Click here to switch to the map view.

The map label for this gene is ureC

Identifier: 99080226

GI number: 99080226

Start: 393082

End: 394794

Strand: Reverse

Name: ureC

Synonym: TM1040_0385

Alternate gene names: 99080226

Gene position: 394794-393082 (Counterclockwise)

Preceding gene: 99080227

Following gene: 99080225

Centisome position: 12.33

GC content: 61.88

Gene sequence:

>1713_bases
ATGCCCGCCAACATCCCTCGCTCTGACTATGCCGCCATGTATGGGCCGACCACCGGCGACCGCGTGCGGCTGGCCGATAC
TGACCTGATCATCGAGGTGGAGCGCGACCTCACCGGCCCTTACGGCGAAGAGGTCAAATTTGGCGGCGGCAAGGTGATCC
GCGACGGGATGGGACAGGCGCAGACGACGCGCGCGGGCGGCGCGGTCGATACCGTGATTACCAACGCGCTGATCCTTGAT
TGGACCGGCATCTACAAGGCTGACGTCGGGCTGAAAGACGGGCGCATCCATGCCATCGGTAAGGCCGGCAACCCCGACAC
TCAACCCAATGTGACCATTATCGTTGGCCCCGGCACCGAGGTGATCGCGGGCGAAGGGCGCATCCTGACGGCAGGCGGGT
TTGACAGCCATATCCATTATATCTGCCCGCAACAGATCGAGGATGCGCTGCACTCGGGTCTGACCACCATGCTCGGCGGC
GGCACCGGGCCAGCCCATGGGACTTTGGCCACCACCTGCACCCCCGGTGCCTGGCACCTGGGTCGGATGATGCAGGCCGC
AGATGCGTTTCCGATGAACCTGGCGTTTGCAGGCAAAGGGAATGCCTCGCTGCCCGCCGCCATTGAAGAACAGGTTAACG
CAGGCGCCTGCGCGCTGAAACTGCATGAGGACTGGGGCACCACACCCGCTGCCATCGACTGCTGCCTCGGGGTGGCCGAT
GCAATGGATGTGCAGGTGATGATCCATACAGACACGCTCAATGAGTCGGGGTTTGTGGAACACACCGTCAAGGCCATGAA
AGGCCGCACCATCCACGCCTTTCACACCGAAGGTGCGGGCGGTGGCCACGCACCGGACATCATCAAGATCTGCGGTGAGG
AGTTCGTGTTGCCCTCCTCGACCAACCCGACCCGCCCCTTCACCGTGAACACCATCGAAGAGCACCTCGACATGCTCATG
GTCTGTCATCACCTCGACAAATCCATCCCCGAGGATGTGGCCTTTGCCGAGAGCCGGATCCGGCGCGAAACCATTGCCGC
CGAGGACATCCTGCACGACATGGGGGCCTTCTCGATCATCGCAAGCGACAGCCAGGCGATGGGACGCGTGGGCGAGGTCA
TCATTCGCACATGGCAGACCGCAGACAAGATGAAGAAACAGCGCGGCCGCCTGAGCGAGGAAACAGGTGAGAACGACAAC
TTTCGCGTGCGGCGCTATGTGGCAAAATACACCATCAACCCGGCGATCGCGCATGGGATCGCGCATGAAATTGGCTCTAT
CGAGGTGGGCAAGCGCGCGGATCTGGTGCTGTGGAACCCAGCCTTCTTTGGTGTAAAGCCCGAGATGGTCCTGATGGGCG
GCACCATCGCCTGCGCGCAAATGGGCGATCCCAACGCCTCCATTCCGACGCCGCAGCCGGTCTATTCGCGTCCCATGTGG
GGCGCTTACGGGCGCTCGGTCGAGCATTCTGCCGTCACCTTTGTGTCCGAGGCCGCGCAGGCCGCAGGCATCGGTAAGAC
ACTGGGTCTTGCAAAACAGACACTTGCGGTAAAGGGCACACGCGGGATCGGGAAGTCAGCACTCAAGCTCAACACCGCCA
CGCCTGAGATCGAGGTTCACCCTGAAACCTATGAGGTACGCGCGAATGGGGAGCTTTTGACCTGTCAGCCCGCCGAGGAA
CTGCCCTTGGCACAGCGATATTTCCTCTTCTAA

Upstream 100 bases:

>100_bases
CGTCTGCAGCTTTCAGGCGCAAGTACGCCGCGGCCTGTCTTTCGCCTTCTAAACGTCTCGTCTGAGATTTTCGACCGTCT
CCTCCGATAGGAATTCAATC

Downstream 100 bases:

>100_bases
GGTTGAGCGACCCTCAATTCAGGAGCCCATAATGTCGCGCCTTTCTGCCGTTCTTCTTGCTGCCATTCTGCCGCTGCCCC
TGTGGGCACAGGCATGTCCG

Product: urease subunit alpha

Products: NA

Alternate protein names: Urea amidohydrolase subunit alpha

Number of amino acids: Translated: 570; Mature: 569

Protein sequence:

>570_residues
MPANIPRSDYAAMYGPTTGDRVRLADTDLIIEVERDLTGPYGEEVKFGGGKVIRDGMGQAQTTRAGGAVDTVITNALILD
WTGIYKADVGLKDGRIHAIGKAGNPDTQPNVTIIVGPGTEVIAGEGRILTAGGFDSHIHYICPQQIEDALHSGLTTMLGG
GTGPAHGTLATTCTPGAWHLGRMMQAADAFPMNLAFAGKGNASLPAAIEEQVNAGACALKLHEDWGTTPAAIDCCLGVAD
AMDVQVMIHTDTLNESGFVEHTVKAMKGRTIHAFHTEGAGGGHAPDIIKICGEEFVLPSSTNPTRPFTVNTIEEHLDMLM
VCHHLDKSIPEDVAFAESRIRRETIAAEDILHDMGAFSIIASDSQAMGRVGEVIIRTWQTADKMKKQRGRLSEETGENDN
FRVRRYVAKYTINPAIAHGIAHEIGSIEVGKRADLVLWNPAFFGVKPEMVLMGGTIACAQMGDPNASIPTPQPVYSRPMW
GAYGRSVEHSAVTFVSEAAQAAGIGKTLGLAKQTLAVKGTRGIGKSALKLNTATPEIEVHPETYEVRANGELLTCQPAEE
LPLAQRYFLF

Sequences:

>Translated_570_residues
MPANIPRSDYAAMYGPTTGDRVRLADTDLIIEVERDLTGPYGEEVKFGGGKVIRDGMGQAQTTRAGGAVDTVITNALILD
WTGIYKADVGLKDGRIHAIGKAGNPDTQPNVTIIVGPGTEVIAGEGRILTAGGFDSHIHYICPQQIEDALHSGLTTMLGG
GTGPAHGTLATTCTPGAWHLGRMMQAADAFPMNLAFAGKGNASLPAAIEEQVNAGACALKLHEDWGTTPAAIDCCLGVAD
AMDVQVMIHTDTLNESGFVEHTVKAMKGRTIHAFHTEGAGGGHAPDIIKICGEEFVLPSSTNPTRPFTVNTIEEHLDMLM
VCHHLDKSIPEDVAFAESRIRRETIAAEDILHDMGAFSIIASDSQAMGRVGEVIIRTWQTADKMKKQRGRLSEETGENDN
FRVRRYVAKYTINPAIAHGIAHEIGSIEVGKRADLVLWNPAFFGVKPEMVLMGGTIACAQMGDPNASIPTPQPVYSRPMW
GAYGRSVEHSAVTFVSEAAQAAGIGKTLGLAKQTLAVKGTRGIGKSALKLNTATPEIEVHPETYEVRANGELLTCQPAEE
LPLAQRYFLF
>Mature_569_residues
PANIPRSDYAAMYGPTTGDRVRLADTDLIIEVERDLTGPYGEEVKFGGGKVIRDGMGQAQTTRAGGAVDTVITNALILDW
TGIYKADVGLKDGRIHAIGKAGNPDTQPNVTIIVGPGTEVIAGEGRILTAGGFDSHIHYICPQQIEDALHSGLTTMLGGG
TGPAHGTLATTCTPGAWHLGRMMQAADAFPMNLAFAGKGNASLPAAIEEQVNAGACALKLHEDWGTTPAAIDCCLGVADA
MDVQVMIHTDTLNESGFVEHTVKAMKGRTIHAFHTEGAGGGHAPDIIKICGEEFVLPSSTNPTRPFTVNTIEEHLDMLMV
CHHLDKSIPEDVAFAESRIRRETIAAEDILHDMGAFSIIASDSQAMGRVGEVIIRTWQTADKMKKQRGRLSEETGENDNF
RVRRYVAKYTINPAIAHGIAHEIGSIEVGKRADLVLWNPAFFGVKPEMVLMGGTIACAQMGDPNASIPTPQPVYSRPMWG
AYGRSVEHSAVTFVSEAAQAAGIGKTLGLAKQTLAVKGTRGIGKSALKLNTATPEIEVHPETYEVRANGELLTCQPAEEL
PLAQRYFLF

Specific function: Unknown

COG id: COG0804

COG function: function code E; Urea amidohydrolase (urease) alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 urease domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): URE1_SILST (Q1GJP8)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_612380.1
- ProteinModelPortal:   Q1GJP8
- SMR:   Q1GJP8
- STRING:   Q1GJP8
- GeneID:   4078618
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_0385
- NMPDR:   fig|292414.1.peg.2440
- eggNOG:   COG0804
- HOGENOM:   HBG357507
- OMA:   TIHAFHT
- ProtClustDB:   PRK13207
- BioCyc:   SSP292414:TM1040_0385-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01953
- InterPro:   IPR006680
- InterPro:   IPR011059
- InterPro:   IPR011612
- InterPro:   IPR005848
- InterPro:   IPR017951
- InterPro:   IPR017950
- PRINTS:   PR01752
- TIGRFAMs:   TIGR01792

Pfam domain/function: PF01979 Amidohydro_1; PF00449 Urease_alpha; SSF51338 Metalo_hydrolase

EC number: =3.5.1.5

Molecular weight: Translated: 60835; Mature: 60704

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS01120 UREASE_1; PS00145 UREASE_2; PS51368 UREASE_3

Important sites: ACT_SITE 323-323 BINDING 222-222

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPANIPRSDYAAMYGPTTGDRVRLADTDLIIEVERDLTGPYGEEVKFGGGKVIRDGMGQA
CCCCCCCCCCCEEECCCCCCEEEEECCEEEEEEECCCCCCCCCCEEECCCEEEECCCCCC
QTTRAGGAVDTVITNALILDWTGIYKADVGLKDGRIHAIGKAGNPDTQPNVTIIVGPGTE
CCCCCCCCHHHHHHCEEEEEECCCEEECCCCCCCEEEEEECCCCCCCCCCEEEEECCCCE
VIAGEGRILTAGGFDSHIHYICPQQIEDALHSGLTTMLGGGTGPAHGTLATTCTPGAWHL
EEECCCEEEEECCCCCCEEEECHHHHHHHHHCCCHHHHCCCCCCCCCCEEEECCCCHHHH
GRMMQAADAFPMNLAFAGKGNASLPAAIEEQVNAGACALKLHEDWGTTPAAIDCCLGVAD
HHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCC
AMDVQVMIHTDTLNESGFVEHTVKAMKGRTIHAFHTEGAGGGHAPDIIKICGEEFVLPSS
CCEEEEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHCCCCEECCCC
TNPTRPFTVNTIEEHLDMLMVCHHLDKSIPEDVAFAESRIRRETIAAEDILHDMGAFSII
CCCCCCEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
ASDSQAMGRVGEVIIRTWQTADKMKKQRGRLSEETGENDNFRVRRYVAKYTINPAIAHGI
ECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCEEEEEEEEHHCCCHHHHHHH
AHEIGSIEVGKRADLVLWNPAFFGVKPEMVLMGGTIACAQMGDPNASIPTPQPVYSRPMW
HHHHCCEEECCCCCEEEECCHHCCCCCCEEEECCEEEEEECCCCCCCCCCCCCCCCCCCC
GAYGRSVEHSAVTFVSEAAQAAGIGKTLGLAKQTLAVKGTRGIGKSALKLNTATPEIEVH
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHEEEECCCCCCCCEEEEECCCCEEEEC
PETYEVRANGELLTCQPAEELPLAQRYFLF
CCEEEEEECCCEEEECCHHHCCCHHHHHCC
>Mature Secondary Structure 
PANIPRSDYAAMYGPTTGDRVRLADTDLIIEVERDLTGPYGEEVKFGGGKVIRDGMGQA
CCCCCCCCCCEEECCCCCCEEEEECCEEEEEEECCCCCCCCCCEEECCCEEEECCCCCC
QTTRAGGAVDTVITNALILDWTGIYKADVGLKDGRIHAIGKAGNPDTQPNVTIIVGPGTE
CCCCCCCCHHHHHHCEEEEEECCCEEECCCCCCCEEEEEECCCCCCCCCCEEEEECCCCE
VIAGEGRILTAGGFDSHIHYICPQQIEDALHSGLTTMLGGGTGPAHGTLATTCTPGAWHL
EEECCCEEEEECCCCCCEEEECHHHHHHHHHCCCHHHHCCCCCCCCCCEEEECCCCHHHH
GRMMQAADAFPMNLAFAGKGNASLPAAIEEQVNAGACALKLHEDWGTTPAAIDCCLGVAD
HHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCC
AMDVQVMIHTDTLNESGFVEHTVKAMKGRTIHAFHTEGAGGGHAPDIIKICGEEFVLPSS
CCEEEEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHCCCCEECCCC
TNPTRPFTVNTIEEHLDMLMVCHHLDKSIPEDVAFAESRIRRETIAAEDILHDMGAFSII
CCCCCCEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
ASDSQAMGRVGEVIIRTWQTADKMKKQRGRLSEETGENDNFRVRRYVAKYTINPAIAHGI
ECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCEEEEEEEEHHCCCHHHHHHH
AHEIGSIEVGKRADLVLWNPAFFGVKPEMVLMGGTIACAQMGDPNASIPTPQPVYSRPMW
HHHHCCEEECCCCCEEEECCHHCCCCCCEEEECCEEEEEECCCCCCCCCCCCCCCCCCCC
GAYGRSVEHSAVTFVSEAAQAAGIGKTLGLAKQTLAVKGTRGIGKSALKLNTATPEIEVH
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHEEEECCCCCCCCEEEEECCCCEEEEC
PETYEVRANGELLTCQPAEELPLAQRYFLF
CCEEEEEECCCEEEECCHHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA