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The map label for this gene is fabG [C]

Identifier: 99080249

GI number: 99080249

Start: 419138

End: 419860

Strand: Reverse

Name: fabG [C]

Synonym: TM1040_0408

Alternate gene names: 99080249

Gene position: 419860-419138 (Counterclockwise)

Preceding gene: 99080250

Following gene: 99080248

Centisome position: 13.12

GC content: 59.75

Gene sequence:

>723_bases
ATGAGCTTCAAAAATCAAACATGGTGGATCATCGGCGCGAGCGAGGGTCTTGGGCGCGCATTGGCCGAAGCCCTCGACCA
AGAAGGCGCATCCTTGATCCTGTCTGCACGCAACGCAGACCGTCTGCAGGCGCTTTCTGACGGGCTCGGTGATGCGCAAG
CCCTGCCTATGGATGTCACCGATTCGCGCTCGGTTGCGAGTGCCGCCGAAGCCGCCTCTGATGCTGACGGGGTGATCTAT
TGTGCCGGTCTGTACGACCCGATGACAGTACAGGAATGGGAACCCGAAACCGCAGAGGCCATCTGCGAAGTCAATTTCAT
GGGCGCAATGCGCGCCATGGGACGGGTGGCCCCACGGTTCGCCAGACGCGGGCATGGGCATATTGTGTTGATTGGCTCGC
TCGCGGGGTTCACCGGGCTTCCGGGGGCAATCGGCTATGGCGCCTCCAAGGCGGCAGTGATGCATCTGGGCGAGAACCTG
CACCGCGATCTGCGCGACAGCGGCGTGAAAGTACAGGTGGTCAATCCAGGCTTTATCAAGACCCGGCTTACGGCCAAGAA
TGACTTCAAGATGCCGATGATCCAGACCCCCGAAGATGCCGCTGCCTGCTGCATCAAGGCGATGCGCTCAAATCGGTTCC
AGACTTCTTTTCCCGCGCCGTTTTCGTGGGTGTTTCGCATCGCTGCACTCCTGCCCCGCAAATTGGTAACGAGGTTGATA
TGA

Upstream 100 bases:

>100_bases
CCATCATGAACCGTTCCGAGATGCGCAAATTCGGCATCAAGGTTGCAGAGCTTGTCGCCACCATTCGCCCCGCGCCCGAC
ACAGACGCACCGGAACAGTC

Downstream 100 bases:

>100_bases
CAGACCCGCGCACAGTCGTGATTTTTGGAGCCTCAGGCGGCATTGGCCGCGCCCTGGTGGAAACCTATGCCGGCATGTCG
GCGGTTGAGACGGTCCATGC

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MSFKNQTWWIIGASEGLGRALAEALDQEGASLILSARNADRLQALSDGLGDAQALPMDVTDSRSVASAAEAASDADGVIY
CAGLYDPMTVQEWEPETAEAICEVNFMGAMRAMGRVAPRFARRGHGHIVLIGSLAGFTGLPGAIGYGASKAAVMHLGENL
HRDLRDSGVKVQVVNPGFIKTRLTAKNDFKMPMIQTPEDAAACCIKAMRSNRFQTSFPAPFSWVFRIAALLPRKLVTRLI

Sequences:

>Translated_240_residues
MSFKNQTWWIIGASEGLGRALAEALDQEGASLILSARNADRLQALSDGLGDAQALPMDVTDSRSVASAAEAASDADGVIY
CAGLYDPMTVQEWEPETAEAICEVNFMGAMRAMGRVAPRFARRGHGHIVLIGSLAGFTGLPGAIGYGASKAAVMHLGENL
HRDLRDSGVKVQVVNPGFIKTRLTAKNDFKMPMIQTPEDAAACCIKAMRSNRFQTSFPAPFSWVFRIAALLPRKLVTRLI
>Mature_239_residues
SFKNQTWWIIGASEGLGRALAEALDQEGASLILSARNADRLQALSDGLGDAQALPMDVTDSRSVASAAEAASDADGVIYC
AGLYDPMTVQEWEPETAEAICEVNFMGAMRAMGRVAPRFARRGHGHIVLIGSLAGFTGLPGAIGYGASKAAVMHLGENLH
RDLRDSGVKVQVVNPGFIKTRLTAKNDFKMPMIQTPEDAAACCIKAMRSNRFQTSFPAPFSWVFRIAALLPRKLVTRLI

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=196, Percent_Identity=27.5510204081633, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI19743808, Length=228, Percent_Identity=28.0701754385965, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI7706318, Length=188, Percent_Identity=29.2553191489362, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI150247226, Length=198, Percent_Identity=30.3030303030303, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI210032110, Length=237, Percent_Identity=25.3164556962025, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4503817, Length=235, Percent_Identity=26.8085106382979, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI226371731, Length=192, Percent_Identity=27.6041666666667, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI32483357, Length=219, Percent_Identity=24.2009132420091, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI223718074, Length=190, Percent_Identity=29.4736842105263, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787335, Length=189, Percent_Identity=33.3333333333333, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1787820, Length=214, Percent_Identity=29.9065420560748, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1786701, Length=187, Percent_Identity=29.9465240641711, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87082100, Length=188, Percent_Identity=27.1276595744681, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1786812, Length=192, Percent_Identity=29.6875, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=247, Percent_Identity=26.7206477732794, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI193203117, Length=245, Percent_Identity=26.9387755102041, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=247, Percent_Identity=25.1012145748988, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17567345, Length=218, Percent_Identity=25.6880733944954, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI23397609, Length=187, Percent_Identity=31.5508021390374, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21358495, Length=198, Percent_Identity=27.2727272727273, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17737361, Length=202, Percent_Identity=30.1980198019802, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI116007236, Length=211, Percent_Identity=29.8578199052133, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357041, Length=191, Percent_Identity=28.7958115183246, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161076933, Length=188, Percent_Identity=22.8723404255319, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24584748, Length=188, Percent_Identity=22.8723404255319, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28571526, Length=191, Percent_Identity=27.2251308900524, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI281364892, Length=244, Percent_Identity=23.3606557377049, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 25796; Mature: 25665

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFKNQTWWIIGASEGLGRALAEALDQEGASLILSARNADRLQALSDGLGDAQALPMDVT
CCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCC
DSRSVASAAEAASDADGVIYCAGLYDPMTVQEWEPETAEAICEVNFMGAMRAMGRVAPRF
CCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ARRGHGHIVLIGSLAGFTGLPGAIGYGASKAAVMHLGENLHRDLRDSGVKVQVVNPGFIK
HHCCCCCEEEEECCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEE
TRLTAKNDFKMPMIQTPEDAAACCIKAMRSNRFQTSFPAPFSWVFRIAALLPRKLVTRLI
EEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SFKNQTWWIIGASEGLGRALAEALDQEGASLILSARNADRLQALSDGLGDAQALPMDVT
CCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCC
DSRSVASAAEAASDADGVIYCAGLYDPMTVQEWEPETAEAICEVNFMGAMRAMGRVAPRF
CCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ARRGHGHIVLIGSLAGFTGLPGAIGYGASKAAVMHLGENLHRDLRDSGVKVQVVNPGFIK
HHCCCCCEEEEECCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEE
TRLTAKNDFKMPMIQTPEDAAACCIKAMRSNRFQTSFPAPFSWVFRIAALLPRKLVTRLI
EEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1730672 [H]