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The map label for this gene is bcd [H]

Identifier: 99080573

GI number: 99080573

Start: 789814

End: 790977

Strand: Direct

Name: bcd [H]

Synonym: TM1040_0732

Alternate gene names: 99080573

Gene position: 789814-790977 (Clockwise)

Preceding gene: 99080572

Following gene: 99080574

Centisome position: 24.67

GC content: 59.28

Gene sequence:

>1164_bases
ATGTTCAACGCAAGCATGACATTCGATCTAGGCGAGGACGTAAACGCCCTGCGCGACATGGTGCACCGCTGGGCGCAGGA
GCGCGTCAAACCGATGGCGCAGGAGATCGACCAGAAAAACGAATTCCCCGCCGAGCTCTGGAAAGAGATGGGCGAGCTGG
GTCTTCTGGGCATCACCGTGGATGAGGAGTTTGGCGGCGCGGGCATGTCCTATCTGGCGCATACCGTCGCGGTCGAGGAA
ATCGCGCGGGCCTCGGCCTCCGTATCGCTGTCTTACGGCGCGCATTCCAACCTTTGCGTCAACCAGATCAAGCTCAACGG
CAATGCCGAGCAAAAAGCCAAATACCTGCCGCGCCTCATTTCTGGCGAACATGTGGGCGCGCTGGCAATGTCCGAGGCTG
GCGCGGGTTCCGACGTGGTTTCGATGTCGCTGCGCGCCGAAAAGCGCAACGACCGCTTTGTTCTGAACGGCAACAAATAC
TGGATCACCAATGGTCCTGACGCGGACACGCTGGTGGTCTATGCCAAGACTGATCCAGGGGCGGGCTCCAAAGGCATCAC
CGCCTTCCTGATCGAGAAGGAATTCAAGGGCTTTTCCACCTCCAAGCATTTCGACAAGCTTGGCATGCGTGGCTCAAACA
CCGCGGAGCTGGTCTTTGAGGATGTGGAAGTTCCGTTTGAAAACGTGCTTGGCGAAGAGGGCAAGGGCGTACGCGTCCTG
ATGTCCGGTCTGGATTACGAACGCGTGGTGCTTGCGGGGATCGGCACCGGCATCATGGCCTCCTGCATGGATGAGATGAT
GCCCTATATGGCCGAACGCAAACAATTTGGCCAACCCATCGGGAACTTCCAGCTGATGCAGGGCAAGATCGCGGATATGT
ACACTGCGATGAACACCGCACGCGCCTACGTCTATGAGGTCGCCAAGGCTTGCGACAAGGGCACCGTGACCCGTCAGGAT
GCGGCGGCCTGCTGTCTCTACGCCTCTGAGGTGGCGATGACGCAGGCGCATCAGGCGGTACAGGCCTTTGGCGGGGCGGG
TTATCTGAGCGACAATCCGGTCGGTCGGATCTTCCGCGATGCCAAGCTGATGGAGATCGGAGCGGGCACGTCAGAAATTC
GACGCATGCTGATCGGGCGCGAGTTGATGGGCCATATGAGCTAA

Upstream 100 bases:

>100_bases
CGCGCTGCTCTGTGCAACATCAGCGTTGACCGCTTCGCAGCTCTGTGTCATTTATTGAACAAGTGTTCATTAAATATCGT
GACTCGGGAGGAGACGCGCA

Downstream 100 bases:

>100_bases
GGCGCAGATGCGGGTCGCCTATTGGTTCCCGGTTGCAATGCTGGCGCTTGTGCTGGCGGTTGTCGGGTTCCGTTACGGGC
TGATCCGGCAGGGGATCACC

Product: isovaleryl-CoA dehydrogenase

Products: NA

Alternate protein names: Butyryl-CoA dehydrogenase; SCAD [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MFNASMTFDLGEDVNALRDMVHRWAQERVKPMAQEIDQKNEFPAELWKEMGELGLLGITVDEEFGGAGMSYLAHTVAVEE
IARASASVSLSYGAHSNLCVNQIKLNGNAEQKAKYLPRLISGEHVGALAMSEAGAGSDVVSMSLRAEKRNDRFVLNGNKY
WITNGPDADTLVVYAKTDPGAGSKGITAFLIEKEFKGFSTSKHFDKLGMRGSNTAELVFEDVEVPFENVLGEEGKGVRVL
MSGLDYERVVLAGIGTGIMASCMDEMMPYMAERKQFGQPIGNFQLMQGKIADMYTAMNTARAYVYEVAKACDKGTVTRQD
AAACCLYASEVAMTQAHQAVQAFGGAGYLSDNPVGRIFRDAKLMEIGAGTSEIRRMLIGRELMGHMS

Sequences:

>Translated_387_residues
MFNASMTFDLGEDVNALRDMVHRWAQERVKPMAQEIDQKNEFPAELWKEMGELGLLGITVDEEFGGAGMSYLAHTVAVEE
IARASASVSLSYGAHSNLCVNQIKLNGNAEQKAKYLPRLISGEHVGALAMSEAGAGSDVVSMSLRAEKRNDRFVLNGNKY
WITNGPDADTLVVYAKTDPGAGSKGITAFLIEKEFKGFSTSKHFDKLGMRGSNTAELVFEDVEVPFENVLGEEGKGVRVL
MSGLDYERVVLAGIGTGIMASCMDEMMPYMAERKQFGQPIGNFQLMQGKIADMYTAMNTARAYVYEVAKACDKGTVTRQD
AAACCLYASEVAMTQAHQAVQAFGGAGYLSDNPVGRIFRDAKLMEIGAGTSEIRRMLIGRELMGHMS
>Mature_387_residues
MFNASMTFDLGEDVNALRDMVHRWAQERVKPMAQEIDQKNEFPAELWKEMGELGLLGITVDEEFGGAGMSYLAHTVAVEE
IARASASVSLSYGAHSNLCVNQIKLNGNAEQKAKYLPRLISGEHVGALAMSEAGAGSDVVSMSLRAEKRNDRFVLNGNKY
WITNGPDADTLVVYAKTDPGAGSKGITAFLIEKEFKGFSTSKHFDKLGMRGSNTAELVFEDVEVPFENVLGEEGKGVRVL
MSGLDYERVVLAGIGTGIMASCMDEMMPYMAERKQFGQPIGNFQLMQGKIADMYTAMNTARAYVYEVAKACDKGTVTRQD
AAACCLYASEVAMTQAHQAVQAFGGAGYLSDNPVGRIFRDAKLMEIGAGTSEIRRMLIGRELMGHMS

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=60, Blast_Score=468, Evalue=1e-132,
Organism=Homo sapiens, GI226958414, Length=346, Percent_Identity=61.271676300578, Blast_Score=444, Evalue=1e-125,
Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=39.5225464190981, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI4501859, Length=366, Percent_Identity=36.6120218579235, Blast_Score=260, Evalue=1e-69,
Organism=Homo sapiens, GI21361497, Length=386, Percent_Identity=36.2694300518135, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=33.4224598930481, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI4557231, Length=379, Percent_Identity=33.509234828496, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI187960098, Length=379, Percent_Identity=33.509234828496, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI7656849, Length=378, Percent_Identity=32.8042328042328, Blast_Score=211, Evalue=9e-55,
Organism=Homo sapiens, GI76496475, Length=411, Percent_Identity=33.3333333333333, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI4557235, Length=411, Percent_Identity=33.3333333333333, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI4503943, Length=380, Percent_Identity=31.3157894736842, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI7669494, Length=347, Percent_Identity=32.5648414985591, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI48976061, Length=287, Percent_Identity=26.1324041811847, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI211971008, Length=287, Percent_Identity=26.1324041811847, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI38505218, Length=378, Percent_Identity=20.8994708994709, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1786223, Length=382, Percent_Identity=27.7486910994764, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI87081958, Length=349, Percent_Identity=30.3724928366762, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI87082384, Length=253, Percent_Identity=25.296442687747, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87081702, Length=287, Percent_Identity=26.4808362369338, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=56.763925729443, Blast_Score=448, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=36.3881401617251, Blast_Score=256, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17569725, Length=385, Percent_Identity=35.3246753246753, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=35.5795148247978, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17534899, Length=385, Percent_Identity=34.5454545454545, Blast_Score=241, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17570075, Length=385, Percent_Identity=34.5454545454545, Blast_Score=235, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI71990804, Length=294, Percent_Identity=38.4353741496599, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17533517, Length=378, Percent_Identity=31.7460317460317, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71985184, Length=349, Percent_Identity=31.8051575931232, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=35.4014598540146, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17505929, Length=358, Percent_Identity=31.5642458100559, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=38.961038961039, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17551932, Length=368, Percent_Identity=29.8913043478261, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17534353, Length=381, Percent_Identity=28.6089238845144, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71985192, Length=294, Percent_Identity=32.312925170068, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=30.1255230125523, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI86563381, Length=279, Percent_Identity=25.4480286738351, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI86563383, Length=279, Percent_Identity=25.4480286738351, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21355753, Length=380, Percent_Identity=56.3157894736842, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI21356377, Length=374, Percent_Identity=39.3048128342246, Blast_Score=275, Evalue=3e-74,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=37.7005347593583, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24666513, Length=376, Percent_Identity=37.2340425531915, Blast_Score=258, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=36.4116094986807, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI281363737, Length=383, Percent_Identity=33.9425587467363, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI19920834, Length=379, Percent_Identity=28.4960422163588, Blast_Score=155, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.2 [H]

Molecular weight: Translated: 42133; Mature: 42133

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNASMTFDLGEDVNALRDMVHRWAQERVKPMAQEIDQKNEFPAELWKEMGELGLLGITV
CCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEEE
DEEFGGAGMSYLAHTVAVEEIARASASVSLSYGAHSNLCVNQIKLNGNAEQKAKYLPRLI
CCCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEEEEECCCHHHHHHHHHHHH
SGEHVGALAMSEAGAGSDVVSMSLRAEKRNDRFVLNGNKYWITNGPDADTLVVYAKTDPG
CCCCCCEEEECCCCCCCHHEEEEHHHCCCCCEEEECCCEEEECCCCCCCEEEEEEECCCC
AGSKGITAFLIEKEFKGFSTSKHFDKLGMRGSNTAELVFEDVEVPFENVLGEEGKGVRVL
CCCCCCEEEEEEHHHCCCCCHHHHHHHCCCCCCHHHHEEEHHCCCHHHHCCCCCCCCEEH
MSGLDYERVVLAGIGTGIMASCMDEMMPYMAERKQFGQPIGNFQLMQGKIADMYTAMNTA
CCCCCHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHH
RAYVYEVAKACDKGTVTRQDAAACCLYASEVAMTQAHQAVQAFGGAGYLSDNPVGRIFRD
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHC
AKLMEIGAGTSEIRRMLIGRELMGHMS
CCCEEECCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFNASMTFDLGEDVNALRDMVHRWAQERVKPMAQEIDQKNEFPAELWKEMGELGLLGITV
CCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEEE
DEEFGGAGMSYLAHTVAVEEIARASASVSLSYGAHSNLCVNQIKLNGNAEQKAKYLPRLI
CCCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEEEEECCCHHHHHHHHHHHH
SGEHVGALAMSEAGAGSDVVSMSLRAEKRNDRFVLNGNKYWITNGPDADTLVVYAKTDPG
CCCCCCEEEECCCCCCCHHEEEEHHHCCCCCEEEECCCEEEECCCCCCCEEEEEEECCCC
AGSKGITAFLIEKEFKGFSTSKHFDKLGMRGSNTAELVFEDVEVPFENVLGEEGKGVRVL
CCCCCCEEEEEEHHHCCCCCHHHHHHHCCCCCCHHHHEEEHHCCCHHHHCCCCCCCCEEH
MSGLDYERVVLAGIGTGIMASCMDEMMPYMAERKQFGQPIGNFQLMQGKIADMYTAMNTA
CCCCCHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHH
RAYVYEVAKACDKGTVTRQDAAACCLYASEVAMTQAHQAVQAFGGAGYLSDNPVGRIFRD
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHC
AKLMEIGAGTSEIRRMLIGRELMGHMS
CCCEEECCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]