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The map label for this gene is mco [H]

Identifier: 99080130

GI number: 99080130

Start: 295557

End: 296987

Strand: Reverse

Name: mco [H]

Synonym: TM1040_0289

Alternate gene names: 99080130

Gene position: 296987-295557 (Counterclockwise)

Preceding gene: 99080139

Following gene: 99080126

Centisome position: 9.28

GC content: 65.2

Gene sequence:

>1431_bases
ATGACATCGAAATCCAAAAGGTGTGTCATGAACCCCAGCCGTCGCCATGTCCTTGCAGGTCTCACCGCATGTGCCAGCCT
GCCCGCCCTGCCCCGCTTTGCACAGGCCAGCACAGAGACAAATGTGGAATCAGCGGCGCATCGTCTGACCCTTGCCCCGG
CCCGCCAGCAGATTGCACCAACCGACTATCCCGCCACAGATCTGTGGTGCGTCAACGGCACAATGCCGGGCGAAACCCTG
CGCCGGACACAGGGCGCGCGTCTGGTGGTTGAGGTCGACAACCAGCTCCCGCAGGCCACAAGCCTCCATTGGCACGGCAT
CCGCATCGACAATGCCATGGACGGGGTGCCGGGCGTCACCCAGGATCCGATCCAGCCCGGCACGCGCTTCACCTATGACT
TCGCCCTGCCCGATGCGGGCACATATTGGTATCATTCCCACGCGCAATCGGTGGAGCAGGTCGAACGTGGCCTGCAAGGC
GCATTGATCATCGAAGAACCCGACGCGCCCGACGTGGATCAGGACCTGCCGCTGGTGATCGACGACCTGCGCGTCACAGC
CGAGGCGGCGATAGATGCCAATTTCGCCGTGCCGCACGATCTGTCACACGCCGGGCGCATGGGGAACATCCTGCTCTGCA
ATGGCAAAATGGTTGCCGATCATCCCGTCAAAACCGGAGACCGCTTGCGCCTGCGCCTCATCAACAGCGCCAATGCGCGT
ATCTTCACCCTCGGCCTGCAGGGCCTCGAGGGCTGGGTGATGGCCTATGACGGTATGCCGCTGGCCACCCCTGAGGCGCT
GCCGGACCGGCTCCTGCTTGCCCCCGCCCAGCGCGTCGACCTCTTTGTGGATGTGACCGCAGCCGCAGGCGAAGACGCCT
TCCTTGTACAGTTTGAACGCGATGGTGGCTACGAGCTTGCGCGCTTCCCGGTGGCTTCCGGCACCCGCGCCCGCCGCCCC
GCGCCCAGCGCTCTGCCCCCCAATCCCGACTTCCCGATCGACCTCCCGTCCGCGCGCAGCGTCGATCTCATCACCGAGGG
CGGCGCGATGGCGTGGCTCAGCGGCGCCAGGTTCAAGGGCGAGGATCTCTCCGGTCAGGATCTCGCCCAATTGGGGCAGT
TCTGGGCGTTCAACGGCAGCGCCGGCCGCCCGCCTGAGCCCTTTGTGACCGCGCGCCTCGGCGAGACCATTCGCATCCGC
ATGGTCAACGACACTCGCTTTCCGCATGCGATGCACCTCCATGGCATGCATTTCTCCGAGGTCCGTGCGGACGGCAGCCT
CGGCCCCCTGCGCGACACACTCCTGATGCTGCAGGGAGAGACCCGCGAGATCGCTTTTCAGGCGCACAACGCAGGCGACT
GGCTCTTTCACTGCCATATGTTGTCGCATCACGCCGCGGGCATGGGCACATGGGTGCGCGTCACAGCCTGA

Upstream 100 bases:

>100_bases
CCAGACGCAAGCCCCGACCAGCTCCTCGCTGAACGCTTCACAAATGCGACAGCTTCCAGTGGGTGGAAGTCTTGCCCCCG
CGCGGCCGCCCACTAGGGTT

Downstream 100 bases:

>100_bases
CGCCGCCCTTTCTTCTAACAGAAAATATCCCCGCCGGAGGCCTTCAGGTTTTGTCCGCAAAACCTGATTTACTCTCCTTG
GCGCTGGATGCGTTTCTTGG

Product: multicopper oxidase, type 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MTSKSKRCVMNPSRRHVLAGLTACASLPALPRFAQASTETNVESAAHRLTLAPARQQIAPTDYPATDLWCVNGTMPGETL
RRTQGARLVVEVDNQLPQATSLHWHGIRIDNAMDGVPGVTQDPIQPGTRFTYDFALPDAGTYWYHSHAQSVEQVERGLQG
ALIIEEPDAPDVDQDLPLVIDDLRVTAEAAIDANFAVPHDLSHAGRMGNILLCNGKMVADHPVKTGDRLRLRLINSANAR
IFTLGLQGLEGWVMAYDGMPLATPEALPDRLLLAPAQRVDLFVDVTAAAGEDAFLVQFERDGGYELARFPVASGTRARRP
APSALPPNPDFPIDLPSARSVDLITEGGAMAWLSGARFKGEDLSGQDLAQLGQFWAFNGSAGRPPEPFVTARLGETIRIR
MVNDTRFPHAMHLHGMHFSEVRADGSLGPLRDTLLMLQGETREIAFQAHNAGDWLFHCHMLSHHAAGMGTWVRVTA

Sequences:

>Translated_476_residues
MTSKSKRCVMNPSRRHVLAGLTACASLPALPRFAQASTETNVESAAHRLTLAPARQQIAPTDYPATDLWCVNGTMPGETL
RRTQGARLVVEVDNQLPQATSLHWHGIRIDNAMDGVPGVTQDPIQPGTRFTYDFALPDAGTYWYHSHAQSVEQVERGLQG
ALIIEEPDAPDVDQDLPLVIDDLRVTAEAAIDANFAVPHDLSHAGRMGNILLCNGKMVADHPVKTGDRLRLRLINSANAR
IFTLGLQGLEGWVMAYDGMPLATPEALPDRLLLAPAQRVDLFVDVTAAAGEDAFLVQFERDGGYELARFPVASGTRARRP
APSALPPNPDFPIDLPSARSVDLITEGGAMAWLSGARFKGEDLSGQDLAQLGQFWAFNGSAGRPPEPFVTARLGETIRIR
MVNDTRFPHAMHLHGMHFSEVRADGSLGPLRDTLLMLQGETREIAFQAHNAGDWLFHCHMLSHHAAGMGTWVRVTA
>Mature_475_residues
TSKSKRCVMNPSRRHVLAGLTACASLPALPRFAQASTETNVESAAHRLTLAPARQQIAPTDYPATDLWCVNGTMPGETLR
RTQGARLVVEVDNQLPQATSLHWHGIRIDNAMDGVPGVTQDPIQPGTRFTYDFALPDAGTYWYHSHAQSVEQVERGLQGA
LIIEEPDAPDVDQDLPLVIDDLRVTAEAAIDANFAVPHDLSHAGRMGNILLCNGKMVADHPVKTGDRLRLRLINSANARI
FTLGLQGLEGWVMAYDGMPLATPEALPDRLLLAPAQRVDLFVDVTAAAGEDAFLVQFERDGGYELARFPVASGTRARRPA
PSALPPNPDFPIDLPSARSVDLITEGGAMAWLSGARFKGEDLSGQDLAQLGQFWAFNGSAGRPPEPFVTARLGETIRIRM
VNDTRFPHAMHLHGMHFSEVRADGSLGPLRDTLLMLQGETREIAFQAHNAGDWLFHCHMLSHHAAGMGTWVRVTA

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=456, Percent_Identity=26.5350877192982, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1789394, Length=450, Percent_Identity=27.1111111111111, Blast_Score=82, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6323703, Length=452, Percent_Identity=23.8938053097345, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321067, Length=250, Percent_Identity=24.8, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI18859919, Length=266, Percent_Identity=28.9473684210526, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28574104, Length=100, Percent_Identity=43, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI221330000, Length=286, Percent_Identity=26.5734265734266, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585842, Length=286, Percent_Identity=26.5734265734266, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281360167, Length=286, Percent_Identity=26.5734265734266, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221329998, Length=286, Percent_Identity=26.5734265734266, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24650186, Length=306, Percent_Identity=24.5098039215686, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 51846; Mature: 51715

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSKSKRCVMNPSRRHVLAGLTACASLPALPRFAQASTETNVESAAHRLTLAPARQQIAP
CCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHEEEECCCHHHCCC
TDYPATDLWCVNGTMPGETLRRTQGARLVVEVDNQLPQATSLHWHGIRIDNAMDGVPGVT
CCCCCCEEEEECCCCCHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCCCCCC
QDPIQPGTRFTYDFALPDAGTYWYHSHAQSVEQVERGLQGALIIEEPDAPDVDQDLPLVI
CCCCCCCCEEEEEEECCCCCCEEEHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEE
DDLRVTAEAAIDANFAVPHDLSHAGRMGNILLCNGKMVADHPVKTGDRLRLRLINSANAR
ECCEEEEHHHCCCCCCCCCCCHHCCCCCCEEEECCEEEECCCCCCCCEEEEEEEECCCCE
IFTLGLQGLEGWVMAYDGMPLATPEALPDRLLLAPAQRVDLFVDVTAAAGEDAFLVQFER
EEEEECCCCCCEEEEECCCCCCCCHHCCCCEEECCCCCEEEEEEEEECCCCCEEEEEEEC
DGGYELARFPVASGTRARRPAPSALPPNPDFPIDLPSARSVDLITEGGAMAWLSGARFKG
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCC
EDLSGQDLAQLGQFWAFNGSAGRPPEPFVTARLGETIRIRMVNDTRFPHAMHLHGMHFSE
CCCCCHHHHHHHHEEEECCCCCCCCCCEEEEECCCEEEEEEEECCCCCCEEEECCCCHHH
VRADGSLGPLRDTLLMLQGETREIAFQAHNAGDWLFHCHMLSHHAAGMGTWVRVTA
HCCCCCCCCCCCEEEEEECCCEEEEEEECCCCCEEEEEEEHHHCCCCCCCEEEEEC
>Mature Secondary Structure 
TSKSKRCVMNPSRRHVLAGLTACASLPALPRFAQASTETNVESAAHRLTLAPARQQIAP
CCCCCCEEECCCHHHHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHEEEECCCHHHCCC
TDYPATDLWCVNGTMPGETLRRTQGARLVVEVDNQLPQATSLHWHGIRIDNAMDGVPGVT
CCCCCCEEEEECCCCCHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCCCCCC
QDPIQPGTRFTYDFALPDAGTYWYHSHAQSVEQVERGLQGALIIEEPDAPDVDQDLPLVI
CCCCCCCCEEEEEEECCCCCCEEEHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEE
DDLRVTAEAAIDANFAVPHDLSHAGRMGNILLCNGKMVADHPVKTGDRLRLRLINSANAR
ECCEEEEHHHCCCCCCCCCCCHHCCCCCCEEEECCEEEECCCCCCCCEEEEEEEECCCCE
IFTLGLQGLEGWVMAYDGMPLATPEALPDRLLLAPAQRVDLFVDVTAAAGEDAFLVQFER
EEEEECCCCCCEEEEECCCCCCCCHHCCCCEEECCCCCEEEEEEEEECCCCCEEEEEEEC
DGGYELARFPVASGTRARRPAPSALPPNPDFPIDLPSARSVDLITEGGAMAWLSGARFKG
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCC
EDLSGQDLAQLGQFWAFNGSAGRPPEPFVTARLGETIRIRMVNDTRFPHAMHLHGMHFSE
CCCCCHHHHHHHHEEEECCCCCCCCCCEEEEECCCEEEEEEEECCCCCCEEEECCCCHHH
VRADGSLGPLRDTLLMLQGETREIAFQAHNAGDWLFHCHMLSHHAAGMGTWVRVTA
HCCCCCCCCCCCEEEEEECCCEEEEEEECCCCCEEEEEEEHHHCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]