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The map label for this gene is algC [H]

Identifier: 99080493

GI number: 99080493

Start: 698293

End: 699789

Strand: Reverse

Name: algC [H]

Synonym: TM1040_0652

Alternate gene names: 99080493

Gene position: 699789-698293 (Counterclockwise)

Preceding gene: 99080494

Following gene: 99080490

Centisome position: 21.86

GC content: 60.19

Gene sequence:

>1497_bases
ATGACCAAGCCGCTGCCAGAGGTGACCCCCAACAGCTGGAGTTTCCTGCGCGACGCCATGATCAAGCCCACCGGCTTTCG
TGAATATGACGCGCGCTGGAAATACCCCGAAGAGATCAACCTCCCGGGGATGACCGCGCTCGGTCTTGGTCTTGGAACGC
AGATGATCCGCCGTGGCATCGCGCCTGTCATCGCAGTGGGCAATGATTATCGCGACTACTCGCTGGCGATCAAAAACGCG
CTGATCCTTGGCCTGATGCAGGCCGGGATCAAAGTGAAGGACATCGGACCTGCGCTTTCGCCCATGGCCTATTTTGCCCA
GTTCCATCTGGACGTCCCGGCCGTTGCCATGGTCACCGCCTCGCACAACCCAAATGGCTGGACCGGCGTAAAGATGGGCT
TTGACCGCCCCCTCACCCATGGCCCGGATGAAATGAGTGAGCTGCGCGACATCGTGCTGAACGGCGAAGGCGAACGCCGC
GAGGGGGGCTCTTACGAATTTGTCGAAGGCGTCAAGGAAGCCTATATCGACGACCTTGTGGGCGATTTCAAAATGTCGCG
TCCGCTCAAGGTGGTCTGCGCAACCGGCAATGGCACCGCCTCGGCCTTCGCACCCGAAGTCTTTGAGCGCATCGGCGTCG
AGGTTGTGCCCAGCCACAACGCCCTTGATTACACGTTCCCCCATTACAACCCCAACCCCGAAGCGCTGGAGATGTTGCAC
GACATGTCCGCGAGCGTCAAAGCCTCGGGTGCTGATCTGGCGCTTGGATTTGACGGCGACGGCGACCGCTGCGGCGTGGT
GGATGACGAGGGCGAAGAGATCTTTGCGGACAAGGTTGGCGTGATCATGGCCCGTGACCTCTCCAAACTGCATCCGGGCT
CCACCTTTGTTGCGGATGTCAAATCCACGGGCCTCTTTGCCTCTGACCCGGAACTGCAGAAAAACGGCGTCAAAGCCGAC
TACTGGAAAACCGGTCACAGCCACATGAAGCGGCGGGTCAAGGAAATTGGCGCCCTGGCTGGTTTTGAGAAATCCGGCCA
TTATTTCCTCGCCGAACCAGTGGGACGCGGCTACGACTGTGGCATGCGCGTCGCGGTCGAGGTCTGCAAGATGCTCGACC
GAAACCCAGACATGAAGATGTCCGACCTGCGCAAGGCGCTGCCCCGCACCTGGGCAACGCCCACCATGTCGCCCTATGCC
GCAGACACCGAGAAATACGACATCCTCGCCCGGCTGGTCGACAAACTTGTCGCCAAACACGACGCAGGTGAGCTCATGGC
AGGCCGCACCATCAAAGAGGTCGTGACCGTGAATGGCGCCCGCGTGATCCTCGACAATGGCTCCTGGGGGCTGGTGCGCG
CGTCCTCCAACACCCCCAACCTCGTGGTGGTCTGCGAAAGCTCTGAAAGCGAAGACGAAATGCGCGCTATCTTTGCCGAC
ATCGATGCGGTTATCCGCACCGAACCCGCTGTTGGCGATTACGATCAGACCATCTGA

Upstream 100 bases:

>100_bases
TCAAAGATATGCCGCAATTGATTGAGACTTTGATGGGCTTTGACGCACTTGCCAAAGCCAACCCCATCCGCATCTGATTT
TGAAAGAACGAGGATCTCCC

Downstream 100 bases:

>100_bases
TCCAGGCAAAAACACGACCGCGCCCTCATACGAGGGGCGCGGCCGTGTATCTATGCATCATCTATTTGCAAATACCTAGG
GGTCCGGGGCAGCGCCCCGG

Product: phosphoglucomutase/phosphomannomutase alpha/beta/subunit

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MTKPLPEVTPNSWSFLRDAMIKPTGFREYDARWKYPEEINLPGMTALGLGLGTQMIRRGIAPVIAVGNDYRDYSLAIKNA
LILGLMQAGIKVKDIGPALSPMAYFAQFHLDVPAVAMVTASHNPNGWTGVKMGFDRPLTHGPDEMSELRDIVLNGEGERR
EGGSYEFVEGVKEAYIDDLVGDFKMSRPLKVVCATGNGTASAFAPEVFERIGVEVVPSHNALDYTFPHYNPNPEALEMLH
DMSASVKASGADLALGFDGDGDRCGVVDDEGEEIFADKVGVIMARDLSKLHPGSTFVADVKSTGLFASDPELQKNGVKAD
YWKTGHSHMKRRVKEIGALAGFEKSGHYFLAEPVGRGYDCGMRVAVEVCKMLDRNPDMKMSDLRKALPRTWATPTMSPYA
ADTEKYDILARLVDKLVAKHDAGELMAGRTIKEVVTVNGARVILDNGSWGLVRASSNTPNLVVVCESSESEDEMRAIFAD
IDAVIRTEPAVGDYDQTI

Sequences:

>Translated_498_residues
MTKPLPEVTPNSWSFLRDAMIKPTGFREYDARWKYPEEINLPGMTALGLGLGTQMIRRGIAPVIAVGNDYRDYSLAIKNA
LILGLMQAGIKVKDIGPALSPMAYFAQFHLDVPAVAMVTASHNPNGWTGVKMGFDRPLTHGPDEMSELRDIVLNGEGERR
EGGSYEFVEGVKEAYIDDLVGDFKMSRPLKVVCATGNGTASAFAPEVFERIGVEVVPSHNALDYTFPHYNPNPEALEMLH
DMSASVKASGADLALGFDGDGDRCGVVDDEGEEIFADKVGVIMARDLSKLHPGSTFVADVKSTGLFASDPELQKNGVKAD
YWKTGHSHMKRRVKEIGALAGFEKSGHYFLAEPVGRGYDCGMRVAVEVCKMLDRNPDMKMSDLRKALPRTWATPTMSPYA
ADTEKYDILARLVDKLVAKHDAGELMAGRTIKEVVTVNGARVILDNGSWGLVRASSNTPNLVVVCESSESEDEMRAIFAD
IDAVIRTEPAVGDYDQTI
>Mature_497_residues
TKPLPEVTPNSWSFLRDAMIKPTGFREYDARWKYPEEINLPGMTALGLGLGTQMIRRGIAPVIAVGNDYRDYSLAIKNAL
ILGLMQAGIKVKDIGPALSPMAYFAQFHLDVPAVAMVTASHNPNGWTGVKMGFDRPLTHGPDEMSELRDIVLNGEGERRE
GGSYEFVEGVKEAYIDDLVGDFKMSRPLKVVCATGNGTASAFAPEVFERIGVEVVPSHNALDYTFPHYNPNPEALEMLHD
MSASVKASGADLALGFDGDGDRCGVVDDEGEEIFADKVGVIMARDLSKLHPGSTFVADVKSTGLFASDPELQKNGVKADY
WKTGHSHMKRRVKEIGALAGFEKSGHYFLAEPVGRGYDCGMRVAVEVCKMLDRNPDMKMSDLRKALPRTWATPTMSPYAA
DTEKYDILARLVDKLVAKHDAGELMAGRTIKEVVTVNGARVILDNGSWGLVRASSNTPNLVVVCESSESEDEMRAIFADI
DAVIRTEPAVGDYDQTI

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=346, Percent_Identity=32.0809248554913, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789566, Length=352, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 54356; Mature: 54225

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPLPEVTPNSWSFLRDAMIKPTGFREYDARWKYPEEINLPGMTALGLGLGTQMIRRGI
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
APVIAVGNDYRDYSLAIKNALILGLMQAGIKVKDIGPALSPMAYFAQFHLDVPAVAMVTA
CCEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHCCCCEEEEEEE
SHNPNGWTGVKMGFDRPLTHGPDEMSELRDIVLNGEGERREGGSYEFVEGVKEAYIDDLV
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHH
GDFKMSRPLKVVCATGNGTASAFAPEVFERIGVEVVPSHNALDYTFPHYNPNPEALEMLH
HHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEECCCCCEEEECCCCCCCHHHHHHHH
DMSASVKASGADLALGFDGDGDRCGVVDDEGEEIFADKVGVIMARDLSKLHPGSTFVADV
HHCCCCCCCCCEEEEEECCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEH
KSTGLFASDPELQKNGVKADYWKTGHSHMKRRVKEIGALAGFEKSGHYFLAEPVGRGYDC
HCCCCCCCCCCHHHCCCCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCC
GMRVAVEVCKMLDRNPDMKMSDLRKALPRTWATPTMSPYAADTEKYDILARLVDKLVAKH
HHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
DAGELMAGRTIKEVVTVNGARVILDNGSWGLVRASSNTPNLVVVCESSESEDEMRAIFAD
CCCHHHHCCHHHHHHEECCCEEEEECCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHHH
IDAVIRTEPAVGDYDQTI
HHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TKPLPEVTPNSWSFLRDAMIKPTGFREYDARWKYPEEINLPGMTALGLGLGTQMIRRGI
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
APVIAVGNDYRDYSLAIKNALILGLMQAGIKVKDIGPALSPMAYFAQFHLDVPAVAMVTA
CCEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHCCCCEEEEEEE
SHNPNGWTGVKMGFDRPLTHGPDEMSELRDIVLNGEGERREGGSYEFVEGVKEAYIDDLV
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHH
GDFKMSRPLKVVCATGNGTASAFAPEVFERIGVEVVPSHNALDYTFPHYNPNPEALEMLH
HHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEECCCCCEEEECCCCCCCHHHHHHHH
DMSASVKASGADLALGFDGDGDRCGVVDDEGEEIFADKVGVIMARDLSKLHPGSTFVADV
HHCCCCCCCCCEEEEEECCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEH
KSTGLFASDPELQKNGVKADYWKTGHSHMKRRVKEIGALAGFEKSGHYFLAEPVGRGYDC
HCCCCCCCCCCHHHCCCCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCC
GMRVAVEVCKMLDRNPDMKMSDLRKALPRTWATPTMSPYAADTEKYDILARLVDKLVAKH
HHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
DAGELMAGRTIKEVVTVNGARVILDNGSWGLVRASSNTPNLVVVCESSESEDEMRAIFAD
CCCHHHHCCHHHHHHEECCCEEEEECCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHHH
IDAVIRTEPAVGDYDQTI
HHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]