BacMap

Definition	Ruegeria sp. TM1040, complete genome.
Accession	NC_008044
Length	3,200,938

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The map label for this gene is hmuV

Identifier: 99080184

GI number: 99080184

Start: 349883

End: 350665

Strand: Reverse

Name: hmuV

Synonym: TM1040_0343

Alternate gene names: 99080184

Gene position: 350665-349883 (Counterclockwise)

Preceding gene: 99080185

Following gene: 99080177

Centisome position: 10.96

GC content: 63.73

Gene sequence:

>783_bases
ATGACCTTGCATGCACAGCAGATTTCCCTCTCGATCGGCAAAAAGCAGATCCTGAAGGATGTGACGTTCGCGGCACGCGC
TGGGGCGCTCTCCGCGATCGTGGGACCAAATGGCTCCGGCAAGTCCACCTTGCTCAAGGCCTTGGTTGCAGAGCTGCCGT
CAGAGGGACAGATCTCCCTCAACGGGCGGCTGTTGCAGGACTACGCCGCCTGGGAGCTGGCAAGCCTGCGCGGGGTGTTG
CCACAGGCCGCCCATCTCGCCTTTCCGTTCACGGTGCTGGAGGTAGTGCGACTGGGGCTGATGGCCGGGCCTGAGGCACA
GAACACGCGGCTTCCCTTTGAGGCACTGGCCCGCGTGGACCTTGAGGGCTATGCCGGGCGCTCCTATCAGGAACTCTCCG
GAGGCGAACAACAGCGGGTCCAGCTGGCGCGGGTTCTGGCGCAGGTCGGCGCTCCGATGCGGGAGGGGCAACCTTGCTGG
TTGTTTCTGGACGAGCCTGTCTCCAGTCTCGACATCGCCCATCAGCTGACGGTGATGGATATCGCGCGCCAGTTTGCGGA
TGGCGGTGGCGGGGTGGTTGCGGTGATGCACGACCTGAACCTCACCGCGATGTATGCCGATCACGTGCATGTCATGACCG
GCGGAGAGACCGCAGGTGCCGGAACAGTGGCGGACGTTCTGACCGATCAACGCCTGTCAGAGGTCTACGGATGCGACCTG
CGCATCGGAAAAGTGCCCGCAGATGCCGCCGTCTTTGTTCTGCCGCAAACGGCGCGGGCATGA

Upstream 100 bases:

>100_bases
TCATCGCGCCTGCCGAACTGCCAATCGGCATCGTCACAGCCGTCCTTGGCGCGCCAGTGTTTCTGTGGATCTTGCTGAAA
CGACGGGGGATGGTGGATCA

Downstream 100 bases:

>100_bases
CTCTACTGCGGATCGGCGCCTGCACCGCTCCGCGCATCCAAACGATAAAACCCAAGGCCCGTGTTTGCGGCCTTGGGTTT
TCTGATTGGGTATGACGCCC

Product: hemin importer ATP-binding subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTLHAQQISLSIGKKQILKDVTFAARAGALSAIVGPNGSGKSTLLKALVAELPSEGQISLNGRLLQDYAAWELASLRGVL
PQAAHLAFPFTVLEVVRLGLMAGPEAQNTRLPFEALARVDLEGYAGRSYQELSGGEQQRVQLARVLAQVGAPMREGQPCW
LFLDEPVSSLDIAHQLTVMDIARQFADGGGGVVAVMHDLNLTAMYADHVHVMTGGETAGAGTVADVLTDQRLSEVYGCDL
RIGKVPADAAVFVLPQTARA

Sequences:

>Translated_260_residues
MTLHAQQISLSIGKKQILKDVTFAARAGALSAIVGPNGSGKSTLLKALVAELPSEGQISLNGRLLQDYAAWELASLRGVL
PQAAHLAFPFTVLEVVRLGLMAGPEAQNTRLPFEALARVDLEGYAGRSYQELSGGEQQRVQLARVLAQVGAPMREGQPCW
LFLDEPVSSLDIAHQLTVMDIARQFADGGGGVVAVMHDLNLTAMYADHVHVMTGGETAGAGTVADVLTDQRLSEVYGCDL
RIGKVPADAAVFVLPQTARA
>Mature_259_residues
TLHAQQISLSIGKKQILKDVTFAARAGALSAIVGPNGSGKSTLLKALVAELPSEGQISLNGRLLQDYAAWELASLRGVLP
QAAHLAFPFTVLEVVRLGLMAGPEAQNTRLPFEALARVDLEGYAGRSYQELSGGEQQRVQLARVLAQVGAPMREGQPCWL
FLDEPVSSLDIAHQLTVMDIARQFADGGGGVVAVMHDLNLTAMYADHVHVMTGGETAGAGTVADVLTDQRLSEVYGCDLR
IGKVPADAAVFVLPQTARA

Specific function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system

COG id: COG4559

COG function: function code P; ABC-type hemin transport system, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI9665248, Length=249, Percent_Identity=31.7269076305221, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI42490749, Length=221, Percent_Identity=29.8642533936652, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI156105685, Length=221, Percent_Identity=31.2217194570136, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1786345, Length=257, Percent_Identity=35.0194552529183, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790739, Length=261, Percent_Identity=32.9501915708812, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786803, Length=261, Percent_Identity=31.8007662835249, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1788002, Length=216, Percent_Identity=34.7222222222222, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788165, Length=208, Percent_Identity=34.1346153846154, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI87081834, Length=211, Percent_Identity=33.175355450237, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87081709, Length=227, Percent_Identity=32.15859030837, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1789593, Length=251, Percent_Identity=25.8964143426295, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789032, Length=238, Percent_Identity=31.9327731092437, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789873, Length=214, Percent_Identity=32.2429906542056, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787029, Length=238, Percent_Identity=29.4117647058824, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788225, Length=227, Percent_Identity=31.7180616740088, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1786872, Length=218, Percent_Identity=29.3577981651376, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI87081791, Length=233, Percent_Identity=31.3304721030043, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786398, Length=224, Percent_Identity=31.25, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1790544, Length=267, Percent_Identity=25.4681647940075, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1789891, Length=230, Percent_Identity=30.8695652173913, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788761, Length=232, Percent_Identity=31.0344827586207, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1786563, Length=208, Percent_Identity=31.25, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789672, Length=210, Percent_Identity=29.0476190476191, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787089, Length=244, Percent_Identity=26.6393442622951, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788506, Length=223, Percent_Identity=27.8026905829596, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI2367384, Length=210, Percent_Identity=31.4285714285714, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787370, Length=222, Percent_Identity=28.8288288288288, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790467, Length=224, Percent_Identity=27.6785714285714, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788644, Length=229, Percent_Identity=34.061135371179, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787105, Length=208, Percent_Identity=34.6153846153846, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789991, Length=251, Percent_Identity=26.6932270916335, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787758, Length=216, Percent_Identity=29.6296296296296, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786319, Length=247, Percent_Identity=26.7206477732794, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790534, Length=214, Percent_Identity=31.7757009345794, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1787712, Length=236, Percent_Identity=28.3898305084746, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787759, Length=253, Percent_Identity=28.4584980237154, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787112, Length=240, Percent_Identity=30.4166666666667, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1786703, Length=201, Percent_Identity=34.8258706467662, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786698, Length=205, Percent_Identity=31.219512195122, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787164, Length=235, Percent_Identity=31.4893617021277, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788053, Length=207, Percent_Identity=31.8840579710145, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788450, Length=232, Percent_Identity=27.5862068965517, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI87081782, Length=229, Percent_Identity=26.6375545851528, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI25146777, Length=227, Percent_Identity=29.9559471365639, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71992285, Length=223, Percent_Identity=30.9417040358744, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71992290, Length=221, Percent_Identity=28.9592760180996, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI212646699, Length=217, Percent_Identity=29.4930875576037, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71996809, Length=220, Percent_Identity=30.4545454545455, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17558664, Length=224, Percent_Identity=29.4642857142857, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193211015, Length=220, Percent_Identity=30.4545454545455, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193211017, Length=220, Percent_Identity=30.4545454545455, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193209708, Length=244, Percent_Identity=27.0491803278689, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115534520, Length=232, Percent_Identity=26.2931034482759, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71984940, Length=215, Percent_Identity=29.3023255813954, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323959, Length=223, Percent_Identity=32.7354260089686, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21357907, Length=224, Percent_Identity=31.6964285714286, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28574533, Length=236, Percent_Identity=27.1186440677966, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HMUV_SILST (Q1GJU0)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_612338.1
- ProteinModelPortal:   Q1GJU0
- SMR:   Q1GJU0
- STRING:   Q1GJU0
- GeneID:   4076044
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_0343
- NMPDR:   fig|292414.1.peg.2683
- eggNOG:   COG4559
- HOGENOM:   HBG758042
- OMA:   MEITRAY
- PhylomeDB:   Q1GJU0
- ProtClustDB:   PRK13548
- BioCyc:   SSP292414:TM1040_0343-MONOMER
- HAMAP:   MF_01718
- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR015863
- InterPro:   IPR003593
- SMART:   SM00382

Pfam domain/function: PF00005 ABC_tran

EC number: NA

Molecular weight: Translated: 27537; Mature: 27406

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51261 HMUV

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLHAQQISLSIGKKQILKDVTFAARAGALSAIVGPNGSGKSTLLKALVAELPSEGQISL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEEE
NGRLLQDYAAWELASLRGVLPQAAHLAFPFTVLEVVRLGLMAGPEAQNTRLPFEALARVD
CCEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHC
LEGYAGRSYQELSGGEQQRVQLARVLAQVGAPMREGQPCWLFLDEPVSSLDIAHQLTVMD
CCCCCCCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHH
IARQFADGGGGVVAVMHDLNLTAMYADHVHVMTGGETAGAGTVADVLTDQRLSEVYGCDL
HHHHHCCCCCCEEEEEECCCEEEEEECEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCE
RIGKVPADAAVFVLPQTARA
EECCCCCCCEEEEECCCCCC
>Mature Secondary Structure 
TLHAQQISLSIGKKQILKDVTFAARAGALSAIVGPNGSGKSTLLKALVAELPSEGQISL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEEE
NGRLLQDYAAWELASLRGVLPQAAHLAFPFTVLEVVRLGLMAGPEAQNTRLPFEALARVD
CCEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHC
LEGYAGRSYQELSGGEQQRVQLARVLAQVGAPMREGQPCWLFLDEPVSSLDIAHQLTVMD
CCCCCCCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHH
IARQFADGGGGVVAVMHDLNLTAMYADHVHVMTGGETAGAGTVADVLTDQRLSEVYGCDL
HHHHHCCCCCCEEEEEECCCEEEEEECEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCE
RIGKVPADAAVFVLPQTARA
EECCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA