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The map label for this gene is hmuU [H]

Identifier: 99080185

GI number: 99080185

Start: 350662

End: 351750

Strand: Reverse

Name: hmuU [H]

Synonym: TM1040_0344

Alternate gene names: 99080185

Gene position: 351750-350662 (Counterclockwise)

Preceding gene: 99080186

Following gene: 99080184

Centisome position: 10.99

GC content: 64.37

Gene sequence:

>1089_bases
ATGGTGGCACTGAGTGACCCCTCCCCCGGGCCCTATGCGCGCGACATCAGACAGCTTGATCGCCGCATCCTCGCGCGCCG
CCTGAGCGTCGTTCTTGTGGTGCTGCTGGCCCTTGCCATCGTTGTAAACCTCGCCCTCGGCGCCTCTGGTACCTCGCTCT
GGGGGGCGCTTGGCAAACTCCTCTCCGGTCAGGACCTCAGCACAATGGAGCGCGTTGTCCTCTGGGACATTCGCCTGCCG
CGCGTGCTCCTGTGTGTCCTGGTGGGGGCCGCGCTTGCGGTCTCGGGGGCAGTGATGCAGGGCCTGTTTCGCAACCCGCT
TGCCGATCCGGGCCTTGTCGGCGTGGGAGCCGGCGCAGGTCTTGGCGCGATCCTGTCGATTGTTCTCGGGGGCCTGCTTC
CGGTCGGGGTGCAGGGCCTCTTTGGTCATTATGTAACCCCGGCTGCGGCCTTTGTCGGCGGCTGGGGGAGCACCTTGATC
CTCTACCGTGTCTCAACCCGCGCCGGGCGCACGTCTGTGGCAACGATGCTGCTGGCGGGGATTGCACTCGGAGCGCTTGC
AGGCGCGGTTTCCGGCATTCTGGTCTATATGGCCGACGACAACCAATTGCGTGACCTGACATTCTGGCAGATGGGCTCCC
TTGCCGGGGCCACATGGGAGAAATCCATGATCGCAGGTCCAGTGATCGTGATCGCCATCGCGGGTGCGACATGGCTTGCG
CATGGGTTGAACTGTCTGGCGCTTGGAGAAGCGGCCGCCGCCCATATGGGCATTTCAGTTCAGCGCATGAAAAACGCCGC
GATCTTCTCGGTTGCTGCGGCCACCGGCGTCGCCGTTGCGGCCACCGGGGGCATAGGCTTTGTAGGCATCGTGGTCCCGC
ATGTGCTGCGCCTTGCCACAGGGCCGGATCATGGCACGCTTTTGCCCAATGCGGCCCTCCTTGGCGCGACGCTGCTGCTT
GGCGCCGACCTCATCAGCCGTACCATCATCGCGCCTGCCGAACTGCCAATCGGCATCGTCACAGCCGTCCTTGGCGCGCC
AGTGTTTCTGTGGATCTTGCTGAAACGACGGGGGATGGTGGATCAATGA

Upstream 100 bases:

>100_bases
CGTTGTGCGCATGAATGGCCTCTATCTACTGGGGTTTGGTCCGCGGACAGCGGATGCGGCGCTGACACTCGCCCGCGCTT
TATATGGTGAGATCTGAACC

Downstream 100 bases:

>100_bases
CCTTGCATGCACAGCAGATTTCCCTCTCGATCGGCAAAAAGCAGATCCTGAAGGATGTGACGTTCGCGGCACGCGCTGGG
GCGCTCTCCGCGATCGTGGG

Product: transport system permease protein

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MVALSDPSPGPYARDIRQLDRRILARRLSVVLVVLLALAIVVNLALGASGTSLWGALGKLLSGQDLSTMERVVLWDIRLP
RVLLCVLVGAALAVSGAVMQGLFRNPLADPGLVGVGAGAGLGAILSIVLGGLLPVGVQGLFGHYVTPAAAFVGGWGSTLI
LYRVSTRAGRTSVATMLLAGIALGALAGAVSGILVYMADDNQLRDLTFWQMGSLAGATWEKSMIAGPVIVIAIAGATWLA
HGLNCLALGEAAAAHMGISVQRMKNAAIFSVAAATGVAVAATGGIGFVGIVVPHVLRLATGPDHGTLLPNAALLGATLLL
GADLISRTIIAPAELPIGIVTAVLGAPVFLWILLKRRGMVDQ

Sequences:

>Translated_362_residues
MVALSDPSPGPYARDIRQLDRRILARRLSVVLVVLLALAIVVNLALGASGTSLWGALGKLLSGQDLSTMERVVLWDIRLP
RVLLCVLVGAALAVSGAVMQGLFRNPLADPGLVGVGAGAGLGAILSIVLGGLLPVGVQGLFGHYVTPAAAFVGGWGSTLI
LYRVSTRAGRTSVATMLLAGIALGALAGAVSGILVYMADDNQLRDLTFWQMGSLAGATWEKSMIAGPVIVIAIAGATWLA
HGLNCLALGEAAAAHMGISVQRMKNAAIFSVAAATGVAVAATGGIGFVGIVVPHVLRLATGPDHGTLLPNAALLGATLLL
GADLISRTIIAPAELPIGIVTAVLGAPVFLWILLKRRGMVDQ
>Mature_362_residues
MVALSDPSPGPYARDIRQLDRRILARRLSVVLVVLLALAIVVNLALGASGTSLWGALGKLLSGQDLSTMERVVLWDIRLP
RVLLCVLVGAALAVSGAVMQGLFRNPLADPGLVGVGAGAGLGAILSIVLGGLLPVGVQGLFGHYVTPAAAFVGGWGSTLI
LYRVSTRAGRTSVATMLLAGIALGALAGAVSGILVYMADDNQLRDLTFWQMGSLAGATWEKSMIAGPVIVIAIAGATWLA
HGLNCLALGEAAAAHMGISVQRMKNAAIFSVAAATGVAVAATGGIGFVGIVVPHVLRLATGPDHGTLLPNAALLGATLLL
GADLISRTIIAPAELPIGIVTAVLGAPVFLWILLKRRGMVDQ

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=295, Percent_Identity=43.728813559322, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI1790740, Length=298, Percent_Identity=37.9194630872483, Blast_Score=161, Evalue=7e-41,
Organism=Escherichia coli, GI1790741, Length=327, Percent_Identity=32.7217125382263, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1786805, Length=296, Percent_Identity=38.1756756756757, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1786804, Length=281, Percent_Identity=34.8754448398576, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI1786347, Length=344, Percent_Identity=29.0697674418605, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36846; Mature: 36846

Theoretical pI: Translated: 10.42; Mature: 10.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVALSDPSPGPYARDIRQLDRRILARRLSVVLVVLLALAIVVNLALGASGTSLWGALGKL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LSGQDLSTMERVVLWDIRLPRVLLCVLVGAALAVSGAVMQGLFRNPLADPGLVGVGAGAG
HCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCC
LGAILSIVLGGLLPVGVQGLFGHYVTPAAAFVGGWGSTLILYRVSTRAGRTSVATMLLAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHH
IALGALAGAVSGILVYMADDNQLRDLTFWQMGSLAGATWEKSMIAGPVIVIAIAGATWLA
HHHHHHHHHHHCEEEEEECCCCCHHHHHHHHCCCCCCCHHHHHHCCCEEEEEEHHHHHHH
HGLNCLALGEAAAAHMGISVQRMKNAAIFSVAAATGVAVAATGGIGFVGIVVPHVLRLAT
HCCCCEEHHHHHHHHHCCHHHHHHCHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHC
GPDHGTLLPNAALLGATLLLGADLISRTIIAPAELPIGIVTAVLGAPVFLWILLKRRGMV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DQ
CC
>Mature Secondary Structure
MVALSDPSPGPYARDIRQLDRRILARRLSVVLVVLLALAIVVNLALGASGTSLWGALGKL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LSGQDLSTMERVVLWDIRLPRVLLCVLVGAALAVSGAVMQGLFRNPLADPGLVGVGAGAG
HCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCC
LGAILSIVLGGLLPVGVQGLFGHYVTPAAAFVGGWGSTLILYRVSTRAGRTSVATMLLAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHH
IALGALAGAVSGILVYMADDNQLRDLTFWQMGSLAGATWEKSMIAGPVIVIAIAGATWLA
HHHHHHHHHHHCEEEEEECCCCCHHHHHHHHCCCCCCCHHHHHHCCCEEEEEEHHHHHHH
HGLNCLALGEAAAAHMGISVQRMKNAAIFSVAAATGVAVAATGGIGFVGIVVPHVLRLAT
HCCCCEEHHHHHHHHHCCHHHHHHCHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHC
GPDHGTLLPNAALLGATLLLGADLISRTIIAPAELPIGIVTAVLGAPVFLWILLKRRGMV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DQ
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]