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The map label for this gene is holB [H]

Identifier: 94986361

GI number: 94986361

Start: 2387367

End: 2388317

Strand: Reverse

Name: holB [H]

Synonym: Dgeo_2262

Alternate gene names: 94986361

Gene position: 2388317-2387367 (Counterclockwise)

Preceding gene: 94986362

Following gene: 94986360

Centisome position: 96.8

GC content: 69.82

Gene sequence:

>951_bases
ATGTCTACCTCTTCCCCTGCTTCCTCTGCCCTCCTCCACGGCCCGCTGCTCGAACAGACGGGCGTCTTTCGCGGCAACGC
ACTGCTGCTCACCGGTCCGGCCCGAGTCGGGAAGCGTGACGTGGCGTTTGCTGTCGCCGCGCAGCACAACTGCTCGGGTA
CGCGGGGCATGTACGGCGAGGCGTGCGGCAGTTGCCCCTCTTGTCGGGCGCTTGCGGCGGGGGTGCACCCCGACCTGCTG
CTGGTCGAGCCGCGGGCCACCACCACAACCGGCCGGGCAGCGCGGCGCAAAGTGATTCCCATCGGCGCGATTCTGGCGGA
CCGTGACAAGGGGCGTGAATACGAGACGCATGTCTTCGAGTTTCTAGAGCTGCGGCCTACCTTTCGCCGCCGGGTGGTGG
TGGTGGACGGCGCCGAGCACCTGGGACCGGAGGCCGCCAACGCCCTGCTCAAACTGGTGGAGGAGCCGCCACATGGGGCG
CTGTTTGTGTTCTTGGCCGAGGACCTGCGCGCCGTGATCCCCACCATCGTGAGCCGCAGTGCTCGCCTGAGTGTCACGCC
CGCCCCCGACCCGGCGATCGAGCGCATCCTGGCCCTGAGTGGCGAGGTGCCCGACGCCGAGCTGGTCGCCTTTGCCGCGG
GGCGGGCGGGCGTGCTTGCGGACCGCGAGGCGGTGCGGTCGGCCCTCGCGGATGCGGCAGAGTTCACGCAAGCGCTCGGG
GTGAGCCTGCTTGCCGCCCTGGAAGCTGCGGAGCGGTTGGAGAAACGCTGGGACGTCACCTGGCATCCCGAGGCGCTGCG
CTTCGCCTGGCGCATGCGGTCTTCCCATGCCCGCGCTCGTGCCGACGCCGCCCTCGACGCCCTACAAGCCGCACTGGAAG
CCTACGCCAGCCCGAGCCTCAGTTTTCAGGTGTTCGCCCTGAACCTGCGGGAGGCGTTCGGGGAGGGGTGA

Upstream 100 bases:

>100_bases
GGGTGTAGGTTGTGGGTGCAGGGGCCGCCACGAGCGCCTGAGCTGCGACTCGCCCACAACCGGCAATTCCCTCACCGGCG
ACTCCCTGACTCGCACCCTC

Downstream 100 bases:

>100_bases
GGGGTCGCTCCTTGCTCTGCTCCGTCCTAGACTCACGCCATGATCAAGCCGAGACAACACGGCGCGGCGCGGGTGTGGGT
CCTGCCGACCGGGCCGCTTC

Product: DNA polymerase III subunit, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MSTSSPASSALLHGPLLEQTGVFRGNALLLTGPARVGKRDVAFAVAAQHNCSGTRGMYGEACGSCPSCRALAAGVHPDLL
LVEPRATTTTGRAARRKVIPIGAILADRDKGREYETHVFEFLELRPTFRRRVVVVDGAEHLGPEAANALLKLVEEPPHGA
LFVFLAEDLRAVIPTIVSRSARLSVTPAPDPAIERILALSGEVPDAELVAFAAGRAGVLADREAVRSALADAAEFTQALG
VSLLAALEAAERLEKRWDVTWHPEALRFAWRMRSSHARARADAALDALQAALEAYASPSLSFQVFALNLREAFGEG

Sequences:

>Translated_316_residues
MSTSSPASSALLHGPLLEQTGVFRGNALLLTGPARVGKRDVAFAVAAQHNCSGTRGMYGEACGSCPSCRALAAGVHPDLL
LVEPRATTTTGRAARRKVIPIGAILADRDKGREYETHVFEFLELRPTFRRRVVVVDGAEHLGPEAANALLKLVEEPPHGA
LFVFLAEDLRAVIPTIVSRSARLSVTPAPDPAIERILALSGEVPDAELVAFAAGRAGVLADREAVRSALADAAEFTQALG
VSLLAALEAAERLEKRWDVTWHPEALRFAWRMRSSHARARADAALDALQAALEAYASPSLSFQVFALNLREAFGEG
>Mature_315_residues
STSSPASSALLHGPLLEQTGVFRGNALLLTGPARVGKRDVAFAVAAQHNCSGTRGMYGEACGSCPSCRALAAGVHPDLLL
VEPRATTTTGRAARRKVIPIGAILADRDKGREYETHVFEFLELRPTFRRRVVVVDGAEHLGPEAANALLKLVEEPPHGAL
FVFLAEDLRAVIPTIVSRSARLSVTPAPDPAIERILALSGEVPDAELVAFAAGRAGVLADREAVRSALADAAEFTQALGV
SLLAALEAAERLEKRWDVTWHPEALRFAWRMRSSHARARADAALDALQAALEAYASPSLSFQVFALNLREAFGEG

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0470

COG function: function code L; ATPase involved in DNA replication

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003959
- InterPro:   IPR004622 [H]

Pfam domain/function: PF00004 AAA [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 33682; Mature: 33551

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSSPASSALLHGPLLEQTGVFRGNALLLTGPARVGKRDVAFAVAAQHNCSGTRGMYGE
CCCCCCCHHHHHCCCHHHHCCCCCCCEEEEECCHHCCCCHHEEEEEECCCCCCCCCCCHH
ACGSCPSCRALAAGVHPDLLLVEPRATTTTGRAARRKVIPIGAILADRDKGREYETHVFE
HHCCCCCHHHHHCCCCCCEEEECCCCCCCCCHHHHCEECEEHHEEECCCCCCHHHHHHHH
FLELRPTFRRRVVVVDGAEHLGPEAANALLKLVEEPPHGALFVFLAEDLRAVIPTIVSRS
HHHHCCCHHCEEEEEECHHHCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCC
ARLSVTPAPDPAIERILALSGEVPDAELVAFAAGRAGVLADREAVRSALADAAEFTQALG
CEEEECCCCCHHHHHHHHHCCCCCCHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
VSLLAALEAAERLEKRWDVTWHPEALRFAWRMRSSHARARADAALDALQAALEAYASPSL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SFQVFALNLREAFGEG
EEEEEEEEHHHHCCCC
>Mature Secondary Structure 
STSSPASSALLHGPLLEQTGVFRGNALLLTGPARVGKRDVAFAVAAQHNCSGTRGMYGE
CCCCCCHHHHHCCCHHHHCCCCCCCEEEEECCHHCCCCHHEEEEEECCCCCCCCCCCHH
ACGSCPSCRALAAGVHPDLLLVEPRATTTTGRAARRKVIPIGAILADRDKGREYETHVFE
HHCCCCCHHHHHCCCCCCEEEECCCCCCCCCHHHHCEECEEHHEEECCCCCCHHHHHHHH
FLELRPTFRRRVVVVDGAEHLGPEAANALLKLVEEPPHGALFVFLAEDLRAVIPTIVSRS
HHHHCCCHHCEEEEEECHHHCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCC
ARLSVTPAPDPAIERILALSGEVPDAELVAFAAGRAGVLADREAVRSALADAAEFTQALG
CEEEECCCCCHHHHHHHHHCCCCCCHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
VSLLAALEAAERLEKRWDVTWHPEALRFAWRMRSSHARARADAALDALQAALEAYASPSL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SFQVFALNLREAFGEG
EEEEEEEEHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550441; 10984043 [H]