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The map label for this gene is maeA [H]

Identifier: 94986253

GI number: 94986253

Start: 2268909

End: 2270645

Strand: Reverse

Name: maeA [H]

Synonym: Dgeo_2154

Alternate gene names: 94986253

Gene position: 2270645-2268909 (Counterclockwise)

Preceding gene: 94986254

Following gene: 94986248

Centisome position: 92.03

GC content: 66.03

Gene sequence:

>1737_bases
ATGGCGCACATCTCCCGCTACTACGATGTGAAACGTGACCCTGCCGGGCACCGTGTGCTGGAAGTGCGGGTAACCGGTTT
TCCGCTGCTGCATCTGCCGCTGCTCAACAAGTCGACGGCCTTCACCGAAGAGGAACGCCGCCTGCTGGGCTTGGAGGGGC
TGCTGCCGCCCGGCGTCAGCACCTTGGGGGAGCAGAAGGAGCGGGCCTACCTGCGGTTTCGCCAACAGGGCACACCGCTG
GAAAAGCACGCCTACCTGCGCAACCTGCAGGACTACAACGAGGTGCTGTTTTTCGCCCTGCTGGAAAACCACCTCGAGGA
GATGCTGCCCATCATCTACACCCCCACGGTGGGCGACGCGGTGCGGGAGTTCTCGCGGCTGTACCGCTATCCGCGCGGTT
TTGCGCTGAGCACGGCGCATGTGGGGCGGGTGCGCGAACTCCTGGACAATGTCCATCAGCAGGACGTGCGGATGATCGTG
GCAACTGATTCCAGCGCGATTTTGGGCATCGGCGACCAAGGCTTTGGGGGCATGGCGATCTCCATCGGCAAGCTCAGCCT
GTACACGGTCGCGGGCGGAGTGGGCCCCGACAAGACGCTGCCGGTCGAGTTGGACGTCGGCACGGGCCGCCAGGATCTGA
TTGAAGACCCCCTCTACCTGGGGGCTCGCCACCCTCGCTTGACCGGCGAGGCGTATGACGCGTTCCTGGACGCCTTTGTG
GAGGCCGTGAGGGACCGTTATCCCAAGGCGATCATCCAGTGGGAGGACTTCTCGAAGGACACAGCCTTCCGGGTGCTGGA
GCGCTACCGCAAGGTGGTGCCGAGTTTCAATGACGATATTCAGGGCACCGGCGCGGTCACCTTGGCAGGTGTGCTGCGAG
CCTGCGCGCTTAAGGGCGAACAGCTCCGCGAGCAGGTGATTGTGATTCACGGAGCGGGTGCCGGAGGTGCCGGTGTCGCC
GCCGCGATCCGTGAGGGGATGCGGCAGGAGGGGCTGGGCGAGGACGAAATTGCCCGCCGGGTCTTTGTCCTCGATTCGCG
CGGCCTCCTGACCGATGACCGCTCGCTGGAGGCCTACAAGCAGCCGCTCGCCACACCGAAGCGCCTCACCGACGGCTGGA
CAGGAACCGACCTCCTGAGCGTGGTGCGGGAGGCGGGAGCGACCGTGCTGCTGGGCCTCAGCGGACAGGGTGGCATCTTC
AACGAACCCATCGTGCGTGCGGTGCATGCCCAGACGGCCCGGCCCGTCGTCTTTCCGCTCTCTAACCCCACGGCCAACAC
CGAGGCCCTGCCGGAAGACATCCTGCGCTGGACAGACGGCGCCGCCATCGTGGCGACCGGCAGTCCCTTCCCGGACGTGA
CGTTGAACGGCCAGACGCACGTGATCGGGCAGGGCAACAACGCCTTCATCTTTCCCGGCCTGGGCCTTGCCGCTGTTCTC
ACTCGCGCCTCGGAGATCACAGACGGGATGGTGGCCGAGGCGGCCTATGCGCTGGCCGACTTCACGGCCCGCACCTATCC
CGAACGCACCTATCCGCCCACCCGCGCCCTACGCGACGCCAGCCGTGCCGTTGCCCTGCGGGTAGCTCGCAAAGCCATTC
TGGAAGGCGTCGCCCGCGAGGAAAAGGTGCAGGGCCTCGACGACGACGCCCTCGCCGCCTTTATCGACAGCCGTTTCTGG
GTGCCAAAGTATCTGCCGTACCGCATGGCGGAGGGAGCCGGGCCGGATCTGGGGTGA

Upstream 100 bases:

>100_bases
CCCAAGTACCTGCCGCTCCGGAAGGCGGCGGGGGCGCGTGACTGAAACCTCTGCTCTAGGCAGGCTGGCCACGGCGTACG
TCCCCTGGCTAGGCTGAGGC

Downstream 100 bases:

>100_bases
GGGCGGCCCAGCGAGCAGCCAGAAAGGCAAAGCAAAAGGTGCAAAGCCTCCGCTTCGGCGGAGGCTTTTGCATCGTGCAT
CGTCTCTGGCCATTAACTGG

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 578; Mature: 577

Protein sequence:

>578_residues
MAHISRYYDVKRDPAGHRVLEVRVTGFPLLHLPLLNKSTAFTEEERRLLGLEGLLPPGVSTLGEQKERAYLRFRQQGTPL
EKHAYLRNLQDYNEVLFFALLENHLEEMLPIIYTPTVGDAVREFSRLYRYPRGFALSTAHVGRVRELLDNVHQQDVRMIV
ATDSSAILGIGDQGFGGMAISIGKLSLYTVAGGVGPDKTLPVELDVGTGRQDLIEDPLYLGARHPRLTGEAYDAFLDAFV
EAVRDRYPKAIIQWEDFSKDTAFRVLERYRKVVPSFNDDIQGTGAVTLAGVLRACALKGEQLREQVIVIHGAGAGGAGVA
AAIREGMRQEGLGEDEIARRVFVLDSRGLLTDDRSLEAYKQPLATPKRLTDGWTGTDLLSVVREAGATVLLGLSGQGGIF
NEPIVRAVHAQTARPVVFPLSNPTANTEALPEDILRWTDGAAIVATGSPFPDVTLNGQTHVIGQGNNAFIFPGLGLAAVL
TRASEITDGMVAEAAYALADFTARTYPERTYPPTRALRDASRAVALRVARKAILEGVAREEKVQGLDDDALAAFIDSRFW
VPKYLPYRMAEGAGPDLG

Sequences:

>Translated_578_residues
MAHISRYYDVKRDPAGHRVLEVRVTGFPLLHLPLLNKSTAFTEEERRLLGLEGLLPPGVSTLGEQKERAYLRFRQQGTPL
EKHAYLRNLQDYNEVLFFALLENHLEEMLPIIYTPTVGDAVREFSRLYRYPRGFALSTAHVGRVRELLDNVHQQDVRMIV
ATDSSAILGIGDQGFGGMAISIGKLSLYTVAGGVGPDKTLPVELDVGTGRQDLIEDPLYLGARHPRLTGEAYDAFLDAFV
EAVRDRYPKAIIQWEDFSKDTAFRVLERYRKVVPSFNDDIQGTGAVTLAGVLRACALKGEQLREQVIVIHGAGAGGAGVA
AAIREGMRQEGLGEDEIARRVFVLDSRGLLTDDRSLEAYKQPLATPKRLTDGWTGTDLLSVVREAGATVLLGLSGQGGIF
NEPIVRAVHAQTARPVVFPLSNPTANTEALPEDILRWTDGAAIVATGSPFPDVTLNGQTHVIGQGNNAFIFPGLGLAAVL
TRASEITDGMVAEAAYALADFTARTYPERTYPPTRALRDASRAVALRVARKAILEGVAREEKVQGLDDDALAAFIDSRFW
VPKYLPYRMAEGAGPDLG
>Mature_577_residues
AHISRYYDVKRDPAGHRVLEVRVTGFPLLHLPLLNKSTAFTEEERRLLGLEGLLPPGVSTLGEQKERAYLRFRQQGTPLE
KHAYLRNLQDYNEVLFFALLENHLEEMLPIIYTPTVGDAVREFSRLYRYPRGFALSTAHVGRVRELLDNVHQQDVRMIVA
TDSSAILGIGDQGFGGMAISIGKLSLYTVAGGVGPDKTLPVELDVGTGRQDLIEDPLYLGARHPRLTGEAYDAFLDAFVE
AVRDRYPKAIIQWEDFSKDTAFRVLERYRKVVPSFNDDIQGTGAVTLAGVLRACALKGEQLREQVIVIHGAGAGGAGVAA
AIREGMRQEGLGEDEIARRVFVLDSRGLLTDDRSLEAYKQPLATPKRLTDGWTGTDLLSVVREAGATVLLGLSGQGGIFN
EPIVRAVHAQTARPVVFPLSNPTANTEALPEDILRWTDGAAIVATGSPFPDVTLNGQTHVIGQGNNAFIFPGLGLAAVLT
RASEITDGMVAEAAYALADFTARTYPERTYPPTRALRDASRAVALRVARKAILEGVAREEKVQGLDDDALAAFIDSRFWV
PKYLPYRMAEGAGPDLG

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=531, Percent_Identity=39.1713747645951, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI62420882, Length=559, Percent_Identity=37.7459749552773, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI62420880, Length=559, Percent_Identity=37.7459749552773, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI239049447, Length=559, Percent_Identity=37.7459749552773, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI4505145, Length=555, Percent_Identity=37.2972972972973, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI270265879, Length=462, Percent_Identity=39.8268398268398, Blast_Score=342, Evalue=5e-94,
Organism=Escherichia coli, GI87081919, Length=559, Percent_Identity=45.438282647585, Blast_Score=470, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17537199, Length=510, Percent_Identity=40, Blast_Score=356, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6322823, Length=567, Percent_Identity=40.9171075837742, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI281362672, Length=566, Percent_Identity=38.5159010600707, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI281362674, Length=566, Percent_Identity=38.5159010600707, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI21356279, Length=566, Percent_Identity=38.5159010600707, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24646386, Length=559, Percent_Identity=37.567084078712, Blast_Score=364, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24646388, Length=559, Percent_Identity=37.567084078712, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI78707242, Length=514, Percent_Identity=35.9922178988327, Blast_Score=324, Evalue=1e-88,
Organism=Drosophila melanogaster, GI78707238, Length=514, Percent_Identity=35.9922178988327, Blast_Score=324, Evalue=1e-88,
Organism=Drosophila melanogaster, GI78707240, Length=511, Percent_Identity=36.0078277886497, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI78707232, Length=504, Percent_Identity=34.1269841269841, Blast_Score=319, Evalue=4e-87,
Organism=Drosophila melanogaster, GI281363505, Length=501, Percent_Identity=34.1317365269461, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI78707236, Length=501, Percent_Identity=34.1317365269461, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI281363503, Length=497, Percent_Identity=34.0040241448692, Blast_Score=315, Evalue=7e-86,
Organism=Drosophila melanogaster, GI19922384, Length=523, Percent_Identity=28.2982791586998, Blast_Score=216, Evalue=4e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 63138; Mature: 63006

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHISRYYDVKRDPAGHRVLEVRVTGFPLLHLPLLNKSTAFTEEERRLLGLEGLLPPGVS
CCCCHHHHCCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCHH
TLGEQKERAYLRFRQQGTPLEKHAYLRNLQDYNEVLFFALLENHLEEMLPIIYTPTVGDA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHH
VREFSRLYRYPRGFALSTAHVGRVRELLDNVHQQDVRMIVATDSSAILGIGDQGFGGMAI
HHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHCEEEEEEECCCEEEECCCCCCCCEEE
SIGKLSLYTVAGGVGPDKTLPVELDVGTGRQDLIEDPLYLGARHPRLTGEAYDAFLDAFV
EECCEEEEEEECCCCCCCEEEEEEECCCCHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHH
EAVRDRYPKAIIQWEDFSKDTAFRVLERYRKVVPSFNDDIQGTGAVTLAGVLRACALKGE
HHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCH
QLREQVIVIHGAGAGGAGVAAAIREGMRQEGLGEDEIARRVFVLDSRGLLTDDRSLEAYK
HHCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHCEEEEEECCCCCCCCCHHHHHH
QPLATPKRLTDGWTGTDLLSVVREAGATVLLGLSGQGGIFNEPIVRAVHAQTARPVVFPL
HCCCCCHHHCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEC
SNPTANTEALPEDILRWTDGAAIVATGSPFPDVTLNGQTHVIGQGNNAFIFPGLGLAAVL
CCCCCCCHHCHHHHHHHCCCCEEEECCCCCCCEEECCCEEEEECCCCEEEECCCHHHHHH
TRASEITDGMVAEAAYALADFTARTYPERTYPPTRALRDASRAVALRVARKAILEGVARE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKVQGLDDDALAAFIDSRFWVPKYLPYRMAEGAGPDLG
HHHCCCCHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCC
>Mature Secondary Structure 
AHISRYYDVKRDPAGHRVLEVRVTGFPLLHLPLLNKSTAFTEEERRLLGLEGLLPPGVS
CCCHHHHCCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCHH
TLGEQKERAYLRFRQQGTPLEKHAYLRNLQDYNEVLFFALLENHLEEMLPIIYTPTVGDA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHH
VREFSRLYRYPRGFALSTAHVGRVRELLDNVHQQDVRMIVATDSSAILGIGDQGFGGMAI
HHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHCEEEEEEECCCEEEECCCCCCCCEEE
SIGKLSLYTVAGGVGPDKTLPVELDVGTGRQDLIEDPLYLGARHPRLTGEAYDAFLDAFV
EECCEEEEEEECCCCCCCEEEEEEECCCCHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHH
EAVRDRYPKAIIQWEDFSKDTAFRVLERYRKVVPSFNDDIQGTGAVTLAGVLRACALKGE
HHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCH
QLREQVIVIHGAGAGGAGVAAAIREGMRQEGLGEDEIARRVFVLDSRGLLTDDRSLEAYK
HHCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHCEEEEEECCCCCCCCCHHHHHH
QPLATPKRLTDGWTGTDLLSVVREAGATVLLGLSGQGGIFNEPIVRAVHAQTARPVVFPL
HCCCCCHHHCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEC
SNPTANTEALPEDILRWTDGAAIVATGSPFPDVTLNGQTHVIGQGNNAFIFPGLGLAAVL
CCCCCCCHHCHHHHHHHCCCCEEEECCCCCCCEEECCCEEEEECCCCEEEECCCHHHHHH
TRASEITDGMVAEAAYALADFTARTYPERTYPPTRALRDASRAVALRVARKAILEGVARE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKVQGLDDDALAAFIDSRFWVPKYLPYRMAEGAGPDLG
HHHCCCCHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA