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The map label for this gene is adk [H]

Identifier: 99080117

GI number: 99080117

Start: 283078

End: 283659

Strand: Direct

Name: adk [H]

Synonym: TM1040_0276

Alternate gene names: 99080117

Gene position: 283078-283659 (Clockwise)

Preceding gene: 99080116

Following gene: 99080118

Centisome position: 8.84

GC content: 61.51

Gene sequence:

>582_bases
ATGACCAATATTATTCTTCTGGGCCCGCCCGGCGCGGGCAAGGGAACGCAGGCCAGCCACCTGGTCAAGACCCGCAACAT
GACCCAGCTCTCCACCGGGGACATGCTGCGCGCGGCGCAGTCCTCCGGCTCCGAGATGGGCAAGAAGGTCGCGGCGATCA
TGGCCGAGGGCAAGCTCGTCACGGATCAGATCGTGATCGGTCTTATTCGCGAGCGTCTGCAAGAAGGTTCCGAGGGCGGC
TTCATCTTTGACGGCTTCCCACGCACCCTCGCGCAGGCAGACGCGCTCGAGAAGCTCCTGACCGAAATGGGCCTGAAGCT
TGATGCAGTGATCGAGATGCAGGTGGATGACGAGGTGCTCGTGAAGCGCATCGTCAACCGCGCCGAAGAGGCCCGCGCTG
CGGGCAAGGAAGCGCGCGCCGATGACAATGAGGACTCGGTCCGTATCCGGCTGATGGAATACTACAAGAAGACCTCGCCG
CTTATCGGCTATTACTGGGCCAAGGGCAATCTGCAGCGTCTGGACGGCATGGCCTCCATCGACGAAGTGCAGAAATCCAT
CGCTTGGATTCTGGGCGACTGA

Upstream 100 bases:

>100_bases
TACAGAGCCATCTTCTCGCGCATCAGTACGAAGGCCTCATTGAGAAGAGCCAGCTGCGCGGTCGGAACAAGAAACGCACC
AAACGGGGACCGTCTCGTCG

Downstream 100 bases:

>100_bases
TCGCACCCGTCGCGTTCACGCGGTGCATGAAATAGACCAGACAGGCTGCCCTTGGGCGGCCTGTTTTGTTTTGGACGCAG
GGCAGGGCGCAGGGGTGGGC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MTNIILLGPPGAGKGTQASHLVKTRNMTQLSTGDMLRAAQSSGSEMGKKVAAIMAEGKLVTDQIVIGLIRERLQEGSEGG
FIFDGFPRTLAQADALEKLLTEMGLKLDAVIEMQVDDEVLVKRIVNRAEEARAAGKEARADDNEDSVRIRLMEYYKKTSP
LIGYYWAKGNLQRLDGMASIDEVQKSIAWILGD

Sequences:

>Translated_193_residues
MTNIILLGPPGAGKGTQASHLVKTRNMTQLSTGDMLRAAQSSGSEMGKKVAAIMAEGKLVTDQIVIGLIRERLQEGSEGG
FIFDGFPRTLAQADALEKLLTEMGLKLDAVIEMQVDDEVLVKRIVNRAEEARAAGKEARADDNEDSVRIRLMEYYKKTSP
LIGYYWAKGNLQRLDGMASIDEVQKSIAWILGD
>Mature_192_residues
TNIILLGPPGAGKGTQASHLVKTRNMTQLSTGDMLRAAQSSGSEMGKKVAAIMAEGKLVTDQIVIGLIRERLQEGSEGGF
IFDGFPRTLAQADALEKLLTEMGLKLDAVIEMQVDDEVLVKRIVNRAEEARAAGKEARADDNEDSVRIRLMEYYKKTSPL
IGYYWAKGNLQRLDGMASIDEVQKSIAWILGD

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=205, Percent_Identity=42.4390243902439, Blast_Score=156, Evalue=1e-38,
Organism=Homo sapiens, GI7524346, Length=205, Percent_Identity=42.4390243902439, Blast_Score=155, Evalue=1e-38,
Organism=Homo sapiens, GI4502011, Length=190, Percent_Identity=33.6842105263158, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI7706497, Length=196, Percent_Identity=30.1020408163265, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI28144897, Length=182, Percent_Identity=31.8681318681319, Blast_Score=97, Evalue=7e-21,
Organism=Homo sapiens, GI19923437, Length=193, Percent_Identity=31.0880829015544, Blast_Score=97, Evalue=7e-21,
Organism=Homo sapiens, GI28144899, Length=182, Percent_Identity=31.8681318681319, Blast_Score=97, Evalue=8e-21,
Organism=Homo sapiens, GI310110345, Length=193, Percent_Identity=26.9430051813472, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI53832003, Length=193, Percent_Identity=26.9430051813472, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI8051579, Length=193, Percent_Identity=26.9430051813472, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI53832001, Length=193, Percent_Identity=26.9430051813472, Blast_Score=83, Evalue=1e-16,
Organism=Escherichia coli, GI1786680, Length=216, Percent_Identity=45.8333333333333, Blast_Score=169, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17552384, Length=211, Percent_Identity=36.9668246445498, Blast_Score=143, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17567503, Length=184, Percent_Identity=37.5, Blast_Score=128, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17533833, Length=194, Percent_Identity=28.8659793814433, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17550688, Length=196, Percent_Identity=27.5510204081633, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI25147457, Length=196, Percent_Identity=31.1224489795918, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=189, Percent_Identity=39.1534391534392, Blast_Score=137, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6322828, Length=188, Percent_Identity=30.3191489361702, Blast_Score=104, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=32.8282828282828, Blast_Score=98, Evalue=9e-22,
Organism=Drosophila melanogaster, GI22026816, Length=211, Percent_Identity=40.2843601895735, Blast_Score=148, Evalue=2e-36,
Organism=Drosophila melanogaster, GI17647141, Length=167, Percent_Identity=35.9281437125749, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24663208, Length=167, Percent_Identity=35.9281437125749, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI221459597, Length=181, Percent_Identity=31.4917127071823, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21356893, Length=181, Percent_Identity=31.4917127071823, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17737899, Length=193, Percent_Identity=34.1968911917098, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24645822, Length=193, Percent_Identity=34.1968911917098, Blast_Score=101, Evalue=4e-22,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 21113; Mature: 20981

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNIILLGPPGAGKGTQASHLVKTRNMTQLSTGDMLRAAQSSGSEMGKKVAAIMAEGKLV
CCCEEEECCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHCCCHH
TDQIVIGLIRERLQEGSEGGFIFDGFPRTLAQADALEKLLTEMGLKLDAVIEMQVDDEVL
HHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCHHHH
VKRIVNRAEEARAAGKEARADDNEDSVRIRLMEYYKKTSPLIGYYWAKGNLQRLDGMASI
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHCCHHHH
DEVQKSIAWILGD
HHHHHHHHHHCCC
>Mature Secondary Structure 
TNIILLGPPGAGKGTQASHLVKTRNMTQLSTGDMLRAAQSSGSEMGKKVAAIMAEGKLV
CCEEEECCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHCCCHH
TDQIVIGLIRERLQEGSEGGFIFDGFPRTLAQADALEKLLTEMGLKLDAVIEMQVDDEVL
HHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCHHHH
VKRIVNRAEEARAAGKEARADDNEDSVRIRLMEYYKKTSPLIGYYWAKGNLQRLDGMASI
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHCCHHHH
DEVQKSIAWILGD
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA