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The map label for this gene is ung

Identifier: 94986158

GI number: 94986158

Start: 2166292

End: 2167029

Strand: Reverse

Name: ung

Synonym: Dgeo_2059

Alternate gene names: 94986158

Gene position: 2167029-2166292 (Counterclockwise)

Preceding gene: 94986159

Following gene: 94986157

Centisome position: 87.83

GC content: 67.07

Gene sequence:

>738_bases
ATGAGCGACCCTGCCTCCCTCTTTGGCCTGCCTCCTGATCCCGACGCGGCGCCCCCCGTGCACCTCCCCGGCGACTGGGA
CGAGGTGCTCAGGGGCGAGACAAGTCAACCCTACTTCCGTGAGCTCTGGGCCTTTGTTCAGCGTGAGCGGGAGGCCGGAC
CAGTGTATCCGGCGCCGGAAGATCTCTTCAGTGCCCTGCGCCTGACCCCATACCGCGACGTGAAGGTGCTGATTCTGGGC
CAGGATCCCTACCACGGCGCGGGACAGGCCCACGGCCTGAGCTTCAGCGTGCGGCCCGGCGTGCGGGTGCCCCCCAGCCT
CCAGAACATCTACAAGGAACTGCGCGACGACGTGGGCTTCAAGCCGCCTCGGCACGGCTCCCTGGTGTCCTGGGCGCGGC
AGGGGGTGTTGCTGCTGAATGCCGTCCTGACGGTCCGCGAAGGTGAGCCGAACAGCCACGCCGGGAAGGGCTGGGAAAGC
TTCACCGACGCGATCATCCGCGCCGTGAATGAGAAGCCCACGCGAGTGGTGTTTGTGCTGTGGGGGGCGTATGCCCGCAA
AAAGGCCAAGCTCGTCACCCAGCCGCAGCACGTCATCATCGAGTCGGCTCATCCCAGCCCCCTCAGCGTGGCGAAATTCC
TGGGGACGCGGCCTTTCAGCCGGATCAATGCCGCGCTGGAGGCGGCAGGCGAGACACCCATCGACTGGCAGCTTCCCGCT
GAGCCGGAGGTGGCGTGA

Upstream 100 bases:

>100_bases
GCGGCTGGGGGTGTAGGGAGCTTTCCGCTCCACTTCCACTTGAGCGTTCCTTGAGGCGAGAGCGCCTTCCCTGCCGGGAG
CGGGAGACTGAAGCTCGCCC

Downstream 100 bases:

>100_bases
TGGCGGGCCGTACCGACCTGCTGCACGAGGAGTACCTGCGCCGCGAGGGGAACAAACCCGGTGAGTTCCGCTACTTCTGG
CCGGACGGAGAAGAGTACAC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MSDPASLFGLPPDPDAAPPVHLPGDWDEVLRGETSQPYFRELWAFVQREREAGPVYPAPEDLFSALRLTPYRDVKVLILG
QDPYHGAGQAHGLSFSVRPGVRVPPSLQNIYKELRDDVGFKPPRHGSLVSWARQGVLLLNAVLTVREGEPNSHAGKGWES
FTDAIIRAVNEKPTRVVFVLWGAYARKKAKLVTQPQHVIIESAHPSPLSVAKFLGTRPFSRINAALEAAGETPIDWQLPA
EPEVA

Sequences:

>Translated_245_residues
MSDPASLFGLPPDPDAAPPVHLPGDWDEVLRGETSQPYFRELWAFVQREREAGPVYPAPEDLFSALRLTPYRDVKVLILG
QDPYHGAGQAHGLSFSVRPGVRVPPSLQNIYKELRDDVGFKPPRHGSLVSWARQGVLLLNAVLTVREGEPNSHAGKGWES
FTDAIIRAVNEKPTRVVFVLWGAYARKKAKLVTQPQHVIIESAHPSPLSVAKFLGTRPFSRINAALEAAGETPIDWQLPA
EPEVA
>Mature_244_residues
SDPASLFGLPPDPDAAPPVHLPGDWDEVLRGETSQPYFRELWAFVQREREAGPVYPAPEDLFSALRLTPYRDVKVLILGQ
DPYHGAGQAHGLSFSVRPGVRVPPSLQNIYKELRDDVGFKPPRHGSLVSWARQGVLLLNAVLTVREGEPNSHAGKGWESF
TDAIIRAVNEKPTRVVFVLWGAYARKKAKLVTQPQHVIIESAHPSPLSVAKFLGTRPFSRINAALEAAGETPIDWQLPAE
PEVA

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=221, Percent_Identity=51.131221719457, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI6224979, Length=221, Percent_Identity=51.131221719457, Blast_Score=229, Evalue=2e-60,
Organism=Escherichia coli, GI1788934, Length=223, Percent_Identity=54.2600896860987, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17556304, Length=214, Percent_Identity=48.5981308411215, Blast_Score=227, Evalue=4e-60,
Organism=Saccharomyces cerevisiae, GI6323620, Length=231, Percent_Identity=41.991341991342, Blast_Score=171, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_DEIGD (Q1IWN1)

Other databases:

- EMBL:   CP000359
- RefSeq:   YP_605522.1
- ProteinModelPortal:   Q1IWN1
- SMR:   Q1IWN1
- STRING:   Q1IWN1
- GeneID:   4058405
- GenomeReviews:   CP000359_GR
- KEGG:   dge:Dgeo_2059
- NMPDR:   fig|68909.1.peg.2244
- eggNOG:   COG0692
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- PhylomeDB:   Q1IWN1
- ProtClustDB:   PRK05254
- BioCyc:   DGEO319795:DGEO_2059-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 27000; Mature: 26869

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 82-82

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPASLFGLPPDPDAAPPVHLPGDWDEVLRGETSQPYFRELWAFVQREREAGPVYPAPE
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHH
DLFSALRLTPYRDVKVLILGQDPYHGAGQAHGLSFSVRPGVRVPPSLQNIYKELRDDVGF
HHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCC
KPPRHGSLVSWARQGVLLLNAVLTVREGEPNSHAGKGWESFTDAIIRAVNEKPTRVVFVL
CCCCCCCHHHHHHCCHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEE
WGAYARKKAKLVTQPQHVIIESAHPSPLSVAKFLGTRPFSRINAALEAAGETPIDWQLPA
ECHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCC
EPEVA
CCCCC
>Mature Secondary Structure 
SDPASLFGLPPDPDAAPPVHLPGDWDEVLRGETSQPYFRELWAFVQREREAGPVYPAPE
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHH
DLFSALRLTPYRDVKVLILGQDPYHGAGQAHGLSFSVRPGVRVPPSLQNIYKELRDDVGF
HHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCC
KPPRHGSLVSWARQGVLLLNAVLTVREGEPNSHAGKGWESFTDAIIRAVNEKPTRVVFVL
CCCCCCCHHHHHHCCHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEE
WGAYARKKAKLVTQPQHVIIESAHPSPLSVAKFLGTRPFSRINAALEAAGETPIDWQLPA
ECHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCC
EPEVA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA