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The map label for this gene is cofH [H]

Identifier: 94986097

GI number: 94986097

Start: 2099344

End: 2100525

Strand: Reverse

Name: cofH [H]

Synonym: Dgeo_1998

Alternate gene names: 94986097

Gene position: 2100525-2099344 (Counterclockwise)

Preceding gene: 94986098

Following gene: 94986095

Centisome position: 85.14

GC content: 64.21

Gene sequence:

>1182_bases
ATGACTGCGCCGATGCATTCCGCGGGTGCCGAGATTCTTCAGAAGGCCGCGTCCGGTGAGCGCCTGAGTGCCCACGAGAT
CGAGGCATTGTATCGGCTGCCGCTGCCCGACGTGGCGGCGGTCGCGCACGAGCTGCGGCTGAGGCGCACCAACCCCGACG
TGGTGACCTTTCTGATCGACCGCAACATCAACTACACCAACATCTGCAACGTGGCCTGCAACTTCTGCGCCTTCTACCGC
ACGCGCAGGCAGCCGGACAGCTATACCCTCGACTACAACCAGATCAGCGCCAAGATCAGCGAGTTAGAGGCCGCCGGCGG
CACCCGCATCCTGATGCAGGGTGGCGTGAATGCCGAGCTGCCGCTGGATTACTACACCGGCTTGCTGCGGCACATCAAGG
CCCATCATCCCACTATCAAGATCGACGCCTTCTCGCCCGAAGAAGTGCTCTTTATGGAAAAGACCTTCGGCCTCACGCTC
GACGAGCTGCTCGACACGCTGATTGCAGCGGGGCTGGATGGGTTGCCCGGCGCGGGTGGCGAGATCCTGGAAGACGAGGT
GCGCAAGAAGGCAGCACCCGCTCGGATCCGCTCCGAGGACTGGTTTCGGATCATCGACGCCGCCCAGCGCAAGGGCCTCT
ATACGATCGCCACGATGGTGATCGGCTTCGGCGAAACCTATGCCCAGCGCACCCGTCATCTCCTGCAGATCCGCGAGCAG
CAGGACCGTGCCCAGGTCCTCTACGGCGGCAACGGCTTTTCCGGCTTCGCGATGTGGACCCTCCAAACCGAGCACACCCG
GCTGCACGGCAAGGCGCCCGGCGCCAGCGCTCACGAATACCTGCAGCAGCTTGCCGTCGCCCGGATCGCCCTCGACAACG
TGCCGAACCTCCAGGCGTCGTGGCCGGGACAGGGCTTCAAGGTTGCGCAGGCATCGCTCTACTACGGCGCAAACGACCTT
GGTTCCACCATGATGGAGGAGAACGTCGTCAGTGCGGCGGGCGGACACGGGCGCCACAAGGCGACGGTGCGCGAACTCAT
CCGGATTGCCGTGGACGCGGGCTTCACACCTGCGATCCGCAACAGCCGTTTTCAGATCATCGAGTGGCCCGACGTGGGTG
CGTATTTGGACCACGCGGAGATGAATCCCGAGGCCATGCGGGCGGTCGGTGCCTCGGGGTAA

Upstream 100 bases:

>100_bases
CCCGGAGCTGGCCGAAGAGCGGTGAGGGCGCGACCCCCCAGCACTGACTGGGCGCTTGTGCCGGGACGCCTGCCGCCCCT
CTGGGTGCTAGCCTGCCCCC

Downstream 100 bases:

>100_bases
GCGGGCACATGAGCCTCAGGTCCCCTCAGGGGAACAGCAGCGTTTGCGAGGCTCTGGCCTTTTCCCAGCGTGATTACGCG
GCGCCATCCAGCTGCGCTTG

Product: hypothetical protein

Products: NA

Alternate protein names: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2 [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTAPMHSAGAEILQKAASGERLSAHEIEALYRLPLPDVAAVAHELRLRRTNPDVVTFLIDRNINYTNICNVACNFCAFYR
TRRQPDSYTLDYNQISAKISELEAAGGTRILMQGGVNAELPLDYYTGLLRHIKAHHPTIKIDAFSPEEVLFMEKTFGLTL
DELLDTLIAAGLDGLPGAGGEILEDEVRKKAAPARIRSEDWFRIIDAAQRKGLYTIATMVIGFGETYAQRTRHLLQIREQ
QDRAQVLYGGNGFSGFAMWTLQTEHTRLHGKAPGASAHEYLQQLAVARIALDNVPNLQASWPGQGFKVAQASLYYGANDL
GSTMMEENVVSAAGGHGRHKATVRELIRIAVDAGFTPAIRNSRFQIIEWPDVGAYLDHAEMNPEAMRAVGASG

Sequences:

>Translated_393_residues
MTAPMHSAGAEILQKAASGERLSAHEIEALYRLPLPDVAAVAHELRLRRTNPDVVTFLIDRNINYTNICNVACNFCAFYR
TRRQPDSYTLDYNQISAKISELEAAGGTRILMQGGVNAELPLDYYTGLLRHIKAHHPTIKIDAFSPEEVLFMEKTFGLTL
DELLDTLIAAGLDGLPGAGGEILEDEVRKKAAPARIRSEDWFRIIDAAQRKGLYTIATMVIGFGETYAQRTRHLLQIREQ
QDRAQVLYGGNGFSGFAMWTLQTEHTRLHGKAPGASAHEYLQQLAVARIALDNVPNLQASWPGQGFKVAQASLYYGANDL
GSTMMEENVVSAAGGHGRHKATVRELIRIAVDAGFTPAIRNSRFQIIEWPDVGAYLDHAEMNPEAMRAVGASG
>Mature_392_residues
TAPMHSAGAEILQKAASGERLSAHEIEALYRLPLPDVAAVAHELRLRRTNPDVVTFLIDRNINYTNICNVACNFCAFYRT
RRQPDSYTLDYNQISAKISELEAAGGTRILMQGGVNAELPLDYYTGLLRHIKAHHPTIKIDAFSPEEVLFMEKTFGLTLD
ELLDTLIAAGLDGLPGAGGEILEDEVRKKAAPARIRSEDWFRIIDAAQRKGLYTIATMVIGFGETYAQRTRHLLQIREQQ
DRAQVLYGGNGFSGFAMWTLQTEHTRLHGKAPGASAHEYLQQLAVARIALDNVPNLQASWPGQGFKVAQASLYYGANDLG
STMMEENVVSAAGGHGRHKATVRELIRIAVDAGFTPAIRNSRFQIIEWPDVGAYLDHAEMNPEAMRAVGASG

Specific function: Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) [H]

COG id: COG1060

COG function: function code HR; Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. CofH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR019940
- InterPro:   IPR006638
- InterPro:   IPR020050
- InterPro:   IPR005244
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 43274; Mature: 43143

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPMHSAGAEILQKAASGERLSAHEIEALYRLPLPDVAAVAHELRLRRTNPDVVTFLID
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEEE
RNINYTNICNVACNFCAFYRTRRQPDSYTLDYNQISAKISELEAAGGTRILMQGGVNAEL
CCCCHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHCCCCEEEEECCCCCCC
PLDYYTGLLRHIKAHHPTIKIDAFSPEEVLFMEKTFGLTLDELLDTLIAAGLDGLPGAGG
CHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEHHHHCCCHHHHHHHHHHCCCCCCCCCCC
EILEDEVRKKAAPARIRSEDWFRIIDAAQRKGLYTIATMVIGFGETYAQRTRHLLQIREQ
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
QDRAQVLYGGNGFSGFAMWTLQTEHTRLHGKAPGASAHEYLQQLAVARIALDNVPNLQAS
CCCEEEEECCCCCCCEEEEEEEECHHEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
WPGQGFKVAQASLYYGANDLGSTMMEENVVSAAGGHGRHKATVRELIRIAVDAGFTPAIR
CCCCCCEEEHHHEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHC
NSRFQIIEWPDVGAYLDHAEMNPEAMRAVGASG
CCCEEEEECCCCCCHHCCCCCCHHHHHHHCCCC
>Mature Secondary Structure 
TAPMHSAGAEILQKAASGERLSAHEIEALYRLPLPDVAAVAHELRLRRTNPDVVTFLID
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEEE
RNINYTNICNVACNFCAFYRTRRQPDSYTLDYNQISAKISELEAAGGTRILMQGGVNAEL
CCCCHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHCCCCEEEEECCCCCCC
PLDYYTGLLRHIKAHHPTIKIDAFSPEEVLFMEKTFGLTLDELLDTLIAAGLDGLPGAGG
CHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEHHHHCCCHHHHHHHHHHCCCCCCCCCCC
EILEDEVRKKAAPARIRSEDWFRIIDAAQRKGLYTIATMVIGFGETYAQRTRHLLQIREQ
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
QDRAQVLYGGNGFSGFAMWTLQTEHTRLHGKAPGASAHEYLQQLAVARIALDNVPNLQAS
CCCEEEEECCCCCCCEEEEEEEECHHEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
WPGQGFKVAQASLYYGANDLGSTMMEENVVSAAGGHGRHKATVRELIRIAVDAGFTPAIR
CCCCCCEEEHHHEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHC
NSRFQIIEWPDVGAYLDHAEMNPEAMRAVGASG
CCCEEEEECCCCCCHHCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA