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The map label for this gene is cobS [H]

Identifier: 99080484

GI number: 99080484

Start: 688037

End: 689023

Strand: Reverse

Name: cobS [H]

Synonym: TM1040_0643

Alternate gene names: 99080484

Gene position: 689023-688037 (Counterclockwise)

Preceding gene: 99080485

Following gene: 99080483

Centisome position: 21.53

GC content: 58.66

Gene sequence:

>987_bases
ATGACCGACGGCCTGCTGGATATGAACGCAAAACCAACCGAGACGATTTCGGTACGTGAGGTCTTTGGCATCGACACCGA
CATGACGGTGAAGGGCTTTGCAGAAGGGACCGACCGCGTTCCGGCGCTGGATCCCACCTATAAATTCGATCCCGACACCA
CGATGGCGATCCTTGCCGGCTTCAGCCACAACCGGCGCGTCATGATCCAGGGTTACCACGGCACGGGGAAATCCACCCAT
ATCGAACAGGTCGCCGCACGTCTGAACTGGCCCTCGGTGCGGGTCAACCTCGACAGCCACATCTCCCGGATCGACCTCAT
CGGCAAGGACGCGATCAAGCTGCGCGATGGCAAGCAAGTCACCGAGTTCCACGAGGGCATCCTGCCCTGGGCGCTGCGCA
ACCCGGTTGCGATCGTATTCGACGAATATGACGCAGGGCGCGCCGATGTGATGTTTGTGATCCAGCGCGTGCTGGAGCAT
GACGGCAAGCTGACGCTGCTTGATCAGAACGAGATCATCACCCCGAACCCCTTCTTCCGCCTCTTTGCCACCGCCAACAC
AGTCGGCCTCGGGGACACAACCGGGCTCTATCACGGCACCCAGCAGATCAACCAGGCACAGATGGACCGCTGGTCGCTGG
TGGCGACATTGAACTATCTGAGCCACGACGCTGAAACCGCTATCGTCCTGTCGAAGACGCCGCATTACAACACCGAAAAG
GGCCGCAAGCAGATCGCTCAGATGGTTACGGTGGCGGATCTGACCCGGACTGCCTTTATGAACGGTGATCTGTCGACCGT
GATGTCGCCGCGGACCGTGATCAACTGGGCGCAGAACGCCGAAATCTTCCGCGACATTGGCTATGCCTTCCGTCTGTCGT
TCCTCAATAAATGTGACGAACTGGAACGCCAGACCGTGGCTGAGTTCTATCAGCGCTGTTTTGACGAGGAACTGCCTGAA
AGCGCTGCAAATGTGAGCCTCGGATAA

Upstream 100 bases:

>100_bases
ACCAATCGCGCGATTACATGCAACTGCACCCCGAGAGTGACCGACGGGCCACAAGGCAGCCATCCCGCGCCCGTGACTGA
CAAGACAAGGACTGACACCT

Downstream 100 bases:

>100_bases
GAGCGGGGTTCGGACGGCTACGCCGTCCGACCGGTGCCTGCGCCCCCTCGACGGGGGCGCAGGCACCCCCGCCCCTTGCG
GGACGCGACCCGTCAGCCTC

Product: hydrogenobyrinic acid a,c-diamide cobaltochelatase

Products: NA

Alternate protein names: Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobS [H]

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MTDGLLDMNAKPTETISVREVFGIDTDMTVKGFAEGTDRVPALDPTYKFDPDTTMAILAGFSHNRRVMIQGYHGTGKSTH
IEQVAARLNWPSVRVNLDSHISRIDLIGKDAIKLRDGKQVTEFHEGILPWALRNPVAIVFDEYDAGRADVMFVIQRVLEH
DGKLTLLDQNEIITPNPFFRLFATANTVGLGDTTGLYHGTQQINQAQMDRWSLVATLNYLSHDAETAIVLSKTPHYNTEK
GRKQIAQMVTVADLTRTAFMNGDLSTVMSPRTVINWAQNAEIFRDIGYAFRLSFLNKCDELERQTVAEFYQRCFDEELPE
SAANVSLG

Sequences:

>Translated_328_residues
MTDGLLDMNAKPTETISVREVFGIDTDMTVKGFAEGTDRVPALDPTYKFDPDTTMAILAGFSHNRRVMIQGYHGTGKSTH
IEQVAARLNWPSVRVNLDSHISRIDLIGKDAIKLRDGKQVTEFHEGILPWALRNPVAIVFDEYDAGRADVMFVIQRVLEH
DGKLTLLDQNEIITPNPFFRLFATANTVGLGDTTGLYHGTQQINQAQMDRWSLVATLNYLSHDAETAIVLSKTPHYNTEK
GRKQIAQMVTVADLTRTAFMNGDLSTVMSPRTVINWAQNAEIFRDIGYAFRLSFLNKCDELERQTVAEFYQRCFDEELPE
SAANVSLG
>Mature_327_residues
TDGLLDMNAKPTETISVREVFGIDTDMTVKGFAEGTDRVPALDPTYKFDPDTTMAILAGFSHNRRVMIQGYHGTGKSTHI
EQVAARLNWPSVRVNLDSHISRIDLIGKDAIKLRDGKQVTEFHEGILPWALRNPVAIVFDEYDAGRADVMFVIQRVLEHD
GKLTLLDQNEIITPNPFFRLFATANTVGLGDTTGLYHGTQQINQAQMDRWSLVATLNYLSHDAETAIVLSKTPHYNTEKG
RKQIAQMVTVADLTRTAFMNGDLSTVMSPRTVINWAQNAEIFRDIGYAFRLSFLNKCDELERQTVAEFYQRCFDEELPES
AANVSLG

Specific function: Catalyzes cobalt insertion in the corrin ring [H]

COG id: COG0714

COG function: function code R; MoxR-like ATPases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI24415404, Length=248, Percent_Identity=25.4032258064516, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323135, Length=145, Percent_Identity=30.3448275862069, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI161076560, Length=145, Percent_Identity=31.0344827586207, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI161076562, Length=145, Percent_Identity=31.0344827586207, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011704
- InterPro:   IPR006537 [H]

Pfam domain/function: PF07728 AAA_5 [H]

EC number: =6.6.1.2 [H]

Molecular weight: Translated: 36804; Mature: 36673

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDGLLDMNAKPTETISVREVFGIDTDMTVKGFAEGTDRVPALDPTYKFDPDTTMAILAG
CCCCCCCCCCCCCCEEEEHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEC
FSHNRRVMIQGYHGTGKSTHIEQVAARLNWPSVRVNLDSHISRIDLIGKDAIKLRDGKQV
CCCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCCCEEECCCCHH
TEFHEGILPWALRNPVAIVFDEYDAGRADVMFVIQRVLEHDGKLTLLDQNEIITPNPFFR
HHHHCCCCCHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCEECCCCCEE
LFATANTVGLGDTTGLYHGTQQINQAQMDRWSLVATLNYLSHDAETAIVLSKTPHYNTEK
EEEECCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHH
GRKQIAQMVTVADLTRTAFMNGDLSTVMSPRTVINWAQNAEIFRDIGYAFRLSFLNKCDE
HHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LERQTVAEFYQRCFDEELPESAANVSLG
HHHHHHHHHHHHHHHHHCCHHHCCCCCC
>Mature Secondary Structure 
TDGLLDMNAKPTETISVREVFGIDTDMTVKGFAEGTDRVPALDPTYKFDPDTTMAILAG
CCCCCCCCCCCCCEEEEHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEC
FSHNRRVMIQGYHGTGKSTHIEQVAARLNWPSVRVNLDSHISRIDLIGKDAIKLRDGKQV
CCCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCCCEEECCCCHH
TEFHEGILPWALRNPVAIVFDEYDAGRADVMFVIQRVLEHDGKLTLLDQNEIITPNPFFR
HHHHCCCCCHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCEECCCCCEE
LFATANTVGLGDTTGLYHGTQQINQAQMDRWSLVATLNYLSHDAETAIVLSKTPHYNTEK
EEEECCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHH
GRKQIAQMVTVADLTRTAFMNGDLSTVMSPRTVINWAQNAEIFRDIGYAFRLSFLNKCDE
HHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LERQTVAEFYQRCFDEELPESAANVSLG
HHHHHHHHHHHHHHHHHCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1917840 [H]