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The map label for this gene is ywrD [H]

Identifier: 99079905

GI number: 99079905

Start: 68184

End: 69761

Strand: Reverse

Name: ywrD [H]

Synonym: TM1040_0064

Alternate gene names: 99079905

Gene position: 69761-68184 (Counterclockwise)

Preceding gene: 99079906

Following gene: 99079903

Centisome position: 2.18

GC content: 62.8

Gene sequence:

>1578_bases
ATGCGTGATTTCCAGACACCGGGCCGCTCTGCGGTCTTTGCGCAAAACGGCCTATGTGCCACGTCCCACCCGCTGGCCGC
TCAGGTTGCGGTGGATGTGTTGAAACGCGGCGGCAACGCCATGGATGCCGCGATTGCTGGCGCCGTTCTTTTGGGGATTT
GTGAGCCGCAAATGACCGGAATCGGTGGCGACTGCTTTGTGCTCTACAATCGCGCGGGCGAAACAACCGTGCGGGCGCTG
AATGGATCAGGTCGTGCCCCGAAGGCTGCACAGGCCGCAGATCTGCGCGCTCGTGGCCTGGAGGCGGTGCCGCTGAACAG
TGCCGATGCCGTGACCGTGCCCGGTGCGATTGATGCATTCTGCCATCTCTCTGAAACCGAAGGTAAACTTGGCCTCGATG
CGCTCCTGGCGCCATCTATCCACTACGCCGAGGAAGGCGTGCCGGTCGCACCGCGCGTGGCCTTCGACTGGGGCAACGAC
GCCGAAACACTGCAGGGCAGCGCACGCGACACCTACCTGATCAACGGGCGCGTGCCGCGCGTCGGAGAGATCTTCCGCGC
CCCCGGCCAGGCCGAAGTGCTGCGCCGCATTGCCCGCGACGGGCGCGACGCGTTCTACAGCGGTGAAATCGCAGAAGACA
TGATTTCAGCCCTCACCACACGCGGTGGGGTGCACACCGCCGAGGATTTTGCGGCCACCCAAGCCACCGCGACCGACCCG
ATCCAAGGGCACTACAAAGGGGTCGACCTGCTGGAGCATCCACCCAACGGGCAAGGGGCAACGGCGATCCTGATGCTCAA
CATCCTGAAGCATTTCGACATCGCGGGGATGGATCCATTTGGTGCCGCGCGCGCCCACATCGAGGCCGAGGCAGCCAAGC
TGGCATATGACACGCGCAACCGGTTCCTCGCCGACCCCGACCATATGTCGCGTCTTGATTACATGTTGGCGCCGGAAACC
GCTGAGAAGCTGGCCGCGCTAATTGACCCCAAACGCGCGATGGCGTCGCCCGCCGACATCAGCGAAGCAGTCCACAAAGA
CACCATCTACATCACCGTGGTCGACAAGGACCGCATGGCCGTTTCGCTGATTTATTCAATTTTTCATGGGTTTGGCTCCG
GGATTGCCTCCGACAAATTCGGTATCCTGCTGCAGAACCGAGGGGCGGGTTTCTGCCTCGAGGACGGGCACGCCAACGAG
CTTGCAGGCGGCAAGCGTCCGATGCACACGATCATCCCGGCCATGCTGGCCGAAAACGGGCGCATCACCATGCCATTTGG
CGTAATGGGCGGCGCATACCAGCCCAATGGCCACGCCCGGTTTGTCTCCAACCTGCGTGACTTTGGCATGGAGCCGCAGG
CGGCCATGGACGCCCCCCGCGCCTTTACCGATCGCGGCGTCTTCAACGTTGAGCGCGGATACAGCGATGCTGTCCGCGCC
GAACTAACGGAGATGGGCCACAAGGTGGATATCCCTACCACCGCAATCGGCGGCTCGCAGGCGATCCACATTCACGACAC
CGGTGTGTTGGAGGGTGCAAGCGATCCACGCAAGGATGGTTGCGCGCTCGGTTACTAA

Upstream 100 bases:

>100_bases
CAGCACACTCTCAGCATTCCAGCGTTCGCAGCCTTGGCGTTTTTGCCATTGCCACTTTGCCCCAGACCACTAGGCTCTGC
GCGAAAAAGGGAGAACAGGA

Downstream 100 bases:

>100_bases
AACCACGCGGGATGCCGGGCCACACCCGGCGTCCCCATCAGTTCAACTGGTATTGCAACTGATAATTGCCGTCATCAAAG
CCCGTGAACATCTCGTGCAG

Product: gamma-glutamyltransferase 2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MRDFQTPGRSAVFAQNGLCATSHPLAAQVAVDVLKRGGNAMDAAIAGAVLLGICEPQMTGIGGDCFVLYNRAGETTVRAL
NGSGRAPKAAQAADLRARGLEAVPLNSADAVTVPGAIDAFCHLSETEGKLGLDALLAPSIHYAEEGVPVAPRVAFDWGND
AETLQGSARDTYLINGRVPRVGEIFRAPGQAEVLRRIARDGRDAFYSGEIAEDMISALTTRGGVHTAEDFAATQATATDP
IQGHYKGVDLLEHPPNGQGATAILMLNILKHFDIAGMDPFGAARAHIEAEAAKLAYDTRNRFLADPDHMSRLDYMLAPET
AEKLAALIDPKRAMASPADISEAVHKDTIYITVVDKDRMAVSLIYSIFHGFGSGIASDKFGILLQNRGAGFCLEDGHANE
LAGGKRPMHTIIPAMLAENGRITMPFGVMGGAYQPNGHARFVSNLRDFGMEPQAAMDAPRAFTDRGVFNVERGYSDAVRA
ELTEMGHKVDIPTTAIGGSQAIHIHDTGVLEGASDPRKDGCALGY

Sequences:

>Translated_525_residues
MRDFQTPGRSAVFAQNGLCATSHPLAAQVAVDVLKRGGNAMDAAIAGAVLLGICEPQMTGIGGDCFVLYNRAGETTVRAL
NGSGRAPKAAQAADLRARGLEAVPLNSADAVTVPGAIDAFCHLSETEGKLGLDALLAPSIHYAEEGVPVAPRVAFDWGND
AETLQGSARDTYLINGRVPRVGEIFRAPGQAEVLRRIARDGRDAFYSGEIAEDMISALTTRGGVHTAEDFAATQATATDP
IQGHYKGVDLLEHPPNGQGATAILMLNILKHFDIAGMDPFGAARAHIEAEAAKLAYDTRNRFLADPDHMSRLDYMLAPET
AEKLAALIDPKRAMASPADISEAVHKDTIYITVVDKDRMAVSLIYSIFHGFGSGIASDKFGILLQNRGAGFCLEDGHANE
LAGGKRPMHTIIPAMLAENGRITMPFGVMGGAYQPNGHARFVSNLRDFGMEPQAAMDAPRAFTDRGVFNVERGYSDAVRA
ELTEMGHKVDIPTTAIGGSQAIHIHDTGVLEGASDPRKDGCALGY
>Mature_525_residues
MRDFQTPGRSAVFAQNGLCATSHPLAAQVAVDVLKRGGNAMDAAIAGAVLLGICEPQMTGIGGDCFVLYNRAGETTVRAL
NGSGRAPKAAQAADLRARGLEAVPLNSADAVTVPGAIDAFCHLSETEGKLGLDALLAPSIHYAEEGVPVAPRVAFDWGND
AETLQGSARDTYLINGRVPRVGEIFRAPGQAEVLRRIARDGRDAFYSGEIAEDMISALTTRGGVHTAEDFAATQATATDP
IQGHYKGVDLLEHPPNGQGATAILMLNILKHFDIAGMDPFGAARAHIEAEAAKLAYDTRNRFLADPDHMSRLDYMLAPET
AEKLAALIDPKRAMASPADISEAVHKDTIYITVVDKDRMAVSLIYSIFHGFGSGIASDKFGILLQNRGAGFCLEDGHANE
LAGGKRPMHTIIPAMLAENGRITMPFGVMGGAYQPNGHARFVSNLRDFGMEPQAAMDAPRAFTDRGVFNVERGYSDAVRA
ELTEMGHKVDIPTTAIGGSQAIHIHDTGVLEGASDPRKDGCALGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=556, Percent_Identity=27.158273381295, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI73915090, Length=556, Percent_Identity=27.158273381295, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI73915096, Length=556, Percent_Identity=27.158273381295, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI73915094, Length=556, Percent_Identity=27.158273381295, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI113429324, Length=537, Percent_Identity=27.1880819366853, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI113429326, Length=543, Percent_Identity=27.0718232044199, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI153266885, Length=531, Percent_Identity=25.2354048964218, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI153266901, Length=532, Percent_Identity=25.187969924812, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI109148539, Length=449, Percent_Identity=28.0623608017817, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI153266907, Length=530, Percent_Identity=23.5849056603774, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI1789856, Length=542, Percent_Identity=32.2878228782288, Blast_Score=212, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI193208247, Length=500, Percent_Identity=26.2, Blast_Score=122, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI193208245, Length=500, Percent_Identity=26.2, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI72000294, Length=499, Percent_Identity=24.6492985971944, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI212646519, Length=499, Percent_Identity=24.6492985971944, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17506189, Length=484, Percent_Identity=25.8264462809917, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17542894, Length=468, Percent_Identity=25.6410256410256, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI161077880, Length=550, Percent_Identity=25.4545454545455, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI45551474, Length=550, Percent_Identity=25.4545454545455, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI161077878, Length=550, Percent_Identity=25.4545454545455, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24642670, Length=550, Percent_Identity=25.4545454545455, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24642666, Length=550, Percent_Identity=25.4545454545455, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI18859741, Length=506, Percent_Identity=24.3083003952569, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI161077496, Length=453, Percent_Identity=24.5033112582781, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI18859893, Length=434, Percent_Identity=25.8064516129032, Blast_Score=93, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 55642; Mature: 55642

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDFQTPGRSAVFAQNGLCATSHPLAAQVAVDVLKRGGNAMDAAIAGAVLLGICEPQMTG
CCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHCC
IGGDCFVLYNRAGETTVRALNGSGRAPKAAQAADLRARGLEAVPLNSADAVTVPGAIDAF
CCCCEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHCCCEEECCCCCCCEECCCHHHHH
CHLSETEGKLGLDALLAPSIHYAEEGVPVAPRVAFDWGNDAETLQGSARDTYLINGRVPR
EECCCCCCCCCHHHHHCCCHHHHCCCCCCCCEEEEECCCCHHHHCCCCCCEEEECCCCCC
VGEIFRAPGQAEVLRRIARDGRDAFYSGEIAEDMISALTTRGGVHTAEDFAATQATATDP
HHHHHCCCCHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCC
IQGHYKGVDLLEHPPNGQGATAILMLNILKHFDIAGMDPFGAARAHIEAEAAKLAYDTRN
CCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
RFLADPDHMSRLDYMLAPETAEKLAALIDPKRAMASPADISEAVHKDTIYITVVDKDRMA
CCCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCCCHHHHHHHCCCEEEEEEECCCHHH
VSLIYSIFHGFGSGIASDKFGILLQNRGAGFCLEDGHANELAGGKRPMHTIIPAMLAENG
HHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHCCC
RITMPFGVMGGAYQPNGHARFVSNLRDFGMEPQAAMDAPRAFTDRGVFNVERGYSDAVRA
CEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHCCCCHHHCCCCEEECCCCHHHHHH
ELTEMGHKVDIPTTAIGGSQAIHIHDTGVLEGASDPRKDGCALGY
HHHHCCCEECCCCEECCCCCEEEEECCCEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MRDFQTPGRSAVFAQNGLCATSHPLAAQVAVDVLKRGGNAMDAAIAGAVLLGICEPQMTG
CCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHCC
IGGDCFVLYNRAGETTVRALNGSGRAPKAAQAADLRARGLEAVPLNSADAVTVPGAIDAF
CCCCEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHCCCEEECCCCCCCEECCCHHHHH
CHLSETEGKLGLDALLAPSIHYAEEGVPVAPRVAFDWGNDAETLQGSARDTYLINGRVPR
EECCCCCCCCCHHHHHCCCHHHHCCCCCCCCEEEEECCCCHHHHCCCCCCEEEECCCCCC
VGEIFRAPGQAEVLRRIARDGRDAFYSGEIAEDMISALTTRGGVHTAEDFAATQATATDP
HHHHHCCCCHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCC
IQGHYKGVDLLEHPPNGQGATAILMLNILKHFDIAGMDPFGAARAHIEAEAAKLAYDTRN
CCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
RFLADPDHMSRLDYMLAPETAEKLAALIDPKRAMASPADISEAVHKDTIYITVVDKDRMA
CCCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCCCHHHHHHHCCCEEEEEEECCCHHH
VSLIYSIFHGFGSGIASDKFGILLQNRGAGFCLEDGHANELAGGKRPMHTIIPAMLAENG
HHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHCCC
RITMPFGVMGGAYQPNGHARFVSNLRDFGMEPQAAMDAPRAFTDRGVFNVERGYSDAVRA
CEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHCCCCHHHCCCCEEECCCCHHHHHH
ELTEMGHKVDIPTTAIGGSQAIHIHDTGVLEGASDPRKDGCALGY
HHHHCCCEECCCCEECCCCCEEEEECCCEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]