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The map label for this gene is arlS [H]

Identifier: 94986414

GI number: 94986414

Start: 2436787

End: 2438361

Strand: Reverse

Name: arlS [H]

Synonym: Dgeo_2317

Alternate gene names: 94986414

Gene position: 2438361-2436787 (Counterclockwise)

Preceding gene: 94986415

Following gene: 94986411

Centisome position: 98.83

GC content: 66.92

Gene sequence:

>1575_bases
GTGACGCTGCGCTGGCGGCTCACGCTGTTCTATACGGTGCTGCTCGCGGCGCTGCTGACAGCGGTGGCGGTGGCGGTGCT
GCTGATCATGCGCAGCAGCCTGATGAGCGATCTGGACCGCGATCTGCAAGATACCTACCGGCGCTTTACCGATATCGTCA
GCCAGCTCGCGCTGAATGATCCCGGAACCGCCCAGGAGCGTGACCAGGCCGGGCTCCTCCCCCGCGTCCGTTATCTCTTC
CCCGATGACGCCATTCAGATCGAGGATCTCTCCTTTTTTAACGATGCCCAGGCGCTGGCCATGGCACTGGAGTCCGCCCG
CACGCCGGCCGAGCGCGAGAACCTGCTCCGGTTTCTGCGGACCCTGAGCCAGAGCACCCGCCTGAGCATCGGCTTGGACC
GCCAGGCTCCCTTGCAACTGAGTGACGCGGAGCTCATCCGGCTGATCACCTCGCCCGCCGGACAGATCATCATCCGGCGC
GACGTGAAAGATCCCTACAGCAATCGCAAAACCCCGTACCGCGTCCTGGTCAAGCTGGGGCCAGTGCAGCTCACCCCGCC
GGTGCTGGGGGTGACCCGCCCGTCCTTTGCCCTGACCTACGTGGGCCGCAGCCTAGAACCGGTGATGTACACCCTGTCTC
AACTGCAGCAGGTGATCTTGGTGCTGCTGCTTTTGGGCCTGATTGCTTCGGGGGTGGGTGCTTACCTGCTGGCCGGGCAG
GCTCTGCGGCCCCTGCGTCAGGTGCAGCGCGCCGCCGAGCGGATCGGCGGGCAGAATCTGGGCGAGCGCGTGCCCGAGCC
TCAGACCGGCGACGAGGTGCAGGCGCTCGCCCACGCGCTGAACGCGATGCTGAGCCGGCTGGAGGCCAGCTTCGAGGCGC
AGCGGCGCTTCACGAGTGACGCGAGCCACGAGCTGCGTACGCCTGTCACCGCCATCAGCGGCCACGCCAGTTACCTGCTG
CGCCGGACCGACCCCACCGAGGGGCAGCGTGAGAGTCTGAACATCATCCGCCGCGAGTCCGAACGGCTCACCAACCTGAT
TGCCAGCCTGCTGCAACTTGCCCGCTCGGACAGCGGCGCGTTGGTGCTGACGCGCCAGCCTATCCTCTCGGGCCTCTTTC
TAGCTGAGATCGCCCGCGAGCTGCTGCCGCTCGCGCAGGCACAGGGCACCGAATTGGTCGCGCAGGGACAGGACGTTGCC
TTTGAGGGTGACCCCGACCGCCTCAAACAGGTGATCATTAATCTGGTTGGCAACGCGCTCAAGGCCGGCGCGCGCCATGT
CACCCTGGGCAGCCAGCCGGCGGAGGGCGGGCGTGAGGTGCGGCTCTGGGTGCAAGACGATGGCCCCGGCATTCCGTCTG
AACATCTGGCGCGCCTCTTTGACCGCTTTTACCGGGTCGAGGACAGCCGCAGCCGTGACCAGGGGGGCGCGGGCCTAGGC
CTCAGCATTGCCAAGGGCATTGTTGACGCGCACGGCGGGCGCATCTGGCTGGAAAGCGAGGTGGGCCGCGGCACGACGGC
CTATGTGCAGCTCCCGGTGGGGAATGTCCCGGAGCTGGAGGAGGACGTGCCCTAG

Upstream 100 bases:

>100_bases
GCTACGTGCTGCGTGAGGAGTAGAGCGAGCCGGGCGGGCGTTAGACTGCGGGCGTGACCCGGTCGAACGTGCCCCGCCCC
GCCTGTTTGGAGGGCCGCCG

Downstream 100 bases:

>100_bases
CGCTACGTGCCCTGAAGCTTCCGTGCAAGACTGTCAGACGGACCCTGACTCCTGCAGCTACCCCAGCATCAAGGCGTGCA
GCTCCTCCATCAGCGCCTCG

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:

>524_residues
MTLRWRLTLFYTVLLAALLTAVAVAVLLIMRSSLMSDLDRDLQDTYRRFTDIVSQLALNDPGTAQERDQAGLLPRVRYLF
PDDAIQIEDLSFFNDAQALAMALESARTPAERENLLRFLRTLSQSTRLSIGLDRQAPLQLSDAELIRLITSPAGQIIIRR
DVKDPYSNRKTPYRVLVKLGPVQLTPPVLGVTRPSFALTYVGRSLEPVMYTLSQLQQVILVLLLLGLIASGVGAYLLAGQ
ALRPLRQVQRAAERIGGQNLGERVPEPQTGDEVQALAHALNAMLSRLEASFEAQRRFTSDASHELRTPVTAISGHASYLL
RRTDPTEGQRESLNIIRRESERLTNLIASLLQLARSDSGALVLTRQPILSGLFLAEIARELLPLAQAQGTELVAQGQDVA
FEGDPDRLKQVIINLVGNALKAGARHVTLGSQPAEGGREVRLWVQDDGPGIPSEHLARLFDRFYRVEDSRSRDQGGAGLG
LSIAKGIVDAHGGRIWLESEVGRGTTAYVQLPVGNVPELEEDVP

Sequences:

>Translated_524_residues
MTLRWRLTLFYTVLLAALLTAVAVAVLLIMRSSLMSDLDRDLQDTYRRFTDIVSQLALNDPGTAQERDQAGLLPRVRYLF
PDDAIQIEDLSFFNDAQALAMALESARTPAERENLLRFLRTLSQSTRLSIGLDRQAPLQLSDAELIRLITSPAGQIIIRR
DVKDPYSNRKTPYRVLVKLGPVQLTPPVLGVTRPSFALTYVGRSLEPVMYTLSQLQQVILVLLLLGLIASGVGAYLLAGQ
ALRPLRQVQRAAERIGGQNLGERVPEPQTGDEVQALAHALNAMLSRLEASFEAQRRFTSDASHELRTPVTAISGHASYLL
RRTDPTEGQRESLNIIRRESERLTNLIASLLQLARSDSGALVLTRQPILSGLFLAEIARELLPLAQAQGTELVAQGQDVA
FEGDPDRLKQVIINLVGNALKAGARHVTLGSQPAEGGREVRLWVQDDGPGIPSEHLARLFDRFYRVEDSRSRDQGGAGLG
LSIAKGIVDAHGGRIWLESEVGRGTTAYVQLPVGNVPELEEDVP
>Mature_523_residues
TLRWRLTLFYTVLLAALLTAVAVAVLLIMRSSLMSDLDRDLQDTYRRFTDIVSQLALNDPGTAQERDQAGLLPRVRYLFP
DDAIQIEDLSFFNDAQALAMALESARTPAERENLLRFLRTLSQSTRLSIGLDRQAPLQLSDAELIRLITSPAGQIIIRRD
VKDPYSNRKTPYRVLVKLGPVQLTPPVLGVTRPSFALTYVGRSLEPVMYTLSQLQQVILVLLLLGLIASGVGAYLLAGQA
LRPLRQVQRAAERIGGQNLGERVPEPQTGDEVQALAHALNAMLSRLEASFEAQRRFTSDASHELRTPVTAISGHASYLLR
RTDPTEGQRESLNIIRRESERLTNLIASLLQLARSDSGALVLTRQPILSGLFLAEIARELLPLAQAQGTELVAQGQDVAF
EGDPDRLKQVIINLVGNALKAGARHVTLGSQPAEGGREVRLWVQDDGPGIPSEHLARLFDRFYRVEDSRSRDQGGAGLGL
SIAKGIVDAHGGRIWLESEVGRGTTAYVQLPVGNVPELEEDVP

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transf

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=318, Percent_Identity=30.5031446540881, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=35.2678571428571, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1788393, Length=287, Percent_Identity=32.0557491289199, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1790346, Length=261, Percent_Identity=30.6513409961686, Blast_Score=113, Evalue=4e-26,
Organism=Escherichia coli, GI1789149, Length=370, Percent_Identity=28.3783783783784, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1787894, Length=319, Percent_Identity=28.8401253918495, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=29.8642533936652, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI145693157, Length=241, Percent_Identity=29.4605809128631, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI48994928, Length=248, Percent_Identity=30.241935483871, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1790551, Length=275, Percent_Identity=30.5454545454545, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1786912, Length=224, Percent_Identity=31.6964285714286, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1788713, Length=249, Percent_Identity=27.710843373494, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87082128, Length=297, Percent_Identity=27.6094276094276, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788279, Length=312, Percent_Identity=25, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1789403, Length=311, Percent_Identity=28.6173633440514, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788549, Length=261, Percent_Identity=26.4367816091954, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI87081816, Length=237, Percent_Identity=29.535864978903, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1790861, Length=295, Percent_Identity=27.4576271186441, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790300, Length=241, Percent_Identity=30.2904564315353, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789808, Length=296, Percent_Identity=27.7027027027027, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787374, Length=262, Percent_Identity=24.0458015267176, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 57579; Mature: 57448

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRWRLTLFYTVLLAALLTAVAVAVLLIMRSSLMSDLDRDLQDTYRRFTDIVSQLALND
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGTAQERDQAGLLPRVRYLFPDDAIQIEDLSFFNDAQALAMALESARTPAERENLLRFLR
CCCCCCHHHCCCCCHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
TLSQSTRLSIGLDRQAPLQLSDAELIRLITSPAGQIIIRRDVKDPYSNRKTPYRVLVKLG
HHHHCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCEEEEEEC
PVQLTPPVLGVTRPSFALTYVGRSLEPVMYTLSQLQQVILVLLLLGLIASGVGAYLLAGQ
CEEECCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALRPLRQVQRAAERIGGQNLGERVPEPQTGDEVQALAHALNAMLSRLEASFEAQRRFTSD
HHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ASHELRTPVTAISGHASYLLRRTDPTEGQRESLNIIRRESERLTNLIASLLQLARSDSGA
CHHHHHCCHHHHCCHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LVLTRQPILSGLFLAEIARELLPLAQAQGTELVAQGQDVAFEGDPDRLKQVIINLVGNAL
EEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEECCCHHHHHHHHHHHHHHHH
KAGARHVTLGSQPAEGGREVRLWVQDDGPGIPSEHLARLFDRFYRVEDSRSRDQGGAGLG
HCCCCEEECCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC
LSIAKGIVDAHGGRIWLESEVGRGTTAYVQLPVGNVPELEEDVP
HHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCCCCHHCCCC
>Mature Secondary Structure 
TLRWRLTLFYTVLLAALLTAVAVAVLLIMRSSLMSDLDRDLQDTYRRFTDIVSQLALND
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGTAQERDQAGLLPRVRYLFPDDAIQIEDLSFFNDAQALAMALESARTPAERENLLRFLR
CCCCCCHHHCCCCCHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
TLSQSTRLSIGLDRQAPLQLSDAELIRLITSPAGQIIIRRDVKDPYSNRKTPYRVLVKLG
HHHHCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCEEEEEEC
PVQLTPPVLGVTRPSFALTYVGRSLEPVMYTLSQLQQVILVLLLLGLIASGVGAYLLAGQ
CEEECCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALRPLRQVQRAAERIGGQNLGERVPEPQTGDEVQALAHALNAMLSRLEASFEAQRRFTSD
HHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ASHELRTPVTAISGHASYLLRRTDPTEGQRESLNIIRRESERLTNLIASLLQLARSDSGA
CHHHHHCCHHHHCCHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LVLTRQPILSGLFLAEIARELLPLAQAQGTELVAQGQDVAFEGDPDRLKQVIINLVGNAL
EEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEECCCHHHHHHHHHHHHHHHH
KAGARHVTLGSQPAEGGREVRLWVQDDGPGIPSEHLARLFDRFYRVEDSRSRDQGGAGLG
HCCCCEEECCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC
LSIAKGIVDAHGGRIWLESEVGRGTTAYVQLPVGNVPELEEDVP
HHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA