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The map label for this gene is pepQ [H]

Identifier: 99080482

GI number: 99080482

Start: 683825

End: 685609

Strand: Reverse

Name: pepQ [H]

Synonym: TM1040_0641

Alternate gene names: 99080482

Gene position: 685609-683825 (Counterclockwise)

Preceding gene: 99080483

Following gene: 99080481

Centisome position: 21.42

GC content: 62.86

Gene sequence:

>1785_bases
ATGTTTCAAAACTTTGATGTCACGGCCCGTCCCGAGCAGGGCCCGGCGCGCCTTGCCGCGCTTCGCGCTGAGATGGAGCG
AGACAAGATCGACGGTTTTTTGGTCCCGCGCGCCGATGCGCATCAAGGCGAATACGTCGCCCCACGGGATGAACGTCTGG
CGTGGCTCACCGGCTTTACCGGCTCTGCGGGATTCTGCGCCGTGCTGCCGCATATTGCTGGCGTGTTTATCGACGGGCGC
TATCGCACACAGGTCAAAGGCCAAGTCGCGGATGTCTATACCCCTGTTCCTTGGCCGGATGTGACTTTGGGCGATTGGCT
GGTGGAGCAACTGCCAGAGGGCGGGATTGTCGCCTATGACCCCTGGCTGCATTCCCTGCAGGAGATCCGCGACCTGACCG
AGCGGCTCGTCTCGTCGGATATTTCACTGGTGGAAAGCGACAATCTAGTAGACCGCATCTGGCCCGACCAGCCAGCGCCC
CCGATGCAACCGGCTCGGGCGCATTCGGAGGACTATGCCGGAGAGAGCGCCGAGAAGAAGGCTCAGCGCCTGGCCGAGGG
CCTGCGTAAAAGCGGACAGTCCGCAGCGGTCATCACTCTTCCAGACAGCATCATGTGGCTCCTGAATATCCGTGGTTCTG
ACATTCCGCGCAATCCGGTCGCCCATGCTTTTGCGATCCTGCATGATGACGCCCGAGTGGACCTGTTTATGGCAGCAGAG
AAGCTCTCTGAGCTCGTATTGGGCGCGCATGTGACCCTACACGCGCCTGATCGCTTTCTCGAGGCCACAGCCGGCCTCAA
TGGTCAGGTCGCGGTGGACGCGCGCAGCCTGCCACAGGCTGTTGCACGGGTTTTGGGCGACAGGCTGGCGGCGGTCGGAG
ACCCCTGCGCCCTGCCAAAGGCCCGCAAGAACGCCGCCGAGATCGCAGGCAGCGCGGCCGCACATCTGCGCGATGGGGCT
GCCGTTGTCGAAACGCTGGCTTGGCTCGATACGCAGGAACCGGGCACGATTACCGAAATCGACGTGGTCAAGACACTCGA
AGGGTTCCGCGCGGCAGATCCCGCGTTGCGTGACATCAGCTTTGAAACCATCGCAGGGACAGGCGCCAATGGCGCAATCA
TGCATTACCGTGTGACACATGATACCAATGCGACGCTCCAAGAGGGTCATCTTCTGGTGCTCGACAGCGGCGGGCAATAT
CTCGATGGCACCACCGACATCACCCGCACCATCGCCATTGGATCGCCGGGCCGTGAGGAAGCCGAAGCCTTTACGCGCGT
CCTGCAGGGCATGATCGCGGTCTCCCGGTTGCGTTGGCCCGAGGGGCGGTCCGGGCGCGAACTTGAGGCTATCGGCCGCC
TGCCTCTCTGGATGGCTGGACAGGATTTCAACCATGGGCTTGGTCATGGCGTCGGCGCCTTCCTCAGCGTACATGAAGGA
CCGCAGGGTCTTTCCCGCATTAATACGGTACCGCTTGAGCCGGGCATGATCCTGTCCAACGAGCCGGGCTACTACCGGGA
GGGCGCCTTTGGCATCCGGATTGAAAACCTCGTAGTGGTAGAAGAGGCCCCAGCCCTTGACACCGCCGACCCAGACCGCA
AGATGCTCGCGTGGCGCACGCTGACGTTTGCGCCCATCGACCGCCGTTTGGTGGTGCCCGAGATGCTGAGCTCGGGGGAG
CGCGAGTGGCTCAATAGCTATCACGCAGAGGTAAACCGCACTATCGCGCCGCGCGTCAGCGCCGCTGCGGCAGAGTGGTT
GAACGCGGCCTGCGCGCCGCTGTGA

Upstream 100 bases:

>100_bases
AACAAACCACTTCCGGCCACGCGCCAGTGTCGCCGTGGGCAATCCCTGATCCGCTTCACCGACGTCCTCGCGAAGAGTGA
CTCATCTTGAGGAGAGACAA

Downstream 100 bases:

>100_bases
TACATGACTGTTACAATGACCGGGCAGAAGCCTTACCAAAGCTAGAAGGAGGGGGAACCCGATGACCAAGATCACGATCC
AAAAAGCAACAGGCCGATGG

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 594; Mature: 594

Protein sequence:

>594_residues
MFQNFDVTARPEQGPARLAALRAEMERDKIDGFLVPRADAHQGEYVAPRDERLAWLTGFTGSAGFCAVLPHIAGVFIDGR
YRTQVKGQVADVYTPVPWPDVTLGDWLVEQLPEGGIVAYDPWLHSLQEIRDLTERLVSSDISLVESDNLVDRIWPDQPAP
PMQPARAHSEDYAGESAEKKAQRLAEGLRKSGQSAAVITLPDSIMWLLNIRGSDIPRNPVAHAFAILHDDARVDLFMAAE
KLSELVLGAHVTLHAPDRFLEATAGLNGQVAVDARSLPQAVARVLGDRLAAVGDPCALPKARKNAAEIAGSAAAHLRDGA
AVVETLAWLDTQEPGTITEIDVVKTLEGFRAADPALRDISFETIAGTGANGAIMHYRVTHDTNATLQEGHLLVLDSGGQY
LDGTTDITRTIAIGSPGREEAEAFTRVLQGMIAVSRLRWPEGRSGRELEAIGRLPLWMAGQDFNHGLGHGVGAFLSVHEG
PQGLSRINTVPLEPGMILSNEPGYYREGAFGIRIENLVVVEEAPALDTADPDRKMLAWRTLTFAPIDRRLVVPEMLSSGE
REWLNSYHAEVNRTIAPRVSAAAAEWLNAACAPL

Sequences:

>Translated_594_residues
MFQNFDVTARPEQGPARLAALRAEMERDKIDGFLVPRADAHQGEYVAPRDERLAWLTGFTGSAGFCAVLPHIAGVFIDGR
YRTQVKGQVADVYTPVPWPDVTLGDWLVEQLPEGGIVAYDPWLHSLQEIRDLTERLVSSDISLVESDNLVDRIWPDQPAP
PMQPARAHSEDYAGESAEKKAQRLAEGLRKSGQSAAVITLPDSIMWLLNIRGSDIPRNPVAHAFAILHDDARVDLFMAAE
KLSELVLGAHVTLHAPDRFLEATAGLNGQVAVDARSLPQAVARVLGDRLAAVGDPCALPKARKNAAEIAGSAAAHLRDGA
AVVETLAWLDTQEPGTITEIDVVKTLEGFRAADPALRDISFETIAGTGANGAIMHYRVTHDTNATLQEGHLLVLDSGGQY
LDGTTDITRTIAIGSPGREEAEAFTRVLQGMIAVSRLRWPEGRSGRELEAIGRLPLWMAGQDFNHGLGHGVGAFLSVHEG
PQGLSRINTVPLEPGMILSNEPGYYREGAFGIRIENLVVVEEAPALDTADPDRKMLAWRTLTFAPIDRRLVVPEMLSSGE
REWLNSYHAEVNRTIAPRVSAAAAEWLNAACAPL
>Mature_594_residues
MFQNFDVTARPEQGPARLAALRAEMERDKIDGFLVPRADAHQGEYVAPRDERLAWLTGFTGSAGFCAVLPHIAGVFIDGR
YRTQVKGQVADVYTPVPWPDVTLGDWLVEQLPEGGIVAYDPWLHSLQEIRDLTERLVSSDISLVESDNLVDRIWPDQPAP
PMQPARAHSEDYAGESAEKKAQRLAEGLRKSGQSAAVITLPDSIMWLLNIRGSDIPRNPVAHAFAILHDDARVDLFMAAE
KLSELVLGAHVTLHAPDRFLEATAGLNGQVAVDARSLPQAVARVLGDRLAAVGDPCALPKARKNAAEIAGSAAAHLRDGA
AVVETLAWLDTQEPGTITEIDVVKTLEGFRAADPALRDISFETIAGTGANGAIMHYRVTHDTNATLQEGHLLVLDSGGQY
LDGTTDITRTIAIGSPGREEAEAFTRVLQGMIAVSRLRWPEGRSGRELEAIGRLPLWMAGQDFNHGLGHGVGAFLSVHEG
PQGLSRINTVPLEPGMILSNEPGYYREGAFGIRIENLVVVEEAPALDTADPDRKMLAWRTLTFAPIDRRLVVPEMLSSGE
REWLNSYHAEVNRTIAPRVSAAAAEWLNAACAPL

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=608, Percent_Identity=36.1842105263158, Blast_Score=352, Evalue=5e-97,
Organism=Homo sapiens, GI93141226, Length=619, Percent_Identity=35.2180936995153, Blast_Score=342, Evalue=7e-94,
Organism=Homo sapiens, GI264681565, Length=608, Percent_Identity=34.703947368421, Blast_Score=323, Evalue=3e-88,
Organism=Escherichia coli, GI1788728, Length=192, Percent_Identity=31.7708333333333, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17509539, Length=618, Percent_Identity=33.3333333333333, Blast_Score=314, Evalue=7e-86,
Organism=Caenorhabditis elegans, GI25149105, Length=611, Percent_Identity=28.1505728314239, Blast_Score=221, Evalue=9e-58,
Organism=Saccharomyces cerevisiae, GI6322999, Length=659, Percent_Identity=30.5007587253414, Blast_Score=297, Evalue=4e-81,
Organism=Drosophila melanogaster, GI17137632, Length=625, Percent_Identity=33.12, Blast_Score=315, Evalue=6e-86,
Organism=Drosophila melanogaster, GI161078230, Length=588, Percent_Identity=32.312925170068, Blast_Score=284, Evalue=1e-76,
Organism=Drosophila melanogaster, GI21357287, Length=588, Percent_Identity=32.312925170068, Blast_Score=284, Evalue=1e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 64447; Mature: 64447

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQNFDVTARPEQGPARLAALRAEMERDKIDGFLVPRADAHQGEYVAPRDERLAWLTGFT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCEEEEECCC
GSAGFCAVLPHIAGVFIDGRYRTQVKGQVADVYTPVPWPDVTLGDWLVEQLPEGGIVAYD
CCCHHHHHHHHHHEEEECCCEEEEECCEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEC
PWLHSLQEIRDLTERLVSSDISLVESDNLVDRIWPDQPAPPMQPARAHSEDYAGESAEKK
HHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHCCCCCCCCCCCCCCCCCHHCCCCHHHHH
AQRLAEGLRKSGQSAAVITLPDSIMWLLNIRGSDIPRNPVAHAFAILHDDARVDLFMAAE
HHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCCCHHHHHHHEEECCCCCHHHHHHH
KLSELVLGAHVTLHAPDRFLEATAGLNGQVAVDARSLPQAVARVLGDRLAAVGDPCALPK
HHHHHHHCCEEEEECCHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCH
ARKNAAEIAGSAAAHLRDGAAVVETLAWLDTQEPGTITEIDVVKTLEGFRAADPALRDIS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHCCCCHHHHCC
FETIAGTGANGAIMHYRVTHDTNATLQEGHLLVLDSGGQYLDGTTDITRTIAIGSPGREE
CCEEECCCCCCEEEEEEEECCCCCEEECCCEEEECCCCCCCCCCCCCEEEEEECCCCHHH
AEAFTRVLQGMIAVSRLRWPEGRSGRELEAIGRLPLWMAGQDFNHGLGHGVGAFLSVHEG
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCEEECCCCCCCCCCCCHHHHEEECCC
PQGLSRINTVPLEPGMILSNEPGYYREGAFGIRIENLVVVEEAPALDTADPDRKMLAWRT
CHHHHHCCCCCCCCCEEECCCCCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCCEEEEEE
LTFAPIDRRLVVPEMLSSGEREWLNSYHAEVNRTIAPRVSAAAAEWLNAACAPL
EEECCCCCEEECHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFQNFDVTARPEQGPARLAALRAEMERDKIDGFLVPRADAHQGEYVAPRDERLAWLTGFT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCEEEEECCC
GSAGFCAVLPHIAGVFIDGRYRTQVKGQVADVYTPVPWPDVTLGDWLVEQLPEGGIVAYD
CCCHHHHHHHHHHEEEECCCEEEEECCEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEC
PWLHSLQEIRDLTERLVSSDISLVESDNLVDRIWPDQPAPPMQPARAHSEDYAGESAEKK
HHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHCCCCCCCCCCCCCCCCCHHCCCCHHHHH
AQRLAEGLRKSGQSAAVITLPDSIMWLLNIRGSDIPRNPVAHAFAILHDDARVDLFMAAE
HHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCCCHHHHHHHEEECCCCCHHHHHHH
KLSELVLGAHVTLHAPDRFLEATAGLNGQVAVDARSLPQAVARVLGDRLAAVGDPCALPK
HHHHHHHCCEEEEECCHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCH
ARKNAAEIAGSAAAHLRDGAAVVETLAWLDTQEPGTITEIDVVKTLEGFRAADPALRDIS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHCCCCHHHHCC
FETIAGTGANGAIMHYRVTHDTNATLQEGHLLVLDSGGQYLDGTTDITRTIAIGSPGREE
CCEEECCCCCCEEEEEEEECCCCCEEECCCEEEECCCCCCCCCCCCCEEEEEECCCCHHH
AEAFTRVLQGMIAVSRLRWPEGRSGRELEAIGRLPLWMAGQDFNHGLGHGVGAFLSVHEG
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCEEECCCCCCCCCCCCHHHHEEECCC
PQGLSRINTVPLEPGMILSNEPGYYREGAFGIRIENLVVVEEAPALDTADPDRKMLAWRT
CHHHHHCCCCCCCCCEEECCCCCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCCEEEEEE
LTFAPIDRRLVVPEMLSSGEREWLNSYHAEVNRTIAPRVSAAAAEWLNAACAPL
EEECCCCCEEECHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]