAGVLATVKRDAIERQGGTWSAEEEAQFKQPT
CCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCC
IDMFAEQSHPLYASARLWDDGIIDPRKSRDVLSLSLSAALNAPIEDTRFGVFRM
HHHHHCCCCCEEEEEEECCCCCCCCCCCCCEEEEEHHHHHCCCCCCCCCCEECC
>Mature Secondary Structure
MKLQSKAMPSSEGFKANKAAHLSALAEISEAAEAARLGGGEKSRARHESRGKMLPRRRVA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHH
NLLDPGSPFLEVGATAAHGMYGGAAPAAGVIAGIGRVHGQEVMVVCNDATVKGGTYFPMT
HHCCCCCCHHHHCCHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCEECCCEECCHH
VKKHLRAQEIAEENNLPCVYLVDSGGANLPQQDEVFPDRDHFGRIFYNQARMSAKGIPQI
HHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHEEHHHHHCCCCCCEE
AVVMGSCTAGGAYVPAMSDVTIIVKEQGTIFLAGPPLVKAATGEVVSAEDLGGGDVHTRL
EEEEECCCCCCEECCCCCCEEEEEECCCEEEEECCCCEEECCCCEEECCCCCCCHHHHHH
SGVADYLAEDDAHALALARRAVSHLNRTKPQGVNWQSPEEPAYDPEEILGVVPGDLRTPY
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHEECCCCCCCCH
DIREVIARLVDGSRFDEFKPRFGETLVTGFAHLKGCPIGIIANNGVLFSEAAQKGAHFVE
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCEEEHHHHHCCHHHHH
LCSQRKIPLVFLQNITGFMVGRKYENEGIARHGAKMVTAVASTNVPKITMLVGGSFGAGN
HHHCCCCCEEEECCCHHHHHCCEECCCCHHHHCHHHHHHHHCCCCCEEEEEEECCCCCCC
YGMAGRAYSPRFLWTWPNSRISVMGGEQAAGVLATVKRDAIERQGGTWSAEEEAQFKQPT
CCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCC
IDMFAEQSHPLYASARLWDDGIIDPRKSRDVLSLSLSAALNAPIEDTRFGVFRM
HHHHHCCCCCEEEEEEECCCCCCCCCCCCCEEEEEHHHHHCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]