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The map label for this gene is ribA [H]

Identifier: 99079891

GI number: 99079891

Start: 52702

End: 53790

Strand: Reverse

Name: ribA [H]

Synonym: TM1040_0050

Alternate gene names: 99079891

Gene position: 53790-52702 (Counterclockwise)

Preceding gene: 99079893

Following gene: 99079890

Centisome position: 1.68

GC content: 60.97

Gene sequence:

>1089_bases
ATGAGCCTAATGCCGACAATGCTGGAGCGGATCGCCCGCGCCCGAGTGGATCTGAGGATGGGACTGCCGGTGATCTTGAC
CACCGGTGAGAGCGCCATTCTTGCCATTTCCGTCGAGAGTCTCAGCCCTGAGCGGCTTACGGATCTGCGCAGCCTCGGCC
CGGTGACTCTGGCGCTGACTGCACGGCGGGCGGCCACGCTGAAGGCGCGCGTTTATGACAATGATATTGCGCGCGTCACG
GTGCCCAGCGACGCAGGCCTGGCCTGGGTTCAGGCGCTGGCGGACCCTGCGGATGATCTCGAGACCCCGATGAAAGGCCC
CCTATTGAGTGAGCGCGAAGGCGATGCGTCCCTGCCGCGCCTTGCAATAGCAATGGTAAAATCCGCCCGTCTTCTGCCTG
CGACCGCCTACGTCGCGCTTGAGAATGCTGGTGACTTTGCGCTGAAACACGACCTGACCCTGCTGCCGCAGTCCGCAGCC
GAGCCTCTGCTGAATACCAGCTCGCCCCTCCACCCGGTTGCGGCCGCACGCCTGCCGATGGAGGCCTCCGAGGCAGGTCG
CTTGCATATCTTTCGCCCAGAGGATGGCGGCGAGGAGCACTATGCGATCGAGATCGGTCGCCCGGATCGGAGCCAGCCAG
TCTTGGCGCGGTTACACTCAGCCTGTTTCACCGGTGATGTGTTGGGGTCATTGAAATGTGACTGCGGACCGCAGCTGCGC
GGAGCATTGAGTCACATGGGCCAAGAGGGCGCGGGCATCCTGCTGTATCTCAACCAAGAGGGCCGCGGCATCGGGCTGGC
CAATAAGATGCGCGCCTATTCCCTTCAAGATCAGGGATTTGACACAGTCGAGGCCAATCATCGCCTTGGCTTTGAGGATG
ATGAGCGCGATTTTCGCCTTGGCGCGTCGATTTTGCGCGAACTTGGGTTTTCTTCCGTGCGCCTCATGACCAACAATCCC
GGCAAGATCGCCATGATGGAGAAAACCGGGATTTCCGTTGTCGAACGCGTACCGCTCAAGGTCGGTGAGAACGCGTTTAA
CCGTCACTATCTCGCGACCAAGGCTGCAAAATCAGGCCACATGCTATGA

Upstream 100 bases:

>100_bases
AGCTTCACGTCGACGTGTCCGCAGACGCGGAAATATTTCACTTTTGCAGCAATTGAGCATAGGAGTAAGCTCCTGATGTT
ACAGCCGGGACGAAGACCTG

Downstream 100 bases:

>100_bases
GCCCCGCAGACCTAGTTCTGACACCGAAGGGCCTGCGATTCATGGGTCGGCTTCTGCCCTGTACGATCGGCAAGGGCGGA
CTTTCGACGGCGAAACGCGA

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSLMPTMLERIARARVDLRMGLPVILTTGESAILAISVESLSPERLTDLRSLGPVTLALTARRAATLKARVYDNDIARVT
VPSDAGLAWVQALADPADDLETPMKGPLLSEREGDASLPRLAIAMVKSARLLPATAYVALENAGDFALKHDLTLLPQSAA
EPLLNTSSPLHPVAAARLPMEASEAGRLHIFRPEDGGEEHYAIEIGRPDRSQPVLARLHSACFTGDVLGSLKCDCGPQLR
GALSHMGQEGAGILLYLNQEGRGIGLANKMRAYSLQDQGFDTVEANHRLGFEDDERDFRLGASILRELGFSSVRLMTNNP
GKIAMMEKTGISVVERVPLKVGENAFNRHYLATKAAKSGHML

Sequences:

>Translated_362_residues
MSLMPTMLERIARARVDLRMGLPVILTTGESAILAISVESLSPERLTDLRSLGPVTLALTARRAATLKARVYDNDIARVT
VPSDAGLAWVQALADPADDLETPMKGPLLSEREGDASLPRLAIAMVKSARLLPATAYVALENAGDFALKHDLTLLPQSAA
EPLLNTSSPLHPVAAARLPMEASEAGRLHIFRPEDGGEEHYAIEIGRPDRSQPVLARLHSACFTGDVLGSLKCDCGPQLR
GALSHMGQEGAGILLYLNQEGRGIGLANKMRAYSLQDQGFDTVEANHRLGFEDDERDFRLGASILRELGFSSVRLMTNNP
GKIAMMEKTGISVVERVPLKVGENAFNRHYLATKAAKSGHML
>Mature_361_residues
SLMPTMLERIARARVDLRMGLPVILTTGESAILAISVESLSPERLTDLRSLGPVTLALTARRAATLKARVYDNDIARVTV
PSDAGLAWVQALADPADDLETPMKGPLLSEREGDASLPRLAIAMVKSARLLPATAYVALENAGDFALKHDLTLLPQSAAE
PLLNTSSPLHPVAAARLPMEASEAGRLHIFRPEDGGEEHYAIEIGRPDRSQPVLARLHSACFTGDVLGSLKCDCGPQLRG
ALSHMGQEGAGILLYLNQEGRGIGLANKMRAYSLQDQGFDTVEANHRLGFEDDERDFRLGASILRELGFSSVRLMTNNPG
KIAMMEKTGISVVERVPLKVGENAFNRHYLATKAAKSGHML

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=166, Percent_Identity=59.6385542168675, Blast_Score=208, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6319438, Length=175, Percent_Identity=42.2857142857143, Blast_Score=124, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 39056; Mature: 38925

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLMPTMLERIARARVDLRMGLPVILTTGESAILAISVESLSPERLTDLRSLGPVTLALT
CCCCHHHHHHHHHHHHHHCCCCCEEEECCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEE
ARRAATLKARVYDNDIARVTVPSDAGLAWVQALADPADDLETPMKGPLLSEREGDASLPR
HHHHHEEEEEEECCCEEEEEECCCCCHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCHHH
LAIAMVKSARLLPATAYVALENAGDFALKHDLTLLPQSAAEPLLNTSSPLHPVAAARLPM
HHHHHHHCCCCCCEEEEEEEECCCCEEEECCCEECCCHHHCHHHCCCCCCCCHHHHHCCC
EASEAGRLHIFRPEDGGEEHYAIEIGRPDRSQPVLARLHSACFTGDVLGSLKCDCGPQLR
CCCCCCCEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCHHHHCCCCCCCHHHH
GALSHMGQEGAGILLYLNQEGRGIGLANKMRAYSLQDQGFDTVEANHRLGFEDDERDFRL
HHHHHCCCCCCEEEEEECCCCCCCCCHHHHHEEECCCCCCCEEECCCCCCCCCCCHHHHH
GASILRELGFSSVRLMTNNPGKIAMMEKTGISVVERVPLKVGENAFNRHYLATKAAKSGH
HHHHHHHCCCCEEEEEECCCCEEEEEECCCCHHHHHCCHHCCCCHHCCCCEEECCCCCCC
ML
CC
>Mature Secondary Structure 
SLMPTMLERIARARVDLRMGLPVILTTGESAILAISVESLSPERLTDLRSLGPVTLALT
CCCHHHHHHHHHHHHHHCCCCCEEEECCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEE
ARRAATLKARVYDNDIARVTVPSDAGLAWVQALADPADDLETPMKGPLLSEREGDASLPR
HHHHHEEEEEEECCCEEEEEECCCCCHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCHHH
LAIAMVKSARLLPATAYVALENAGDFALKHDLTLLPQSAAEPLLNTSSPLHPVAAARLPM
HHHHHHHCCCCCCEEEEEEEECCCCEEEECCCEECCCHHHCHHHCCCCCCCCHHHHHCCC
EASEAGRLHIFRPEDGGEEHYAIEIGRPDRSQPVLARLHSACFTGDVLGSLKCDCGPQLR
CCCCCCCEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCHHHHCCCCCCCHHHH
GALSHMGQEGAGILLYLNQEGRGIGLANKMRAYSLQDQGFDTVEANHRLGFEDDERDFRL
HHHHHCCCCCCEEEEEECCCCCCCCCHHHHHEEECCCCCCCEEECCCCCCCCCCCHHHHH
GASILRELGFSSVRLMTNNPGKIAMMEKTGISVVERVPLKVGENAFNRHYLATKAAKSGH
HHHHHHHCCCCEEEEEECCCCEEEEEECCCCHHHHHCCHHCCCCHHCCCCEEECCCCCCC
ML
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7883178 [H]