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The map label for this gene is moeA [H]

Identifier: 94986043

GI number: 94986043

Start: 2046132

End: 2047328

Strand: Reverse

Name: moeA [H]

Synonym: Dgeo_1944

Alternate gene names: 94986043

Gene position: 2047328-2046132 (Counterclockwise)

Preceding gene: 94986045

Following gene: 94986039

Centisome position: 82.98

GC content: 70.93

Gene sequence:

>1197_bases
ATGACTGATGCCCGTCCCGACTTTCCCATGCAGGTCAGCGTCGAGCAGGCGCGTGAGGGGCTGGCTGCGCTGCTGCCCAC
ACCCGGCACCGAAACCGTGACGTTGACGCAGAGCCGCGGACAAATCCTGGCCGCCGACCTCACCGCACGCGTGAGCCACC
CCAGCGCCACCGAGAGTGCCCTCGATGGCATCGCCGCCCGCGCGGCAGACACGCTGGGTGCCAGTGCTGCCGCGCCCGTG
CGTTTGCGCGTGGTGGGGGAGAGCCGCGCGGGCGTGCCCTTTTCGGGGACAGTCGGTCCGGGCGAGTGTGTGCGGATCTA
CACGGGGGCACCCCTTCCCCCCGGCACGGACGCGATCTGTCCGGTCGAGCAGCTGCGCGAGGACGGCCCGGAGCAGGTCC
TCCTGACCCGGCCCGCCAGCTCCGGCGACGTGCGTCAGGAGGGCAGCGATTTCCGGGCAGGGGAGGTTGTGCTGCGCGCT
GGCCTCCTCCTGACGCCGCCACGGGTTGCGTTGGCGGCGGCGCTCGGCCACGCCGAGATTCCGGTTCGGCGCCGCCTGCG
GGTCGCGCTGCTTTCGACCGGGGACGAGGTGATTGAACCCGGACAGCCCTTGCGGGCCGGCCAGGTGTACGACAGTAACC
GCTGCGGCCTGCAAGCCATGCTGGAGGAGTGCGGCTGTGAGGTGCTCTCCCTCGGCCACGCGCCCGACAGCCCCGAGCGG
CTGGCGCAGGCGGTCGAGGCGGCGGGCGGGGCGGACCTGCTGCTCACGAGTGGGGGCGTCAGCATGGGCCGTTACGACTT
CATGCGCGATCTGCTCCTAGAGCGGGGGCAGGTGATCTTCTGGAAGGTGCGAATGCGCCCCGGTGGTCCAGCTCTGCTGG
GGCGCTGGCAGGGTCTCCCGGTGTTTGGCCTGCCGGGCAACCCGGTGAGCAGTCTGGTCGTGTTTCGGGTGATTGTGCGC
CCGGCGCTAACCGGTCAGCTGGAGCCTGCGCTTCGGCTGCGGGCGGGCACGCCCTTTCGCGGCCTCCCGGACAAGGTCGC
CTATTGGCGCGGGGTGCTGCGCGAAGGACAGGTGGACGCCTACGAAAAGCAGGGGAGCGGGGTCCTGCGCTCCCTGAGTG
AGGCGAACGCACTGGTGGTGGTGCCCGAGGGGAGCGACGTGCAGGTGGGAGAGGAGGTGGAGGTGATGCTGCTCTGA

Upstream 100 bases:

>100_bases
TGCCTCCGCAGTCTACCCTCTCCGCCCAAGCTGAACCGGAAACGGCAAATGCCCGAACGCTTAACCGTTGTGCTGTTGCC
CGTGGTCCTATCCTGCCTGT

Downstream 100 bases:

>100_bases
GCCGCTCCGGATCACCCAAACCCGCAGCCGCCCGCTCAGCGGCAGCTTGGGGTGGCGGCGGACCGCTGGGTTCGTGCTAC
AGCAGCGCTCGGTGATCCGC

Product: MoeA-like protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTDARPDFPMQVSVEQAREGLAALLPTPGTETVTLTQSRGQILAADLTARVSHPSATESALDGIAARAADTLGASAAAPV
RLRVVGESRAGVPFSGTVGPGECVRIYTGAPLPPGTDAICPVEQLREDGPEQVLLTRPASSGDVRQEGSDFRAGEVVLRA
GLLLTPPRVALAAALGHAEIPVRRRLRVALLSTGDEVIEPGQPLRAGQVYDSNRCGLQAMLEECGCEVLSLGHAPDSPER
LAQAVEAAGGADLLLTSGGVSMGRYDFMRDLLLERGQVIFWKVRMRPGGPALLGRWQGLPVFGLPGNPVSSLVVFRVIVR
PALTGQLEPALRLRAGTPFRGLPDKVAYWRGVLREGQVDAYEKQGSGVLRSLSEANALVVVPEGSDVQVGEEVEVMLL

Sequences:

>Translated_398_residues
MTDARPDFPMQVSVEQAREGLAALLPTPGTETVTLTQSRGQILAADLTARVSHPSATESALDGIAARAADTLGASAAAPV
RLRVVGESRAGVPFSGTVGPGECVRIYTGAPLPPGTDAICPVEQLREDGPEQVLLTRPASSGDVRQEGSDFRAGEVVLRA
GLLLTPPRVALAAALGHAEIPVRRRLRVALLSTGDEVIEPGQPLRAGQVYDSNRCGLQAMLEECGCEVLSLGHAPDSPER
LAQAVEAAGGADLLLTSGGVSMGRYDFMRDLLLERGQVIFWKVRMRPGGPALLGRWQGLPVFGLPGNPVSSLVVFRVIVR
PALTGQLEPALRLRAGTPFRGLPDKVAYWRGVLREGQVDAYEKQGSGVLRSLSEANALVVVPEGSDVQVGEEVEVMLL
>Mature_397_residues
TDARPDFPMQVSVEQAREGLAALLPTPGTETVTLTQSRGQILAADLTARVSHPSATESALDGIAARAADTLGASAAAPVR
LRVVGESRAGVPFSGTVGPGECVRIYTGAPLPPGTDAICPVEQLREDGPEQVLLTRPASSGDVRQEGSDFRAGEVVLRAG
LLLTPPRVALAAALGHAEIPVRRRLRVALLSTGDEVIEPGQPLRAGQVYDSNRCGLQAMLEECGCEVLSLGHAPDSPERL
AQAVEAAGGADLLLTSGGVSMGRYDFMRDLLLERGQVIFWKVRMRPGGPALLGRWQGLPVFGLPGNPVSSLVVFRVIVRP
ALTGQLEPALRLRAGTPFRGLPDKVAYWRGVLREGQVDAYEKQGSGVLRSLSEANALVVVPEGSDVQVGEEVEVMLL

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=422, Percent_Identity=33.6492890995261, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI10880983, Length=422, Percent_Identity=33.6492890995261, Blast_Score=183, Evalue=2e-46,
Organism=Escherichia coli, GI1787049, Length=378, Percent_Identity=39.9470899470899, Blast_Score=242, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI25147659, Length=302, Percent_Identity=30.4635761589404, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17562606, Length=257, Percent_Identity=29.5719844357977, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17136978, Length=306, Percent_Identity=32.0261437908497, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24638841, Length=306, Percent_Identity=32.0261437908497, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 41957; Mature: 41825

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDARPDFPMQVSVEQAREGLAALLPTPGTETVTLTQSRGQILAADLTARVSHPSATESA
CCCCCCCCCCEEEHHHHHCCCEEECCCCCCCEEEEECCCCCEEEEEHEEECCCCCHHHHH
LDGIAARAADTLGASAAAPVRLRVVGESRAGVPFSGTVGPGECVRIYTGAPLPPGTDAIC
HHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCC
PVEQLREDGPEQVLLTRPASSGDVRQEGSDFRAGEVVLRAGLLLTPPRVALAAALGHAEI
CHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCEECCHHHHHHHHHCCCCC
PVRRRLRVALLSTGDEVIEPGQPLRAGQVYDSNRCGLQAMLEECGCEVLSLGHAPDSPER
CHHHHEEEEEECCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEECCCCCCCHHH
LAQAVEAAGGADLLLTSGGVSMGRYDFMRDLLLERGQVIFWKVRMRPGGPALLGRWQGLP
HHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHCCCCCCE
VFGLPGNPVSSLVVFRVIVRPALTGQLEPALRLRAGTPFRGLPDKVAYWRGVLREGQVDA
EECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCH
YEKQGSGVLRSLSEANALVVVPEGSDVQVGEEVEVMLL
HHHCCCHHHHHHHHCCEEEEEECCCCCCCCCCEEEEEC
>Mature Secondary Structure 
TDARPDFPMQVSVEQAREGLAALLPTPGTETVTLTQSRGQILAADLTARVSHPSATESA
CCCCCCCCCEEEHHHHHCCCEEECCCCCCCEEEEECCCCCEEEEEHEEECCCCCHHHHH
LDGIAARAADTLGASAAAPVRLRVVGESRAGVPFSGTVGPGECVRIYTGAPLPPGTDAIC
HHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCC
PVEQLREDGPEQVLLTRPASSGDVRQEGSDFRAGEVVLRAGLLLTPPRVALAAALGHAEI
CHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCEECCHHHHHHHHHCCCCC
PVRRRLRVALLSTGDEVIEPGQPLRAGQVYDSNRCGLQAMLEECGCEVLSLGHAPDSPER
CHHHHEEEEEECCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEECCCCCCCHHH
LAQAVEAAGGADLLLTSGGVSMGRYDFMRDLLLERGQVIFWKVRMRPGGPALLGRWQGLP
HHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHCCCCCCE
VFGLPGNPVSSLVVFRVIVRPALTGQLEPALRLRAGTPFRGLPDKVAYWRGVLREGQVDA
EECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCH
YEKQGSGVLRSLSEANALVVVPEGSDVQVGEEVEVMLL
HHHCCCHHHHHHHHCCEEEEEECCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]