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The map label for this gene is irlR [H]

Identifier: 94986248

GI number: 94986248

Start: 2261548

End: 2262213

Strand: Reverse

Name: irlR [H]

Synonym: Dgeo_2149

Alternate gene names: 94986248

Gene position: 2262213-2261548 (Counterclockwise)

Preceding gene: 94986253

Following gene: 94986247

Centisome position: 91.69

GC content: 63.51

Gene sequence:

>666_bases
GTGAGTGCCCAACGAATTCTCGTGATCGAGGACGATCTCGACATTGCCAACGTGCTGAGGCTGGACCTGACGGATGCGGG
GTATGCGGTCGAACATGCTGACTCGGCCATGAACGGCCTGATTCGCGCTCGCGAAGACCACCCCGACCTGATCCTGCTTG
ATCTCGGCCTGCCCGACTTCGACGGCGGCGACGTGGTGCAGCGCTTACGCAAGAACAGCGCCGTGCCGATTATCGTGCTG
ACCGCCCGTGACACGGTGGATGAAAAAGTCCGCCTGCTGGGCCTGGGCGCCGACGACTACCTGATCAAGCCTTTCCACCC
CGATGAGCTGATCGCCCGCGTCAAGGTGCAGCTGCGCCAACGTGTCAGTGAGAGTCTCAGCATGGGCGACCTGACGCTCG
ACCCTCAAAAACGGCTGGTGACCTACAAGAACGAGGAGTTGCGCCTCTCGCCCAAGGAGTTCGACATTCTGGCCCTGCTG
ATTCGCCAGCCCGGTCGGGTGTACTCGCGCCAGGAGATCGGCCAGGAAATCTGGCAGGGCCGCCTGCCGGAAGGCAGCAA
TGTGGTGGACGTGCACATGGCGAACCTGCGGGCCAAACTGCGCGACCTCGACGGGTATGGTCTGCTGCGGACCGTGCGCG
GCGTCGGCTATGCGCTGCGCGGCTGA

Upstream 100 bases:

>100_bases
CCCGCCGCCGTTGCCCCGCCCACTCCCTTGCCCAGTCCACCTGGAGCGGTGAGCGCCACAACGCGTGTGAAGCCGCTGTG
AAGGCAGGTATCATGAAGGG

Downstream 100 bases:

>100_bases
TCCAGAGAGGAACTGATGCCGGAACAGGCGCCTCCATCCCCTCTTGGTGCTCTTGCGGGCGCGGATTTGTTGCCGCTTCT
CACGGCGCTGCCCGATCCGG

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MSAQRILVIEDDLDIANVLRLDLTDAGYAVEHADSAMNGLIRAREDHPDLILLDLGLPDFDGGDVVQRLRKNSAVPIIVL
TARDTVDEKVRLLGLGADDYLIKPFHPDELIARVKVQLRQRVSESLSMGDLTLDPQKRLVTYKNEELRLSPKEFDILALL
IRQPGRVYSRQEIGQEIWQGRLPEGSNVVDVHMANLRAKLRDLDGYGLLRTVRGVGYALRG

Sequences:

>Translated_221_residues
MSAQRILVIEDDLDIANVLRLDLTDAGYAVEHADSAMNGLIRAREDHPDLILLDLGLPDFDGGDVVQRLRKNSAVPIIVL
TARDTVDEKVRLLGLGADDYLIKPFHPDELIARVKVQLRQRVSESLSMGDLTLDPQKRLVTYKNEELRLSPKEFDILALL
IRQPGRVYSRQEIGQEIWQGRLPEGSNVVDVHMANLRAKLRDLDGYGLLRTVRGVGYALRG
>Mature_220_residues
SAQRILVIEDDLDIANVLRLDLTDAGYAVEHADSAMNGLIRAREDHPDLILLDLGLPDFDGGDVVQRLRKNSAVPIIVLT
ARDTVDEKVRLLGLGADDYLIKPFHPDELIARVKVQLRQRVSESLSMGDLTLDPQKRLVTYKNEELRLSPKEFDILALLI
RQPGRVYSRQEIGQEIWQGRLPEGSNVVDVHMANLRAKLRDLDGYGLLRTVRGVGYALRG

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=217, Percent_Identity=39.63133640553, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1786784, Length=220, Percent_Identity=38.6363636363636, Blast_Score=147, Evalue=5e-37,
Organism=Escherichia coli, GI1789402, Length=219, Percent_Identity=40.6392694063927, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=38.2222222222222, Blast_Score=140, Evalue=8e-35,
Organism=Escherichia coli, GI1790860, Length=230, Percent_Identity=37.3913043478261, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI1786911, Length=218, Percent_Identity=38.0733944954128, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=38.3561643835616, Blast_Score=134, Evalue=3e-33,
Organism=Escherichia coli, GI1787375, Length=217, Percent_Identity=35.0230414746544, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=35.6828193832599, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=32.1739130434783, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=30.8695652173913, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1790863, Length=235, Percent_Identity=29.7872340425532, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI145693140, Length=238, Percent_Identity=30.672268907563, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=30.2631578947368, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=35.9649122807018, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=32.7102803738318, Blast_Score=68, Evalue=4e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24810; Mature: 24679

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQRILVIEDDLDIANVLRLDLTDAGYAVEHADSAMNGLIRAREDHPDLILLDLGLPDF
CCCCEEEEEECCCCHHHHEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
DGGDVVQRLRKNSAVPIIVLTARDTVDEKVRLLGLGADDYLIKPFHPDELIARVKVQLRQ
CCHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCCCEECCCCHHHHHHHHHHHHHH
RVSESLSMGDLTLDPQKRLVTYKNEELRLSPKEFDILALLIRQPGRVYSRQEIGQEIWQG
HHHHHCCCCCEEECCHHHEEEECCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHCC
RLPEGSNVVDVHMANLRAKLRDLDGYGLLRTVRGVGYALRG
CCCCCCCEEEEEHHHHHHHHHCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SAQRILVIEDDLDIANVLRLDLTDAGYAVEHADSAMNGLIRAREDHPDLILLDLGLPDF
CCCEEEEEECCCCHHHHEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
DGGDVVQRLRKNSAVPIIVLTARDTVDEKVRLLGLGADDYLIKPFHPDELIARVKVQLRQ
CCHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCCCEECCCCHHHHHHHHHHHHHH
RVSESLSMGDLTLDPQKRLVTYKNEELRLSPKEFDILALLIRQPGRVYSRQEIGQEIWQG
HHHHHCCCCCEEECCHHHEEEECCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHCC
RLPEGSNVVDVHMANLRAKLRDLDGYGLLRTVRGVGYALRG
CCCCCCCEEEEEHHHHHHHHHCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]