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The map label for this gene is cynR [H]

Identifier: 99080354

GI number: 99080354

Start: 539153

End: 540061

Strand: Direct

Name: cynR [H]

Synonym: TM1040_0513

Alternate gene names: 99080354

Gene position: 539153-540061 (Clockwise)

Preceding gene: 99080353

Following gene: 99080355

Centisome position: 16.84

GC content: 63.59

Gene sequence:

>909_bases
ATGGACGCGCTTGAGACAAAGTTCCTGCGCGAGTTTCTCGCGGTGGCGCATGAAGGTTCGATCCGGCGCGCGGCAGACCG
GCTCAACGTGGTGCCTTCTGCAATTTCGCGCAAGATTGCCGAGGCCGAGGCGCGGCTCGGGGTCACGCTGTTTGAACGCA
GCTCCAAGGGGGTTGTCCTCACCGAGGCCGGGGAACTCTTGCGCGAGCACGCGCAACACATGCGGGACGAGCAGACCTAC
CTGCTGGATCAGATCGGCCATTTTCGCGACGGGCGCAGCCAGATCGTGCGTATTGCAACAGGCGAGGGGTTTGCCGCTGA
CCTGATGGGCAAGGGGCTGTTGGGGCTGACGCGCGCGCATCCCGAGCTTCGGTTTATTGTCGACCACGCGGGCACGGATG
AGATCCAGCGCAAGGTCATCGAGGGTGAAAGCGACATCGGCATTGCCTATAACCCCCTGATCACAGACGCGACCCGATCA
CTGGCCCAAGCGCGGCAATCGCTCTGTGTGATCGCCCCGACGCACTCGCCTTTGGCCCAGCGAAAGAGCGTGACCCTTGC
CGAGGTGCTGGAGCATCCGGTGGCGATGCTCAATGCCGGCTATGCCATCCGGCATCTGGTCGGGCAGGCAGCTGCGGACC
GGGGGTTGGCGCTGCGGGTACAGGCGGAGATGGCCTCGATCCCGTTGCTGATCCACTATGTCTGCGCGGGGGTCGGGATC
AGCTTTCTGCCGCGCTTTTGCGCCACCAGTCAGGCTGAACGCGGCGATCTGGCGGTACTCGACATCGAAGAATCCTCGCT
GCAGCAGGTCAGCACCCATCTGATGGTGCGCGCGCGCCGACGCCTGCCAAAGTCGGTGGCATTGGTGGCACGATATCTCG
CCGAGAATATGCAGGCCTTTCGCGACTGA

Upstream 100 bases:

>100_bases
ATCCGGGTCTGCACTCAGCCAAATTTGATTTCAATGATGCCGTGCTCCCAGTCGGGGCCGAGTTCTGGGTGCGGCTGGCC
CGCCGCCAGCTGGCGACCTG

Downstream 100 bases:

>100_bases
CCGCACAATGCGTTGCTATGATGGCAACGCATTGTGCGCAAACGACCATCTTCCTGAGATCACCCTAGCTGCGGTTTCCT
GATGTAAAGCGCCCAAGGTG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MDALETKFLREFLAVAHEGSIRRAADRLNVVPSAISRKIAEAEARLGVTLFERSSKGVVLTEAGELLREHAQHMRDEQTY
LLDQIGHFRDGRSQIVRIATGEGFAADLMGKGLLGLTRAHPELRFIVDHAGTDEIQRKVIEGESDIGIAYNPLITDATRS
LAQARQSLCVIAPTHSPLAQRKSVTLAEVLEHPVAMLNAGYAIRHLVGQAAADRGLALRVQAEMASIPLLIHYVCAGVGI
SFLPRFCATSQAERGDLAVLDIEESSLQQVSTHLMVRARRRLPKSVALVARYLAENMQAFRD

Sequences:

>Translated_302_residues
MDALETKFLREFLAVAHEGSIRRAADRLNVVPSAISRKIAEAEARLGVTLFERSSKGVVLTEAGELLREHAQHMRDEQTY
LLDQIGHFRDGRSQIVRIATGEGFAADLMGKGLLGLTRAHPELRFIVDHAGTDEIQRKVIEGESDIGIAYNPLITDATRS
LAQARQSLCVIAPTHSPLAQRKSVTLAEVLEHPVAMLNAGYAIRHLVGQAAADRGLALRVQAEMASIPLLIHYVCAGVGI
SFLPRFCATSQAERGDLAVLDIEESSLQQVSTHLMVRARRRLPKSVALVARYLAENMQAFRD
>Mature_302_residues
MDALETKFLREFLAVAHEGSIRRAADRLNVVPSAISRKIAEAEARLGVTLFERSSKGVVLTEAGELLREHAQHMRDEQTY
LLDQIGHFRDGRSQIVRIATGEGFAADLMGKGLLGLTRAHPELRFIVDHAGTDEIQRKVIEGESDIGIAYNPLITDATRS
LAQARQSLCVIAPTHSPLAQRKSVTLAEVLEHPVAMLNAGYAIRHLVGQAAADRGLALRVQAEMASIPLLIHYVCAGVGI
SFLPRFCATSQAERGDLAVLDIEESSLQQVSTHLMVRARRRLPKSVALVARYLAENMQAFRD

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=244, Percent_Identity=27.8688524590164, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1788748, Length=238, Percent_Identity=26.890756302521, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI145693105, Length=244, Percent_Identity=25.8196721311475, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1787879, Length=266, Percent_Identity=27.0676691729323, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI87082132, Length=264, Percent_Identity=25.7575757575758, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787128, Length=162, Percent_Identity=31.4814814814815, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788297, Length=246, Percent_Identity=26.8292682926829, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789440, Length=171, Percent_Identity=28.0701754385965, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788296, Length=245, Percent_Identity=25.7142857142857, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI87081904, Length=206, Percent_Identity=31.0679611650485, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788481, Length=255, Percent_Identity=27.843137254902, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1790399, Length=256, Percent_Identity=25, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787601, Length=140, Percent_Identity=30.7142857142857, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787589, Length=251, Percent_Identity=26.6932270916335, Blast_Score=61, Evalue=7e-11,
Organism=Escherichia coli, GI1787806, Length=240, Percent_Identity=25.8333333333333, Blast_Score=61, Evalue=8e-11,
Organism=Escherichia coli, GI2367136, Length=135, Percent_Identity=35.5555555555556, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33127; Mature: 33127

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDALETKFLREFLAVAHEGSIRRAADRLNVVPSAISRKIAEAEARLGVTLFERSSKGVVL
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEECCCCCEEE
TEAGELLREHAQHMRDEQTYLLDQIGHFRDGRSQIVRIATGEGFAADLMGKGLLGLTRAH
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEECCCCHHHHHHCCCHHHHHHCC
PELRFIVDHAGTDEIQRKVIEGESDIGIAYNPLITDATRSLAQARQSLCVIAPTHSPLAQ
CCEEEEEECCCHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHCEEEEECCCCCHHH
RKSVTLAEVLEHPVAMLNAGYAIRHLVGQAAADRGLALRVQAEMASIPLLIHYVCAGVGI
HHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCCH
SFLPRFCATSQAERGDLAVLDIEESSLQQVSTHLMVRARRRLPKSVALVARYLAENMQAF
HHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
RD
CC
>Mature Secondary Structure
MDALETKFLREFLAVAHEGSIRRAADRLNVVPSAISRKIAEAEARLGVTLFERSSKGVVL
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEECCCCCEEE
TEAGELLREHAQHMRDEQTYLLDQIGHFRDGRSQIVRIATGEGFAADLMGKGLLGLTRAH
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEECCCCHHHHHHCCCHHHHHHCC
PELRFIVDHAGTDEIQRKVIEGESDIGIAYNPLITDATRSLAQARQSLCVIAPTHSPLAQ
CCEEEEEECCCHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHCEEEEECCCCCHHH
RKSVTLAEVLEHPVAMLNAGYAIRHLVGQAAADRGLALRVQAEMASIPLLIHYVCAGVGI
HHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCCH
SFLPRFCATSQAERGDLAVLDIEESSLQQVSTHLMVRARRRLPKSVALVARYLAENMQAF
HHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
RD
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]