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The map label for this gene is pntB [H]

Identifier: 99080548

GI number: 99080548

Start: 759629

End: 761062

Strand: Reverse

Name: pntB [H]

Synonym: TM1040_0707

Alternate gene names: 99080548

Gene position: 761062-759629 (Counterclockwise)

Preceding gene: 99080549

Following gene: 99080547

Centisome position: 23.78

GC content: 61.37

Gene sequence:

>1434_bases
ATGGACTTTGGATTCACGACGGCGGCCTATGTGGTCGCAGCGGTTCTCTTTATCCTTTCGCTGGGCGGACTCTCGGGCCA
GGAAAGCGCCAAACGTGCAGTCTGGTACGGGATTGTCGGCATGGCGCTGGCGGTCTTTGCAACCCTCATCGGGCCGGGCT
CTGGCCTGTGGTTCCTGTCTCTGGTGCTGATCGGCGCAGGCGGTGTGATCGGCTACATGCTGGCCTCGAAGGTCGAGATG
ACCCAGATGCCGGAACTGGTGGCAGGCATGCATGCGCTGGTGGGTCTGGCCGCGGTTTTGGTGGGCTTCAACGCTCATAT
CGAACTGGGCCGGGTGCTCGCGATGGACGAAGGCGCGCGCAAATCGCTCGAAGGCTTTGCCGCGCTCCTCGCCAAGAAAG
ACAGCGTGGAGATCAACATCCTGCGGGTCGAGGTTTTCCTTGGCGTCTTTATCGGGGCGGTGACCTTTACGGGCTCGGTG
ATTGCCTATGGCAAACTCTCCGGCAAAGTGTCCTCGGCGGCGACCAAGCTGCCCGGTGGGCATATGCTGAACATCGGCGC
AGCGGGCATCTCGCTTCTGTGCCTGTTCTGGTACCTCGGTGCAGGTGGCATGCTGCCGCTGGTGCTGATGACGCTGGCGG
CCTTGTTCATCGGCTATCACCTGATCATGGGCATTGGTGGTGCGGACATGCCGGTGGTGGTGTCCATGCTCAACAGCTAC
TCCGGCTGGGCCGCTGCGGCGATTGGCTTCAGCCTCGGCAATGATCTGTTGATCGTGGTCGGCGCTCTGGTGGGCTCTTC
TGGCGCGATCCTGAGCTACATCATGTGCAAGGCGATGAACCGCTCGTTTGTCTCGGTGATCCTTGGCGGTTTTGGCGGCA
GCGCTGGTCCCGCAATGGAAGTTGAGGGCGAACAGGTGGCGATCGACGCCGATGGCGTGGCCACGGCCCTGGAAGACGCC
GACAGCATCGTCATCATCCCCGGCTACGGCATGGCGGTGGCGCAGGCGCAGTCCAATGTGGCCGAGCTCACCCGCCGTCT
GCGCGCCAAGGGCAAGAACGTGCGCTTTGCGATCCACCCGGTGGCGGGCCGCTTGCCCGGACACATGAACGTGCTTCTGG
CCGAGGCCAAGGTGCCCTACGACATCGTGTTGGAGATGGATGAGATCAACGATGATTTCCCGGAGACGGATGTGGCCATC
GTTATTGGCTCTAACGACATCGTGAACCCGGCCGCCCAGGAAGACCCCAACTCGCCCATCGCTGGCATGCCGGTTCTGGA
GTGCTGGAAAGCGAAGCAGGTCTTTGTCTCCAAGCGCGGTCAGGGCACGGGTTATTCCGGAATCGAGAACCCGCTGTTCT
TTAAGGAAAACACCCGCATGTTCTACGGCGACGCAAAACAGTCTCTCGCAACGCTGCTAAATCTCATCGACTGA

Upstream 100 bases:

>100_bases
GCTCTCAGTGTCTTTATGGCCGGGATCAACATCTTTGGCGGCTTCCTCGTGACACGGCGCATGCTCGCCATGTTCCAGAA
ATCCTAAAGGAGGAGAGATC

Downstream 100 bases:

>100_bases
TCGAGAGAGACCCCAAATACCAAGAAGGGCGCCCCAATCAGGGCGCCCTTTCTTTTTGAATGCACGGCATCTTTTGCGAT
GACTCAAGAAACGGCTGGGG

Product: NAD(P) transhydrogenase, beta subunit

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Pyridine nucleotide transhydrogenase subunit beta [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MDFGFTTAAYVVAAVLFILSLGGLSGQESAKRAVWYGIVGMALAVFATLIGPGSGLWFLSLVLIGAGGVIGYMLASKVEM
TQMPELVAGMHALVGLAAVLVGFNAHIELGRVLAMDEGARKSLEGFAALLAKKDSVEINILRVEVFLGVFIGAVTFTGSV
IAYGKLSGKVSSAATKLPGGHMLNIGAAGISLLCLFWYLGAGGMLPLVLMTLAALFIGYHLIMGIGGADMPVVVSMLNSY
SGWAAAAIGFSLGNDLLIVVGALVGSSGAILSYIMCKAMNRSFVSVILGGFGGSAGPAMEVEGEQVAIDADGVATALEDA
DSIVIIPGYGMAVAQAQSNVAELTRRLRAKGKNVRFAIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINDDFPETDVAI
VIGSNDIVNPAAQEDPNSPIAGMPVLECWKAKQVFVSKRGQGTGYSGIENPLFFKENTRMFYGDAKQSLATLLNLID

Sequences:

>Translated_477_residues
MDFGFTTAAYVVAAVLFILSLGGLSGQESAKRAVWYGIVGMALAVFATLIGPGSGLWFLSLVLIGAGGVIGYMLASKVEM
TQMPELVAGMHALVGLAAVLVGFNAHIELGRVLAMDEGARKSLEGFAALLAKKDSVEINILRVEVFLGVFIGAVTFTGSV
IAYGKLSGKVSSAATKLPGGHMLNIGAAGISLLCLFWYLGAGGMLPLVLMTLAALFIGYHLIMGIGGADMPVVVSMLNSY
SGWAAAAIGFSLGNDLLIVVGALVGSSGAILSYIMCKAMNRSFVSVILGGFGGSAGPAMEVEGEQVAIDADGVATALEDA
DSIVIIPGYGMAVAQAQSNVAELTRRLRAKGKNVRFAIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINDDFPETDVAI
VIGSNDIVNPAAQEDPNSPIAGMPVLECWKAKQVFVSKRGQGTGYSGIENPLFFKENTRMFYGDAKQSLATLLNLID
>Mature_477_residues
MDFGFTTAAYVVAAVLFILSLGGLSGQESAKRAVWYGIVGMALAVFATLIGPGSGLWFLSLVLIGAGGVIGYMLASKVEM
TQMPELVAGMHALVGLAAVLVGFNAHIELGRVLAMDEGARKSLEGFAALLAKKDSVEINILRVEVFLGVFIGAVTFTGSV
IAYGKLSGKVSSAATKLPGGHMLNIGAAGISLLCLFWYLGAGGMLPLVLMTLAALFIGYHLIMGIGGADMPVVVSMLNSY
SGWAAAAIGFSLGNDLLIVVGALVGSSGAILSYIMCKAMNRSFVSVILGGFGGSAGPAMEVEGEQVAIDADGVATALEDA
DSIVIIPGYGMAVAQAQSNVAELTRRLRAKGKNVRFAIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINDDFPETDVAI
VIGSNDIVNPAAQEDPNSPIAGMPVLECWKAKQVFVSKRGQGTGYSGIENPLFFKENTRMFYGDAKQSLATLLNLID

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=481, Percent_Identity=47.6091476091476, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI122939153, Length=481, Percent_Identity=47.6091476091476, Blast_Score=409, Evalue=1e-114,
Organism=Escherichia coli, GI1787886, Length=483, Percent_Identity=60.4554865424431, Blast_Score=544, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17550456, Length=479, Percent_Identity=47.5991649269311, Blast_Score=375, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 49659; Mature: 49659

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFGFTTAAYVVAAVLFILSLGGLSGQESAKRAVWYGIVGMALAVFATLIGPGSGLWFLS
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LVLIGAGGVIGYMLASKVEMTQMPELVAGMHALVGLAAVLVGFNAHIELGRVLAMDEGAR
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECEEEECCCCHH
KSLEGFAALLAKKDSVEINILRVEVFLGVFIGAVTFTGSVIAYGKLSGKVSSAATKLPGG
HHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCC
HMLNIGAAGISLLCLFWYLGAGGMLPLVLMTLAALFIGYHLIMGIGGADMPVVVSMLNSY
CEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
SGWAAAAIGFSLGNDLLIVVGALVGSSGAILSYIMCKAMNRSFVSVILGGFGGSAGPAME
CCHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCEE
VEGEQVAIDADGVATALEDADSIVIIPGYGMAVAQAQSNVAELTRRLRAKGKNVRFAIHP
ECCCEEEEECCCHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
VAGRLPGHMNVLLAEAKVPYDIVLEMDEINDDFPETDVAIVIGSNDIVNPAAQEDPNSPI
CCCCCCCCCEEEEECCCCCEEEEEEEHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCC
AGMPVLECWKAKQVFVSKRGQGTGYSGIENPLFFKENTRMFYGDAKQSLATLLNLID
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCEEEECCHHHHHHHHHHHCC
>Mature Secondary Structure
MDFGFTTAAYVVAAVLFILSLGGLSGQESAKRAVWYGIVGMALAVFATLIGPGSGLWFLS
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LVLIGAGGVIGYMLASKVEMTQMPELVAGMHALVGLAAVLVGFNAHIELGRVLAMDEGAR
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECEEEECCCCHH
KSLEGFAALLAKKDSVEINILRVEVFLGVFIGAVTFTGSVIAYGKLSGKVSSAATKLPGG
HHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCC
HMLNIGAAGISLLCLFWYLGAGGMLPLVLMTLAALFIGYHLIMGIGGADMPVVVSMLNSY
CEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
SGWAAAAIGFSLGNDLLIVVGALVGSSGAILSYIMCKAMNRSFVSVILGGFGGSAGPAME
CCHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCEE
VEGEQVAIDADGVATALEDADSIVIIPGYGMAVAQAQSNVAELTRRLRAKGKNVRFAIHP
ECCCEEEEECCCHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
VAGRLPGHMNVLLAEAKVPYDIVLEMDEINDDFPETDVAIVIGSNDIVNPAAQEDPNSPI
CCCCCCCCCEEEEECCCCCEEEEEEEHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCC
AGMPVLECWKAKQVFVSKRGQGTGYSGIENPLFFKENTRMFYGDAKQSLATLLNLID
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCEEEECCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]