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The map label for this gene is rsbW [H]

Identifier: 99079906

GI number: 99079906

Start: 70069

End: 70509

Strand: Reverse

Name: rsbW [H]

Synonym: TM1040_0065

Alternate gene names: 99079906

Gene position: 70509-70069 (Counterclockwise)

Preceding gene: 99079907

Following gene: 99079905

Centisome position: 2.2

GC content: 58.73

Gene sequence:

>441_bases
ATGGTTGAGACTTTCGCCTGCTCCTTCAGGGCGACCGAGATTGAAGCCCGACGCGGCATCGTTTTGGTGGTTCAGCGGCT
GAAGGACATGGGTATTGCCGATACCCGGGTCGACGAGGTGCAGATCGCCCTCGCCGAGGCTGTGAATAACGTTGTCGAAC
ATGCCTATGCCGAAACGGCGACGGGTGATGTTCTCATACGCTGCAACCTCCATTCCGACCGCCTGTGGGTAGAAATACGC
GACGCGGGCACGCCGTTCCCCGATGCCAAACTTCCCGAAGGCAAGCCCGCGTTGGTGGATCCGAGCACGCCGCTCGAAGA
TCTGCCCGAAGGTGGCTTTGGCTGGTTCTTGATCCGTGAGCTGGCAAGCGACATCCAGTACCAGCGCAATCCTGACAACA
ACCAGCTGTCGCTGTGCTTTGAGATCCAGCTCACGCAATAA

Upstream 100 bases:

>100_bases
GGACACCGTCTTTAGCCTGTTCGACACACTGCAAGAAGCGCTCGATACTGAGCATGCAGAGAATTGAAACTGCCGGGATT
GTCTTTGAGGACCAAAATTC

Downstream 100 bases:

>100_bases
GCGACCGGTCGGGAGTTTCGTAAAATCACGAATAACTCGGGGGTGCGCGCCGCATTCCTGCCATAAAAGCGGCCAACAGA
CGCCTCACTCCTCAGCAAAG

Product: putative anti-sigma regulatory factor, serine/threonine protein kinase

Products: NA

Alternate protein names: Anti-sigma-B factor; Sigma-B negative effector rsbW [H]

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MVETFACSFRATEIEARRGIVLVVQRLKDMGIADTRVDEVQIALAEAVNNVVEHAYAETATGDVLIRCNLHSDRLWVEIR
DAGTPFPDAKLPEGKPALVDPSTPLEDLPEGGFGWFLIRELASDIQYQRNPDNNQLSLCFEIQLTQ

Sequences:

>Translated_146_residues
MVETFACSFRATEIEARRGIVLVVQRLKDMGIADTRVDEVQIALAEAVNNVVEHAYAETATGDVLIRCNLHSDRLWVEIR
DAGTPFPDAKLPEGKPALVDPSTPLEDLPEGGFGWFLIRELASDIQYQRNPDNNQLSLCFEIQLTQ
>Mature_146_residues
MVETFACSFRATEIEARRGIVLVVQRLKDMGIADTRVDEVQIALAEAVNNVVEHAYAETATGDVLIRCNLHSDRLWVEIR
DAGTPFPDAKLPEGKPALVDPSTPLEDLPEGGFGWFLIRELASDIQYQRNPDNNQLSLCFEIQLTQ

Specific function: Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, rsbV. Upon phosphorylation of rsbV, rsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B

COG id: COG2172

COG function: function code T; Anti-sigma regulatory factor (Ser/Thr protein kinase)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anti-sigma-factor family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010193
- InterPro:   IPR003594 [H]

Pfam domain/function: PF02518 HATPase_c [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 16297; Mature: 16297

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVETFACSFRATEIEARRGIVLVVQRLKDMGIADTRVDEVQIALAEAVNNVVEHAYAETA
CCCEEEECEECCCHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
TGDVLIRCNLHSDRLWVEIRDAGTPFPDAKLPEGKPALVDPSTPLEDLPEGGFGWFLIRE
CCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCEECCCCCHHHCCCCCHHHHHHHH
LASDIQYQRNPDNNQLSLCFEIQLTQ
HHHHHCCCCCCCCCEEEEEEEEEECC
>Mature Secondary Structure
MVETFACSFRATEIEARRGIVLVVQRLKDMGIADTRVDEVQIALAEAVNNVVEHAYAETA
CCCEEEECEECCCHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
TGDVLIRCNLHSDRLWVEIRDAGTPFPDAKLPEGKPALVDPSTPLEDLPEGGFGWFLIRE
CCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCEECCCCCHHHCCCCCHHHHHHHH
LASDIQYQRNPDNNQLSLCFEIQLTQ
HHHHHCCCCCCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA