Click here to switch to the map view.

The map label for this gene is trxB [H]

Identifier: 99080455

GI number: 99080455

Start: 654406

End: 655347

Strand: Reverse

Name: trxB [H]

Synonym: TM1040_0614

Alternate gene names: 99080455

Gene position: 655347-654406 (Counterclockwise)

Preceding gene: 99080457

Following gene: 99080454

Centisome position: 20.47

GC content: 61.57

Gene sequence:

>942_bases
ATGAGCGACACGCGCCACACCAAGGTTCTGATCATCGGCTCCGGCCCGGCCGGCTATACGGCCGCCGTTTACGCAAGCCG
TGCGATGCTCGAGCCGATTCTTGTGCAGGGCATCGAGCCGGGTGGCCAGCTGACCACCACCACCGAAGTAGAGAACTGGC
CCGGTCACACCGAGATCCAAGGCCCTGATCTCATGGTGAATATGGAAAGCCACGCCCGCGCGATGGGGACCGAGATCATC
GGTGACATCATCACCTCGCTTGACACCTCGAGCCGTCCTTTCGTGGCCAAGGGCGACAGCGGCACCACCTACACGGCGGA
TGCAGTGATCCTCGCCACAGGCGCGCGGGCCAAATGGCTTGGCCTGCCCTCGGAAGAAAAGTTCAAGGGCTTTGGCGTCT
CAGCCTGCGCCACCTGCGACGGGTTCTTCTATCGCGGTCAGGAGATCGTGGTGATCGGCGGCGGCAACACCGCAGTCGAA
GAAGCCCTGTTCCTGACCAATTTTGCCTCCAAGGTCACATTGATCCATCGCCGCGACGAGCTGCGCGCCGAAAAGATCCT
GATCGACCGGCTGATGAAAAACGAGAAGATCGAGCCGCTGTGGTTCCACGAACTCGATGAGGTGGTCGGCACCGATGCGC
CCCTGGGCGTTGAAGCCGTGCGAGTCAAACACACCAAGACAGGCGAGATCACAGAGATTCCCGCCAAGGGCGTCTTTGTC
GCCATTGGCCACGCGCCTGCCACCGAACTGGTCAAAGACGTGCTGGAAACCCACAACGGCGGCTATGTCAAAGTGAAACC
CGGCACCACCGAAACGTCGATCCCCGGAATTTTTGCGGCGGGCGACCTGACAGACCATAAATACCGCCAAGCCGTCACCT
CGGCGGGCATGGGCTGCATGGCCGCCCTCGACGCAGAGCGTTTCCTCGCCGAGCAAGAGTGA

Upstream 100 bases:

>100_bases
TAGACGTGCAAACGAAGGTCTTTAAGCATGCGCGCGTCGCAGTTATATGCAGTCCTCGACGGCGGCAAGACCGCAAGCAC
AAAACACCTGGGGAAAAACC

Downstream 100 bases:

>100_bases
GGATCAACCTTTCCTTGGAAGGCGCGCGAAGACTGACCGCTTCGCGCGCCTTTTCCATGGTCATTCCCATGGATCGTTTT
TCAGCTTGCGAACTAATACG

Product: thioredoxin reductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSDTRHTKVLIIGSGPAGYTAAVYASRAMLEPILVQGIEPGGQLTTTTEVENWPGHTEIQGPDLMVNMESHARAMGTEII
GDIITSLDTSSRPFVAKGDSGTTYTADAVILATGARAKWLGLPSEEKFKGFGVSACATCDGFFYRGQEIVVIGGGNTAVE
EALFLTNFASKVTLIHRRDELRAEKILIDRLMKNEKIEPLWFHELDEVVGTDAPLGVEAVRVKHTKTGEITEIPAKGVFV
AIGHAPATELVKDVLETHNGGYVKVKPGTTETSIPGIFAAGDLTDHKYRQAVTSAGMGCMAALDAERFLAEQE

Sequences:

>Translated_313_residues
MSDTRHTKVLIIGSGPAGYTAAVYASRAMLEPILVQGIEPGGQLTTTTEVENWPGHTEIQGPDLMVNMESHARAMGTEII
GDIITSLDTSSRPFVAKGDSGTTYTADAVILATGARAKWLGLPSEEKFKGFGVSACATCDGFFYRGQEIVVIGGGNTAVE
EALFLTNFASKVTLIHRRDELRAEKILIDRLMKNEKIEPLWFHELDEVVGTDAPLGVEAVRVKHTKTGEITEIPAKGVFV
AIGHAPATELVKDVLETHNGGYVKVKPGTTETSIPGIFAAGDLTDHKYRQAVTSAGMGCMAALDAERFLAEQE
>Mature_312_residues
SDTRHTKVLIIGSGPAGYTAAVYASRAMLEPILVQGIEPGGQLTTTTEVENWPGHTEIQGPDLMVNMESHARAMGTEIIG
DIITSLDTSSRPFVAKGDSGTTYTADAVILATGARAKWLGLPSEEKFKGFGVSACATCDGFFYRGQEIVVIGGGNTAVEE
ALFLTNFASKVTLIHRRDELRAEKILIDRLMKNEKIEPLWFHELDEVVGTDAPLGVEAVRVKHTKTGEITEIPAKGVFVA
IGHAPATELVKDVLETHNGGYVKVKPGTTETSIPGIFAAGDLTDHKYRQAVTSAGMGCMAALDAERFLAEQE

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787114, Length=318, Percent_Identity=59.748427672956, Blast_Score=364, Evalue=1e-102,
Organism=Escherichia coli, GI87081763, Length=309, Percent_Identity=32.0388349514563, Blast_Score=132, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6320560, Length=319, Percent_Identity=49.8432601880878, Blast_Score=293, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6321898, Length=324, Percent_Identity=46.6049382716049, Blast_Score=276, Evalue=4e-75,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 33530; Mature: 33398

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTRHTKVLIIGSGPAGYTAAVYASRAMLEPILVQGIEPGGQLTTTTEVENWPGHTEIQ
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCC
GPDLMVNMESHARAMGTEIIGDIITSLDTSSRPFVAKGDSGTTYTADAVILATGARAKWL
CCCEEEECHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEECEEEEEECCCEEEE
GLPSEEKFKGFGVSACATCDGFFYRGQEIVVIGGGNTAVEEALFLTNFASKVTLIHRRDE
CCCCHHHHCCCCCHHHHHCCCEEECCCEEEEEECCCHHHHHHHHHHHHHHHEEEEECHHH
LRAEKILIDRLMKNEKIEPLWFHELDEVVGTDAPLGVEAVRVKHTKTGEITEIPAKGVFV
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEECCCCCEEE
AIGHAPATELVKDVLETHNGGYVKVKPGTTETSIPGIFAAGDLTDHKYRQAVTSAGMGCM
EECCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCHH
AALDAERFLAEQE
HHHHHHHHHHCCC
>Mature Secondary Structure 
SDTRHTKVLIIGSGPAGYTAAVYASRAMLEPILVQGIEPGGQLTTTTEVENWPGHTEIQ
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCC
GPDLMVNMESHARAMGTEIIGDIITSLDTSSRPFVAKGDSGTTYTADAVILATGARAKWL
CCCEEEECHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEECEEEEEECCCEEEE
GLPSEEKFKGFGVSACATCDGFFYRGQEIVVIGGGNTAVEEALFLTNFASKVTLIHRRDE
CCCCHHHHCCCCCHHHHHCCCEEECCCEEEEEECCCHHHHHHHHHHHHHHHEEEEECHHH
LRAEKILIDRLMKNEKIEPLWFHELDEVVGTDAPLGVEAVRVKHTKTGEITEIPAKGVFV
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEECCCCCEEE
AIGHAPATELVKDVLETHNGGYVKVKPGTTETSIPGIFAAGDLTDHKYRQAVTSAGMGCM
EECCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCHH
AALDAERFLAEQE
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]