Click here to switch to the map view.

The map label for this gene is argD [H]

Identifier: 99080506

GI number: 99080506

Start: 710999

End: 712174

Strand: Direct

Name: argD [H]

Synonym: TM1040_0665

Alternate gene names: 99080506

Gene position: 710999-712174 (Clockwise)

Preceding gene: 99080504

Following gene: 99080507

Centisome position: 22.21

GC content: 61.31

Gene sequence:

>1176_bases
ATGATCCCCTCCGTTCTTCCGACCTATAACCGGGCGCCCTTGAACTTCGTCAAAGGCGAAGGGTCTTGGCTGATCGAGGC
GGATGGACGACGTTTTCTGGATCTGGGCTCTGGCATCGCGGTGAACGCGCTGGGCCATGCGCATCCTGCACTGGTGGAGG
CGCTGACCGCGCAGGCGCAGAACCTTTGGCATGTCTCCAACCTCTATGAAATCCCGCAGCAGCAGGCTCTGGCCGACAAG
CTGGTGGCGGAGAGTTTTGCGGATACGGTGTTCTTCACCAACTCCGGCACCGAATCCTGCGAGCTGGCCGTCAAGATGGC
GCGCAAGTACCACTATGAAAAAGGCCACCCGGAAAAAGTCGAGATCATTACCTTCGAGGGTTCTTTTCATGGCCGCTCCT
CGGCGGGGATCGCCGCCGCGGGATCTGAGAAAATGACCAAGGGGTTTGGTCCCCTGTTGCCGGGATTCGTACATCTCCCC
TGGGGCGATGCGCAGGCGGTTGCGGCCGCCATCGACGACAAGACCGCAGCCATTCTGGTTGAGCCGGTGCAGGGCGAGGG
CGGCATTCGCCCGATGCCCGATCAGGACCTCAAGGATCTCAGGGCGCTTTGTGACGAACATGGCCTCCTTCTCATTCTCG
ATGAGGTGCAATGCGGCGTGGGACGCACCGGTAAACTCTTTGCCCATGAATGGGCCGGTATCGCGCCCGACATCATGATG
GTCGCCAAAGGCATCGGAGGCGGTTTTCCTCTCGGCGCCGTCCTCGCGTCCGAAGAGGCCGCCTCGGGTATGACCGCCGG
CACCCATGGCTCCACCTATGGAGGCAACCCTTTGGGCTGTGCTGTGGGTTGCGCGGTGATGGATCACGTTGCCGCACCGG
ATTTTCTGTCTGAGGTCAATCGCAAGGCGGGCCTCCTGCGCCAGAAACTCGAAGGTCTCGTGGCCTCTCACCCGGATGTT
TTCGAGGAGGTGCGCGGCTCGGGCCTGATGCTTGGCCTCAAATGTAGGGCTGTCAACGCAGAGGTTGTCAAAGCAGGCTA
CGATGCCGAAGTCATTACCGTGCCCGCCGCCGACAATGTGATCCGCCTCTTGCCCGCACTTACCATCACCGACGCCGACA
TCGAAGAAGCGATCACCCGTCTTGATGCCGCGGCCACTGCGGTCGAAGCCGCCTGA

Upstream 100 bases:

>100_bases
CCCTTCAAAACCTACCGGACCTCTTATTGACCGTCGCCCCGTAGTGGGGCACTGATTTGGTCCTGATCCCCGTTCGAACT
CTCCATAAAGGATGTTTCAG

Downstream 100 bases:

>100_bases
CCTTCATCTTTTTACAAATAGCTCGGGGGTGCGGGGGCTGGCCCCCGCATGTCCCTCTCCAGAAAGCGACGACAACATGA
ACCATTTCCTCGATATCCAT

Product: acetylornithine transaminase protein

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MIPSVLPTYNRAPLNFVKGEGSWLIEADGRRFLDLGSGIAVNALGHAHPALVEALTAQAQNLWHVSNLYEIPQQQALADK
LVAESFADTVFFTNSGTESCELAVKMARKYHYEKGHPEKVEIITFEGSFHGRSSAGIAAAGSEKMTKGFGPLLPGFVHLP
WGDAQAVAAAIDDKTAAILVEPVQGEGGIRPMPDQDLKDLRALCDEHGLLLILDEVQCGVGRTGKLFAHEWAGIAPDIMM
VAKGIGGGFPLGAVLASEEAASGMTAGTHGSTYGGNPLGCAVGCAVMDHVAAPDFLSEVNRKAGLLRQKLEGLVASHPDV
FEEVRGSGLMLGLKCRAVNAEVVKAGYDAEVITVPAADNVIRLLPALTITDADIEEAITRLDAAATAVEAA

Sequences:

>Translated_391_residues
MIPSVLPTYNRAPLNFVKGEGSWLIEADGRRFLDLGSGIAVNALGHAHPALVEALTAQAQNLWHVSNLYEIPQQQALADK
LVAESFADTVFFTNSGTESCELAVKMARKYHYEKGHPEKVEIITFEGSFHGRSSAGIAAAGSEKMTKGFGPLLPGFVHLP
WGDAQAVAAAIDDKTAAILVEPVQGEGGIRPMPDQDLKDLRALCDEHGLLLILDEVQCGVGRTGKLFAHEWAGIAPDIMM
VAKGIGGGFPLGAVLASEEAASGMTAGTHGSTYGGNPLGCAVGCAVMDHVAAPDFLSEVNRKAGLLRQKLEGLVASHPDV
FEEVRGSGLMLGLKCRAVNAEVVKAGYDAEVITVPAADNVIRLLPALTITDADIEEAITRLDAAATAVEAA
>Mature_391_residues
MIPSVLPTYNRAPLNFVKGEGSWLIEADGRRFLDLGSGIAVNALGHAHPALVEALTAQAQNLWHVSNLYEIPQQQALADK
LVAESFADTVFFTNSGTESCELAVKMARKYHYEKGHPEKVEIITFEGSFHGRSSAGIAAAGSEKMTKGFGPLLPGFVHLP
WGDAQAVAAAIDDKTAAILVEPVQGEGGIRPMPDQDLKDLRALCDEHGLLLILDEVQCGVGRTGKLFAHEWAGIAPDIMM
VAKGIGGGFPLGAVLASEEAASGMTAGTHGSTYGGNPLGCAVGCAVMDHVAAPDFLSEVNRKAGLLRQKLEGLVASHPDV
FEEVRGSGLMLGLKCRAVNAEVVKAGYDAEVITVPAADNVIRLLPALTITDADIEEAITRLDAAATAVEAA

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=388, Percent_Identity=32.7319587628866, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI13994255, Length=440, Percent_Identity=29.3181818181818, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI284507298, Length=302, Percent_Identity=35.4304635761589, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI37574042, Length=440, Percent_Identity=28.4090909090909, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI226442705, Length=435, Percent_Identity=27.5862068965517, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI226442709, Length=399, Percent_Identity=29.3233082706767, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI24119277, Length=428, Percent_Identity=25.4672897196262, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI188536080, Length=417, Percent_Identity=25.4196642685851, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI38679950, Length=417, Percent_Identity=25.4196642685851, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI38679946, Length=417, Percent_Identity=25.4196642685851, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1789759, Length=393, Percent_Identity=43.5114503816794, Blast_Score=327, Evalue=9e-91,
Organism=Escherichia coli, GI1788044, Length=393, Percent_Identity=43.0025445292621, Blast_Score=317, Evalue=7e-88,
Organism=Escherichia coli, GI145693181, Length=388, Percent_Identity=35.3092783505155, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI1789016, Length=405, Percent_Identity=33.8271604938272, Blast_Score=194, Evalue=8e-51,
Organism=Escherichia coli, GI1787560, Length=399, Percent_Identity=34.5864661654135, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1786991, Length=411, Percent_Identity=31.3868613138686, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1786349, Length=296, Percent_Identity=33.1081081081081, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI25144271, Length=388, Percent_Identity=34.2783505154639, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI32564660, Length=439, Percent_Identity=30.751708428246, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI25144274, Length=280, Percent_Identity=36.0714285714286, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71992977, Length=430, Percent_Identity=26.5116279069767, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI71981843, Length=164, Percent_Identity=30.4878048780488, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6324432, Length=400, Percent_Identity=37.25, Blast_Score=273, Evalue=4e-74,
Organism=Saccharomyces cerevisiae, GI6323470, Length=394, Percent_Identity=32.741116751269, Blast_Score=194, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6321456, Length=371, Percent_Identity=25.6064690026954, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324386, Length=330, Percent_Identity=25.1515151515152, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21357415, Length=388, Percent_Identity=34.020618556701, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI28574759, Length=450, Percent_Identity=29.7777777777778, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI161085790, Length=448, Percent_Identity=29.2410714285714, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI21356575, Length=440, Percent_Identity=27.0454545454545, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI281366494, Length=425, Percent_Identity=23.5294117647059, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24667139, Length=425, Percent_Identity=23.5294117647059, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24667143, Length=425, Percent_Identity=23.5294117647059, Blast_Score=92, Evalue=8e-19,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 41034; Mature: 41034

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPSVLPTYNRAPLNFVKGEGSWLIEADGRRFLDLGSGIAVNALGHAHPALVEALTAQAQ
CCCCCCCCCCCCCCEEEECCCCEEEEECCCEEEECCCCCEEECCCCCCHHHHHHHHHHHH
NLWHVSNLYEIPQQQALADKLVAESFADTVFFTNSGTESCELAVKMARKYHYEKGHPEKV
HHHHHHHHHHCCHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEE
EIITFEGSFHGRSSAGIAAAGSEKMTKGFGPLLPGFVHLPWGDAQAVAAAIDDKTAAILV
EEEEEECCCCCCCCCCEEECCCHHHHHCCCCCCCCEEECCCCCHHHHHHHHCCCCEEEEE
EPVQGEGGIRPMPDQDLKDLRALCDEHGLLLILDEVQCGVGRTGKLFAHEWAGIAPDIMM
EEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHCCCCHHHHH
VAKGIGGGFPLGAVLASEEAASGMTAGTHGSTYGGNPLGCAVGCAVMDHVAAPDFLSEVN
HHHHCCCCCCHHHHHHCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHH
RKAGLLRQKLEGLVASHPDVFEEVRGSGLMLGLKCRAVNAEVVKAGYDAEVITVPAADNV
HHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEEEEEEECCHHHHHCCCCCEEEEECCCCHH
IRLLPALTITDADIEEAITRLDAAATAVEAA
HHHHCCCEECCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIPSVLPTYNRAPLNFVKGEGSWLIEADGRRFLDLGSGIAVNALGHAHPALVEALTAQAQ
CCCCCCCCCCCCCCEEEECCCCEEEEECCCEEEECCCCCEEECCCCCCHHHHHHHHHHHH
NLWHVSNLYEIPQQQALADKLVAESFADTVFFTNSGTESCELAVKMARKYHYEKGHPEKV
HHHHHHHHHHCCHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEE
EIITFEGSFHGRSSAGIAAAGSEKMTKGFGPLLPGFVHLPWGDAQAVAAAIDDKTAAILV
EEEEEECCCCCCCCCCEEECCCHHHHHCCCCCCCCEEECCCCCHHHHHHHHCCCCEEEEE
EPVQGEGGIRPMPDQDLKDLRALCDEHGLLLILDEVQCGVGRTGKLFAHEWAGIAPDIMM
EEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHCCCCHHHHH
VAKGIGGGFPLGAVLASEEAASGMTAGTHGSTYGGNPLGCAVGCAVMDHVAAPDFLSEVN
HHHHCCCCCCHHHHHHCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHH
RKAGLLRQKLEGLVASHPDVFEEVRGSGLMLGLKCRAVNAEVVKAGYDAEVITVPAADNV
HHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEEEEEEECCHHHHHCCCCCEEEEECCCCHH
IRLLPALTITDADIEEAITRLDAAATAVEAA
HHHHCCCEECCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]