Click here to switch to the map view.

The map label for this gene is kefC [H]

Identifier: 99080420

GI number: 99080420

Start: 616034

End: 617911

Strand: Reverse

Name: kefC [H]

Synonym: TM1040_0579

Alternate gene names: 99080420

Gene position: 617911-616034 (Counterclockwise)

Preceding gene: 99080421

Following gene: 99080418

Centisome position: 19.3

GC content: 58.84

Gene sequence:

>1878_bases
ATGGATAGTTTTCTCTCTCAGGCCTCAATCTACCTCGCCGCCGCCGTGATCGCCGTACCCATCGCCGCCCGGTTGGGTTT
GGGGTCGGTGCTCGGATACCTCGCCGCGGGCATCATCATCGGTCCGATCTTGGGTCTTGTCGGGGCGGAAGCCGAGGAAC
TCCAGCATTTTGCCGAGTTTGGCGTCGTGATGATGCTGTTTCTGATCGGCCTCGAGCTCGACCCGCGCGCGCTCTGGGCG
ATGCGACACCACTTGATCGGACTCGGTGGGTTACAAATCACCGCTTCAACCGCACTCCTTGCGGGGGCTGCGATCTTTTT
TGGCCACAGCTGGCAAGTGGGCCTTGCCGTCGGGCTGGCGCTCTCGCTGTCATCAACAGCCATCGTGCTGCAAACGCTTT
CGGAAAAAGGGCTGACGCGCACTGGAGGGGGCAGAGCGACCTTCTCTGTCTTGCTCACCCAGGACATTGCAGTCATTCCG
ATCCTGGCTCTGCTGCCGCTGTTGGCGACACAACATGCACTATCCCTGTCCGAGGATGGCTCCATCGTGCGCGCAGAAGA
AGCGCATGGCGCGGGACACCACTCGCTCTCGCTCGTAGAAGGGCTGCCTGGCTGGGCCGTCACCCTGACGACAATCGGCG
CCATCGCCTTCGTGATTCTGGCGGGCGTCTATCTGACCCGTCCGGTGTTTCGCTTCATTCACGCCTCCAACCTGCGCGAG
ATGTATACGGCACTGGCCCTTCTGATCGTTGTTGGAATTTCCTTCCTGATGACCTTGGTCGGGTTGTCCCCGGCGTTGGG
CGCCTTTCTCGCCGGTGTTGTGCTCGCGAACAGCGAGTTCCGCCACGAGCTGGAGAGCGACCTCGAACCCTTCAAAGGGC
TCCTGTTGGGGCTATTCTTCATCACCGTCGGAGCAGGTATCAACTATCGCTTGTTCCTAGCCGAGCCCGGGGATGTGATC
GGTCTCGCCTTGCTCGTGATTTTCGCAAAGGGCGCGGTTTTGTATTTCGTCGGCAGGGCCTTCGGACTGAGAGGGCGCAA
TCATTGGCTCTTCACCCTCGGGCTGGCGCAGGCCGGTGAATTTGGCTTTGTGCTGCTGGCGTTCTCGCTTCAGCTGAATG
TGGTTACGGCCGATCTGTCGGAGAAACTGCTGCTGGTCATCGCGCTGACGATGTTGATCACGCCGCTTTTGTTCATCCTC
TACGAAATCCTATCCAAGCGGATGAAGGACGCCCAAGTCGAACATACGCCCGACGAGATTGACGAAGAAGGCACAGTGAT
CATCGCCGGGATCGGGCGTTTTGGTCAGATCGTGCATCGCCTTGTGAATGCGAGTGGCTTCAAGACCGTTCTTTTGGACA
GCGACATGAAGGCGGTACAGCTGATGCGCCGCTTTGGGGTCAAGAGTTTCCTCGGGGATCCAACCCGTCCAGAGCTGCTG
AAAGCGGCTGGCATCAGCAAGGCAAAAGTGCTGGTTGTCGCGCTCGACGATCAGGAAAGCGCCACAAAACTCGTGACTTA
CGCCCGGCGGAACTATCCAGACATCCATATTGTCGCCCGCGCCTATGATCGCAACCATGTGTTTGAGCTTTATAAAGCGG
GGGCCAATGATATCGTGCGCGAAATGTTCGACAGCTCGCTGCGGGCCGGTCGCTATGTGCTCGAGAATATCGGACTAAGC
GAGTATGAGGCGGCACAGGCCGAACAGACCTTTTACGCGCATGATCGCCACACCATCCGAGAGCTCGCAGGGCATTGGAT
TCCGGGCACTCCCGCAAGCGAGAACCCGGCCTATATCAAACGCGCGAGAGAGCTGGAAAAAGACCTGGAAACGGCGCTGC
TGTCGCTAGCTGAAGACCACATCAAACACCGCGCCTGA

Upstream 100 bases:

>100_bases
GGCTCTCTCGAGCTGCCGCTTTTTTTAACCTGATCGTGACAGAGGGGCCCGAGTCAGCCTATCTCTTTGCCATCTCGTAA
AAAGTTGGCAATATTCTCTT

Downstream 100 bases:

>100_bases
GCGCGAGGCTGATCCCCTGTGCGGGGTCAGCCGTCCGATACTCCGGCTTCGGCAAAGGTGGCCATGCCACTATGACAGGC
CAGCGCACCTTTGAGCACTT

Product: potassium efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 625; Mature: 625

Protein sequence:

>625_residues
MDSFLSQASIYLAAAVIAVPIAARLGLGSVLGYLAAGIIIGPILGLVGAEAEELQHFAEFGVVMMLFLIGLELDPRALWA
MRHHLIGLGGLQITASTALLAGAAIFFGHSWQVGLAVGLALSLSSTAIVLQTLSEKGLTRTGGGRATFSVLLTQDIAVIP
ILALLPLLATQHALSLSEDGSIVRAEEAHGAGHHSLSLVEGLPGWAVTLTTIGAIAFVILAGVYLTRPVFRFIHASNLRE
MYTALALLIVVGISFLMTLVGLSPALGAFLAGVVLANSEFRHELESDLEPFKGLLLGLFFITVGAGINYRLFLAEPGDVI
GLALLVIFAKGAVLYFVGRAFGLRGRNHWLFTLGLAQAGEFGFVLLAFSLQLNVVTADLSEKLLLVIALTMLITPLLFIL
YEILSKRMKDAQVEHTPDEIDEEGTVIIAGIGRFGQIVHRLVNASGFKTVLLDSDMKAVQLMRRFGVKSFLGDPTRPELL
KAAGISKAKVLVVALDDQESATKLVTYARRNYPDIHIVARAYDRNHVFELYKAGANDIVREMFDSSLRAGRYVLENIGLS
EYEAAQAEQTFYAHDRHTIRELAGHWIPGTPASENPAYIKRARELEKDLETALLSLAEDHIKHRA

Sequences:

>Translated_625_residues
MDSFLSQASIYLAAAVIAVPIAARLGLGSVLGYLAAGIIIGPILGLVGAEAEELQHFAEFGVVMMLFLIGLELDPRALWA
MRHHLIGLGGLQITASTALLAGAAIFFGHSWQVGLAVGLALSLSSTAIVLQTLSEKGLTRTGGGRATFSVLLTQDIAVIP
ILALLPLLATQHALSLSEDGSIVRAEEAHGAGHHSLSLVEGLPGWAVTLTTIGAIAFVILAGVYLTRPVFRFIHASNLRE
MYTALALLIVVGISFLMTLVGLSPALGAFLAGVVLANSEFRHELESDLEPFKGLLLGLFFITVGAGINYRLFLAEPGDVI
GLALLVIFAKGAVLYFVGRAFGLRGRNHWLFTLGLAQAGEFGFVLLAFSLQLNVVTADLSEKLLLVIALTMLITPLLFIL
YEILSKRMKDAQVEHTPDEIDEEGTVIIAGIGRFGQIVHRLVNASGFKTVLLDSDMKAVQLMRRFGVKSFLGDPTRPELL
KAAGISKAKVLVVALDDQESATKLVTYARRNYPDIHIVARAYDRNHVFELYKAGANDIVREMFDSSLRAGRYVLENIGLS
EYEAAQAEQTFYAHDRHTIRELAGHWIPGTPASENPAYIKRARELEKDLETALLSLAEDHIKHRA
>Mature_625_residues
MDSFLSQASIYLAAAVIAVPIAARLGLGSVLGYLAAGIIIGPILGLVGAEAEELQHFAEFGVVMMLFLIGLELDPRALWA
MRHHLIGLGGLQITASTALLAGAAIFFGHSWQVGLAVGLALSLSSTAIVLQTLSEKGLTRTGGGRATFSVLLTQDIAVIP
ILALLPLLATQHALSLSEDGSIVRAEEAHGAGHHSLSLVEGLPGWAVTLTTIGAIAFVILAGVYLTRPVFRFIHASNLRE
MYTALALLIVVGISFLMTLVGLSPALGAFLAGVVLANSEFRHELESDLEPFKGLLLGLFFITVGAGINYRLFLAEPGDVI
GLALLVIFAKGAVLYFVGRAFGLRGRNHWLFTLGLAQAGEFGFVLLAFSLQLNVVTADLSEKLLLVIALTMLITPLLFIL
YEILSKRMKDAQVEHTPDEIDEEGTVIIAGIGRFGQIVHRLVNASGFKTVLLDSDMKAVQLMRRFGVKSFLGDPTRPELL
KAAGISKAKVLVVALDDQESATKLVTYARRNYPDIHIVARAYDRNHVFELYKAGANDIVREMFDSSLRAGRYVLENIGLS
EYEAAQAEQTFYAHDRHTIRELAGHWIPGTPASENPAYIKRARELEKDLETALLSLAEDHIKHRA

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=376, Percent_Identity=26.8617021276596, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1786232, Length=585, Percent_Identity=43.9316239316239, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI1789749, Length=611, Percent_Identity=40.4255319148936, Blast_Score=397, Evalue=1e-111,
Organism=Escherichia coli, GI1786685, Length=528, Percent_Identity=28.030303030303, Blast_Score=176, Evalue=6e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 67463; Mature: 67463

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSFLSQASIYLAAAVIAVPIAARLGLGSVLGYLAAGIIIGPILGLVGAEAEELQHFAEF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
GVVMMLFLIGLELDPRALWAMRHHLIGLGGLQITASTALLAGAAIFFGHSWQVGLAVGLA
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHH
LSLSSTAIVLQTLSEKGLTRTGGGRATFSVLLTQDIAVIPILALLPLLATQHALSLSEDG
HHHCHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SIVRAEEAHGAGHHSLSLVEGLPGWAVTLTTIGAIAFVILAGVYLTRPVFRFIHASNLRE
CEEEEHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MYTALALLIVVGISFLMTLVGLSPALGAFLAGVVLANSEFRHELESDLEPFKGLLLGLFF
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
ITVGAGINYRLFLAEPGDVIGLALLVIFAKGAVLYFVGRAFGLRGRNHWLFTLGLAQAGE
HHHCCCCCEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEECCCCCC
FGFVLLAFSLQLNVVTADLSEKLLLVIALTMLITPLLFILYEILSKRMKDAQVEHTPDEI
CHHEEEEHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHC
DEEGTVIIAGIGRFGQIVHRLVNASGFKTVLLDSDMKAVQLMRRFGVKSFLGDPTRPELL
CCCCCEEEEECCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCHHHHCCCCCCHHHH
KAAGISKAKVLVVALDDQESATKLVTYARRNYPDIHIVARAYDRNHVFELYKAGANDIVR
HHCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHCCHHHHHH
EMFDSSLRAGRYVLENIGLSEYEAAQAEQTFYAHDRHTIRELAGHWIPGTPASENPAYIK
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
RARELEKDLETALLSLAEDHIKHRA
HHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDSFLSQASIYLAAAVIAVPIAARLGLGSVLGYLAAGIIIGPILGLVGAEAEELQHFAEF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
GVVMMLFLIGLELDPRALWAMRHHLIGLGGLQITASTALLAGAAIFFGHSWQVGLAVGLA
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHH
LSLSSTAIVLQTLSEKGLTRTGGGRATFSVLLTQDIAVIPILALLPLLATQHALSLSEDG
HHHCHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SIVRAEEAHGAGHHSLSLVEGLPGWAVTLTTIGAIAFVILAGVYLTRPVFRFIHASNLRE
CEEEEHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MYTALALLIVVGISFLMTLVGLSPALGAFLAGVVLANSEFRHELESDLEPFKGLLLGLFF
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
ITVGAGINYRLFLAEPGDVIGLALLVIFAKGAVLYFVGRAFGLRGRNHWLFTLGLAQAGE
HHHCCCCCEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEECCCCCC
FGFVLLAFSLQLNVVTADLSEKLLLVIALTMLITPLLFILYEILSKRMKDAQVEHTPDEI
CHHEEEEHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHC
DEEGTVIIAGIGRFGQIVHRLVNASGFKTVLLDSDMKAVQLMRRFGVKSFLGDPTRPELL
CCCCCEEEEECCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCHHHHCCCCCCHHHH
KAAGISKAKVLVVALDDQESATKLVTYARRNYPDIHIVARAYDRNHVFELYKAGANDIVR
HHCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHCCHHHHHH
EMFDSSLRAGRYVLENIGLSEYEAAQAEQTFYAHDRHTIRELAGHWIPGTPASENPAYIK
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
RARELEKDLETALLSLAEDHIKHRA
HHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA