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The map label for this gene is 99079893

Identifier: 99079893

GI number: 99079893

Start: 54785

End: 55993

Strand: Reverse

Name: 99079893

Synonym: TM1040_0052

Alternate gene names: NA

Gene position: 55993-54785 (Counterclockwise)

Preceding gene: 99079898

Following gene: 99079891

Centisome position: 1.75

GC content: 58.89

Gene sequence:

>1209_bases
ATGACTGGTGGCCACCACCGGGTCGTGCCGCTGTGCGCTAAGGCGCAGACCGCTCTTACACACGACATATCTAACGCCAG
GAGGTTTCTCATGGCACAGGCCGCTTTGCAGCCACAGAACGCTTGCGTTCTCCTCTCGTTTTCCGACGGAACAACGGCGC
AGTACCCCTATATCTGGCTGCGCGACAACGACCCGGAAGGGTTTCACCCTGACACGCAGGAACGGATCACCGATCTTTCT
GCAATATCGCCAGACATTACGGTGGCAGATGTCGAGCTGAACGACTCTCAGCTTCTCATCCACTGGGAAGGCGCTGATTC
CGCCACCAGCCGCTTTGACCTTGATTGGTTGCGCAGCTATGTGCCGGGCACACGCACTGCGGACCCCGCCCGCACCGGGT
TTCAGCACTGGCGCTGCGACCTGGGCGCAGGTGGGATTCCGCGCGCCACAGCACAAGAGATCCTGAGCTCAGATCTTGCC
CTGCGGACATGGCTGGAACAGACCCAAATCTATGGGATCTCCATCGTCGAGGGGCTTGCGGACAGCACCGAGGCGGGCAT
GGATGTGGCACGCCGTATCGGTTTTTTGCGCCAAACCAACTTTGGCGTGACCTTCGAGGTCAAATCCAAACCCAACCCCA
ACAATCTCGCCTATACCCCGATCGCGCTGCCCCTGCATACGGATCTGACCAACCAGGAATTGCCGCCCGGGTTTCAGTTC
CTGCACTGTCTTGCGAACGAGGCCAGGGGCGGTGGTTCTCTGTTTTGCGATGGATATGCCATTGCCGAGGACCTGCGCCG
GGATGATCCCGAGAGTTTTGAGCTTCTATCGACCGTCTCGGTGCCGTTTCGGTTCCACGATCAGGACACCGACATCCGAA
ACCGCAAAAAGGTCATCACGCTGGATGAGGACGGGCGCGTGATCGAGATCTGTTTCAATGCCCATTTGGCGGATATCTTT
GACCTAGAGCCCGCGCTGATGCAGCGCTACTACCGCGCATACCGGAAATTCATGATCCTGACGCGCTCAACCAACTACCT
CGTGACGCTCAAGCTCAAAGGTGGCGAGATGGTTGTGTTTGACAACAGGCGTGTCCTGCATGGCCGCGAGGCCTTTGATC
CTCAGACCGGGTATCGGCACTTGCACGGATGCTATGTGGACCGCGGCGAGTTCGAGAGCCGACTGCGCGTTCTGCATCGC
GGGCAGTGA

Upstream 100 bases:

>100_bases
CATATTCTAGATTTAGCGGAGAACTGTAACTCTGTGAGGACAGGCCGGTCCATGGCACCGCGATTGGGGCAACGCCCCGG
GCACCCTTACAAAAAAGCCT

Downstream 100 bases:

>100_bases
GGCCACAAAAAAGGCCGGGCGCGAAGCCCGGCCAGTCCGACAGGGAGGATGCATATCGTGACCCGGATATGCGCGGGATC
TCTCGAAGGCCTGTTGCGGT

Product: gamma-butyrobetaine,2-oxoglutarate dioxygenase

Products: NA

Alternate protein names: Gamma-butyrobetaine hydroxylase; Gamma-BBH; Gamma-butyrobetaine,2-oxoglutarate dioxygenase [H]

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MTGGHHRVVPLCAKAQTALTHDISNARRFLMAQAALQPQNACVLLSFSDGTTAQYPYIWLRDNDPEGFHPDTQERITDLS
AISPDITVADVELNDSQLLIHWEGADSATSRFDLDWLRSYVPGTRTADPARTGFQHWRCDLGAGGIPRATAQEILSSDLA
LRTWLEQTQIYGISIVEGLADSTEAGMDVARRIGFLRQTNFGVTFEVKSKPNPNNLAYTPIALPLHTDLTNQELPPGFQF
LHCLANEARGGGSLFCDGYAIAEDLRRDDPESFELLSTVSVPFRFHDQDTDIRNRKKVITLDEDGRVIEICFNAHLADIF
DLEPALMQRYYRAYRKFMILTRSTNYLVTLKLKGGEMVVFDNRRVLHGREAFDPQTGYRHLHGCYVDRGEFESRLRVLHR
GQ

Sequences:

>Translated_402_residues
MTGGHHRVVPLCAKAQTALTHDISNARRFLMAQAALQPQNACVLLSFSDGTTAQYPYIWLRDNDPEGFHPDTQERITDLS
AISPDITVADVELNDSQLLIHWEGADSATSRFDLDWLRSYVPGTRTADPARTGFQHWRCDLGAGGIPRATAQEILSSDLA
LRTWLEQTQIYGISIVEGLADSTEAGMDVARRIGFLRQTNFGVTFEVKSKPNPNNLAYTPIALPLHTDLTNQELPPGFQF
LHCLANEARGGGSLFCDGYAIAEDLRRDDPESFELLSTVSVPFRFHDQDTDIRNRKKVITLDEDGRVIEICFNAHLADIF
DLEPALMQRYYRAYRKFMILTRSTNYLVTLKLKGGEMVVFDNRRVLHGREAFDPQTGYRHLHGCYVDRGEFESRLRVLHR
GQ
>Mature_401_residues
TGGHHRVVPLCAKAQTALTHDISNARRFLMAQAALQPQNACVLLSFSDGTTAQYPYIWLRDNDPEGFHPDTQERITDLSA
ISPDITVADVELNDSQLLIHWEGADSATSRFDLDWLRSYVPGTRTADPARTGFQHWRCDLGAGGIPRATAQEILSSDLAL
RTWLEQTQIYGISIVEGLADSTEAGMDVARRIGFLRQTNFGVTFEVKSKPNPNNLAYTPIALPLHTDLTNQELPPGFQFL
HCLANEARGGGSLFCDGYAIAEDLRRDDPESFELLSTVSVPFRFHDQDTDIRNRKKVITLDEDGRVIEICFNAHLADIFD
LEPALMQRYYRAYRKFMILTRSTNYLVTLKLKGGEMVVFDNRRVLHGREAFDPQTGYRHLHGCYVDRGEFESRLRVLHRG
Q

Specific function: Catalyzes the formation of L-carnitine from gamma- butyrobetaine [H]

COG id: COG2175

COG function: function code Q; Probable taurine catabolism dioxygenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-BBH/TMLD family [H]

Homologues:

Organism=Homo sapiens, GI4502369, Length=366, Percent_Identity=31.4207650273224, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI8922625, Length=360, Percent_Identity=29.7222222222222, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI296317249, Length=241, Percent_Identity=29.4605809128631, Blast_Score=118, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17534641, Length=413, Percent_Identity=31.2348668280872, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71992672, Length=394, Percent_Identity=24.8730964467005, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6321766, Length=367, Percent_Identity=24.7956403269755, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24639015, Length=374, Percent_Identity=35.5614973262032, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI221329931, Length=362, Percent_Identity=31.767955801105, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI19922166, Length=387, Percent_Identity=30.4909560723514, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24648401, Length=349, Percent_Identity=29.512893982808, Blast_Score=139, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012775
- InterPro:   IPR010376
- InterPro:   IPR003819 [H]

Pfam domain/function: PF06155 DUF971; PF02668 TauD [H]

EC number: =1.14.11.1 [H]

Molecular weight: Translated: 45387; Mature: 45255

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGGHHRVVPLCAKAQTALTHDISNARRFLMAQAALQPQNACVLLSFSDGTTAQYPYIWL
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEE
RDNDPEGFHPDTQERITDLSAISPDITVADVELNDSQLLIHWEGADSATSRFDLDWLRSY
ECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCEEEEEECCCCCCCCCCCHHHHHHH
VPGTRTADPARTGFQHWRCDLGAGGIPRATAQEILSSDLALRTWLEQTQIYGISIVEGLA
CCCCCCCCHHHHCHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHCC
DSTEAGMDVARRIGFLRQTNFGVTFEVKSKPNPNNLAYTPIALPLHTDLTNQELPPGFQF
CCHHHHHHHHHHHHHHEECCCCEEEEECCCCCCCCEEEEEEEEEEECCCCCCCCCCHHHH
LHCLANEARGGGSLFCDGYAIAEDLRRDDPESFELLSTVSVPFRFHDQDTDIRNRKKVIT
HHHHHHHCCCCCCEEECCHHHHHHHHCCCCHHHHHHHHEECCEEECCCCCCCCCCCEEEE
LDEDGRVIEICFNAHLADIFDLEPALMQRYYRAYRKFMILTRSTNYLVTLKLKGGEMVVF
ECCCCCEEEEEECCCHHHHHCCCHHHHHHHHHHHHHEEEEEECCCEEEEEEECCCEEEEE
DNRRVLHGREAFDPQTGYRHLHGCYVDRGEFESRLRVLHRGQ
CCCEEECCCCCCCCCCCCHHHHEEEEECHHHHHHHHHHHCCC
>Mature Secondary Structure 
TGGHHRVVPLCAKAQTALTHDISNARRFLMAQAALQPQNACVLLSFSDGTTAQYPYIWL
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEE
RDNDPEGFHPDTQERITDLSAISPDITVADVELNDSQLLIHWEGADSATSRFDLDWLRSY
ECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCEEEEEECCCCCCCCCCCHHHHHHH
VPGTRTADPARTGFQHWRCDLGAGGIPRATAQEILSSDLALRTWLEQTQIYGISIVEGLA
CCCCCCCCHHHHCHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHCC
DSTEAGMDVARRIGFLRQTNFGVTFEVKSKPNPNNLAYTPIALPLHTDLTNQELPPGFQF
CCHHHHHHHHHHHHHHEECCCCEEEEECCCCCCCCEEEEEEEEEEECCCCCCCCCCHHHH
LHCLANEARGGGSLFCDGYAIAEDLRRDDPESFELLSTVSVPFRFHDQDTDIRNRKKVIT
HHHHHHHCCCCCCEEECCHHHHHHHHCCCCHHHHHHHHEECCEEECCCCCCCCCCCEEEE
LDEDGRVIEICFNAHLADIFDLEPALMQRYYRAYRKFMILTRSTNYLVTLKLKGGEMVVF
ECCCCCEEEEEECCCHHHHHCCCHHHHHHHHHHHHHEEEEEECCCEEEEEEECCCEEEEE
DNRRVLHGREAFDPQTGYRHLHGCYVDRGEFESRLRVLHRGQ
CCCEEECCCCCCCCCCCCHHHHEEEEECHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8504802 [H]