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The map label for this gene is degP [H]

Identifier: 94986124

GI number: 94986124

Start: 2134119

End: 2135246

Strand: Reverse

Name: degP [H]

Synonym: Dgeo_2025

Alternate gene names: 94986124

Gene position: 2135246-2134119 (Counterclockwise)

Preceding gene: 94986132

Following gene: 94986123

Centisome position: 86.55

GC content: 70.48

Gene sequence:

>1128_bases
GTGCCTTCTGGCACCCTGTCTGCGCCGGGGCCGCTCTACACTGCGGGTGTGCGTGTACGCCCTTTGCCTTGGCTTCCCGT
GCTGTTGCTGCTGGCGCTGGCGGCCTACCTGCTGCCGGAGGGGCGTTTCACTCCGCAGGAGACAGGCGCGGCCTCGCCGC
CCGTCTCGCAGACCCTGCCCAACCAGCTTCCGGCTGAGACCCGTGAGCTGTTCATCCGCTCGCGCCCGGCCGTGGTGCGG
ATTGAGAGCCTAAATCCCAGCACGCGCATGGAGGGCATCGGCACCGGCTTTTTCATCTCCGAGGAGGGCCAGGTGCTGAC
GGCATACCACGTGGTGGGGAGCGGCCAGCTGTTTCAGGTCCAGACCCTCTCGGGTCGCCGCCTGCCTGCCCGCGTGACTG
CCTATGACGCGGGGGCGGACGTGGCGCTCCTCCAGGTGCAGGGCCACGGGCCTTTTCCGGTGCTGAAGCTCGCCACGCGG
CCGCCGCGCGTGGGCGAGACGGTGCTGGCGATCGGCAACAGCGGCGGCGACTTTCTGCAACCGCGCCGGGGACAATTGCT
GCGGCTAGGGGCGGAGGCAGGCCGCGCGGATTTCCCGCAGGGGACGTTGGAGATGACGGCCCCCCTCGCGCCCGGCGACA
GCGGCGGGCCGATCATCGACGGGAACGGGCAGGCGATCGGTGTGGTCAGCTATATCCGGGTGGACGACAGCGGCCAAACC
CGCACCAGCTACGCGGTGCCGGTGACCGAGGGCAACGCCCTGATCACGGCGCTGCGGAGCGGCGAGCAGCGGGACGTGCC
GGTGGCCGGGCTGGTGCTGGACGTGAATCACAGCGGCTTCACGGACCCACCCGGCGGCGTGATCTCCCGGGTGGCGCGGG
GCAGTCCGGCCGCCCGCGCGGGGCTGCGGGGCGCGACCCTTGACGAGAATGGGAACCTCGCGGGCCTGGGGGACGTGATC
ATCCGCGTGAATGGTCAGCGTACCCGTGACGCCAACGAGGTCATCAGCGCGATCCGCCGCGCGCGTGTGGGCGACACCAT
CACGCTGGGGTACGTGCGGGACGGACAGGAGCGCGAGGCCCGCATTGAACTGGTCGGGATGCGCACCCTCCCTGACCTAA
ACGAGTGA

Upstream 100 bases:

>100_bases
ACGAGATCGGGGTAGCCGAACACATGGGGTTCGGATTTGAGGAGCCAGAAACGGGGCGAAGCAGGGAGCATGGGAGGAAG
GTAGCGCGCGGACACCCTCG

Downstream 100 bases:

>100_bases
TCATTCGCCTCGCCGCCCCACCTCACCTGTCCGGCGCATCCTGAAGGCATGTCGCGCGCCTTTGTGAAGGAAGACGGGGG
CGAACGTTGGACCCCGCCCG

Product: peptidase S1 and S6, chymotrypsin/Hap

Products: NA

Alternate protein names: Antigen htrA [H]

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MPSGTLSAPGPLYTAGVRVRPLPWLPVLLLLALAAYLLPEGRFTPQETGAASPPVSQTLPNQLPAETRELFIRSRPAVVR
IESLNPSTRMEGIGTGFFISEEGQVLTAYHVVGSGQLFQVQTLSGRRLPARVTAYDAGADVALLQVQGHGPFPVLKLATR
PPRVGETVLAIGNSGGDFLQPRRGQLLRLGAEAGRADFPQGTLEMTAPLAPGDSGGPIIDGNGQAIGVVSYIRVDDSGQT
RTSYAVPVTEGNALITALRSGEQRDVPVAGLVLDVNHSGFTDPPGGVISRVARGSPAARAGLRGATLDENGNLAGLGDVI
IRVNGQRTRDANEVISAIRRARVGDTITLGYVRDGQEREARIELVGMRTLPDLNE

Sequences:

>Translated_375_residues
MPSGTLSAPGPLYTAGVRVRPLPWLPVLLLLALAAYLLPEGRFTPQETGAASPPVSQTLPNQLPAETRELFIRSRPAVVR
IESLNPSTRMEGIGTGFFISEEGQVLTAYHVVGSGQLFQVQTLSGRRLPARVTAYDAGADVALLQVQGHGPFPVLKLATR
PPRVGETVLAIGNSGGDFLQPRRGQLLRLGAEAGRADFPQGTLEMTAPLAPGDSGGPIIDGNGQAIGVVSYIRVDDSGQT
RTSYAVPVTEGNALITALRSGEQRDVPVAGLVLDVNHSGFTDPPGGVISRVARGSPAARAGLRGATLDENGNLAGLGDVI
IRVNGQRTRDANEVISAIRRARVGDTITLGYVRDGQEREARIELVGMRTLPDLNE
>Mature_374_residues
PSGTLSAPGPLYTAGVRVRPLPWLPVLLLLALAAYLLPEGRFTPQETGAASPPVSQTLPNQLPAETRELFIRSRPAVVRI
ESLNPSTRMEGIGTGFFISEEGQVLTAYHVVGSGQLFQVQTLSGRRLPARVTAYDAGADVALLQVQGHGPFPVLKLATRP
PRVGETVLAIGNSGGDFLQPRRGQLLRLGAEAGRADFPQGTLEMTAPLAPGDSGGPIIDGNGQAIGVVSYIRVDDSGQTR
TSYAVPVTEGNALITALRSGEQRDVPVAGLVLDVNHSGFTDPPGGVISRVARGSPAARAGLRGATLDENGNLAGLGDVII
RVNGQRTRDANEVISAIRRARVGDTITLGYVRDGQEREARIELVGMRTLPDLNE

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI24308541, Length=287, Percent_Identity=27.5261324041812, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4506141, Length=313, Percent_Identity=28.4345047923323, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI7019477, Length=297, Percent_Identity=30.3030303030303, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI22129776, Length=269, Percent_Identity=26.0223048327138, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786356, Length=284, Percent_Identity=26.7605633802817, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789629, Length=318, Percent_Identity=25.1572327044025, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789630, Length=325, Percent_Identity=24.6153846153846, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 39487; Mature: 39356

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSGTLSAPGPLYTAGVRVRPLPWLPVLLLLALAAYLLPEGRFTPQETGAASPPVSQTLP
CCCCCCCCCCCEEECCEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCHHHHCC
NQLPAETRELFIRSRPAVVRIESLNPSTRMEGIGTGFFISEEGQVLTAYHVVGSGQLFQV
CCCCHHHHHHHHCCCCCEEEEECCCCCHHHCCCCCCEEECCCCCEEEEEEEECCCCEEEE
QTLSGRRLPARVTAYDAGADVALLQVQGHGPFPVLKLATRPPRVGETVLAIGNSGGDFLQ
EECCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEECCCCCCCCCEEEEEECCCCCCCC
PRRGQLLRLGAEAGRADFPQGTLEMTAPLAPGDSGGPIIDGNGQAIGVVSYIRVDDSGQT
CCCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCEECCCCCEEEEEEEEEECCCCCC
RTSYAVPVTEGNALITALRSGEQRDVPVAGLVLDVNHSGFTDPPGGVISRVARGSPAARA
EEEEEEEEECCCEEEEEECCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHCCCCHHHC
GLRGATLDENGNLAGLGDVIIRVNGQRTRDANEVISAIRRARVGDTITLGYVRDGQEREA
CCCCCEECCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCE
RIELVGMRTLPDLNE
EEEEEEEECCCCCCC
>Mature Secondary Structure 
PSGTLSAPGPLYTAGVRVRPLPWLPVLLLLALAAYLLPEGRFTPQETGAASPPVSQTLP
CCCCCCCCCCEEECCEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCHHHHCC
NQLPAETRELFIRSRPAVVRIESLNPSTRMEGIGTGFFISEEGQVLTAYHVVGSGQLFQV
CCCCHHHHHHHHCCCCCEEEEECCCCCHHHCCCCCCEEECCCCCEEEEEEEECCCCEEEE
QTLSGRRLPARVTAYDAGADVALLQVQGHGPFPVLKLATRPPRVGETVLAIGNSGGDFLQ
EECCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEECCCCCCCCCEEEEEECCCCCCCC
PRRGQLLRLGAEAGRADFPQGTLEMTAPLAPGDSGGPIIDGNGQAIGVVSYIRVDDSGQT
CCCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCEECCCCCEEEEEEEEEECCCCCC
RTSYAVPVTEGNALITALRSGEQRDVPVAGLVLDVNHSGFTDPPGGVISRVARGSPAARA
EEEEEEEEECCCEEEEEECCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHCCCCHHHC
GLRGATLDENGNLAGLGDVIIRVNGQRTRDANEVISAIRRARVGDTITLGYVRDGQEREA
CCCCCEECCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCE
RIELVGMRTLPDLNE
EEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8027347 [H]