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The map label for this gene is edd [H]

Identifier: 99080217

GI number: 99080217

Start: 384690

End: 386501

Strand: Reverse

Name: edd [H]

Synonym: TM1040_0376

Alternate gene names: 99080217

Gene position: 386501-384690 (Counterclockwise)

Preceding gene: 99080218

Following gene: 99080216

Centisome position: 12.07

GC content: 63.02

Gene sequence:

>1812_bases
ATGTCGCTCAATGCAACACTCGCCGCCGTCACTGACCGTATCATCGAACGCAGCCGCCCCACGCGCGAGGCTTATCTGGC
GCGGATGCGCGCCGCCGCCTCCAAAGGCCCGGCCCGCGCGCATCTGAGTTGCTCCGGTCAGGCCCACGCCTATGCCGCCA
CCGGCCCGGATCAGGAGACACTGGCCACCGGTACAGGCGGGCACCTCGGCATCGTCACCGCCTACAACGACATGCTCTCG
GCGCATCAGCCGTTTGAAACCTACCCCATGCTGATCCGTGAAGCGGTGCGCGAAGCGGGCGGCACCGCGCAGGTGGCCGG
TGGCGTGCCCGCCATGTGCGATGGCATCACGCAGGGCGAAGCCGGCATGGAGCTGTCGCTCTTTTCGCGCGACAGTATTG
CGATGTCCGTCGGCATCGCCCTGTCGCACAACGTCTTTGACGCCACTGTGTTTCTGGGCGTTTGCGACAAGATCGTTCCC
GGCCTTGTGATCGGCGCCCAGGCCTTTGGCCATTTGCCCGCCGTGTTTCTGCCCGCAGGACCGATGACCTCTGGTCTGTC
AAACGACGAAAAAGCGCAGATTCGCCAGAAGTTTGCCAAGGGTGAGATCGGCCGGGACGAGCTACTCAAGGCCGAAATGG
CCGCCTATCACGGCCCCGGCACATGTACGTTCTACGGCACCGCCAACACCAACCAGATGTTGATGGAGTTCATGGGGCTG
CACCTGCCCGGGTCGTCCTTTGTCAATCCCGGCACCGAGTTGCGCGACGCCCTCACCCGCGAAGGCGCCAAACGCGCGCT
GTCGCTCTCGGCGCTTGGCAATCACTACACGCCGACCTGCGATATTCTTGATGAAAAGGCCTTTGTGAACGGCATGGTCG
GGCTGATGGCGACCGGTGGTTCTACCAACCTGCTGATCCATCTTATTGCCATGGCCCGCGCGGGCGGCATCATCCTCGAC
TGGCAGGATTTCTCCGAGATCTCCGATGTGGTGCCGCTGCTGGCGCGCGTCTATCCCAACGGGCTGGCGGATGTGAACCA
CTTCCACGCCGCTGGTGGGCTTGGATACATGATCGGAGAACTCCTCGAGAATGGCTATCTGCACCCCGACACAAAAACCG
TAACCGGCGAGGGGCTTGGCGCCTATCTGATGGAGCCTTTCCTCGACGGTGGCGCGCTCACATGGCGCAAGGGCACCACG
GAATCCCTGAACGACAAGATCGTGCGCCCTGCCTCGGATCCGTTCCAGAAGACCGGTGGCCTTGCACGCCTGACCGGCAA
CCTCGGCACCGGGGTGATGAAGATCTCTGCCGTAGCCGAAGAACACCGCGTCGTTGAGGCACCCGTGCGCGTTTTCCACG
ACCAGGACGAGGCCAAGGCGGCCTTCAAGGCGGGCGAGCTTGATGAAGGCGACGTTGTGATCGTGGTCCGTTTCCAAGGC
CCCAAGGCCAATGGCATGCCGGAGCTGCACTCGATGACACCCTTCCTGTCGATCATGCAGGGGCGGGGCCAGAAGGTGGC
GCTTGTGACCGATGGTCGGATGTCGGGTGCCTCTGGCAAGGTTCCCTCCGCGATCCATGTCGTCCCCGAGGCCCTCGATG
GCGGCGCAATCGCTAAGCTGCAGGATGGCGACATTGTGCGGGTGGATGCGATCTCGGGCAATCTCGAAGTCCTCACAGAA
GGCGTGCTAGACCGCCCGGCGGCAACCGCCGATCTTACCTCTTATCAACACGGCACTGGGCGCGAGCTCTTTGCCCTGTT
TCGCAGTTCCGTGACCTCTGCCGACACCGGCGCAACCGTATTTGGAGTTTGA

Upstream 100 bases:

>100_bases
CCGGCCCCGAGGATGCGCTTTTGCTGCTGCACCGGGATGGCCGCCGCTGGCGCTCCATCGGTGCCTGACCCTGTACTGAG
ATCTGAAAGGAGGCACGCCA

Downstream 100 bases:

>100_bases
CCTCATGACACTTACCCCGCAACAGTCCAGCGCGAAGGCGCGCGAAATCTGCGCCCTCGCCCCGATCGTTCCGGTCCTCG
TTGTGCATGACGTCGCCCAC

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 603; Mature: 602

Protein sequence:

>603_residues
MSLNATLAAVTDRIIERSRPTREAYLARMRAAASKGPARAHLSCSGQAHAYAATGPDQETLATGTGGHLGIVTAYNDMLS
AHQPFETYPMLIREAVREAGGTAQVAGGVPAMCDGITQGEAGMELSLFSRDSIAMSVGIALSHNVFDATVFLGVCDKIVP
GLVIGAQAFGHLPAVFLPAGPMTSGLSNDEKAQIRQKFAKGEIGRDELLKAEMAAYHGPGTCTFYGTANTNQMLMEFMGL
HLPGSSFVNPGTELRDALTREGAKRALSLSALGNHYTPTCDILDEKAFVNGMVGLMATGGSTNLLIHLIAMARAGGIILD
WQDFSEISDVVPLLARVYPNGLADVNHFHAAGGLGYMIGELLENGYLHPDTKTVTGEGLGAYLMEPFLDGGALTWRKGTT
ESLNDKIVRPASDPFQKTGGLARLTGNLGTGVMKISAVAEEHRVVEAPVRVFHDQDEAKAAFKAGELDEGDVVIVVRFQG
PKANGMPELHSMTPFLSIMQGRGQKVALVTDGRMSGASGKVPSAIHVVPEALDGGAIAKLQDGDIVRVDAISGNLEVLTE
GVLDRPAATADLTSYQHGTGRELFALFRSSVTSADTGATVFGV

Sequences:

>Translated_603_residues
MSLNATLAAVTDRIIERSRPTREAYLARMRAAASKGPARAHLSCSGQAHAYAATGPDQETLATGTGGHLGIVTAYNDMLS
AHQPFETYPMLIREAVREAGGTAQVAGGVPAMCDGITQGEAGMELSLFSRDSIAMSVGIALSHNVFDATVFLGVCDKIVP
GLVIGAQAFGHLPAVFLPAGPMTSGLSNDEKAQIRQKFAKGEIGRDELLKAEMAAYHGPGTCTFYGTANTNQMLMEFMGL
HLPGSSFVNPGTELRDALTREGAKRALSLSALGNHYTPTCDILDEKAFVNGMVGLMATGGSTNLLIHLIAMARAGGIILD
WQDFSEISDVVPLLARVYPNGLADVNHFHAAGGLGYMIGELLENGYLHPDTKTVTGEGLGAYLMEPFLDGGALTWRKGTT
ESLNDKIVRPASDPFQKTGGLARLTGNLGTGVMKISAVAEEHRVVEAPVRVFHDQDEAKAAFKAGELDEGDVVIVVRFQG
PKANGMPELHSMTPFLSIMQGRGQKVALVTDGRMSGASGKVPSAIHVVPEALDGGAIAKLQDGDIVRVDAISGNLEVLTE
GVLDRPAATADLTSYQHGTGRELFALFRSSVTSADTGATVFGV
>Mature_602_residues
SLNATLAAVTDRIIERSRPTREAYLARMRAAASKGPARAHLSCSGQAHAYAATGPDQETLATGTGGHLGIVTAYNDMLSA
HQPFETYPMLIREAVREAGGTAQVAGGVPAMCDGITQGEAGMELSLFSRDSIAMSVGIALSHNVFDATVFLGVCDKIVPG
LVIGAQAFGHLPAVFLPAGPMTSGLSNDEKAQIRQKFAKGEIGRDELLKAEMAAYHGPGTCTFYGTANTNQMLMEFMGLH
LPGSSFVNPGTELRDALTREGAKRALSLSALGNHYTPTCDILDEKAFVNGMVGLMATGGSTNLLIHLIAMARAGGIILDW
QDFSEISDVVPLLARVYPNGLADVNHFHAAGGLGYMIGELLENGYLHPDTKTVTGEGLGAYLMEPFLDGGALTWRKGTTE
SLNDKIVRPASDPFQKTGGLARLTGNLGTGVMKISAVAEEHRVVEAPVRVFHDQDEAKAAFKAGELDEGDVVIVVRFQGP
KANGMPELHSMTPFLSIMQGRGQKVALVTDGRMSGASGKVPSAIHVVPEALDGGAIAKLQDGDIVRVDAISGNLEVLTEG
VLDRPAATADLTSYQHGTGRELFALFRSSVTSADTGATVFGV

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=602, Percent_Identity=55.8139534883721, Blast_Score=689, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=579, Percent_Identity=30.9153713298791, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1786464, Length=458, Percent_Identity=33.8427947598253, Blast_Score=172, Evalue=8e-44,
Organism=Escherichia coli, GI2367371, Length=464, Percent_Identity=31.8965517241379, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322476, Length=463, Percent_Identity=32.3974082073434, Blast_Score=187, Evalue=4e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 63374; Mature: 63243

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLNATLAAVTDRIIERSRPTREAYLARMRAAASKGPARAHLSCSGQAHAYAATGPDQET
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCHHH
LATGTGGHLGIVTAYNDMLSAHQPFETYPMLIREAVREAGGTAQVAGGVPAMCDGITQGE
EECCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCCCCCC
AGMELSLFSRDSIAMSVGIALSHNVFDATVFLGVCDKIVPGLVIGAQAFGHLPAVFLPAG
CCCEEEEECCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHEEHHHHHCCCCEEEECCC
PMTSGLSNDEKAQIRQKFAKGEIGRDELLKAEMAAYHGPGTCTFYGTANTNQMLMEFMGL
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCC
HLPGSSFVNPGTELRDALTREGAKRALSLSALGNHYTPTCDILDEKAFVNGMVGLMATGG
CCCCCCCCCCCHHHHHHHHHHHHHHEEEHHHCCCCCCCCHHHHHHHHHHHHCEEEEECCC
STNLLIHLIAMARAGGIILDWQDFSEISDVVPLLARVYPNGLADVNHFHAAGGLGYMIGE
CHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHH
LLENGYLHPDTKTVTGEGLGAYLMEPFLDGGALTWRKGTTESLNDKIVRPASDPFQKTGG
HHHCCCCCCCCCEECCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCEECCCCCHHHHCCC
LARLTGNLGTGVMKISAVAEEHRVVEAPVRVFHDQDEAKAAFKAGELDEGDVVIVVRFQG
EEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEEECC
PKANGMPELHSMTPFLSIMQGRGQKVALVTDGRMSGASGKVPSAIHVVPEALDGGAIAKL
CCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEECHHHCCCCCEEEE
QDGDIVRVDAISGNLEVLTEGVLDRPAATADLTSYQHGTGRELFALFRSSVTSADTGATV
CCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCEE
FGV
ECC
>Mature Secondary Structure 
SLNATLAAVTDRIIERSRPTREAYLARMRAAASKGPARAHLSCSGQAHAYAATGPDQET
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCHHH
LATGTGGHLGIVTAYNDMLSAHQPFETYPMLIREAVREAGGTAQVAGGVPAMCDGITQGE
EECCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCCCCCC
AGMELSLFSRDSIAMSVGIALSHNVFDATVFLGVCDKIVPGLVIGAQAFGHLPAVFLPAG
CCCEEEEECCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHEEHHHHHCCCCEEEECCC
PMTSGLSNDEKAQIRQKFAKGEIGRDELLKAEMAAYHGPGTCTFYGTANTNQMLMEFMGL
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCC
HLPGSSFVNPGTELRDALTREGAKRALSLSALGNHYTPTCDILDEKAFVNGMVGLMATGG
CCCCCCCCCCCHHHHHHHHHHHHHHEEEHHHCCCCCCCCHHHHHHHHHHHHCEEEEECCC
STNLLIHLIAMARAGGIILDWQDFSEISDVVPLLARVYPNGLADVNHFHAAGGLGYMIGE
CHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHH
LLENGYLHPDTKTVTGEGLGAYLMEPFLDGGALTWRKGTTESLNDKIVRPASDPFQKTGG
HHHCCCCCCCCCEECCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCEECCCCCHHHHCCC
LARLTGNLGTGVMKISAVAEEHRVVEAPVRVFHDQDEAKAAFKAGELDEGDVVIVVRFQG
EEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEEECC
PKANGMPELHSMTPFLSIMQGRGQKVALVTDGRMSGASGKVPSAIHVVPEALDGGAIAKL
CCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEECHHHCCCCCEEEE
QDGDIVRVDAISGNLEVLTEGVLDRPAATADLTSYQHGTGRELFALFRSSVTSADTGATV
CCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCEE
FGV
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]