Click here to switch to the map view.

The map label for this gene is groEL [H]

Identifier: 99080438

GI number: 99080438

Start: 637983

End: 639626

Strand: Direct

Name: groEL [H]

Synonym: TM1040_0597

Alternate gene names: 99080438

Gene position: 637983-639626 (Clockwise)

Preceding gene: 99080437

Following gene: 99080439

Centisome position: 19.93

GC content: 59.18

Gene sequence:

>1644_bases
ATGGCTGCTAAGGACGTCAAATTCGACACCGATGCCCGCAACCGTATGCTGAAGGGTGTCAACACCCTCGCAGACGCCGT
TAAAGTGACCCTCGGCCCCAAAGGCCGCAACGTGGTTCTCGAAAAATCCTTCGGCGCACCGCGCATCACCAAAGACGGTG
TGTCTGTTGCCAAGGAAATCGAACTGGAAGACAAGTTCGAGAACATGGGCGCACAGATGGTGAAGGAAGTTGCTTCCCGC
ACCAACGACGAAGCCGGTGACGGCACCACCACCGCGACCGTTCTGGCTCAGTCCATCGTTCGCGAAGGTCTGAAGCAGGT
TGCAGCGGGCCTGAACCCGATGGACCTCAAGCGTGGCATCGATCTGGCAACCGACAAAGTTGTCGAAGCGATCAAAGCCA
TGGCGCGCGAAGTCAAAGACTCCGACGAAGTTGCTCAGGTCGGCACCATCTCCGCGAACGGCGAAGCTGAAATCGGCCGC
CAGATCGCGGACGCGATGCAGAAAGTCGGCAACGACGGCGTCATCACCGTTGAAGAAAACAAAGGTCTGGAAACCGAGAC
CGATGTTGTCGAAGGCATGCAGTTCGACCGCGGCTACCTGTCGCCCTACTTCGTGACCAACGCCGACAAGATGACCGCAG
AGCTCGAAGACTGCCTCATCCTGTTGCACGAGAAGAAACTCTCCTCCCTGCAGCCGATGGTTCCGCTCCTTGAGCAGGTG
ATCCAATCCCAAAAGCCGCTCCTCATCATCGCTGAGGACGTCGAAGGCGAAGCGCTGGCAACTCTGGTTGTGAACAAACT
GCGTGGCGGCCTGAAAATCGCAGCCGTGAAGGCACCTGGCTTCGGCGATCGCCGCAAGGCCATGCTGCAGGACATCGCGA
TCCTGACCGGCGGTCAAGTGATCTCCGAAGACCTCGGCATGAAGCTCGAGTCCGTGACCATGGACATGCTTGGCACCGCC
AAGAAAATCCAGATCACCAAAGACGAGACCACCATCGTTGACGGTGCGGGCGAGAAAGCAGAGATCGAAGCACGTGTTGC
TCAGATCCGCGCTCAGATCGAAGAAACCACTTCCGACTACGACCGTGAGAAGCTGCAAGAGCGCGTTGCCAAACTGGCAG
GCGGTGTTGCCGTGATCCGCGTCGGCGGCATGACCGAAGTCGAAGTGAAAGAGCGCAAAGACCGTGTGGACGATGCTCTG
AACGCAACCCGCGCAGCTGTGCAGGAAGGCGTGATCGTCGGTGGTGGTGTTGCTCTGGTTCAGGCTGGCAAGTCCCTCGA
AGGTCTCACCGGTGTCAACGCAGACCAGAACGCAGGCATCGCAATCGTGCGCCGCGCGCTCGAAGCACCGCTGCGTCAGA
TCGCTGAGAACGCAGGCGTCGACGGCGCCGTGGTTGCAGGCAAGATCCGTGAGTCCGAAGACAAGAACTTCGGCTTCAAC
GCTCAGACCGAAGAATATGGCGACATGTTCTCCTTTGGTGTGATCGATCCGGCCAAAGTGACCCGCACCGCGCTGGAAGA
CGCAGCCTCCATCGCCGGTCTGCTGATCACAACCGAAGCCATGGTTGCAGACAAGCCCGCCAAAGAAGGCGCGGCACCTG
CAGGTGGCATGCCCGACATGGGCGGCATGGGCGGCATGATGTAA

Upstream 100 bases:

>100_bases
GATGATGAAAGAGAGCGACATCATGGGTGTGATCGTCTGAGCCTCGCTCCGACACATCCCACATCGCGTAACAAGACAGT
ATTCTCAAGGAGACTGAATA

Downstream 100 bases:

>100_bases
GTCACGCCATCCAGTCTTGGATGATGACCCTTCGGGGTCGAAAGGGTCGCCTTCGGGCGGCCCTTTTTTGCTGCCTGACC
TCTGTTCGGTGTTTTTTGGG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MAAKDVKFDTDARNRMLKGVNTLADAVKVTLGPKGRNVVLEKSFGAPRITKDGVSVAKEIELEDKFENMGAQMVKEVASR
TNDEAGDGTTTATVLAQSIVREGLKQVAAGLNPMDLKRGIDLATDKVVEAIKAMAREVKDSDEVAQVGTISANGEAEIGR
QIADAMQKVGNDGVITVEENKGLETETDVVEGMQFDRGYLSPYFVTNADKMTAELEDCLILLHEKKLSSLQPMVPLLEQV
IQSQKPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLQDIAILTGGQVISEDLGMKLESVTMDMLGTA
KKIQITKDETTIVDGAGEKAEIEARVAQIRAQIEETTSDYDREKLQERVAKLAGGVAVIRVGGMTEVEVKERKDRVDDAL
NATRAAVQEGVIVGGGVALVQAGKSLEGLTGVNADQNAGIAIVRRALEAPLRQIAENAGVDGAVVAGKIRESEDKNFGFN
AQTEEYGDMFSFGVIDPAKVTRTALEDAASIAGLLITTEAMVADKPAKEGAAPAGGMPDMGGMGGMM

Sequences:

>Translated_547_residues
MAAKDVKFDTDARNRMLKGVNTLADAVKVTLGPKGRNVVLEKSFGAPRITKDGVSVAKEIELEDKFENMGAQMVKEVASR
TNDEAGDGTTTATVLAQSIVREGLKQVAAGLNPMDLKRGIDLATDKVVEAIKAMAREVKDSDEVAQVGTISANGEAEIGR
QIADAMQKVGNDGVITVEENKGLETETDVVEGMQFDRGYLSPYFVTNADKMTAELEDCLILLHEKKLSSLQPMVPLLEQV
IQSQKPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLQDIAILTGGQVISEDLGMKLESVTMDMLGTA
KKIQITKDETTIVDGAGEKAEIEARVAQIRAQIEETTSDYDREKLQERVAKLAGGVAVIRVGGMTEVEVKERKDRVDDAL
NATRAAVQEGVIVGGGVALVQAGKSLEGLTGVNADQNAGIAIVRRALEAPLRQIAENAGVDGAVVAGKIRESEDKNFGFN
AQTEEYGDMFSFGVIDPAKVTRTALEDAASIAGLLITTEAMVADKPAKEGAAPAGGMPDMGGMGGMM
>Mature_546_residues
AAKDVKFDTDARNRMLKGVNTLADAVKVTLGPKGRNVVLEKSFGAPRITKDGVSVAKEIELEDKFENMGAQMVKEVASRT
NDEAGDGTTTATVLAQSIVREGLKQVAAGLNPMDLKRGIDLATDKVVEAIKAMAREVKDSDEVAQVGTISANGEAEIGRQ
IADAMQKVGNDGVITVEENKGLETETDVVEGMQFDRGYLSPYFVTNADKMTAELEDCLILLHEKKLSSLQPMVPLLEQVI
QSQKPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLQDIAILTGGQVISEDLGMKLESVTMDMLGTAK
KIQITKDETTIVDGAGEKAEIEARVAQIRAQIEETTSDYDREKLQERVAKLAGGVAVIRVGGMTEVEVKERKDRVDDALN
ATRAAVQEGVIVGGGVALVQAGKSLEGLTGVNADQNAGIAIVRRALEAPLRQIAENAGVDGAVVAGKIRESEDKNFGFNA
QTEEYGDMFSFGVIDPAKVTRTALEDAASIAGLLITTEAMVADKPAKEGAAPAGGMPDMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=53.030303030303, Blast_Score=558, Evalue=1e-159,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=53.030303030303, Blast_Score=558, Evalue=1e-159,
Organism=Homo sapiens, GI5453607, Length=539, Percent_Identity=23.191094619666, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI261399877, Length=511, Percent_Identity=22.8962818003914, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI261399875, Length=470, Percent_Identity=23.1914893617021, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790586, Length=531, Percent_Identity=67.984934086629, Blast_Score=707, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=50.1893939393939, Blast_Score=539, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI193210679, Length=221, Percent_Identity=46.1538461538462, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17564182, Length=553, Percent_Identity=22.9656419529837, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=54.7528517110266, Blast_Score=578, Evalue=1e-166,
Organism=Saccharomyces cerevisiae, GI6322350, Length=548, Percent_Identity=23.7226277372263, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322524, Length=535, Percent_Identity=20.5607476635514, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641193, Length=525, Percent_Identity=55.047619047619, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24641191, Length=525, Percent_Identity=55.047619047619, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI45550936, Length=528, Percent_Identity=52.6515151515151, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45550132, Length=528, Percent_Identity=52.6515151515151, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45550935, Length=528, Percent_Identity=52.6515151515151, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI17864606, Length=527, Percent_Identity=44.9715370018975, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24584129, Length=547, Percent_Identity=35.1005484460695, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI19921262, Length=547, Percent_Identity=35.1005484460695, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI24645179, Length=509, Percent_Identity=21.2180746561886, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28571140, Length=571, Percent_Identity=21.5411558669002, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI18858175, Length=571, Percent_Identity=21.5411558669002, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583944, Length=188, Percent_Identity=25.531914893617, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57937; Mature: 57806

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFDTDARNRMLKGVNTLADAVKVTLGPKGRNVVLEKSFGAPRITKDGVSVAKEI
CCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHH
ELEDKFENMGAQMVKEVASRTNDEAGDGTTTATVLAQSIVREGLKQVAAGLNPMDLKRGI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
DLATDKVVEAIKAMAREVKDSDEVAQVGTISANGEAEIGRQIADAMQKVGNDGVITVEEN
CHHHHHHHHHHHHHHHHHCCCHHHHHHEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECC
KGLETETDVVEGMQFDRGYLSPYFVTNADKMTAELEDCLILLHEKKLSSLQPMVPLLEQV
CCCCCHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
IQSQKPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLQDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEDLGMKLESVTMDMLGTAKKIQITKDETTIVDGAGEKAEIEARVAQIRAQIEETTSDY
HHHHHCCCHHHHHHHHHCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIRVGGMTEVEVKERKDRVDDALNATRAAVQEGVIVGGGVALV
HHHHHHHHHHHHHCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHH
QAGKSLEGLTGVNADQNAGIAIVRRALEAPLRQIAENAGVDGAVVAGKIRESEDKNFGFN
HCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHCCCCCCCCCC
AQTEEYGDMFSFGVIDPAKVTRTALEDAASIAGLLITTEAMVADKPAKEGAAPAGGMPDM
CCCHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GGMGGMM
CCCCCCC
>Mature Secondary Structure 
AAKDVKFDTDARNRMLKGVNTLADAVKVTLGPKGRNVVLEKSFGAPRITKDGVSVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHH
ELEDKFENMGAQMVKEVASRTNDEAGDGTTTATVLAQSIVREGLKQVAAGLNPMDLKRGI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
DLATDKVVEAIKAMAREVKDSDEVAQVGTISANGEAEIGRQIADAMQKVGNDGVITVEEN
CHHHHHHHHHHHHHHHHHCCCHHHHHHEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECC
KGLETETDVVEGMQFDRGYLSPYFVTNADKMTAELEDCLILLHEKKLSSLQPMVPLLEQV
CCCCCHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
IQSQKPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLQDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEDLGMKLESVTMDMLGTAKKIQITKDETTIVDGAGEKAEIEARVAQIRAQIEETTSDY
HHHHHCCCHHHHHHHHHCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIRVGGMTEVEVKERKDRVDDALNATRAAVQEGVIVGGGVALV
HHHHHHHHHHHHHCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHH
QAGKSLEGLTGVNADQNAGIAIVRRALEAPLRQIAENAGVDGAVVAGKIRESEDKNFGFN
HCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHCCCCCCCCCC
AQTEEYGDMFSFGVIDPAKVTRTALEDAASIAGLLITTEAMVADKPAKEGAAPAGGMPDM
CCCHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GGMGGMM
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA