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The map label for this gene is zwf [H]

Identifier: 99080218

GI number: 99080218

Start: 386534

End: 387985

Strand: Reverse

Name: zwf [H]

Synonym: TM1040_0377

Alternate gene names: 99080218

Gene position: 387985-386534 (Counterclockwise)

Preceding gene: 99080219

Following gene: 99080217

Centisome position: 12.12

GC content: 60.88

Gene sequence:

>1452_bases
ATGGTATCCCGCGTCATCCCCGTCGACAGTTTCGACTTCGTCTTGTTCGGCGCCACCGGCGACCTTGCCCGACGCAAGAT
CCTGCCAAGCCTGTTCCACCGCTTTCAGATCGGCCAGTTCGACGACAACAGCCGCATCATCGGGGCCTCGCGTTCCAAGA
TGGATCAGGGTGAGTTTCAGACCCTCGTGGGCGATGCGCTCAAGGAATTCGGCGACATCCCCGCCGATGCAGAACCAGAT
GTGGAGCGGTTTCTGTCGCTTCTGGATTACGCATCGGTAGATGCCAAGGGCGATGGCGGCTGGTCGGATCTGGGCAGCAA
GCTGCGCGATGGCGTAGTGCGGGCGTTTTATCTCTCGGTCGCGCCTTCGCTCTTTGGCGACATCGCCGGGCGGCTCAAAT
CCACGGGTATCGCGGACGACCAGAGCCGCATCGTGGTGGAAAAACCCTTCGGTCACGATCTGGCCTCGGCACAGGCGTTG
AATGCGGCCCTGCGCGAGCACTTTGAGGAAAGCCAGATCTACCGGATCGACCACTACCTTGGCAAAGAGACGGTGCAGAA
CCTGATGGCGCTGCGCTTTGCCAATTCGCTTTTTGAGCCGCAGTGGAATTCGCATCACATCGACCATGTGCAGATCACCG
TCTCCGAGAGCATCTCGGTTGCGGGTCGGGGCGAGTATTACGACAAATCCGGCGCCATGCGGGATATGGTGCAGAACCAC
CTGATGCAGCTTCTGTGCCTCACCGCGATGGAGCCTCCCTCCACCTTTGAACCCAATGCGGTGCGCAATGAAAAACTCAA
GGTAATCGAGAGCCTCGTACCCGTGGCCGCAGATGACATCGTGCGCGGCCAGTATCGCGCCAAATCTGGGAACGACAGCT
ACCTTGACCACGCAGGTGACCCGCAGTCGCGCACCGAGAGCTTTGTCGCGATGAAGGTCGAGGTGGCAAACTGGCGCTGG
GCAGGGACACCGTTCTACCTGCGCACCGGCAAATGCTTGCGCGAGCGCGTGTCGGAGATTGCGGTGTATTTTCGCAAACC
GCCGCACAATATTTTTGGCGAGGACAATGCGATTGATGGCAATATGCTGGTCATTCGCCTGCAACCCGACGAAGGCATCA
CGCTCAAGACCACGATCAAGGATCCCGGCCCCGGAGGCATGCGCCTGACGTCTGCGGACCTCGATATGACCTTTGCTGAC
AGCCTGCCCGAAGCGGGTCGCCCGCAGGACGCCTATGAGCGCCTCATCATGGATGTGATCCGGGGCAATCAGACCCTGTT
CATGCGCGGCGATGAGGTCGAAGCTGCCTGGACCTGGGCCGACCCGATCATCAACGCGTGGGACACATCCACCCGCGCGC
CGCAACCCTATGACCAAGGTGGCTCCGGCCCCGAGGATGCGCTTTTGCTGCTGCACCGGGATGGCCGCCGCTGGCGCTCC
ATCGGTGCCTGA

Upstream 100 bases:

>100_bases
GCCGATGGTCGAAGGGGCAGATGCATCCCAAAAAGACGCCTCCACCCGCGGCCTGCTCGCCAAACTCTCCACCTGACCGT
CAACCAAGAGGAAGACACCC

Downstream 100 bases:

>100_bases
CCCTGTACTGAGATCTGAAAGGAGGCACGCCAATGTCGCTCAATGCAACACTCGCCGCCGTCACTGACCGTATCATCGAA
CGCAGCCGCCCCACGCGCGA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MVSRVIPVDSFDFVLFGATGDLARRKILPSLFHRFQIGQFDDNSRIIGASRSKMDQGEFQTLVGDALKEFGDIPADAEPD
VERFLSLLDYASVDAKGDGGWSDLGSKLRDGVVRAFYLSVAPSLFGDIAGRLKSTGIADDQSRIVVEKPFGHDLASAQAL
NAALREHFEESQIYRIDHYLGKETVQNLMALRFANSLFEPQWNSHHIDHVQITVSESISVAGRGEYYDKSGAMRDMVQNH
LMQLLCLTAMEPPSTFEPNAVRNEKLKVIESLVPVAADDIVRGQYRAKSGNDSYLDHAGDPQSRTESFVAMKVEVANWRW
AGTPFYLRTGKCLRERVSEIAVYFRKPPHNIFGEDNAIDGNMLVIRLQPDEGITLKTTIKDPGPGGMRLTSADLDMTFAD
SLPEAGRPQDAYERLIMDVIRGNQTLFMRGDEVEAAWTWADPIINAWDTSTRAPQPYDQGGSGPEDALLLLHRDGRRWRS
IGA

Sequences:

>Translated_483_residues
MVSRVIPVDSFDFVLFGATGDLARRKILPSLFHRFQIGQFDDNSRIIGASRSKMDQGEFQTLVGDALKEFGDIPADAEPD
VERFLSLLDYASVDAKGDGGWSDLGSKLRDGVVRAFYLSVAPSLFGDIAGRLKSTGIADDQSRIVVEKPFGHDLASAQAL
NAALREHFEESQIYRIDHYLGKETVQNLMALRFANSLFEPQWNSHHIDHVQITVSESISVAGRGEYYDKSGAMRDMVQNH
LMQLLCLTAMEPPSTFEPNAVRNEKLKVIESLVPVAADDIVRGQYRAKSGNDSYLDHAGDPQSRTESFVAMKVEVANWRW
AGTPFYLRTGKCLRERVSEIAVYFRKPPHNIFGEDNAIDGNMLVIRLQPDEGITLKTTIKDPGPGGMRLTSADLDMTFAD
SLPEAGRPQDAYERLIMDVIRGNQTLFMRGDEVEAAWTWADPIINAWDTSTRAPQPYDQGGSGPEDALLLLHRDGRRWRS
IGA
>Mature_483_residues
MVSRVIPVDSFDFVLFGATGDLARRKILPSLFHRFQIGQFDDNSRIIGASRSKMDQGEFQTLVGDALKEFGDIPADAEPD
VERFLSLLDYASVDAKGDGGWSDLGSKLRDGVVRAFYLSVAPSLFGDIAGRLKSTGIADDQSRIVVEKPFGHDLASAQAL
NAALREHFEESQIYRIDHYLGKETVQNLMALRFANSLFEPQWNSHHIDHVQITVSESISVAGRGEYYDKSGAMRDMVQNH
LMQLLCLTAMEPPSTFEPNAVRNEKLKVIESLVPVAADDIVRGQYRAKSGNDSYLDHAGDPQSRTESFVAMKVEVANWRW
AGTPFYLRTGKCLRERVSEIAVYFRKPPHNIFGEDNAIDGNMLVIRLQPDEGITLKTTIKDPGPGGMRLTSADLDMTFAD
SLPEAGRPQDAYERLIMDVIRGNQTLFMRGDEVEAAWTWADPIINAWDTSTRAPQPYDQGGSGPEDALLLLHRDGRRWRS
IGA

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=492, Percent_Identity=36.7886178861789, Blast_Score=305, Evalue=5e-83,
Organism=Homo sapiens, GI109389365, Length=492, Percent_Identity=36.7886178861789, Blast_Score=305, Evalue=6e-83,
Organism=Homo sapiens, GI52145310, Length=491, Percent_Identity=30.142566191446, Blast_Score=193, Evalue=3e-49,
Organism=Escherichia coli, GI1788158, Length=481, Percent_Identity=43.8669438669439, Blast_Score=406, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17538218, Length=482, Percent_Identity=35.0622406639004, Blast_Score=303, Evalue=9e-83,
Organism=Saccharomyces cerevisiae, GI6324088, Length=465, Percent_Identity=37.2043010752688, Blast_Score=303, Evalue=5e-83,
Organism=Drosophila melanogaster, GI24643350, Length=472, Percent_Identity=36.6525423728814, Blast_Score=301, Evalue=5e-82,
Organism=Drosophila melanogaster, GI24643352, Length=472, Percent_Identity=36.6525423728814, Blast_Score=301, Evalue=6e-82,
Organism=Drosophila melanogaster, GI221513548, Length=492, Percent_Identity=28.4552845528455, Blast_Score=212, Evalue=5e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 53783; Mature: 53783

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSRVIPVDSFDFVLFGATGDLARRKILPSLFHRFQIGQFDDNSRIIGASRSKMDQGEFQ
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHH
TLVGDALKEFGDIPADAEPDVERFLSLLDYASVDAKGDGGWSDLGSKLRDGVVRAFYLSV
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
APSLFGDIAGRLKSTGIADDQSRIVVEKPFGHDLASAQALNAALREHFEESQIYRIDHYL
HHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEEHHHHH
GKETVQNLMALRFANSLFEPQWNSHHIDHVQITVSESISVAGRGEYYDKSGAMRDMVQNH
CHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCEEECCCCCCCCCCCHHHHHHHHH
LMQLLCLTAMEPPSTFEPNAVRNEKLKVIESLVPVAADDIVRGQYRAKSGNDSYLDHAGD
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
PQSRTESFVAMKVEVANWRWAGTPFYLRTGKCLRERVSEIAVYFRKPPHNIFGEDNAIDG
CHHHHCCEEEEEEEECCEEECCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
NMLVIRLQPDEGITLKTTIKDPGPGGMRLTSADLDMTFADSLPEAGRPQDAYERLIMDVI
CEEEEEECCCCCEEEEEEECCCCCCCCEEEECCCCCHHHHCCCCCCCCHHHHHHHHHHHH
RGNQTLFMRGDEVEAAWTWADPIINAWDTSTRAPQPYDQGGSGPEDALLLLHRDGRRWRS
CCCCEEEEECCCCCEEEEECCCHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHC
IGA
CCC
>Mature Secondary Structure
MVSRVIPVDSFDFVLFGATGDLARRKILPSLFHRFQIGQFDDNSRIIGASRSKMDQGEFQ
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHH
TLVGDALKEFGDIPADAEPDVERFLSLLDYASVDAKGDGGWSDLGSKLRDGVVRAFYLSV
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
APSLFGDIAGRLKSTGIADDQSRIVVEKPFGHDLASAQALNAALREHFEESQIYRIDHYL
HHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEEHHHHH
GKETVQNLMALRFANSLFEPQWNSHHIDHVQITVSESISVAGRGEYYDKSGAMRDMVQNH
CHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCEEECCCCCCCCCCCHHHHHHHHH
LMQLLCLTAMEPPSTFEPNAVRNEKLKVIESLVPVAADDIVRGQYRAKSGNDSYLDHAGD
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
PQSRTESFVAMKVEVANWRWAGTPFYLRTGKCLRERVSEIAVYFRKPPHNIFGEDNAIDG
CHHHHCCEEEEEEEECCEEECCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
NMLVIRLQPDEGITLKTTIKDPGPGGMRLTSADLDMTFADSLPEAGRPQDAYERLIMDVI
CEEEEEECCCCCEEEEEEECCCCCCCCEEEECCCCCHHHHCCCCCCCCHHHHHHHHHHHH
RGNQTLFMRGDEVEAAWTWADPIINAWDTSTRAPQPYDQGGSGPEDALLLLHRDGRRWRS
CCCCEEEEECCCCCEEEEECCCHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHC
IGA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]